Recombinant Human CASP9 Protein (Lys100-270Thr), SUMO tagged

• Cat.No.: CASP9-0864H
• Product Overview: Recombinant human Caspase 9 (Lys100-270Thr) fused with SUMO tag was expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Tag: SUMO
• Protein Length: Lys100-270Thr
• Description: Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly (ADP-ribose) polymerase (PARP). Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9.
• Form: Lyophilized powder/frozen liquid
• Molecular Mass: 34.58 kDa
• Purity: >90% as determined by SDS-PAGE.
• Notes: For research use only.
• Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles.
  Store at 2 to 8 centigrade for one week.
  Store at -20 to -80 centigrade for twelve months from the date of receipt.
• Storage Buffer: Supplied as solution form in PBS pH 7.5 or lyophilized from PBS pH 7.5.
• Reconstitution: Reconstitute in sterile water for a stock solution.
• Shipping: They are shipped out with dry ice/blue ice unless customers require otherwise.

Gene Information

• Gene Name: CASP9 caspase 9, apoptosis-related cysteine peptidase [ Homo sapiens (human) ]
• Official Symbol: CASP9
• Synonyms: CASP9; caspase 9, apoptosis-related cysteine peptidase; caspase 9, apoptosis related cysteine protease; caspase-9; APAF 3; ICE LAP6; MCH6; PPP1R56; protein phosphatase 1; regulatory subunit 56; apoptotic protease MCH-6; ICE-like apoptotic protease 6; apoptotic protease activating factor 3; protein phosphatase 1, regulatory subunit 56; APAF3; APAF-3; ICE-LAP6; CASPASE-9c
• Gene ID: 842
• mRNA Refseq: NM_001229
• Protein Refseq: NP_001220
• MIM: 602234
• UniProt ID: P55211