EFNA5 Protein


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Official Full Name ephrin-A5
Background Ephrin-A5, a member of the ephrin gene family, prevents axon bundling in cocultures of cortical neurons with astrocytes, a model of late stage nervous system development and differentiation. The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, particularly in the nervous system. EPH receptors typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin ligands and receptors have been named by the Eph Nomenclature Committee (1997). Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are similarly divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands.
Synonyms EFNA5; ephrin-A5; EPLG7; AF1; LERK7; AL-1; LERK-7; eph-related receptor tyrosine kinase ligand 7; EFL5; RAGS; GLC1M
    • Species :
    • Canine
    • Chicken
    • Cynomolgus Monkey
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • Human Cell
    • Insect Cell
    • Mammalian Cell
    • Mammalian cells
    • Wheat Germ
    • Tag :
    • Fc
    • GST
    • hIgG/His
    • His
    • T7
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human EFNA5-16H Recombinant Human EFNA5 Protein, hIgG/His-tagged Insect Cell hIgG/His
    Human EFNA5-1133H Recombinant Human EFNA5 protein, His & T7-tagged E.coli His/T7
    Human EFNA5-1611H Recombinant Human Ephrin-A5 Mammalian cells N/A
    Human EFNA5-2734HCL Recombinant Human EFNA5 cell lysate Human Cell N/A
    Human EFNA5-28471TH Recombinant Human EFNA5 Wheat Germ N/A
    Human EFNA5-3101H Recombinant Human EFNA5 Protein, GST-tagged Wheat Germ GST
    Human EFNA5-700H Recombinant Human EFNA5, His tagged Human Cell His
    Human EFNA5-79H Recombinant Human EFNA5, Fc tagged Human Cell Fc
    Mouse EFNA5-2156MCL Recombinant Mouse EFNA5 cell lysate Human Cell N/A
    Mouse Efna5-4059M Recombinant Mouse Efna5, Fc tagged Human Cell Fc
    Mouse Efna5-4060M Recombinant Mouse Efna5, His tagged Human Cell His
    Mouse Efna5-880M Recombinant Mouse Efna5 Protein, Fc Chimera Mammalian cells Fc
    Rat Efna5-1574R Recombinant Rat Efna5 protein, Fc-tagged HEK293 Fc
    Rat EFNA5-1574RCL Recombinant Rat EFNA5 cell lysate Human Cell N/A
    Rat Efna5-1620R Recombinant Rat Efna5 protein, His-tagged HEK293 His
    Rat EFNA5-2025R Recombinant Rat EFNA5 Protein Mammalian Cell His
    Rat EFNA5-470R Recombinant Rat EFNA5 Protein (21-203 aa), His-tagged E.coli His
    Cynomolgus Monkey EFNA5-1430C Recombinant Cynomolgus EFNA5 protein, His-tagged HEK293 His
    Cynomolgus Monkey EFNA5-1430CCL Recombinant Cynomolgus EFNA5 cell lysate Human Cell N/A
    Cynomolgus Monkey EFNA5-1431C Recombinant Cynomolgus EFNA5 protein, Fc-tagged HEK293 Fc
    Rhesus Macaque EFNA5-1393R Recombinant Rhesus monkey EFNA5 Protein, His-tagged Mammalian Cell His
    Canine EFNA5-993C Recombinant Canine EFNA5 protein, Fc-tagged HEK293 Fc
    Canine EFNA5-993CCL Recombinant Canine EFNA5 cell lysate Human Cell N/A
    Chicken EFNA5-6739C Recombinant Chicken EFNA5 Mammalian Cell His

    EFNA5 involved in several pathways and played different roles in them. We selected most pathways EFNA5 participated on our site, such as Axon guidance, Developmental Biology, EPH-Ephrin signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with EFNA5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Axon guidance DPYSL5B; DPYSL2; EPHB4A; COL9A1B; CSF2RB; NADL1.1; EFNB3B; PLXNC1; UNC5A; PAK2
    Developmental Biology EFNA2A; LGI1A; CFC1; MED6; FRS2B; RGMB; SALL4; PEBP1; SPTA1; DUSP6
    EPH-Ephrin signaling EFNA3; EFNA1A; MYL9; EFNB2A; EFNA2; EFNA5; EFNB3B; EFNB2; EPHA2A; EFNA4
    EPH-ephrin mediated repulsion of cells EFNA1A; EFNA1B; EFNB1; EFNA2A; EFNA4; EPHA4A; EFNA3; EFNA3B; EFNB2A; CLTB
    EPHA forward signaling ARHGEF15; EPHA2; EFNA2; CRKL; EFNA5; EFNA3; BLK; EFNA1
    EPHA-mediated growth cone collapse SHB; EFNA3; EFNA2; EFNA4; EPHA4A; EPHA2A; EPHA10; EFNA2A; EFNA1B; MYL12B
    EPHB forward signaling EFNB2; ITSN1; EFNB3; EFNA5; GRB7; EFNB1
    Ephrin A reverse signaling EFNA5

    EFNA5 has several biochemical functions, for example, chemorepellent activity, ephrin receptor binding, neurotrophin TRKA receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EFNA5 itself. We selected most functions EFNA5 had, and list some proteins which have the same functions with EFNA5. You can find most of the proteins on our site.

    Function Related Protein
    chemorepellent activity FLRT3; SEMA3BL; SEMA3GB; NRG3; SEMA3GA; SEMA3AA; SEMA6A; FLRT2; SEMA3A; SEMA3G
    ephrin receptor binding PTPN1; EFNA2A; EFNA4; CHN1; CDK5R1; EFNB1; EPHA4; NTRK1; SHC1; EFNA5B
    neurotrophin TRKA receptor binding PIK3R1; FRS2; NGFR; GRB2; EFNA5; SHC1; PLCG1
    neurotrophin TRKB receptor binding BDNF; EFNA5
    neurotrophin TRKC receptor binding EFNA5
    transmembrane receptor protein tyrosine kinase activator activity EGF; GREM1; ANGPT4; NRG3; EFNA5; NRG1

    EFNA5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EFNA5 here. Most of them are supplied by our site. Hope this information will be useful for your research of EFNA5.

    EPHA7; ABL1

    Ramanan, VK; Risacher, SL; et al. APOE and BCHE as modulators of cerebral amyloid deposition: a florbetapir PET genome-wide association study. MOLECULAR PSYCHIATRY 19:351-357(2014).
    Lin, QH; Zhou, N; et al. Mutational Screening of EFNA5 in Chinese Age-Related Cataract Patients. OPHTHALMIC RESEARCH 52:124-129(2014).

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