| Description : |
The product of this gene belongs to the serine/threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This calcium calmodulin-dependent protein kinase is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Several transcript variants encoding distinct isoforms have been identified for this gene. |
| Source : |
Mammalian cells |
| Species : |
Human |
| Tag : |
Flag |
| Form : |
25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
| Bio-activity : |
Enzyme activity regulator |
| Molecular Mass : |
55.1 kDa |
| AA Sequence : |
MATITCTRFTEEYQLFEELGKGAFS VVRRCVKVLAGQEYAAKIINTKKLS ARDHQKLEREARICRLLKHP NIVRLHDSISEEGHHYLIFDLVTGG ELFEDIVAREYYSEADASHCIQQIL EAVLHCHQMGVVHRDLKPEN LLLASKLKGAAVKLADFGLAIEVEG EQQAWFGFAGTPGYLSPEVLRKDPY GKPVDLWACGVILYILLVGY PPFWDEDQHRLYQQIKAGAYDFPSP EWDTVTPEAKDLINKMLTINPSKRI TAAEALKHPWISHRSTVASC MHRQETVDCLKKFNARRKLKGAILT TMLATRNFSGGKSGGNKKSDGVKKR KSSSSVQLMESSESTNTTIE DEDTKVRKQEIIKVTEQLIEAISNG DFESYTKMCDPGMTAFEPEALGNLV EGLDFHRFYFENLWSRNSKP VHTTILNPHIHLMGDESACIAYIRI TQYLDAGGIPRTAQSEETRVWHRRD GKWQIVHFHRSGAPSVLPHTRTRPL EQKLISEEDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining. |
| Stability : |
Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Storage : |
Store at -80 centigrade. |
| Concentration : |
>50 ug/mL as determined by microplate BCA method. |
| Preparation : |
Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
| Protein Families : |
Druggable Genome, Protein Kinase |
| Protein Pathways : |
Calcium signaling pathway, ErbB signaling pathway, Glioma, GnRH signaling pathway, Long-term potentiation, Melanogenesis, Neurotrophin signaling pathway, Olfactory transduction, Oocyte meiosis, Wnt signaling pathway |
