Ephrin-A5, a member of the ephrin gene family, prevents axon bundling in cocultures of cortical neurons with astrocytes, a model of late stage nervous system development and differentiation. The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, particularly in the nervous system. EPH receptors typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin ligands and receptors have been named by the Eph Nomenclature Committee (1997). Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are similarly divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands.
EFNA5 involved in several pathways and played different roles in them. We selected most pathways EFNA5 participated on our site, such as Axon guidance, Developmental Biology, EPH-Ephrin signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with EFNA5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
EFNA5 has several biochemical functions, for example, chemorepellent activity, ephrin receptor binding, neurotrophin TRKA receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EFNA5 itself. We selected most functions EFNA5 had, and list some proteins which have the same functions with EFNA5. You can find most of the proteins on our site.
transmembrane receptor protein tyrosine kinase activator activity
NRG1; EFNA5; NRG3; ANGPT4; GREM1; EGF
EFNA5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EFNA5 here. Most of them are supplied by our site. Hope this information will be useful for your research of EFNA5.
EPHA7; ABL1
Ramanan, VK; Risacher, SL; et al. APOE and BCHE as modulators of cerebral amyloid deposition: a florbetapir PET genome-wide association study. MOLECULAR PSYCHIATRY 19:351-357(2014).
Lin, QH; Zhou, N; et al. Mutational Screening of EFNA5 in Chinese Age-Related Cataract Patients. OPHTHALMIC RESEARCH 52:124-129(2014).
