CRK

  • Official Full Name

    v-crk sarcoma virus CT10 oncogene homolog (avian)

  • Overview

    CrkII, a cellular homologue of v-Crk, belongs to a family of adaptor proteins with an SH2-SH3-SH3 domain structure that transmits signals from tyrosine kinases. The primary function of Crk is to recruit cytoplasmic proteins in the vicinity of tyrosine kin
  • Synonyms

    CRK; v-crk sarcoma virus CT10 oncogene homolog (avian); v crk avian sarcoma virus CT10 oncogene homolog; adapter molecule crk; proto-oncogene c-Crk; p38; CRKII; FLJ38130;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CRK-1886H Recombinant Human CRK Protein, GST-tagged Wheat Germ GST
Human CRK-27823TH Recombinant Human CRK, His-tagged E.coli His 224 amino acids
Human CRK-11582H Recombinant Human CRK, GST-tagged E.coli GST C-term-264a.a.
Human CRK-2854H Recombinant Human CRK, His-tagged E.coli His
Human CRK-7276HCL Recombinant Human CRK 293 Cell Lysate HEK293 N/A
Human CRK-7277HCL Recombinant Human CRK 293 Cell Lysate HEK293 N/A
Human CRK-5279H Recombinant Human CRK Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human CRK-6643H Recombinant Human CRK Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human CRK-661H Recombinant Human CRK Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human CRK-1640HFL Recombinant Full Length Human CRK Protein, C-Flag-tagged Mammalian cells Flag
Human CRK-2067HF Recombinant Full Length Human CRK Protein, GST-tagged In Vitro Cell Free System GST 204 amino acids
Human CRK-661H-B Recombinant Human CRK Protein Pre-coupled Magnetic Beads HEK293
Mouse Crk-2313M Recombinant Mouse Crk Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat CRK-1603R Recombinant Rat CRK Protein Mammalian Cell His
Rat CRK-1260R-B Recombinant Rat CRK Protein Pre-coupled Magnetic Beads HEK293
Rat CRK-1260R Recombinant Rat CRK Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish CRK-1053Z Recombinant Zebrafish CRK Mammalian Cell His
Chicken CRK-1771C Recombinant Chicken CRK Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource
  • CRK Related Signal Pathway

CRK involved in several pathways and played different roles in them. We selected most pathways CRK participated on our site, such as ARMS-mediated activation, Angiopoietin receptor Tie2-mediated signaling, B Cell Receptor Signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CRK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
ARMS-mediated activationDUSP6;AKAP9;RASGRP4;HBEGF;NTF7;FRS2A;KIDINS220B;JAK1;LAMTOR2
Angiopoietin receptor Tie2-mediated signalingGRB14;DOK2;BMX;ELF2;CDKN1A;ELF1;AGTR1;CRK;GRB7
B Cell Receptor Signaling PathwayKRAS;NRAS;HRAS;IGHM;PIK3AP1;NFKB1;NFKBIA;MALT1;PIK3CA
Bacterial invasion of epithelial cellsWASL;SHC2;SHC4;CDC42;SEPT2;SEPT11;HCLS1;CBLB;ARPC5
CXCR4-mediated signaling eventsPAG1;DNM1;BLK;JAK2;MAPKAP1;CRK;GNB2L1;CSK;ADRBK1
Chemokine signaling pathwayGNG13;VAV2;GNAI2;STAT1;IL-8;PIK3CG;CCL13;CXCL8;CCL6
Chronic myeloid leukemiaHRAS;NRAS;ARAF;PTPN11;AKT1;PIK3R3;SHC1;CBL;PIK3R5
Cytokine Signaling in Immune systemSPNA1;RASGRP4;IL17RD;CNKSR1;TAB1;EDARADD;HLA-DQB2;DUSP9;PEA15

CRK has several biochemical functions, for example, SH2 domain binding, SH3/SH2 adaptor activity, ephrin receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CRK itself. We selected most functions CRK had, and list some proteins which have the same functions with CRK. You can find most of the proteins on our site.

Function Related Protein
SH2 domain bindingDAG1;NLK;SYP;SRC;KHDRBS2;LILRB1;AFAP1L2;DLC1;LCK
SH3/SH2 adaptor activitySKAP1;SH3BP2;SKAP2;CRK;GRAP;CNTNAP1;ITSN2;SH2D1A;SH3BGRL
ephrin receptor bindingEFNB2;Anks1;EFNA2A;EFNA3B;EFNA1;EPHA4;CDK5;CHN1;EFNA5B
protein bindingTCEANC;USP25;CCDC88A;HSFX1;VPS25;KRT5;ALDOB;Akap3;LBR
protein phosphorylated amino acid bindingARRB1;BTRC;CRK

CRK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CRK here. Most of them are supplied by our site. Hope this information will be useful for your research of CRK.

CBL; BCAR1; PDGFRA; ABL2

Research Area

Related articles

Li, J; Chen, S; et al. Histone deacetylase 8 regulates cortactin deacetylation and contraction in smooth muscle tissues. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY 307:C288-C295(2014).
Aten, TM; Redmond, MM; et al. Tyrosine phosphorylation of the orphan receptor ESDN/DCBLD2 serves as a scaffold for the signaling adaptor CrkL. FEBS LETTERS 587:2313-2318(2013).
  • Q&As
  • Reviews

Q&As (6)

Ask a question
How is the role of CRK assessed in the disease? 11/04/2022

The role of CRK in disease can be assessed through in-depth analysis of the patient's genomic data, combined with the results of studies in cell models and animal models. This can help doctors better understand the patient's condition and develop more effective treatment plans.

How can I detect the expression level of CRK? 02/18/2022

The expression level of CRK can be detected by immunohistochemistry, western blotting, and real-time PCR. These techniques can detect protein or mRNA levels of CRK in tissues or cells to assess changes in its expression in disease.

Which biomolecules can be used as molecular markers for CRK? 02/03/2022

Certain biomolecules can be used as molecular markers for CRK, such as mRNA or protein of CRK detected in biological samples such as blood and urine. These markers can be used for early diagnosis of disease, prognostic judgment, or monitoring of treatment efficacy.

What are the detection methods for CRK? 01/28/2021

Detection methods for CRK include immunohistochemistry, western blotting, real-time PCR, etc. These methods can detect the expression level of CRK in tissues or cells to assess its status in disease.

What are the treatment strategies for CRK? 06/27/2020

Therapeutic strategies for CRK include inhibition of its activity, regulation of its expression, and gene therapy. For example, the development of small molecule inhibitors or antibody drugs against CRK to inhibit its aberrant activity in disease, or the regulation of CRK expression through gene knockout or overexpression techniques.

What is the main role of CRK in cells? 03/12/2020

As a signal transduction molecule, CRK plays multiple roles within the cell. It can phosphorylate a variety of substrates, affecting their activity or localization. In addition, CRK is also involved in processes such as cytoskeletal reorganization and cell motility.

Customer Reviews (3)

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Reviews
04/17/2022

    The expression is high and the detection is convenient.

    08/22/2020

      The purity and biological activity are excellent, which makes the products extremely reliable.

      07/13/2020

        The background in the Western blot is very clean and shows good antibody specificity.

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