CAMK2A

  • Official Full Name

    calcium/calmodulin-dependent protein kinase II alpha

  • Overview

    The product of this gene belongs to the serine/threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This calcium calmodulin-dependent protein kinase is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Nov 2008]
  • Synonyms

    CAMK2A; calcium/calmodulin-dependent protein kinase II alpha; CAMKA; calcium/calmodulin-dependent protein kinase type II subunit alpha; CaMKIINalpha; CaMK-II alpha subunit; caMK-II subunit alpha; CaM-kinase II alpha chain; CaM kinase II alpha subunit; caM kinase II subunit alpha; calcium/calmodulin-dependent protein kinase II alpha-B subunit; calcium/calmodulin-dependent protein kinase type II alpha chain; calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Insect (sf21)
  • Insect Cell
  • Insect Cells
  • Mammalian Cell
  • Mammalian cells
  • S.frugiperda
  • Sf21
  • Sf9 Insect Cell
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|T7
  • Myc
  • DDK
  • MYC
  • N/A
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CAMK2A-32HFL Active Recombinant Full Length Human CAMK2A Protein, N-His-tagged Sf21 His Full Length
Human CAMK2A-264H Recombinant Human CAMK2A, GST-tagged, Active Sf9 Insect Cell GST
Human CAMK2A-26210TH Recombinant Human CAMK2A N/A
Human CAMK2A-777H Active Recombinant Human CAMK2A protein, GST-tagged Insect Cells GST Met1-His478
Human CAMK2A-1186H Recombinant Human CAMK2A, His-tagged Insect Cell His
Human CAMK2A-0326H Recombinant Human CAMK2A Protein, GST-Tagged Wheat Germ GST
Human CAMK2A-7881HCL Recombinant Human CAMK2A 293 Cell Lysate HEK293 N/A
Human CAMK2A-7880HCL Recombinant Human CAMK2A 293 Cell Lysate HEK293 N/A
Human CAMK2A-9765HF Active Recombinant Full Length Human CAMK2A Protein, GST-tagged Insect (sf21) GST 1-478(end)
Human CAMK2A-2759HF Recombinant Full Length Human CAMK2A Protein, GST-tagged In Vitro Cell Free System GST 478 amino acids
Human CAMK2A-6286H Recombinant Human CAMK2A Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human CAMK2A-3395H Recombinant Human CAMK2A protein, His-tagged E.coli His 1-271 aa
Human CAMK2A-508HFL Active Recombinant Full Length Human CAMK2A Protein, C-Flag-tagged Mammalian cells Flag
Human CAMK2A-490H-B Recombinant Human CAMK2A Protein Pre-coupled Magnetic Beads HEK293
Human CAMK2A-0178H Recombinant Human CAMK2A Protein (A2-H478), GST tagged Insect Cell GST A2-H478
Human CAMK2A-0177H Recombinant Human CAMK2A Protein (A2-H478), Tag Free Insect Cell No tag A2-H478
Human CAMK2A-490H Recombinant Human CAMK2A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse CAMK2A-2666M Recombinant Mouse CAMK2A Protein Mammalian Cell His
Mouse CAMK2A-1197M Recombinant Mouse CAMK2A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse CAMK2A-1197M-B Recombinant Mouse CAMK2A Protein Pre-coupled Magnetic Beads HEK293
Mouse Camk2a-751M Recombinant Mouse Camk2a Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rat Camk2a-746R Active Recombinant Rat Camk2a S.frugiperda N/A
Rat Camk2a-7975R Recombinant Rat Camk2a protein, His & T7-tagged E.coli His/T7 Met1~His478 (Accession # P11275)
Rat CAMK2A-1101R Recombinant Rat CAMK2A Protein Mammalian Cell His
Rat CAMK2A-765R Recombinant Rat CAMK2A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat CAMK2A-765R-B Recombinant Rat CAMK2A Protein Pre-coupled Magnetic Beads HEK293
Zebrafish CAMK2A-2492Z Recombinant Zebrafish CAMK2A Mammalian Cell His
Chicken CAMK2A-5868C Recombinant Chicken CAMK2A Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

CAMK2A involved in several pathways and played different roles in them. We selected most pathways CAMK2A participated on our site, such as ErbB signaling pathway, Calcium signaling pathway, cAMP signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CAMK2A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
ErbB signaling pathwayPRKCBA;PIK3CB;CDKN1BB;AREGB;MAPK9;GRB2A;PIK3R2;PLCG1;MAP2K2A
Calcium signaling pathwayPPP3R1;P2RX7;PPIFB;PDE1C;PPP3CCA;SLC8A1B;PLCZ1;TACR2;PTK2B
cAMP signaling pathwayMAP2K1;ATP2B4;SOX9;NPR1;BDNF;MAP2K2;RELA;GRIA3;ARAP3
HIF- signaling pathwayPRKCA;ARNT;GM5506;RPS6KB2;INS;ERBB2;Il6ra;ANGPT4;CAMK2D
Oocyte meiosisYWHAE1;MAP2K1;YWHAZ;FBXW11A;PPP3CA;YWHAG;PPP1CC;ANAPC13;CALM2
Adrenergic signaling in cardiomyocytesGNAI3;SLC14A2;ATP2B4;CAMK2D1;ACTC1A;CACNB4;ATF2;PPP2R2A;CREB3L2
Wnt signaling pathwayWNT1;AXIN1;PLCB3;FZD3A;WNT5B;TRP53;PPP3CB;CER1;PRKCG
Circadian entrainmentMTNR1B;GNAQ;PRKACA;CAMK2G;CALM3;KCNJ3;Adcy4;CALM1;PRKCB
Long-term potentiationCAMK2D;PRKCB;RPS6KA6;CAMK4;PPP3R2;RAF1;GRIA1;GRIN2B;PPP3CB
Neurotrophin signaling pathwaySH2B1;MAP3K3;SHC2;RAP1B;MAP2K1;RAP1A;RPS6KA6;RIPK2;IRAK1
Cholinergic synapseKCNQ4;KCNJ12;PIK3R2;FOS;GNGT1;CREB3;CHRM1;GNB1;GNB3
Dopaminergic synapseCREB3L3;PPP2CA;CALM2;ITPR1;GNAL;PPP3CB;PLCB1;GNG13;PRKACG
Olfactory transductionOLFR867;OR4C12;OLFR480;OLFR186;PRKG2;PRKG1;OLFR507;OR52B2;OLFR149
Inflammatory mediator regulation of TRP channelsPRKCD;ACCN4;PIK3R5;PLCB3;GNAS;TRPV3;ASIC1;IL1R1;PIK3CA
Insulin secretionPDX1;SNAP25;INS2;PRKCG;PLCB1;CREB3L2;KCNMB3;ATP1B3;RYR2
GnRH signaling pathwayEGFRA;SRC;ADCY1B;PRKACB;CACNA1D;NRAS;MAP2K2;GRB2B;MAPK12A
MelanogenesisGNAS;CALM2A;GNAO1;FZD7B;CALM2B;WNT2BB;GNA11A;MAP2K2A;FZD5
Oxytocin signaling pathwayPLCB1;CACNG4;CAMK2B;CALM2;NPR1;MEF2C;GNAI3;CALM1;KRAS
Aldosterone synthesis and secretionGNA11;HSD3B6;CREB3L4;CAMK4;PRKACB;KCNK9;AGTR1;CREB3L2;ATF4
Gastric acid secretionATP1A1;ATP4B;PLCB3;PRKCA;SST;KCNJ16;CCKBR;GNAI2;CALM1
TuberculosisVDR;IFNA1;PMAP-36;CAP18;TGFB3;MAPK9;IFNA7;RHOA;SRC
Proteoglycans in cancerTWIST2;WNT1;PRKACB;CAV2;FZD9;WNT8A;PTPN11;WNT5B;MAPK13
GliomaCAMK2B;PLCG2;CALM4;PTEN;PIK3R2;MAP2K2;PRKCG;CAMK2D;CALM1

CAMK2A has several biochemical functions, for example, ATP binding, calmodulin binding, calmodulin-dependent protein kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CAMK2A itself. We selected most functions CAMK2A had, and list some proteins which have the same functions with CAMK2A. You can find most of the proteins on our site.

Function Related Protein
ATP bindingPDGFRA;DDX52;DHX9;PSMC1;DDX19A;Fert2;ANKK1;TTLL2;PLK2
calmodulin bindingSMTNL1;SNTB2;CAMK1G;SPHK1;MYH9;PHKB;CAMSAP1;EPB41;IQCB1
calmodulin-dependent protein kinase activityPTK2B;MKNK1;CAMK2B;MYLK2;MAPKAPK2B;DAPK2A;CAMK1D;CAMK2D2;CAMK2B1
glutamate receptor bindingGRIN2A;CAMK2A;PLCG1;SYNDIG1;GRIN1
kinase activitySBK3;MAP2K2A;STK25B;AK5L;PTK2AA;PFKFB4L;NADKD1;HMGXB3;TPK1
protein bindingC2orf63;BAAT;FBN1;MID1IP1;AMPH;ZFP36;SFRP1;FEM1B;BBS5
protein homodimerization activityALDH1A3;UGT1A2;PEX7;Fzd4;P2RX7;HPGD;MCL1B;PVRL2L;BHLHA15
protein serine/threonine kinase activityMAP3K11;SBK1;KSR2;CDK1;BMPR1B;TRPM6;MAPK4;PLK4;NEK11

CAMK2A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CAMK2A here. Most of them are supplied by our site. Hope this information will be useful for your research of CAMK2A.

GRIN2B; ACTN1; CAMK2D; calcium(2+); PPM1F; fem-2; RCHY1; Ppm1f; HSP90AB1; NR2F6; CALM1; CAMK2B; SMAD2; DLG3; CHMP5

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