Active Recombinant Human BMP8B Protein

• Cat.No.: BMP8B-018H
• Product Overview: The mature recombinant human BMP-8b protein consists of 139 amino acids (264-402) without tag was expressed in E. coli.

Specification

• Description: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The encoded protein stimulates thermogenesis in brown adipose tissue. Expression of this gene may be downregulated in pancreatic cancer. This gene may have arose from a gene duplication event and its gene duplicate is also present on chromosome 1.
• Source: E. coli
• Species: Human
• Bio-activity: Measured by its ability to inhibit the cell growth of DU145 human prostate carcinoma cells. The ED50 for this effect is 0.7-3.5 μg/mL.
• Molecular Mass: 16 kDa
• Product-Related Proteins: 264-402
• Endotoxin: < 0.1 EU/μg of the protein as determined by the LAL method
• Purity: > 95 % as determined by SDS-PAGE
• Storage: At -80 centigrade. Avoid repeated freeze-thaw cycles.
• Storage Buffer: PBS
• Protein length: 264-402

Gene Information

• Gene Name: BMP8B bone morphogenetic protein 8b [ Homo sapiens (human) ]
• Official Symbol: BMP8B
• Synonyms: BMP8B; bone morphogenetic protein 8b; OP2; BMP8; bone morphogenetic protein 8B; Names; bone morphogenetic protein 8 (osteogenic protein 2); osteogenic protein 2
• Gene ID: 656
• mRNA Refseq: NM_001720
• Protein Refseq: NP_001711
• MIM: 602284
• UniProt ID: P34820

Reviews

07/06/2021

The knowledgeable and responsive support team is dedicated to resolving issues and providing solutions that are tailored to specific experimental requirements.

09/16/2019

This enables researchers to confidently incorporate BMP8B into their studies, knowing that they have access to a reliable and well-characterized protein that will contribute to robust and accurate results.

04/09/2016

the high-quality BMP8B protein is available in various forms, including recombinant proteins and purified samples, enabling researchers to select the most suitable format for their specific experimental setup.

Q&As

Are there any clinical implications of BMP8B in obesity treatment?

Research suggests that BMP8B could be a potential target for obesity treatment due to its involvement in metabolic regulation, but more studies are needed to fully understand its therapeutic potential.

How is BMP8B linked to cardiovascular health?

BMP8B has been implicated in cardiovascular health, with studies suggesting its involvement in vascular smooth muscle cell function and potential implications for cardiovascular diseases.

Does BMP8B play a role in cancer development or progression?

The role of BMP8B in cancer is still under investigation. Some studies suggest it may influence cancer cell behavior, but the exact mechanisms are not fully understood.

Are there any known side effects associated with manipulating BMP8B levels?

The potential side effects of manipulating BMP8B levels are not yet fully elucidated, and this is an area of active research.

How does BMP8B contribute to fertility?

BMP8B has been associated with female fertility, and studies indicate its involvement in the regulation of ovulation and the menstrual cycle.