Recombinant Human EOMES protein, His & GST-tagged

• Cat.No.: EOMES-1649H
• Product Overview: Recombinant Human EOMES aa. (Leu400~Ser669 (Accession # O95936)) fused with N-terminal His & GST tag was produced in E. coli cells.

Specification

• Description: This gene belongs to the TBR1 (T-box brain protein 1) sub-family of T-box genes that share the common DNA-binding T-box domain. The encoded protein is a transcription factor which is crucial for embryonic development of mesoderm and the central nervous system in vertebrates. The protein may also be necessary for the differentiation of effector CD8+ T cells which are involved in defense against viral infections. A similar gene disrupted in mice is shown to be essential during trophoblast development and gastrulation. Alternative splicing results in multiple transcript variants.
• Source: E. coli
• Species: Human
• Tag: His&GST
• Form: Freeze-dried powder
• Molecular Mass: Predicted Molecular Mass: 60.1kDa
• Protein length: Leu400~Ser669 (Accession # O95936)
• Endotoxin: <1.0EU per 1ug (determined by the LAL method)
• Purity: >90%
• Applications: SDS-PAGE; WB; ELISA; IP.
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
• Storage buffer: Supplied as lyophilized form in 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% sarcosyl, 5% trehalose, and preservative.
• Reconstitution: Reconstitute in sterile ddH2O.
• Isoelectric Point: 5

Gene Information

• Gene Name: EOMES eomesodermin [ Homo sapiens (human) ]
• Official Symbol: EOMES
• Synonyms: EOMES; eomesodermin; TBR2; eomesodermin homolog; T-box brain protein 2
• Gene ID: 8320
• mRNA Refseq: NM_001278182.1
• Protein Refseq: NP_001265111.1
• UniProt ID: O95936

Reviews

07/18/2019

The storage conditions and experimental environment of this protein are simple and convenient without specific conditions.

04/10/2019

Less polluting and minimizes waste.

03/31/2019

You can see that this protein is produced with great care for purity and activity.

Q&As

What is the role of EOMES in lung cancer?

EOMES can affect the production, progression and prognosis of lung cancer by regulating CTLs function and immune surveillance cell types and functions.

What is the role of EOMES in T lymphocyte differentiation and function?

EOMES plays a key role in the differentiation and function of CD8+ T cells, particularly in the formation and stability maintenance of effector memory T cells and cytotoxic T lymphocytes (CTLs).

How can immune-related diseases be studied by EOMES gene?

The molecular mechanisms of EOMES genes can be studied by analyzing the association between the EOMES gene and immune-related diseases such as autoimmune diseases, infectious diseases, etc.

Is there a link between EOMES and certain lymphomas?

Yes, EOMES is strongly associated with the occurrence and progression of a variety of lymphoid tumors (such as Hodgkin lymphoma, T-cell lymphoma, etc.).

How to study the role of EOMES in the immune system?

Mouse gene knockout technology, small RNA interference technology, etc. can be used to study the role of EOMES in the immune system.

How about the role of EOMES in tumor immunotherapy?

EOMES can enhance the reactivity of T lymphocytes in tumor immunotherapy, thereby enhancing the killing ability and therapeutic effect of tumor cells.