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Recombinant Human CASP9 Protein, GST-Tagged

Cat.No. : CASP9-0433H
Product Overview : Human CASP9 full-length ORF (AAH02452.1, 1 a.a. - 416 a.a.) recombinant protein with GST-tag at N-terminal.
  • Specification
  • Gene Information
  • Related Products
Description : This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein can undergo autoproteolytic processing and activation by the apoptosome, a protein complex of cytochrome c and the apoptotic peptidase activating factor 1; this step is thought to be one of the earliest in the caspase activation cascade. This protein is thought to play a central role in apoptosis and to be a tumor suppressor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 71.5 kDa
AA Sequence : MDEADRRLLRRCRLRLVEELQVDQL WDALLSRELFRPHMIEDIQRAGSGS RRDQARQLIIDLETRGSQALPLFIS CLEDTGQDMLASFLRTNRQAAKLSK PTLENLTPVVLRPEIRKPEVLRPET PRPVDIGSGGFGDVGALESLRGNAD LAYILSMEPCGHCLIINNVNFCRES GLRTRTGSNIDCEKLRRRFSSLHFM VEVKGDLTAKKMVLALLELAQQDHG ALDCCVVVILSHGCQASHLQFPGAV YGTDGCPVSVEKIVNIFNGTSCPSL GGKPKLFFIQACGGEQKDHGFEVAS TSPEDESPGSNPEPDATPFQEGLRT FDQLDAISSLPTPSDIFVSYSTFPG FVSWRDPKSGSWYVETLDDIFEQWA HSEDLQSLLLRVANAVSVKGIYKQM PGCFNFLRKKLFFKTS
Applications : Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Gene Name : CASP9 caspase 9, apoptosis-related cysteine peptidase [ Homo sapiens ]
Official Symbol : CASP9
Synonyms : CASP9; caspase 9, apoptosis-related cysteine peptidase; caspase 9, apoptosis related cysteine protease; caspase-9; APAF 3; ICE LAP6; MCH6; PPP1R56; protein phosphatase 1; regulatory subunit 56; apoptotic protease MCH-6; ICE-like apoptotic protease 6; apoptotic protease activating factor 3; protein phosphatase 1, regulatory subunit 56; APAF3; APAF-3; ICE-LAP6; CASPASE-9c;
Gene ID : 842
mRNA Refseq : NM_001229
Protein Refseq : NP_001220
MIM : 602234
UniProt ID : P55211

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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What clinical conditions are associated with dysregulation of CASP9 protein? 10/10/2022

Dysregulation of CASP9 protein is associated with cancer, neurodegenerative diseases, and immune system disorders.

Can CASP9 protein be used as a therapeutic target in autoimmune diseases? 01/16/2021

CASP9 protein is being investigated as a potential therapeutic target in autoimmune diseases to modulate immune cell apoptosis.

How is CASP9 protein implicated in immune system disorders? 10/01/2017

Dysregulation of CASP9 protein can lead to abnormal immune cell apoptosis, contributing to autoimmune diseases and immunodeficiency.

How is CASP9 protein targeted in cancer therapy? 09/06/2017

CASP9 protein is targeted using small molecule inhibitors and therapeutic antibodies to induce apoptosis in cancer cells.

Are there any genetic variations in the CASP9 gene that affect protein function? 08/18/2017

Yes, genetic variations in the CASP9 gene can impact protein function and have been linked to disease susceptibility.

Customer Reviews (3)

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Reviews
04/12/2023

    Its purity and consistency have provided me with reliable and reproducible results, ensuring the accuracy of my research findings.

    04/27/2020

      Their expertise and guidance have helped overcome hurdles, ensuring the smooth progress of my research.

      10/27/2016

        The bands of proteins in Western Blotting experiments were very clear.

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