Active Recombinant Human BMP8B Protein

• Cat.No.: BMP8B-018H
• Product Overview: The mature recombinant human BMP-8b protein consists of 139 amino acids (264-402) without tag was expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Protein Length: 264-402 a.a.
• Description: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The encoded protein stimulates thermogenesis in brown adipose tissue. Expression of this gene may be downregulated in pancreatic cancer. This gene may have arose from a gene duplication event and its gene duplicate is also present on chromosome 1.
• Bio-activity: Measured by its ability to inhibit the cell growth of DU145 human prostate carcinoma cells. The ED50 for this effect is 0.7-3.5 μg/mL.
• Molecular Mass: 16 kDa
• Product-Related Proteins: 264-402
• Endotoxin: < 0.1 EU/μg of the protein as determined by the LAL method
• Purity: > 95 % as determined by SDS-PAGE
• Storage: At -80 centigrade. Avoid repeated freeze-thaw cycles.
• Storage Buffer: PBS

Gene Information

• Gene Name: BMP8B bone morphogenetic protein 8b [ Homo sapiens (human) ]
• Official Symbol: BMP8B
• Synonyms: BMP8B; bone morphogenetic protein 8b; OP2; BMP8; bone morphogenetic protein 8B; Names; bone morphogenetic protein 8 (osteogenic protein 2); osteogenic protein 2
• Gene ID: 656
• mRNA Refseq: NM_001720
• Protein Refseq: NP_001711
• MIM: 602284
• UniProt ID: P34820