ENG

  • Official Full Name

    endoglin

  • Overview

    This gene encodes a homodimeric transmembrane protein which is a major glycoprotein of the vascular endothelium. This protein is a component of the transforming growth factor beta receptor complex and it binds to the beta1 and beta3 peptides with high affinity. Mutations in this gene cause hereditary hemorrhagic telangiectasia, also known as Osler-Rendu-Weber syndrome 1, an autosomal dominant multisystemic vascular dysplasia. This gene may also be involved in preeclampsia and several types of cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2013]
  • Synonyms

    ENG; endoglin; END; HHT1; ORW1; CD105 antigen; ORW; CD105;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Others
  • Antibody
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Rat
  • Sus scrofa (Pig)
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • Human Cell
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Rabbit
  • Sf9 Insect Cell
  • C
  • His
  • Fc Chimera
  • GST
  • hFc
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
  • N
  • Strep II
  • Trx|His
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ENG-26364TH Recombinant Human ENG N/A
Human ENG-133H Recombinant Human Endoglin,Sf9 Sf9 Insect Cell N/A
Human ENG-132H Recombinant Human Endoglin E.coli N/A
Human ENG-63H Active Recombinant Human ENG protein, hFc-tagged HEK293 hFc
Human ENG-783H Recombinant Human ENG Protein, Trx-6His-tagged E.coli Trx/His
Human ENG-3146H Recombinant Human ENG protein(Met1-Gly586), His-tagged HEK293 C-His
Human ENG-428H Recombinant Human endoglin, His-tagged E.coli His
Human ENG-4917H Recombinant Human Endoglin Sf9 Insect Cell N/A
Human ENG-12449H Recombinant Human ENG, GST-tagged E.coli GST
Human ENG-300H Recombinant Human ENG, StrepII-tagged Human Cell Strep II
Human ENG-2457HCL Recombinant Human ENG cell lysate Human Cell N/A
Human ENG-0897H Recombinant Human ENG Protein (Thr27-Gly581), N-His tagged E.coli N-His
Human ENG-1425H Recombinant Human ENG Protein, His-tagged E.coli N-His
Human ENG-027H Recombinant Human ENG Protein, C-His-tagged E.coli C-His
Human ENG-813H Recombinant Human ENG protein, His-Avi-tagged HEK293 His-Avi
Human ENG-5969H Recombinant Human ENG Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human ENG-4297HF Recombinant Full Length Human ENG Protein, GST-tagged In Vitro Cell Free System GST
Human CDA094P Recombinant Human CD-105 Protein E.coli N/A
Human ENG-4076H Recombinant Human ENG Protein (Met1-Gly586), C-His tagged Mammalian cells C-His
Mouse Eng-449M Active Recombinant Mouse Endoglin Mammalian cells N/A
Mouse Eng-982M Recombinant Mouse Endoglin Insect Cell N/A
Mouse Eng-3289M Active Recombinant Mouse Eng protein, His-tagged HEK293 His
Mouse Eng-5693M Recombinant Mouse Eng protein, His-tagged E.coli His
Mouse ENG-2267MCL Recombinant Mouse ENG cell lysate Human Cell N/A
Mouse Eng-10540M Recombinant Mouse Eng Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Eng-7199M Recombinant Mouse Eng Protein Insect Cell
Mouse CAB11530RM Rabbit Anti-Mouse Endoglin Monoclonal Antibody Rabbit N/A
Mouse Eng-2823M Recombinant Mouse Eng Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Eng-10540M-B Recombinant Mouse Eng Protein Pre-coupled Magnetic Beads HEK293
Rat Eng-638R Active Recombinant Rat Eng, Fc Chimera Mammalian cells Fc Chimera
Rat Eng-5694R Recombinant Rat Eng protein, His-tagged E.coli His
Rat Eng-25R Recombinant Rat Eng Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Eng-25R-B Recombinant Rat Eng Protein Pre-coupled Magnetic Beads HEK293
Homo sapiens (Human) RFL23630HF Recombinant Full Length Human Endoglin(Eng) Protein, His-Tagged E.coli expression system His
Sus scrofa (Pig) RFL28093SF Recombinant Full Length Pig Endoglin(Eng) Protein, His-Tagged E.coli expression system His
Chicken ENG-3642C Recombinant Chicken ENG Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ENG Related Articles
  • ENG Related Research Area

ENG involved in several pathways and played different roles in them. We selected most pathways ENG participated on our site, such as HIF-1-alpha transcription factor network, TGF Beta Signaling Pathway, TGF-beta Receptor Signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ENG were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
HIF-1-alpha transcription factor networkCP;GATA2;CITED2;ENG;NDRG1;TFF3;NPM1;PLIN2;COPS5
TGF Beta Signaling PathwayTGFBR3;ZFP423;NOG;FST;ENG;FOXH1;RUNX3;LEFTY1;ZNF423
TGF-beta Receptor Signaling PathwaySTK11IP;FOXH1;SKIA;TRAP1;CTCF;HOXD9A;ZEB1B;DAB2;CITED1

ENG has several biochemical functions, for example, contributes_to BMP binding, activin binding, galactose binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ENG itself. We selected most functions ENG had, and list some proteins which have the same functions with ENG. You can find most of the proteins on our site.

Function Related Protein
contributes_to BMP binding
activin bindingTGFBR3;ACVR1;FSTL3;ACVRL1;FKBP1A;SMURF1;FST;ENG;ACVR2B
galactose bindingLGALS9;CLEC4F;GALK1;COLEC12;ENG
glycosaminoglycan bindingEGFLAM;CCDC80;SPOCK2;SPOCK3;SERPINA5;VCAN;HABP2;NDNF;ENG
protein bindingTMEM8B;SFN;NOL6;NR0B2;WNK1;INO80B;TNFRSF6B;NOSTRIN;PTPN2
protein homodimerization activityWWTR1;HPS4;BHLHE40;KIT;PRPS2;TPD52;PDE2A;PVRL3;PDGFA
transforming growth factor beta bindingCD109;LTBP1;VASN;HYAL2;TGFBR2;ACVR1;THBS1;TGFBR1;ACVRL1
contributes_to transforming growth factor beta bindingENG;TGFBR1;TGFBR2;TGFBR3
transforming growth factor beta receptor, cytoplasmic mediator activityENG;CDKN1B
transforming growth factor beta-activated receptor activityTGFBR3;LTBP1;ACVRL1;BMPR2B;TGFBR2;ENG;BMPR2A;TGFBR1
transmembrane signaling receptor activitySORL1;OR115-6;TNFRSF8;CLDN4;TNFRSF10C;Fzd4;FCGR2C;KIR2DL4;CLEC2H
type I transforming growth factor beta receptor bindingFKBP1A;TGFBR2;TGFB3;TGFB1;SMAD7;SMAD2;ENG;SMAD6;SNX25
type II transforming growth factor beta receptor bindingTGFB1A;TGFBR1;TGFB3;ENG;BAMBI;TGFB1;TGFBR3;TGFB2

ENG has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ENG here. Most of them are supplied by our site. Hope this information will be useful for your research of ENG.

ITGA5; ITGB1; TGFB1; ganglioside_gm1; ARRB2; MMP14; ybgA; lutB; purH

Cansiz, FBC; Dal, H; et al. An orthotropic viscoelastic material model for passive myocardium: theory and algorithmic treatment. COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING 18:1160-1172(2015).
Oke, O; Lettieri, P; et al. An investigation on the mechanics of homogeneous expansion in gas-fluidized beds. CHEMICAL ENGINEERING SCIENCE 127:95-105(2015).
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