FOXP3

  • Official Full Name

    forkhead box P3

  • Overview

    The protein encoded by this gene is a member of the forkhead/winged-helix family of transcriptional regulators. Defects in this gene are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX), also known as X-linked autoimmunity-immunodeficiency syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
  • Synonyms

    FOXP3; forkhead box P3; JM2; AIID; IPEX; PIDX; XPID; DIETER; forkhead box protein P3; scurfin; FOXP3delta7; immunodeficiency, polyendocrinopathy, enteropathy, X-linked; immune dysregulation, polyendocrinopathy, enteropathy, X-linked;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rhesus Macaque
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|GST
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human FOXP3-52H Recombinant Human Forkhead box P3, GST-tagged Wheat Germ GST
Human FOXP3-50H Recombinant Human FOXP3, MYC/DDK-tagged HEK293 Myc/DDK
Human FOXP3-53H Recombinant Human FOXP3 protein, His-tagged E.coli His
Human FOXP3-51H Recombinant Human Forkhead box P3, GST-tagged GST
Human FOXP3-1216H Recombinant Human FOXP3 Protein, His-tagged E.coli His
Human FOXP3-6145HCL Recombinant Human FOXP3 293 Cell Lysate HEK293 N/A
Human FOXP3-6933HF Recombinant Full Length Human FOXP3 Protein, GST-tagged In Vitro Cell Free System GST 431 amino acids
Human FOXP3-720H Recombinant Human FOXP3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human FOXP3-1217H Recombinant Human FOXP3 protein, His-tagged E.coli His Tyr191~Glu412
Human FOXP3-60H Recombinant Human FOXP3 protein, GST-tagged E.coli GST 107-196 aa
Human FOXP3-1306HFL Recombinant Full Length Human FOXP3 Protein, C-Flag-tagged Mammalian cells Flag
Human FOXP3-1215H Recombinant Human FOXP3 protein, His-tagged E.coli His Met1~Arg417
Human FOXP3-59H Recombinant Human FOXP3 protein, His-tagged E.coli His 230-431 aa
Human FOXP3-938H Recombinant Human FOXP3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human FOXP3-938H-B Recombinant Human FOXP3 Protein Pre-coupled Magnetic Beads HEK293
Human FOXP3-2708H Recombinant Human FOXP3 Protein (Gln105-Lys200), N-His tagged E.coli N-His Gln105-Lys200
Mouse Foxp3-1919M Recombinant Mouse Foxp3 protein, His & GST-tagged E.coli His/GST Tyr190~Glu412 (Accession # Q99JB6)
Mouse Foxp3-3079M Recombinant Mouse Foxp3 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rhesus Macaque FOXP3-1746R Recombinant Rhesus monkey FOXP3 Protein, His-tagged Mammalian Cell His
Rhesus Macaque FOXP3-1568R Recombinant Rhesus Macaque FOXP3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque FOXP3-1568R-B Recombinant Rhesus Macaque FOXP3 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

FOXP3 involved in several pathways and played different roles in them. We selected most pathways FOXP3 participated on our site, such as Inflammatory bowel disease (IBD), which may be useful for your reference. Also, other proteins which involved in the same pathway with FOXP3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Inflammatory bowel disease (IBD)IL5;HLA-DPB1;IFNGR2;IFNGR1;STAT4;TBX21;HLA-DQA1;HLA-DOB;IL12RB2

FOXP3 has several biochemical functions, for example, NF-kappaB binding, NFAT protein binding, RNA polymerase II transcription factor activity, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FOXP3 itself. We selected most functions FOXP3 had, and list some proteins which have the same functions with FOXP3. You can find most of the proteins on our site.

Function Related Protein
NF-kappaB bindingCOMMD7;RPS3;BRMS1;HDAC2;RNF25;ANKRD42;MTDH;HDAC3;HDAC1
NFAT protein bindingMAPK14;SFPI1;SPI1;GATA4;FOXP3;PPARA
RNA polymerase II transcription factor activity, sequence-specific DNA bindingTFAP2A;MEF2C;HIF1AL2;ZNF215;SIM1A;ZNF576;JUNBA;TFAP2E;OVOL1
core promoter bindingEP300;TFAP2C;E2F8;E2F2;NKX3;MED1;NKX3-1;HDAC4;INSM1B
histone acetyltransferase bindingCITED2;SP1;ZBTB7A;GLI3;HIF1A;PCNA;MYOCD;NR4A3;TP53
histone deacetylase bindingRFXANK;NACC2;NKX3;SIRT2;HDAC6;MYOCD;HDAC5;RUNX2;SP2
metal ion bindingIRF2BP2;RNF144AA;ITGA2;CA15B;RPAIN;UNC13C;S100A10A;ZNF620;ZDHHC20A
protein bindingPARVB;LRPAP1;NSUN4;BEX1;AHCYL2;GDF5;LDLRAD1;FAM124B;RPGR
protein homodimerization activityBAX;CCBL1;SERPINF2;SLC26A5;SDCBP2;OSTA;CD4;PRKG2;PAFAH1B1
sequence-specific DNA bindingHIVEP2A;CAMTA2;LMX1B;HOXD4;HOXC5;HOXD11A;HOXC12A;HESX1;FOXG1D
transcription corepressor activityCBFA2T2;TFAP2B;SUFU;DRAP1;PRMT5;NR2F2;SKOR2;HIRA;E4F1
transcription factor activity, RNA polymerase II distal enhancer sequence-specific bindingRFX1;SOX9;LEF1;GATA4;POU3F1;MYOG;POU4F1;HNF1B;PDX1
transcription factor activity, sequence-specific DNA bindingZNF167;SOX21;GATAD2A;ZFP322A;ZIK1;ZIC2;ZFP641;POU6F2;HINFP

FOXP3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FOXP3 here. Most of them are supplied by our site. Hope this information will be useful for your research of FOXP3.

PRR20C; RBPMS; IKZF3; mouse_arre2_site_il2_promoter_1; HDAC7; IKZF3; HDAC9; arre2_element_mouse_il2_promoter; Ctla4; il2ra_mouse_gene; Il2; RORC

Research Area

Related articles

Martinson, HA; Jindal, S; et al. Wound healing-like immune program facilitates postpartum mammary gland involution and tumor progression. INTERNATIONAL JOURNAL OF CANCER 136:1803-1813(2015).
Kaser, T; Mair, KH; et al. Natural and inducible Tregs in swine: Helios expression and functional properties. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 49:323-331(2015).
  • Q&As
  • Reviews

Q&As (5)

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Can FOXP3 be a biomarker for certain diseases? 01/05/2019

Yes, elevated or decreased levels of FOXP3 expression can serve as a biomarker for various diseases, including autoimmune conditions and certain cancers.

Can FOXP3 be used as a prognostic marker in cancer patients? 11/19/2018

Yes, the expression of FOXP3 in tumor-infiltrating lymphocytes is studied as a potential prognostic marker in various cancers, with higher levels often associated with a better prognosis.

How does FOXP3 contribute to organ transplantation? 09/01/2017

FOXP3 is crucial for immune tolerance in transplant recipients. Enhancing Treg function, possibly through manipulating FOXP3, is a focus for transplant research to prevent rejection.

How is FOXP3 protein used in cancer research and treatment? 10/13/2016

FOXP3 is studied in cancer to understand its role in suppressing anti-tumor immune responses. Manipulating Tregs or targeting FOXP3 may be explored for cancer immunotherapy.

How does FOXP3 influence allergic responses? 02/15/2016

FOXP3 helps regulate immune responses, including those involved in allergies. Dysfunction in FOXP3 or Tregs may contribute to allergic disorders.

Customer Reviews (3)

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Reviews
09/14/2022

    Its purity and integrity are of the highest standard, ensuring reliable and reproducible results in my research.

    03/09/2016

      The FOXP3 protein offered by the manufacturer is of exceptional quality and is expected to perfectly meet my experimental needs.

      02/03/2016

        The manufacturer's commitment to providing excellent technical support is commendable, as their dedicated team possesses the expertise to solve any issue or query that may arise during my experiments.

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