Recombinant Mouse Crk Protein, Myc/DDK-tagged

Cat.No. : Crk-2313M
Product Overview : Purified recombinant protein of mouse full-length v-crk avian sarcoma virus CT10 oncogene homolog (Crk), with C-terminal MYC/DDK tag, expressed in HEK293T cells.
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Description : This gene is part of a family of adapter proteins that mediate formation of signal transduction complexes in response to extracellular stimuli, such as growth and differentiation factors. Protein-protein interactions occur through the SH2 domain, which binds phosphorylated tyrosine residues, and the SH3 domain, which binds proline-rich peptide motifs. These interactions promote recruitment and activation of effector proteins to regulate cell migration, adhesion, and proliferation. In mouse this protein is essential for embryonic development. Alternatively spliced transcripts encoding different isoforms with distinct biological activity have been described.
Source : HEK293T
Species : Mouse
Tag : Myc&DDK
Molecular Mass : 33.8 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 μg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Crk v-crk avian sarcoma virus CT10 oncogene homolog [ Mus musculus (house mouse) ]
Official Symbol : Crk
Synonyms : CRK; v-crk sarcoma virus CT10 oncogene homolog (avian); adapter molecule crk; p38; proto-oncogene c-crk; CT-10 related kinase 3; v-crk sarcoma virus CT10 oncogene-like protein; avian sarcoma virus CT10 (v-crk) oncogene homolog; Crk3; Crko; Crk-I; Crkol; Crk-II; CrkIII; Crk-III
Gene ID : 12928
mRNA Refseq : NM_133656
Protein Refseq : NP_598417
UniProt ID : Q64010

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.


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Customer Reviews (3)

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    The expression is high and the detection is convenient.


      The purity and biological activity are excellent, which makes the products extremely reliable.


        The background in the Western blot is very clean and shows good antibody specificity.

        Q&As (6)

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        How is the role of CRK assessed in the disease? 11/04/2022

        The role of CRK in disease can be assessed through in-depth analysis of the patient's genomic data, combined with the results of studies in cell models and animal models. This can help doctors better understand the patient's condition and develop more effective treatment plans.

        How can I detect the expression level of CRK? 02/18/2022

        The expression level of CRK can be detected by immunohistochemistry, western blotting, and real-time PCR. These techniques can detect protein or mRNA levels of CRK in tissues or cells to assess changes in its expression in disease.

        Which biomolecules can be used as molecular markers for CRK? 02/03/2022

        Certain biomolecules can be used as molecular markers for CRK, such as mRNA or protein of CRK detected in biological samples such as blood and urine. These markers can be used for early diagnosis of disease, prognostic judgment, or monitoring of treatment efficacy.

        What are the detection methods for CRK? 01/28/2021

        Detection methods for CRK include immunohistochemistry, western blotting, real-time PCR, etc. These methods can detect the expression level of CRK in tissues or cells to assess its status in disease.

        What are the treatment strategies for CRK? 06/27/2020

        Therapeutic strategies for CRK include inhibition of its activity, regulation of its expression, and gene therapy. For example, the development of small molecule inhibitors or antibody drugs against CRK to inhibit its aberrant activity in disease, or the regulation of CRK expression through gene knockout or overexpression techniques.

        What is the main role of CRK in cells? 03/12/2020

        As a signal transduction molecule, CRK plays multiple roles within the cell. It can phosphorylate a variety of substrates, affecting their activity or localization. In addition, CRK is also involved in processes such as cytoskeletal reorganization and cell motility.

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