Recombinant Human EOMES protein, His & GST-tagged

Cat.No. : EOMES-1649H
Product Overview : Recombinant Human EOMES aa. (Leu400~Ser669 (Accession # O95936)) fused with N-terminal His & GST tag was produced in E. coli cells.
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Description : This gene belongs to the TBR1 (T-box brain protein 1) sub-family of T-box genes that share the common DNA-binding T-box domain. The encoded protein is a transcription factor which is crucial for embryonic development of mesoderm and the central nervous system in vertebrates. The protein may also be necessary for the differentiation of effector CD8+ T cells which are involved in defense against viral infections. A similar gene disrupted in mice is shown to be essential during trophoblast development and gastrulation. Alternative splicing results in multiple transcript variants.
Source : E. coli
Species : Human
Tag : His&GST
Form : Freeze-dried powder
Molecular Mass : Predicted Molecular Mass: 60.1kDa
Protein length : Leu400~Ser669 (Accession # O95936)
Endotoxin : <1.0EU per 1ug (determined by the LAL method)
Purity : >90%
Applications : SDS-PAGE; WB; ELISA; IP.
Stability : The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
Storage buffer : Supplied as lyophilized form in 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% sarcosyl, 5% trehalose, and preservative.
Reconstitution : Reconstitute in sterile ddH2O.
Isoelectric Point : 5
Gene Name : EOMES eomesodermin [ Homo sapiens (human) ]
Official Symbol : EOMES
Synonyms : EOMES; eomesodermin; TBR2; eomesodermin homolog; T-box brain protein 2
Gene ID : 8320
mRNA Refseq : NM_001278182.1
Protein Refseq : NP_001265111.1
UniProt ID : O95936

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.


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Customer Reviews (3)

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    The storage conditions and experimental environment of this protein are simple and convenient without specific conditions.


      Less polluting and minimizes waste.


        You can see that this protein is produced with great care for purity and activity.

        Q&As (6)

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        What is the role of EOMES in lung cancer? 12/12/2019

        EOMES can affect the production, progression and prognosis of lung cancer by regulating CTLs function and immune surveillance cell types and functions.

        What is the role of EOMES in T lymphocyte differentiation and function? 10/17/2019

        EOMES plays a key role in the differentiation and function of CD8+ T cells, particularly in the formation and stability maintenance of effector memory T cells and cytotoxic T lymphocytes (CTLs).

        How can immune-related diseases be studied by EOMES gene? 08/18/2019

        The molecular mechanisms of EOMES genes can be studied by analyzing the association between the EOMES gene and immune-related diseases such as autoimmune diseases, infectious diseases, etc.

        Is there a link between EOMES and certain lymphomas? 06/04/2019

        Yes, EOMES is strongly associated with the occurrence and progression of a variety of lymphoid tumors (such as Hodgkin lymphoma, T-cell lymphoma, etc.).

        How to study the role of EOMES in the immune system? 05/23/2019

        Mouse gene knockout technology, small RNA interference technology, etc. can be used to study the role of EOMES in the immune system.

        How about the role of EOMES in tumor immunotherapy? 03/06/2019

        EOMES can enhance the reactivity of T lymphocytes in tumor immunotherapy, thereby enhancing the killing ability and therapeutic effect of tumor cells.

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