Active Recombinant Human BMP8B Protein (Ala264-His402), N-His tagged, Animal-free, Carrier-free

• Cat.No.: BMP8B-283H
• Product Overview: Recombinant Human BMP8B Protein (Ala264-His402) with N-His tag was expressed in E. coli and Animal-free as well as Carrier-free.

Specification

• Description: Bone Morphogenetic Protein-8B (BMP-8B) is an extracellular multifunctional signaling cytokine that is also a member of the TGF-β family. BMP-8B can bind with the TGF-β receptor and is involved in SMAD protein signal transduction. BMP-8B plays a role in bone and cartilage development. It is expressed in brown adipose tissues and the hypothalamus, which can affect thermogenesis and susceptibility to obesity.
• Source: E. coli
• Species: Human
• Tag: His
• Form: Lyophilized
• Bio-activity: Measure by its ability to induce alkaline phosphatase production by ATDC5 cells. The ED50 for this effect is < 21.8 ng/mL.
• Molecular Mass: The protein has a calculated MW of 16.48 kDa.
  The protein migrates as 18 kDa under reducing condition (SDS-PAGE analysis).
• Protein length: Ala264-His402
• Endotoxin: < 0.01 EU/μg of the protein by the LAL method.
• Purity: >98% as determined by SDS-PAGE analysis.
• Storage: This product is stable after storage at:
  -20 centigrade for 12 months in lyophilized state from date of receipt.
  -20 or -80 centigrade for 1 month under sterile conditions after reconstitution.
  Avoid repeated freeze/thaw cycles.
• Storage Buffer: Lyophilized from a 0.2 μm filtered solution containing 20 mM sodium citrate and 0.2 M NaCl, pH 3.5.
• Reconstitution: It is recommended to reconstitute the lyophilized protein in 4 mM HCl to a concentration not less than 200 μg/mL and incubate the stock solution for at least 20 min to ensure sufficient re-dissolved.
• Shipping: The product is shipped with polar packs. Upon receipt, store it immediately at -20 centigrade or lower for long term storage.

Gene Information

• Gene Name: BMP8B bone morphogenetic protein 8b [ Homo sapiens (human) ]
• Official Symbol: BMP8B
• Synonyms: BMP8B; bone morphogenetic protein 8b; BMP8, bone morphogenetic protein 8 (osteogenic protein 2); bone morphogenetic protein 8B; OP 2; osteogenic protein 2; BMP-8; BMP-8B; bone morphogenetic protein 8 (osteogenic protein 2); dJ118J21.1 (bone morphogenetic protein 8 (osteogenic protein 2)); OP2; BMP8; MGC131757
• Gene ID: 656
• mRNA Refseq: NM_001720
• Protein Refseq: NP_001711
• MIM: 602284
• UniProt ID: P34820

Reviews

07/06/2021

The knowledgeable and responsive support team is dedicated to resolving issues and providing solutions that are tailored to specific experimental requirements.

09/16/2019

This enables researchers to confidently incorporate BMP8B into their studies, knowing that they have access to a reliable and well-characterized protein that will contribute to robust and accurate results.

04/09/2016

the high-quality BMP8B protein is available in various forms, including recombinant proteins and purified samples, enabling researchers to select the most suitable format for their specific experimental setup.

Q&As

Are there any clinical implications of BMP8B in obesity treatment?

Research suggests that BMP8B could be a potential target for obesity treatment due to its involvement in metabolic regulation, but more studies are needed to fully understand its therapeutic potential.

How is BMP8B linked to cardiovascular health?

BMP8B has been implicated in cardiovascular health, with studies suggesting its involvement in vascular smooth muscle cell function and potential implications for cardiovascular diseases.

Does BMP8B play a role in cancer development or progression?

The role of BMP8B in cancer is still under investigation. Some studies suggest it may influence cancer cell behavior, but the exact mechanisms are not fully understood.

Are there any known side effects associated with manipulating BMP8B levels?

The potential side effects of manipulating BMP8B levels are not yet fully elucidated, and this is an area of active research.

How does BMP8B contribute to fertility?

BMP8B has been associated with female fertility, and studies indicate its involvement in the regulation of ovulation and the menstrual cycle.