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Official Full Name calcium/calmodulin-dependent protein kinase II alpha
Background The product of this gene belongs to the serine/threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This calcium calmodulin-dependent protein kinase is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Nov 2008]
Synonyms CAMK2A; calcium/calmodulin-dependent protein kinase II alpha; CAMKA; calcium/calmodulin-dependent protein kinase type II subunit alpha; CaMKIINalpha; CaMK-II alpha subunit; caMK-II subunit alpha; CaM-kinase II alpha chain; CaM kinase II alpha subunit; caM kinase II subunit alpha; calcium/calmodulin-dependent protein kinase II alpha-B subunit; calcium/calmodulin-dependent protein kinase type II alpha chain; calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha;
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Insect Cell
    • Mammalian Cell
    • S.frugiperda
    • Sf9 Insect Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • T7
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CAMK2A-0326H Recombinant Human CAMK2A Protein, GST-Tagged Wheat Germ GST
    Human CAMK2A-1186H Recombinant Human CAMK2A, His-tagged Insect Cell His
    Human CAMK2A-26210TH Recombinant Human CAMK2A N/A
    Human CAMK2A-264H Recombinant Human CAMK2A, GST-tagged, Active Sf9 Insect Cell GST
    Human CAMK2A-777H Recombinant Human CAMK2A, GST tagged Insect Cell GST
    Human CAMK2A-7880HCL Recombinant Human CAMK2A 293 Cell Lysate HEK293 N/A
    Human CAMK2A-7881HCL Recombinant Human CAMK2A 293 Cell Lysate HEK293 N/A
    Mouse CAMK2A-2666M Recombinant Mouse CAMK2A Protein Mammalian Cell His
    Rat CAMK2A-1101R Recombinant Rat CAMK2A Protein Mammalian Cell His
    Rat Camk2a-746R Recombinant Rat Camk2a S.frugiperda N/A
    Rat Camk2a-7975R Recombinant Rat Camk2a protein, His & T7-tagged E.coli His/T7
    Chicken CAMK2A-5868C Recombinant Chicken CAMK2A Mammalian Cell His
    Zebrafish CAMK2A-2492Z Recombinant Zebrafish CAMK2A Mammalian Cell His

    camk2a involved in several pathways and played different roles in them. We selected most pathways camk2a participated on our site, such as ErbB signaling pathway, Calcium signaling pathway, cAMP signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with camk2a were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    ErbB signaling pathway RPS6KB1; MTOR; GRB2A; NRG2B; PLCG2; AREG; AKT2; PAK3; MAPK8; TGFA
    Calcium signaling pathway ATP2A1; SPHK2; ATP2B1; GNA15.1; P2RX4B; ADRa1A; CHRM2A; HTR2CL1; PTK2BB; P2RX3B
    cAMP signaling pathway PDE4C; GRIN3B; CREB3L3; PIK3R2; PIK3CD; GLI1; NFKBIA; ROCK2; FSHB; PPP1CA
    HIF- signaling pathway PDHB; PDHA1; IFNG; NFKB1; VHL; PIK3R3; STAT3; NOX1; RELA; LTBR
    Adrenergic signaling in cardiomyocytes CREB3L2; SCN1BA; PPP1CAA; ATP1B3B; CACNB2; ATP1B1B; ATP1A3A; RYR2; ATP1B3A; PRKCA
    Wnt signaling pathway SFRP1; FBXW11; WNT6; NLK; RHOAA; SFRP2; DAAM1; CAMK2D2; WNT16; NFATC4
    Circadian entrainment PLCB4; CAMK2B; PER2; CALM1; KCNJ9; GNAQ; GNG11; GRIA4; PRKCG; GRIN2C
    Long-term potentiation GNAQ; RAF1; PLCB3; GRM1; PPP1CB; PRKACB; PPP1R1A; MAP2K1; CALML3; PRKCG
    Neurotrophin signaling pathway Fasl; MAPK10; FASLG; PIK3CB; NFKBIE; CDC42; HRAS; RAF1; ARHGDIA; CALM2
    Cholinergic synapse KCNQ5; KCNJ14; GNG10; GNAO1; GNAQ; PIK3R1; ATF4; PLCB2; PLCB1; CAMK2D
    Dopaminergic synapse GRIA2; GNAI1; CALML5; KCNJ3; PPP2R2A; GNG8; GNG3; PPP2R3A; PPP2R2D; CREB3
    Olfactory transduction ANO2; OR10H1; OLFR867; OR1L1; OR52J3; OR2L2; OR10A5; OLFR146; RGS2; OLFR154
    Inflammatory mediator regulation of TRP channels PRKCD; ACCN4; PRKCH; PPP1CA; PTGER2; CYP2C55; CYP2C50; ASIC3; PLCB1; CALML5
    Insulin secretion STX1A; SLC2A1; PRKACA; CREB3L2; FFAR1; GNAQ; RYR2; KCNMB1; CAMK2A; CCKAR
    GnRH signaling pathway CAMK2B; CALM1; ADCY1A; MAP2K4A; GRB2; MAP3K1; PRKCB; GNA11A; CAMK2B1; CACNA1D
    Melanogenesis KITLG; KITLGB; PRKACBB; Fzd4; CREB3L3; MITFB; GNA15.4; FZD7B; RAF1; WNT11R
    Oxytocin signaling pathway PRKAB1; PIK3R5; CACNB1; CAMK2B; CACNG8; MYLK2; CAMK1; PRKAG3; PRKCB; PTGS2
    Glucagon signaling pathway PLCB1; PRKACA; LDHB; PRKACG; SIRT1; PKM; PYGB; PPP3CB; GYS1; PRKAG3
    Aldosterone synthesis and secretion CALM3; CAMK1G; CAMK2B; NR4A1; CAMK1; CYP21A2; CAMK1D; PLCB2; PRKD1; NR4A2
    Gastric acid secretion PRKACA; CCKBR; MYLK3; CAMK2A; CALM4; PLCB2; GNAI1; GNAI2; GNAQ; HRH2
    Amphetamine addiction CREB5; GRIA1; SLC6A3; GRIN2B; PRKACA; CAMK4; SIRT1; MAOB; PDYN; SLC18A1
    Tuberculosis IFNA10; ATP6V0A1; MAPK9; NOS2; MAPK10; CD209; AKT1; RFXANK; ATP6V0A2; HLA-DMB
    Proteoglycans in cancer PRKCG; SMO; RAC1; FLNA; Casp3; ERBB4; PIK3CA; SRC; IGF1; PPP1R12A

    camk2a has several biochemical functions, for example, ATP binding, calmodulin binding, calmodulin-dependent protein kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by camk2a itself. We selected most functions camk2a had, and list some proteins which have the same functions with camk2a. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding MARK3; HSPA9; CLPB; MAT2A; AK2; BAT1; GC2; OAS2; UBE2J2; SCYL3
    calmodulin binding CAMK2A; ATPIF1; MARCKSL1; MAPKAPK5; MYH1E; MYH1B; MAP6D1; CAMK1GA; CAMK1GB; CNN1A
    calmodulin-dependent protein kinase activity NETO2; PNCK; MYLK2; MAPKAPK5; SLC14A2; DAPK1; MKNK1; CAMK2G1; MKNK2B; MYLK3
    glutamate receptor binding GRIN2A; PLCG1; CAMK2A; GRIN1; SYNDIG1
    kinase activity PKZ; NMRK2; ACVR2AA; CAMKK1A; STK25B; MAPKAPK2B; CKBA; PRPS1; AK5L; TAOK1
    protein binding ANO6; SLC30A1; IPO5; AZU1; CORO1B; TNFAIP8; NPHS1; CAPN1; MYH9; AP5S1
    protein homodimerization activity NR2F2; HES1; HHEX; SYT16; Il6ra; PARK7; TFRC; SLK; NFS1; NRF1
    protein serine/threonine kinase activity TAF1L; STK32C; MAP4K3; STK33; PASK; LMTK3; PRKAA2; STK31; PSKH1; TTK

    camk2a has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with camk2a here. Most of them are supplied by our site. Hope this information will be useful for your research of camk2a.

    GRIN2B; ACTN1; CAMK2D; calcium(2+); PPM1F; fem-2; RCHY1; Ppm1f; HSP90AB1; NR2F6; CALM1; CAMK2B; SMAD2; DLG3; CHMP5

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