Recombinant Human CRK Protein, GST-tagged
Cat.No. : | CRK-1886H |
Product Overview : | Human CRK full-length ORF ( NP_005197.3, 1 a.a. - 204 a.a.) recombinant protein with GST-tag at N-terminal. |
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Description : | This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. [provided by RefSeq, Jul 2008] |
Source : | Wheat Germ |
Species : | Human |
Tag : | GST |
Molecular Mass : | 49.3 kDa |
AA Sequence : | MAGNFDSEERSSWYWGRLSRQEAVA LLQGQRHGVFLVRDSSTSPGDYVLS VSENSRVSHYIINSSGPRPPVPPSP AQPPPGVSPSRLRIGDQEFDSLPAL LEFYKIHYLDTTTLIEPVSRSRQGS GVILRQEEAEYVRALFDFNGNDEED LPFKKGDILRIRDKPEEQWWNAEDS EGKRGMIPVPYVEKYRPASASVSAL IGGR |
Applications : | Enzyme-linked Immunoabsorbent Assay Western Blot (Recombinant protein) Antibody Production Protein Array |
Notes : | Best use within three months from the date of receipt of this protein. |
Storage : | Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Gene Name : | CRK CRK proto-oncogene, adaptor protein [ Homo sapiens (human) ] |
Official Symbol : | CRK |
Synonyms : | CRK; CRK CRK proto-oncogene, adaptor protein; v-crk sarcoma virus CT10 oncogene homolog (avian); v crk avian sarcoma virus CT10 oncogene homolog; adapter molecule crk; proto-oncogene c-Crk; p38; CRKII; FLJ38130; |
Gene ID : | 1398 |
mRNA Refseq : | NM_005206 |
Protein Refseq : | NP_005197 |
MIM : | 164762 |
UniProt ID : | P46108 |
Products Types
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◆ Lysates | ||
CRK-7277HCL | Recombinant Human CRK 293 Cell Lysate | +Inquiry |
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (3)
Write a reviewThe expression is high and the detection is convenient.
The purity and biological activity are excellent, which makes the products extremely reliable.
The background in the Western blot is very clean and shows good antibody specificity.
Q&As (6)
Ask a questionThe role of CRK in disease can be assessed through in-depth analysis of the patient's genomic data, combined with the results of studies in cell models and animal models. This can help doctors better understand the patient's condition and develop more effective treatment plans.
The expression level of CRK can be detected by immunohistochemistry, western blotting, and real-time PCR. These techniques can detect protein or mRNA levels of CRK in tissues or cells to assess changes in its expression in disease.
Certain biomolecules can be used as molecular markers for CRK, such as mRNA or protein of CRK detected in biological samples such as blood and urine. These markers can be used for early diagnosis of disease, prognostic judgment, or monitoring of treatment efficacy.
Detection methods for CRK include immunohistochemistry, western blotting, real-time PCR, etc. These methods can detect the expression level of CRK in tissues or cells to assess its status in disease.
Therapeutic strategies for CRK include inhibition of its activity, regulation of its expression, and gene therapy. For example, the development of small molecule inhibitors or antibody drugs against CRK to inhibit its aberrant activity in disease, or the regulation of CRK expression through gene knockout or overexpression techniques.
As a signal transduction molecule, CRK plays multiple roles within the cell. It can phosphorylate a variety of substrates, affecting their activity or localization. In addition, CRK is also involved in processes such as cytoskeletal reorganization and cell motility.
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