CRK
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Official Full Name
v-crk sarcoma virus CT10 oncogene homolog (avian)
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Overview
CrkII, a cellular homologue of v-Crk, belongs to a family of adaptor proteins with an SH2-SH3-SH3 domain structure that transmits signals from tyrosine kinases. The primary function of Crk is to recruit cytoplasmic proteins in the vicinity of tyrosine kin -
Synonyms
CRK; v-crk sarcoma virus CT10 oncogene homolog (avian); v crk avian sarcoma virus CT10 oncogene homolog; adapter molecule crk; proto-oncogene c-Crk; p38; CRKII; FLJ38130;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Flag
- GST
- His
- Fc
- Avi
- Myc
- DDK
- Non
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
- CRK Related Signal Pathway
CRK involved in several pathways and played different roles in them. We selected most pathways CRK participated on our site, such as ARMS-mediated activation, Angiopoietin receptor Tie2-mediated signaling, B Cell Receptor Signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CRK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| ARMS-mediated activation | WDR83;SLC14A2;CRK;JAK2;PSMA8;DAB2IPB;DUSP1;HBEGF;KIDINS220B |
| Angiopoietin receptor Tie2-mediated signaling | DOK2;GRB14;ELF2;AGTR1;CDKN1A;GRB7;ELF1;CRK;BMX |
| B Cell Receptor Signaling Pathway | AKT1;GRB2;NFATC2;ARPC1B;RAC1;PPP3CC;SOS1;PIK3R1;CTNNB2 |
| Bacterial invasion of epithelial cells | CLTB;PIK3CB;DNM3;CBLB;VCL;DNM2;PIK3CD;PIK3CG;GAB1 |
| CXCR4-mediated signaling events | GNB2L1;ADRBK1;GNA13;MAPKAP1;CFL1;PAG1;CSK;JAK2;CRK |
| Chemokine signaling pathway | CXCL9;CCL8;ARRB1;PARD3;DOCK2;FGR;PLCB4;PXN;CXCR3 |
| Chronic myeloid leukemia | PIK3R3;STAT5A;TGFBR2;CDK6;RAF1;PTPN11;AKT2;ARAF;SHC2 |
| Cytokine Signaling in Immune system | GBP2;EIF4A2;NUPL2;SPRED2;TRIM5;GBP4;CSK;TNFRSF13C;MX2 |
CRK has several biochemical functions, for example, SH2 domain binding, SH3/SH2 adaptor activity, ephrin receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CRK itself. We selected most functions CRK had, and list some proteins which have the same functions with CRK. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| SH2 domain binding | TRPV4;PAG1;IRS1;INPPL1;DAG1;CRK;LAX1;MS4A2;SRC |
| SH3/SH2 adaptor activity | SHB;LASP1;SLA2;ARHGAP4;SKAP2;STAP1;GAB1;CHN1;PTPN11 |
| ephrin receptor binding | EFNA2;EPHA7;NTRK1;SIPA1L1;PTPN1;PIK3CG;SDCBP;CRK;CBL |
| protein binding | PTK2;SIGLEC8;NT5C2;SIRT3;PIBF1;CCNE1;ITGAV;DYSFIP1;FAM9A |
| protein phosphorylated amino acid binding | CRK;BTRC;ARRB1 |
CRK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CRK here. Most of them are supplied by our site. Hope this information will be useful for your research of CRK.
CBL; BCAR1; PDGFRA; ABL2
Research Area
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Customer Reviews (3)
Write a reviewThe expression is high and the detection is convenient.
The purity and biological activity are excellent, which makes the products extremely reliable.
The background in the Western blot is very clean and shows good antibody specificity.
Q&As (6)
Ask a questionThe role of CRK in disease can be assessed through in-depth analysis of the patient's genomic data, combined with the results of studies in cell models and animal models. This can help doctors better understand the patient's condition and develop more effective treatment plans.
The expression level of CRK can be detected by immunohistochemistry, western blotting, and real-time PCR. These techniques can detect protein or mRNA levels of CRK in tissues or cells to assess changes in its expression in disease.
Certain biomolecules can be used as molecular markers for CRK, such as mRNA or protein of CRK detected in biological samples such as blood and urine. These markers can be used for early diagnosis of disease, prognostic judgment, or monitoring of treatment efficacy.
Detection methods for CRK include immunohistochemistry, western blotting, real-time PCR, etc. These methods can detect the expression level of CRK in tissues or cells to assess its status in disease.
Therapeutic strategies for CRK include inhibition of its activity, regulation of its expression, and gene therapy. For example, the development of small molecule inhibitors or antibody drugs against CRK to inhibit its aberrant activity in disease, or the regulation of CRK expression through gene knockout or overexpression techniques.
As a signal transduction molecule, CRK plays multiple roles within the cell. It can phosphorylate a variety of substrates, affecting their activity or localization. In addition, CRK is also involved in processes such as cytoskeletal reorganization and cell motility.
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