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Official Full Name calcium/calmodulin-dependent protein kinase II alpha
Background The product of this gene belongs to the serine/threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This calcium calmodulin-dependent protein kinase is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Nov 2008]
Synonyms CAMK2A; calcium/calmodulin-dependent protein kinase II alpha; CAMKA; calcium/calmodulin-dependent protein kinase type II subunit alpha; CaMKIINalpha; CaMK-II alpha subunit; caMK-II subunit alpha; CaM-kinase II alpha chain; CaM kinase II alpha subunit; caM kinase II subunit alpha; calcium/calmodulin-dependent protein kinase II alpha-B subunit; calcium/calmodulin-dependent protein kinase type II alpha chain; calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha;
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Insect Cell
    • Mammalian Cell
    • S.frugiperda
    • Sf9 Insect Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • T7
    • MYC/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CAMK2A-0326H Recombinant Human CAMK2A Protein, GST-Tagged Wheat Germ GST
    Human CAMK2A-1186H Recombinant Human CAMK2A, His-tagged Insect Cell His
    Human CAMK2A-26210TH Recombinant Human CAMK2A N/A
    Human CAMK2A-264H Recombinant Human CAMK2A, GST-tagged, Active Sf9 Insect Cell GST
    Human CAMK2A-6286H Recombinant Human CAMK2A Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human CAMK2A-777H Recombinant Human CAMK2A, GST tagged Insect Cell GST
    Human CAMK2A-7880HCL Recombinant Human CAMK2A 293 Cell Lysate HEK293 N/A
    Human CAMK2A-7881HCL Recombinant Human CAMK2A 293 Cell Lysate HEK293 N/A
    Mouse CAMK2A-2666M Recombinant Mouse CAMK2A Protein Mammalian Cell His
    Mouse Camk2a-751M Recombinant Mouse Camk2a Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Rat CAMK2A-1101R Recombinant Rat CAMK2A Protein Mammalian Cell His
    Rat Camk2a-746R Recombinant Rat Camk2a S.frugiperda N/A
    Rat Camk2a-7975R Recombinant Rat Camk2a protein, His & T7-tagged E.coli His/T7
    Chicken CAMK2A-5868C Recombinant Chicken CAMK2A Mammalian Cell His
    Zebrafish CAMK2A-2492Z Recombinant Zebrafish CAMK2A Mammalian Cell His

    camk2a involved in several pathways and played different roles in them. We selected most pathways camk2a participated on our site, such as ErbB signaling pathway, Calcium signaling pathway, cAMP signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with camk2a were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    ErbB signaling pathway NRG2; AREGB; NRAS; MAP2K2; AKT3A; PTK2AA; PLCG2; PTK2AB; CAMK2D1; BADB
    Calcium signaling pathway PTGFR; ERBB3; PHKG2; ADORA2A; PLCG2; PHKG1A; PRKACAB; SLC25A4; ATP2A2B; GNA15.1
    cAMP signaling pathway HTR6; GRIN2B; TNNI3; MAPK1; NPY1R; FOS; AMH; RYR2; PPP1CB; BDNF
    HIF- signaling pathway CAMK2B; NOS3; Trf; RBX1; TFRC; IFNG; HK3; NOX1; RPS6; HKDC1
    Oocyte meiosis RPS6KA1; ANAPC1; PPP2R5A; CPEB3; RPS6KA2; CDC20; PPP2R5CB; CDC25C; BUB1; CUL1
    Adrenergic signaling in cardiomyocytes ADRA1D; ATP1B1B; TPM3; CACNG6A; CALML5; MAPK12A; CACNA2D1A; ATP1A3A; CACNB4; CACNG6
    Wnt signaling pathway LRP6; TP53; RHOAA; PPP3CC; WNT9A; NLK2; BAMBIB; FZD7B; SOST; NKD2B
    Circadian entrainment GNAI2; CACNA1G; NOS1AP; GRIN2C; KCNJ3; PRKCB; PLCB4; CAMK2G; GUCY1A3; GRIA4
    Long-term potentiation PLCB3; KRAS; PLCB4; NRAS; CAMK2G; GRM5; RPS6KA2; GRIA1; GNAQ; ARAF
    Neurotrophin signaling pathway Fasl; PTPN11; PIK3R1; ARHGDIA; HRAS; MAP3K1; SORT1; IRAK4; SHC2; PIK3R2
    Cholinergic synapse CREB3L4; CHRNA4; KCNQ1; GNAI3; SLC5A7; GNG13; CREB5; ACHE; PRKACG; GNGT2
    Dopaminergic synapse FOS; PPP2CB; GNG5; GNAS; PPP2R5C; KIF5B; GRIN2A; CREB3; GNGT1; GNAI3
    Olfactory transduction OLFR18; CAMK2A; CAMK2B; OR12D3; ARRB2; CNGA4; OLFR508; OLFR497; OLFR494; ADRBK2
    Inflammatory mediator regulation of TRP channels Adcy4; MAP2K3; GNAQ; HRH1; ASIC4; PRKACA; PLCG2; TRPV3; CYP2C55; PRKACG
    Insulin secretion KCNN1; KCNMB4; PLCB2; GNA11; SLC2A1; ATP1B2; ATP1B3; GNAS; KCNN3; INS
    GnRH signaling pathway PTK2B; MAPK14A; PRKCD; MAPK13; CALM4; HBEGFA; GRB2A; SOS1; MAPK8; CACNA1SB
    Melanogenesis FZD7B; MAP2K1; CAMK2G1; Adcy4; FZD8; PRKACB; WNT5B; EDNRBA; WNT3A; RAF1
    Oxytocin signaling pathway CACNB3; PPP1CC; PRKCB; CALM4; PIK3CD; FOS; CACNG6; CAMK4; PRKAA1; NRAS
    Glucagon signaling pathway ITPR3; CAMK2A; CALM3; PDE3B; ATF4; PHKA1; PCK2; PDHA1; PRKAG2; PLCB1
    Aldosterone synthesis and secretion CALML3; HSD3B2; CYP11A1; NETO2; NR4A1; AGTR1; NPR1; CREB3; AGTR1B; CREB5
    Gastric acid secretion PLCB1; PLCB2; ATP4B; ATP1B1; CALML5; SLC9A1; CAMK2A; Slc4a2; ATP1A1; KCNJ16
    Amphetamine addiction ATF6B; SLC18A1; TH; ATF2; ARC; GRIN2C; CREB3L2; CREB3L4; JUN; PPP1CA
    Tuberculosis CLEC4M; MAPK10; Ifna15; CALML5; IFNA17; RIPK2; SPHK2; CASP10; CAMK2G; FCGR3A
    Proteoglycans in cancer GPC1; PIK3R5; GPC3; IL12B; WNT2B; AKT1; ITGB1; PRKACA; NUDT16L1; PIK3R2

    camk2a has several biochemical functions, for example, ATP binding, calmodulin binding, calmodulin-dependent protein kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by camk2a itself. We selected most functions camk2a had, and list some proteins which have the same functions with camk2a. You can find most of the proteins on our site.

    Function Related Protein
    calmodulin binding NOS2; RGS2; ADD2; CNN3B; MARCKSL1A; RYR2; IQGAP3; RIT1; MAP6D1; CAMK4
    calmodulin-dependent protein kinase activity PNCK; CAMK2B; CAMK1; DCX; MAPKAPK5; CAMK2G1; CAMK2D2; MKNK1; CAMK1GB; MKNK2A
    glutamate receptor binding PLCG1; GRIN1; GRIN2A; CAMK2A; SYNDIG1
    kinase activity PTK2AB; PHKG1A; Fert2; PRKAR1AA; MAPK8A; TNK2B; MASTL; CDC7; CAMK2A; LRGUK
    protein binding SCP2; METTL15; MAPK8; RBM39; UCHL3; IRF7; CYBRD1; PPIL3; STK39; PITPNC1
    protein homodimerization activity OLFM4; NACC2; HOGA1; IKZF2; CORO1A; GSTZ1; AIMP1; SOD1; CRYBB2; TPD52L2
    protein serine/threonine kinase activity PRKCBB; CSNK1DA; RPS6KA1; GRK5; PRKCQ; PRKY; PDPK1; RPS6KA4; PIM2; PHKG2

    camk2a has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with camk2a here. Most of them are supplied by our site. Hope this information will be useful for your research of camk2a.

    GRIN2B; ACTN1; CAMK2D; calcium(2+); PPM1F; fem-2; RCHY1; Ppm1f; HSP90AB1; NR2F6; CALM1; CAMK2B; SMAD2; DLG3; CHMP5

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