FOXP3
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Official Full Name
forkhead box P3
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Overview
The protein encoded by this gene is a member of the forkhead/winged-helix family of transcriptional regulators. Defects in this gene are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX), also known as X-linked autoimmunity-immunodeficiency syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] -
Synonyms
FOXP3; forkhead box P3; JM2; AIID; IPEX; PIDX; XPID; DIETER; forkhead box protein P3; scurfin; FOXP3delta7; immunodeficiency, polyendocrinopathy, enteropathy, X-linked; immune dysregulation, polyendocrinopathy, enteropathy, X-linked;
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- GST
- His
- Fc
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- N
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- Non
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
FOXP3 involved in several pathways and played different roles in them. We selected most pathways FOXP3 participated on our site, such as Inflammatory bowel disease (IBD), which may be useful for your reference. Also, other proteins which involved in the same pathway with FOXP3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Inflammatory bowel disease (IBD) | HLA-DRA;H2-AA;HLA-DMB;IL18RAP;SMAD2;IL12B;RORA;RELA;HLA-DRB3 |
FOXP3 has several biochemical functions, for example, NF-kappaB binding, NFAT protein binding, RNA polymerase II transcription factor activity, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FOXP3 itself. We selected most functions FOXP3 had, and list some proteins which have the same functions with FOXP3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| NF-kappaB binding | RPS3;AP1S2;TAF4B;HDAC3;NFKBID;COMMD6;NFKBIA;GSK3B;HDAC2 |
| NFAT protein binding | PPARA;FOXP3;SFPI1;MAPK14;SPI1;GATA4 |
| RNA polymerase II transcription factor activity, sequence-specific DNA binding | OVOL1;ETV2;FOXR1;MAZ;TFAP2E;FOXN2B;FOXB1A;ELF2;SP4 |
| core promoter binding | CCAR1;ELK1;MTF1;SAFB;IFI16;MYOG;EZH2;E2F8;REST |
| histone acetyltransferase binding | ETS1;PAX6;EID1;SIRT2;TP53;MYOCD;TRP53;TRIP4;TAF7 |
| histone deacetylase binding | ZNHIT1;WDTC1;HIST1H1B;MEF2B;FOXP3;TCF21;HIF1A;HDAC4;RAD9 |
| metal ion binding | ADAMTS16;NME6;ITGA3;RARGA;RAB11FIP3;ZFP652;BAK1;FEZF1;HDAC9 |
| protein binding | PDE6G;PAPOLA;CDCA5;SETX;FOSL1;NF2;ASL;FAM151B;DIAP1 |
| protein homodimerization activity | BIRC5;GJC3;ABCD1;LCN2;OXCT1;MTMR2;PLCB1;SLIT2;IMPA1 |
| sequence-specific DNA binding | SIX2B;DMBX1B;HOXA11B;MNX1;PRDM16;ZNF831;CALCOCO1;HOXB4A;NANOGP8 |
| transcription corepressor activity | CCND1;ZHX2;ZHX1;C1D;PAWR;TRIM28;EID1;HDAC4;E2F7 |
| transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding | POU3F3;NKX2;RFX1;NKX2-1;SNAI2;CEBPA;NR5A1;SRF;RELA |
| transcription factor activity, sequence-specific DNA binding | DMRT2;HOXC6B;ZNF394;DMRT1;DMRTC1B;NR6A1A;PRDM15;ZNF133;ZFY1 |
FOXP3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FOXP3 here. Most of them are supplied by our site. Hope this information will be useful for your research of FOXP3.
PRR20C; RBPMS; IKZF3; mouse_arre2_site_il2_promoter_1; HDAC7; IKZF3; HDAC9; arre2_element_mouse_il2_promoter; Ctla4; il2ra_mouse_gene; Il2; RORC
Research Area
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Customer Reviews (3)
Write a reviewIts purity and integrity are of the highest standard, ensuring reliable and reproducible results in my research.
The FOXP3 protein offered by the manufacturer is of exceptional quality and is expected to perfectly meet my experimental needs.
The manufacturer's commitment to providing excellent technical support is commendable, as their dedicated team possesses the expertise to solve any issue or query that may arise during my experiments.
Q&As (5)
Ask a questionYes, elevated or decreased levels of FOXP3 expression can serve as a biomarker for various diseases, including autoimmune conditions and certain cancers.
Yes, the expression of FOXP3 in tumor-infiltrating lymphocytes is studied as a potential prognostic marker in various cancers, with higher levels often associated with a better prognosis.
FOXP3 is crucial for immune tolerance in transplant recipients. Enhancing Treg function, possibly through manipulating FOXP3, is a focus for transplant research to prevent rejection.
FOXP3 is studied in cancer to understand its role in suppressing anti-tumor immune responses. Manipulating Tregs or targeting FOXP3 may be explored for cancer immunotherapy.
FOXP3 helps regulate immune responses, including those involved in allergies. Dysfunction in FOXP3 or Tregs may contribute to allergic disorders.
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