CLDN4

  • Official Full Name

    claudin 4

  • Overview

    This gene encodes an integral membrane protein, which belongs to the claudin family. The protein is a component of tight junction strands and may play a role in internal organ development and function during pre- and postnatal life. This gene is deleted in Williams-Beuren syndrome, a neurodevelopmental disorder affecting multiple systems.
  • Synonyms

    CLDN4; claudin 4; CPETR, CPETR1; claudin-4; Clostridium perfringens enterotoxin receptor 1; CPE R; hCPE R; WBSCR8; Williams Beuren syndrome chromosomal region 8 protein; CPE-receptor; Williams-Beuren syndrome chromosomal region 8 protein; CPER; CPE-R; CPE;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Bos taurus (Bovine)
  • Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops)
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Rhesus Macaque
  • Baculovirus-Insect cells
  • E.coli expression system
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • C
  • His
  • Flag
  • GST
  • His (Fc)
  • Avi
  • Twin
  • Strep
  • Myc
  • DDK
  • MYC
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CLDN4-0343H Active Recombinant Human CLDN4 Full Length Transmembrane protein(VLPs) HEK293 N/A Met 1- Val 209
Human CLDN4-256H Active Recombinant Human CLDN4 protein, His-Twin-Strep-tagged(Detergent) Insect Cell His-Twin-Strep Met 1 - Val 209
Human CLDN4-0392H Active Recombinant Human CLDN4 Full Length Transmembrane protein(Nanodisc) HEK293 N/A
Human CLDN4-1443H Recombinant Human CLDN4 Protein, GST-tagged Wheat Germ GST
Human CLDN4-26708TH Recombinant Human CLDN4 Wheat Germ N/A 50 amino acids
Human CLDN4-27272TH Recombinant Human CLDN4 Wheat Germ N/A 209 amino acids
Human CLDN4-7462HCL Recombinant Human CLDN4 293 Cell Lysate HEK293 N/A
Human CLDN4-4751H Recombinant Human CLDN4 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human CLDN4-150H Recombinant Human CLDN4 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Human CLDN4-2058HF Recombinant Full Length Human CLDN4 Protein, GST-tagged In Vitro Cell Free System GST 209 amino acids
Human CLDN4-87HF Recombinant Full Length Human CLDN4 Protein In Vitro Cell Free System 209 amino acids
Human CLDN4-612H Recombinant Human CLDN4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human CLDN4-574HFL Recombinant Full Length Human CLDN4 Protein, C-Flag-tagged Mammalian cells Flag
Human CLDN4-11H Active Recombinant Human CLDN4 Full Length Transmembrane protein, His-tagged(VLPs) HEK293 His 1-209aa
Human CLDN4-612H-B Recombinant Human CLDN4 Protein Pre-coupled Magnetic Beads HEK293
Human CLDN4-0333H Recombinant Human CLDN4 Protein (Met1-Val209), C-His-tagged Baculovirus-Insect cells C-His Met1-Val209
Mouse CLDN4-3538M Recombinant Mouse CLDN4 Protein Mammalian Cell His
Mouse CLDN4-1733M-B Recombinant Mouse CLDN4 Protein Pre-coupled Magnetic Beads HEK293
Mouse CLDN4-1733M Recombinant Mouse CLDN4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Cldn4-901M Recombinant Mouse Cldn4 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Bos taurus (Bovine) RFL1476BF Recombinant Full Length Bovine Claudin-4(Cldn4) Protein, His-Tagged E.coli expression system His Full Length (1-209)
Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops) RFL28924CF Recombinant Full Length Chlorocebus Aethiops Claudin-4(Cldn4) Protein, His-Tagged E.coli expression system His Full Length (1-209)
Homo sapiens (Human) RFL9305HF Recombinant Full Length Human Claudin-4(Cldn4) Protein, His-Tagged E.coli expression system His Full Length (1-209)
Mus musculus (Mouse) RFL15864MF Recombinant Full Length Mouse Claudin-4(Cldn4) Protein, His-Tagged E.coli expression system His Full Length (1-210)
Rhesus Macaque CLDN4-896R Recombinant Rhesus monkey CLDN4 Protein, His-tagged Mammalian Cell His
Rhesus Macaque CLDN4-722R-B Recombinant Rhesus Macaque CLDN4 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque CLDN4-722R Recombinant Rhesus Macaque CLDN4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

CLDN4 involved in several pathways and played different roles in them. We selected most pathways CLDN4 participated on our site, such as Cell adhesion molecules (CAMs), Cell junction organization, Cell-Cell communication, which may be useful for your reference. Also, other proteins which involved in the same pathway with CLDN4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cell adhesion molecules (CAMs)CLDN11;ICAM1;MHC2DEB;CLDN18;ITGB2;LRRC4C;JAM3B;VCAN;CD8A
Cell junction organizationCDH18;PVRL2L;JUP;FERMT2;CDH3;CDH12;RSU1;CDH4;JUPA
Cell-Cell communicationCDH17;CDH18A;DST;NPHS1;CADM2;PLEC;DSCAMA;CADM2B;SKAP2
Cell-cell junction organizationCADM2B;CLDN7;CTNND1;CLDN16;PVRL2L;CDH8;INADL;PVRL1A;CLDN4
Hepatitis CCLDN23;CLDN17;TRAF6;ARAF;TP53;IFNA6;CLDN1;IKBKG;MAPK3
Leukocyte transendothelial migrationTHY1;VCAM1;PRKCA;PTK2;PTK2B;CYBA;MMP9;ITGB2;CLDN17
Tight junctionACTB;RHOA;CLDN15LA;SHROOM4;MYHZ1.1;PRKCG;PRKCQ;MYL5;SRC
Tight junction interactionsINADL;CLDN7;CLDN3;CLDN20;CLDN16;CLDN23;CLDN4

CLDN4 has several biochemical functions, for example, identical protein binding, structural molecule activity, transmembrane signaling receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CLDN4 itself. We selected most functions CLDN4 had, and list some proteins which have the same functions with CLDN4. You can find most of the proteins on our site.

Function Related Protein
identical protein bindingPPP5C;STK10;HSPB1;TMEM115;PYCARD;NELL2;GOT2A;SLK;SOD1
structural molecule activityCLTCA;COL18A1;KRT4;SPRR2F;COPB2;CLDN1;LELP1;CLDN2;CLDNA
transmembrane signaling receptor activityFZD3B;KLRC3;TNFRSF10D;VIPR1B;TLR6;GPR182;NCR2;KLRC1;TNFRSF11A

CLDN4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CLDN4 here. Most of them are supplied by our site. Hope this information will be useful for your research of CLDN4.

TACSTD2

Research Area

Related articles

Liszka, L; et al. DUCTAL ADENOCARCINOMA OF THE PANCREAS USUALLY RETAINED SMAD4 AND p53 PROTEIN STATUS AS WELL AS EXPRESSION OF EPITHELIAL-TO-MESENCHYMAL TRANSITION MARKERS AND CELL CYCLE REGULATORS AT THE STAGE OF LIVER METASTASIS. POLISH JOURNAL OF PATHOLOGY 65:100-112(2014).
Hashimi, SM; Yu, S; et al. Immunotoxin-mediated targeting of claudin-4 inhibits the proliferation of cancer cells. INTERNATIONAL JOURNAL OF ONCOLOGY 42:1911-1918(2013).
  • Q&As
  • Reviews

Q&As (5)

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What are the potential therapeutic implications of targeting CLDN4 in cancer treatment? 10/10/2022

Inhibiting CLDN4 function could enhance the efficacy of existing cancer therapies and potentially lead to the development of new treatment strategies.

How does CLDN4 protein contribute to the pathogenesis of infectious diseases? 01/16/2021

CLDN4 is involved in regulating the entry of certain pathogens into host cells, making it a potential target for the development of antiviral and antibacterial therapies.

Can CLDN4 protein be targeted for the treatment of autoimmune diseases? 10/01/2017

Research is underway to explore the potential of targeting CLDN4 to modulate tissue barrier function and alleviate the symptoms of autoimmune diseases.

How can CLDN4 protein be utilized in the diagnosis and management of IBD? 09/06/2017

Monitoring CLDN4 levels and function may provide valuable insights into the progression of IBD and help in the development of targeted therapies.

In what other clinical settings is CLDN4 protein being investigated? 08/18/2017

CLDN4 is also being studied in the context of kidney disease, skin disorders, and neurodegenerative diseases due to its role in maintaining tissue barrier function.

Customer Reviews (3)

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Reviews
08/05/2021

    The CLDN4 protein showcases outstanding quality, ensuring its suitability for addressing my experimental requirements effectively.

    06/02/2019

      the manufacturer's dedication to excellent technical support assures me that any challenges or obstacles I encounter will be swiftly resolved.

      06/25/2016

        Its top-notch purity and integrity instill confidence in obtaining precise and reliable data, thereby enabling significant advancements in my research.

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