EOMES
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Official Full Name
eomesodermin
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Overview
This gene belongs to the TBR1 (T-box brain protein 1) sub-family of T-box genes that share the common DNA-binding T-box domain. The encoded protein is a transcription factor which is crucial for embryonic development of mesoderm and the central nervous system in vertebrates. The protein may also be necessary for the differentiation of effector CD8+ T cells which are involved in defense against viral infections. A similar gene disrupted in mice is shown to be essential during trophoblast development and gastrulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013] -
Synonyms
EOMES; eomesodermin; TBR2; eomesodermin homolog; T-box brain protein 2;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- Wheat Germ
- GST
- His
- Fc
- Avi
- Myc
- DDK
- Non
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | EOMES-3344H | Recombinant Human EOMES Protein, GST-tagged | Wheat Germ | GST |
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| Human | EOMES-389H | Recombinant Human EOMES Protein, His-tagged | E.coli | His |
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| Human | EOMES-6589HCL | Recombinant Human EOMES 293 Cell Lysate | HEK293 | Non |
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| Human | EOMES-3345H | Recombinant Human EOMES Protein, Myc/DDK-tagged | HEK293T | Myc&DDK |
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| Human | EOMES-1649H | Recombinant Human EOMES protein, His & GST-tagged | E.coli | His&GST | Leu400~Ser669 |
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| Human | EOMES-301271H | Recombinant Human EOMES protein, GST-tagged | E.coli | GST | Met575-Met676 |
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| Mouse | EOMES-5228M | Recombinant Mouse EOMES Protein | Mammalian Cell | His | ||
| Mouse | EOMES-2807M-B | Recombinant Mouse EOMES Protein Pre-coupled Magnetic Beads | HEK293 |
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| Mouse | EOMES-2807M | Recombinant Mouse EOMES Protein, His (Fc)-Avi-tagged | HEK293 | His&Fc&Avi |
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- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
EOMES involved in several pathways and played different roles in them. We selected most pathways EOMES participated on our site, such as Downstream signaling in naive CD8+ T cells, IL12-mediated signaling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with EOMES were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Downstream signaling in naive CD8+ T cells | EGR4;EOMES;JUNB;EGR1 |
| IL12-mediated signaling events | EOMES;GADD45G;HLX |
EOMES has several biochemical functions, for example, DNA binding, RNA polymerase II activating transcription factor binding, RNA polymerase II regulatory region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EOMES itself. We selected most functions EOMES had, and list some proteins which have the same functions with EOMES. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | MBD3;HOXB13A;TP53;DEDD;MGMT;FAM171B;FEZF1;DDX3X;ZNF7 |
| RNA polymerase II activating transcription factor binding | HNF4A;CREBBP;NCOR1;MAD2L2;EGR2;RB1;TBX20;NHLH2;LMO2 |
| RNA polymerase II regulatory region sequence-specific DNA binding | GATA2A;FOXF1;DBP;PRDM15;GATA1;NHLH1;SKINT8;BCL6A;ASCL3 |
| chromatin binding | Ar;SKOR2;CDC45;ZMYND11;CBFA2T3;ANKRD17;GM606;LDB1;ZNF143 |
| sequence-specific DNA binding | PAX3;HOXA7;RXRAB;PAX6A;MAFGA;ELF2;HOXD13A;IRX4B;FOXB1B |
| transcription factor activity, sequence-specific DNA binding | CDX2;RAB11FIP4A;CREBZF;ZNF239;HOMEZB;CDX1B;TAF1B;ESR1;CBFB |
| transcriptional repressor activity, RNA polymerase II transcription factor binding | AHRRA;ELP2;TBX6;EOMES;AHRR;BHLHE40;CREBBP;PITX2;T |
EOMES has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EOMES here. Most of them are supplied by our site. Hope this information will be useful for your research of EOMES.
PFDN1; sgrR; purR2
Research Area
Related articles
- Reviews
- Q&As
Customer Reviews (3)
Write a reviewThe storage conditions and experimental environment of this protein are simple and convenient without specific conditions.
Less polluting and minimizes waste.
You can see that this protein is produced with great care for purity and activity.
Q&As (6)
Ask a questionEOMES can affect the production, progression and prognosis of lung cancer by regulating CTLs function and immune surveillance cell types and functions.
EOMES plays a key role in the differentiation and function of CD8+ T cells, particularly in the formation and stability maintenance of effector memory T cells and cytotoxic T lymphocytes (CTLs).
The molecular mechanisms of EOMES genes can be studied by analyzing the association between the EOMES gene and immune-related diseases such as autoimmune diseases, infectious diseases, etc.
Yes, EOMES is strongly associated with the occurrence and progression of a variety of lymphoid tumors (such as Hodgkin lymphoma, T-cell lymphoma, etc.).
Mouse gene knockout technology, small RNA interference technology, etc. can be used to study the role of EOMES in the immune system.
EOMES can enhance the reactivity of T lymphocytes in tumor immunotherapy, thereby enhancing the killing ability and therapeutic effect of tumor cells.
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