EOMES

  • Official Full Name

    eomesodermin

  • Overview

    This gene belongs to the TBR1 (T-box brain protein 1) sub-family of T-box genes that share the common DNA-binding T-box domain. The encoded protein is a transcription factor which is crucial for embryonic development of mesoderm and the central nervous system in vertebrates. The protein may also be necessary for the differentiation of effector CD8+ T cells which are involved in defense against viral infections. A similar gene disrupted in mice is shown to be essential during trophoblast development and gastrulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]
  • Synonyms

    EOMES; eomesodermin; TBR2; eomesodermin homolog; T-box brain protein 2;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • His|GST
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human EOMES-3344H Recombinant Human EOMES Protein, GST-tagged Wheat Germ GST
Human EOMES-389H Recombinant Human EOMES Protein, His-tagged E.coli His
Human EOMES-6589HCL Recombinant Human EOMES 293 Cell Lysate HEK293 N/A
Human EOMES-3345H Recombinant Human EOMES Protein, Myc/DDK-tagged HEK293T Myc/DDK
Human EOMES-1649H Recombinant Human EOMES protein, His & GST-tagged E.coli His/GST Leu400~Ser669 (Accession # O95936)
Human EOMES-301271H Recombinant Human EOMES protein, GST-tagged E.coli GST Met575-Met676
Mouse EOMES-5228M Recombinant Mouse EOMES Protein Mammalian Cell His
Mouse EOMES-2807M-B Recombinant Mouse EOMES Protein Pre-coupled Magnetic Beads HEK293
Mouse EOMES-2807M Recombinant Mouse EOMES Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

EOMES involved in several pathways and played different roles in them. We selected most pathways EOMES participated on our site, such as Downstream signaling in naive CD8+ T cells, IL12-mediated signaling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with EOMES were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Downstream signaling in naive CD8+ T cellsEGR1;JUNB;EOMES;EGR4
IL12-mediated signaling eventsGADD45G;HLX;EOMES

EOMES has several biochemical functions, for example, DNA binding, RNA polymerase II activating transcription factor binding, RNA polymerase II regulatory region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EOMES itself. We selected most functions EOMES had, and list some proteins which have the same functions with EOMES. You can find most of the proteins on our site.

Function Related Protein
DNA bindingRNF141;ZNF74;ENG1A;ZNF84;GTF2I;RORCA;DDB1;ZNF556;TBX6
RNA polymerase II activating transcription factor bindingPITX2;SIN3A;LMO2;SETD3;CREB1;TBX3;TBX20;T;NHLH2
RNA polymerase II regulatory region sequence-specific DNA bindingZFY2;NR1I3;ESRRG;AEBP1;FOXD3;ETV6;CUX1;KLF12;SP3
chromatin bindingELK1;PBRM1;TTC5;NFATC2;APTX;ASF1A;Trl;GATA6;MEIS1
sequence-specific DNA bindingFOXD5;GRHL1;FOXE3;MNX2A;PBX3B;FOXF1;ZFP423;ISL2;NKX2.1
transcription factor activity, sequence-specific DNA bindingSP1;RORC;CTCF;UBN2A;SOX11;ZBTB11;LZTS1;MEOX1;FOXB1B
transcriptional repressor activity, RNA polymerase II transcription factor bindingMLIP;AHRRA;EOMES;BHLHE40;PITX2;CREBBP;AHRR;ELP2;AHRRB

EOMES has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EOMES here. Most of them are supplied by our site. Hope this information will be useful for your research of EOMES.

PFDN1; sgrR; purR2

Research Area

Related articles

Kim, K; Bang, SY; et al. High-density genotyping of immune loci in Koreans and Europeans identifies eight new rheumatoid arthritis risk loci. ANNALS OF THE RHEUMATIC DISEASES 74:-(2015).
Chen, SH; Lee, LF; et al. Combination of 4-1BB Agonist and PD-1 Antagonist Promotes Antitumor Effector/Memory CD8 T Cells in a Poorly Immunogenic Tumor Model. CANCER IMMUNOLOGY RESEARCH 3:149-160(2015).
  • Q&As
  • Reviews

Q&As (6)

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What is the role of EOMES in lung cancer? 12/12/2019

EOMES can affect the production, progression and prognosis of lung cancer by regulating CTLs function and immune surveillance cell types and functions.

What is the role of EOMES in T lymphocyte differentiation and function? 10/17/2019

EOMES plays a key role in the differentiation and function of CD8+ T cells, particularly in the formation and stability maintenance of effector memory T cells and cytotoxic T lymphocytes (CTLs).

How can immune-related diseases be studied by EOMES gene? 08/18/2019

The molecular mechanisms of EOMES genes can be studied by analyzing the association between the EOMES gene and immune-related diseases such as autoimmune diseases, infectious diseases, etc.

Is there a link between EOMES and certain lymphomas? 06/04/2019

Yes, EOMES is strongly associated with the occurrence and progression of a variety of lymphoid tumors (such as Hodgkin lymphoma, T-cell lymphoma, etc.).

How to study the role of EOMES in the immune system? 05/23/2019

Mouse gene knockout technology, small RNA interference technology, etc. can be used to study the role of EOMES in the immune system.

How about the role of EOMES in tumor immunotherapy? 03/06/2019

EOMES can enhance the reactivity of T lymphocytes in tumor immunotherapy, thereby enhancing the killing ability and therapeutic effect of tumor cells.

Customer Reviews (3)

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Reviews
07/18/2019

    The storage conditions and experimental environment of this protein are simple and convenient without specific conditions.

    04/10/2019

      Less polluting and minimizes waste.

      03/31/2019

        You can see that this protein is produced with great care for purity and activity.

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