Recombinant Full Length Human CRK Protein, C-Flag-tagged
Cat.No. : | CRK-1640HFL |
Product Overview : | Recombinant Full Length Human CRK Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. |
Source : | Mammalian cells |
Species : | Human |
Tag : | Flag |
Form : | 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Molecular Mass : | 33.7 kDa |
AA Sequence : | MAGNFDSEERSSWYWGRLSRQEAVA LLQGQRHGVFLVRDSSTSPGDYVLS VSENSRVSHYIINSSGPRPP VPPSPAQPPPGVSPSRLRIGDQEFD SLPALLEFYKIHYLDTTTLIEPVSR SRQGSGVILRQEEAEYVRAL FDFNGNDEEDLPFKKGDILRIRDKP EEQWWNAEDSEGKRGMIPVPYVEKY RPASASVSALIGGNQEGSHP QPLGGPEPGPYAQPSVNTPLPNLQN GPIYARVIQKRVPNAYDKTALALEV GELVKVTKINVSGQWEGECN GKRGHFPFTHVRLLDQQNPDEDFST RTRPLEQKLISEEDLAANDILDYKD DDDKV |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining. |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade. |
Concentration : | >50 ug/mL as determined by microplate BCA method. |
Preparation : | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
Protein Families : | Druggable Genome, Transcription Factors |
Protein Pathways : | Chemokine signaling pathway, Chronic myeloid leukemia, ErbB signaling pathway, Fc gamma R-mediated phagocytosis, Focal adhesion, Insulin signaling pathway, MAPK signaling pathway, Neurotrophin signaling pathway, Pathways in cancer, Regulation of actin cytoskeleton, Renal cell carcinoma |
Gene Name : | CRK CRK proto-oncogene, adaptor protein [ Homo sapiens (human) ] |
Official Symbol : | CRK |
Synonyms : | p38; CRKII |
Gene ID : | 1398 |
mRNA Refseq : | NM_016823.4 |
Protein Refseq : | NP_058431.2 |
MIM : | 164762 |
UniProt ID : | P46108 |
Products Types
◆ Recombinant Protein | ||
CRK-1260R | Recombinant Rat CRK Protein, His (Fc)-Avi-tagged | +Inquiry |
Crk-2313M | Recombinant Mouse Crk Protein, Myc/DDK-tagged | +Inquiry |
CRK-1886H | Recombinant Human CRK Protein, GST-tagged | +Inquiry |
CRK-661H | Recombinant Human CRK Protein, His (Fc)-Avi-tagged | +Inquiry |
CRK-1603R | Recombinant Rat CRK Protein | +Inquiry |
◆ Lysates | ||
CRK-7276HCL | Recombinant Human CRK 293 Cell Lysate | +Inquiry |
CRK-7277HCL | Recombinant Human CRK 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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