• Official Full Name

    chemokine (C-C motif) ligand 15

  • Background

    Chemokine CC-2 (CCL15) is a small cytokine belonging to the CC chemokine family that is also known as leukotactin-1, MIP5 and HCC-2. CCL15 is expressed in liver, small intestine, colon, and in certain leukocytes and macrophages of the lung. It is chemotactic for neutrophils, monocytes, and lymphocytes and elicits its effects by binding to cell surface chemokine receptors like CCR1 and CCR3. The human CCL15 gene spans four exons and is located in a head-to-tail orientation on chromosome 17 with the gene of another CC chemokine known as CCL14.
  • Synonyms

    LKN1; NCC3; SY15; HCC-2; Lkn-1; MIP-5; NCC-3; SCYL3; MIP-1d; SCYA15; HMRP-2B; chemokine (C-C motif) ligand 15; CCL15_HUMAN; MIP5; C-C motif chemokine 15 [Precursor]; Small-inducible cytokine A15; Macrophage inflammatory protein 5; Chemokine CC-2; MIP-1delta; Leukotactin-1; Mrp-2b; small inducible cytokine subfamily A (Cys-Cys), member 15; CCL15;
    • Type:
    • Recombinant Proteins
    • Cell & Tissue Lysates
    • Species :
    • Human
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Human Cells
    • Wheat Germ
    • Tag :
    • Biotin
    • GST
    • His
    • Myc
    • DDK
    • N/A
    • N
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CCL15-107H Active Human CCL15 N/A
    Human CCL15-422H Recombinant Human CCL15 protein E.coli N/A
    Human CCL15-151H Recombinant Human CCL15 Protein, DYKDDDDK-tagged Human Cells DYKDDDDK
    Human CCL15-256H Recombinant Human CCL15 Protein, His-tagged E.coli His
    Human CCL15-30165TH Recombinant Human CCL15 protein E.coli N/A
    Human CCL15-492H Recombinant Human CCL15 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human CCL15-75H Recombinant Human CCL15 Protein E.coli
    Human CCL15-0611H Recombinant Human CCL15 Protein, GST-Tagged Wheat Germ GST
    Human CCL15-7731HCL Recombinant Human CCL15 293 Cell Lysate HEK293 N/A
    Human CCL15-82H Recombinant Human CCL15 Protein, Biotin-tagged E.coli Biotin
    Human CCL15-326C Recombinant Human CCL15 Protein (92 aa) E.coli
    Human CCL15-3422H Recombinant Human CCL15 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human CCL15-10837H Recombinant Human CCL15, GST-tagged E.coli GST
    Human CCL15-070C Recombinant Human CCL15 Protein (92 aa) E.coli
    Human CCL15-1012H Recombinant Human CCL15 Protein (Ser46-Ile113), GST tagged E.coli GST
    Human CCL15-1174H Recombinant Human CCL15 Protein (Ser46-Ile113), N-GST tagged E.coli N-GST
    Human CCL15-197H Recombinant Human CCL15, His tagged E.coli His
    • Involved Pathway
    • Protein Function
    • Interacting Protein
    • CCL15 Related Articles
    • CCL15 Related Gene Family
    • CCL15 Related Research Area

    CCL15 involved in several pathways and played different roles in them. We selected most pathways CCL15 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CCL15 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interactionEGFRA;FLT4;TNFRSF8;CCL27;CCL19B;IL3RA;IL21R.1;TNFRSF11A;IFNA16
    Chemokine signaling pathwayCCL21B;CXCL9;PTK2B;GNAI1;CCL3;CCL1;PTK2;CXCL6;GNG10

    CCL15 has several biochemical functions, for example, CCR chemokine receptor binding, chemoattractant activity, chemokine activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CCL15 itself. We selected most functions CCL15 had, and list some proteins which have the same functions with CCL15. You can find most of the proteins on our site.

    Function Related Protein
    CCR chemokine receptor bindingCCRL2;CCL15;CCL11;CCL20B;CCL33.3;CCL20;CCL3L3;CXCL32B.1;XCL2
    chemoattractant activityCCL16;FGF2;HGF;HMGB2;VEGFB;HMGB1;NTF3;CXCL12;VEGFA
    chemokine activityCCL20B;CXCL19;XCL1;CCL39.1;CCL17;CCL11;CCL28;CCL21;CCL25
    heparin bindingCCL8;MPO;BMP4;CCL2;PF4V1;CCL23;SLIT1B;HDGF;PGF
    receptor bindingLAMA1;H2-Q10;RSPO2;NOS2;NSG1;AMH;ICAM3;CD70;CADM4

    CCL15 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCL15 here. Most of them are supplied by our site. Hope this information will be useful for your research of CCL15.

    Ahlberg, V; Bengtsson, KL; et al. Global transcriptional response to ISCOM-Matrix adjuvant at the site of administration and in the draining lymph node early after intramuscular injection in pigs. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 38:17-26(2012).
    Lechner, CJ; Gantin, RG; et al. Chemokines and cytokines in patients with an occult Onchocerca volvulus infection. MICROBES AND INFECTION 14:438-446(2012).
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