GAPDH
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Official Full Name
glyceraldehyde-3-phosphate dehydrogenase
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Overview
The product of this gene catalyzes an important energy-yielding step in carbohydrate metabolism, the reversible oxidative phosphorylation of glyceraldehyde-3-phosphate in the presence of inorganic phosphate and nicotinamide adenine dinucleotide (NAD). The enzyme exists as a tetramer of identical chains. Many pseudogenes similar to this locus are present in the human genome. -
Synonyms
GAPDH; G3PD; GAPD; MGC88685; glyceraldehyde-3-phosphate dehydrogenase; OTTHUMP00000174432; OTTHUMP00000174434; Peptidyl-cysteine S-nitrosylase GAPDH; aging-associated gene 9 protein; EC 1.2.1.12; glyceraldehyde 3-phosphate dehydrogenase; EC 2.6.99; EC 1.2.1; GAPDH (N-terminal);
- Recombinant Proteins
- Cell & Tissue Lysates
- Native Proteins
- Protein Pre-coupled Magnetic Beads
- Assay Kits
- Chicken
- Chinese hamster
- Human
- Mouse
- Rabbit
- Rat
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- HEK293T
- Human Heart
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Rabbit
- Wheat Germ
- Flag
- GST
- His
- Fc
- Avi
- SUMO
- T7
- Myc
- DDK
- N
- MBP
- C
- Non
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
GAPDH involved in several pathways and played different roles in them. We selected most pathways GAPDH participated on our site, such as Glycolysis / Gluconeogenesis, Metabolic pathways, Carbon metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with GAPDH were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Glycolysis / Gluconeogenesis | AKR1A1B;GPIB;ACSS1;ALDOCA;GAPDH;ALDH3B2;ALDH3A2A;ADH7;AKR1A1 |
| Metabolic pathways | ALG1;ST6GAL2A;CYP2P8;URAH;UXS1;NDUFA11;ATIC;ALG8;UGT2B7 |
| Carbon metabolism | ALDOB;SDS;TKTB;TPI1;PRPS1A;ENO1;PFKMA;FBP1;ENO1A |
| Biosynthesis of amino acids | TAT;ALDOCA;PKMB;CBSA;GLULB;PRPS2;PAH;PKM2;PFKMA |
| HIF- signaling pathway | ANGPT1;HK1;PIK3R2;TEK;TLR4;IL6R;AKT2;ENO3;PDHA1 |
| Alzheimers disease | GRIN2C;NDUFA1;CALM3;PPP3R1;NDUFB10;NDUFB5;MAPK1;COX5A;NCSTN |
GAPDH has several biochemical functions, for example, NAD binding, NADP binding, glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GAPDH itself. We selected most functions GAPDH had, and list some proteins which have the same functions with GAPDH. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| NAD binding | LDHB;HADHA;GPD1L;AHCY;GPD1;HIBADHB;AOX3;IDH3G;IDH1 |
| NADP binding | NNT;IDH1;NOS1;ASPDH;G6PDX;DPYD;GAPDH;MTRR;CRYZL1 |
| glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity | GAPDH;GAPDHS |
| identical protein binding | KHDC1A;PVRL2;APPL1;C1S;C1QL4;SHANK3;CLDN6;MDM2;GUCY2E |
| microtubule binding | MAPRE2;VAPA;KLC3;DNM2;RAE1;KIF4;CLIP3;SKA2;MAP6 |
| peptidyl-cysteine S-nitrosylase activity | |
| protein binding | FOXK2;NOP10;SLC9A3R2;INSIG2;MED27;PPP1R2P9;SNAPIN;ADAM15;FLT4 |
GAPDH has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GAPDH here. Most of them are supplied by our site. Hope this information will be useful for your research of GAPDH.
EGFR; S100A8; PREP; PCNA
Research Area
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Customer Reviews (3)
Write a reviewCustomer service was patient, prompt and accurate in answering my queries.
High protein concentration, good quality, worth buying!
The product brochure is very detailed and has comprehensive basic information about the GAPDH protein.
Q&As (5)
Ask a questionGAPDH is highly expressed in all tissues with relatively stable expression and is often used as an internal reference protein.
GAPDH is closely related to the study of hepatocellular carcinoma and can be used as one of the indicators for the diagnosis of hepatocellular carcinoma.
GAPDH binds to HDAC1.
GAPDH binds to matrix proteins, regulates host immune responses, and plays a role in pathogen virulence and surface localization, among others.
Interference with GAPDH protein expression results in telomere shortening.
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