GAPDH

  • Official Full Name

    glyceraldehyde-3-phosphate dehydrogenase

  • Overview

    The product of this gene catalyzes an important energy-yielding step in carbohydrate metabolism, the reversible oxidative phosphorylation of glyceraldehyde-3-phosphate in the presence of inorganic phosphate and nicotinamide adenine dinucleotide (NAD). The enzyme exists as a tetramer of identical chains. Many pseudogenes similar to this locus are present in the human genome.
  • Synonyms

    GAPDH; G3PD; GAPD; MGC88685; glyceraldehyde-3-phosphate dehydrogenase; OTTHUMP00000174432; OTTHUMP00000174434; Peptidyl-cysteine S-nitrosylase GAPDH; aging-associated gene 9 protein; EC 1.2.1.12; glyceraldehyde 3-phosphate dehydrogenase; EC 2.6.99; EC 1.2.1; GAPDH (N-terminal);

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Native Proteins
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Chicken
  • Chinese hamster
  • Human
  • Mouse
  • Rabbit
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Human Heart
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Rabbit
  • Wheat Germ
  • C
  • His
  • Flag
  • GST
  • His (Fc)
  • Avi
  • SUMO
  • Myc
  • DDK
  • N/A
  • N
  • T7|His
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human GAPDH-20H Active Recombinant Human GAPDH protein (Bioactivity Validated) E.coli N/A
Human GAPDH-115H Recombinant Human Glyceraldehyde-3-phosphate dehydrogenase E.coli N/A
Human GAPDH-26354TH Recombinant Human GAPDH E.coli N/A
Human GAPDH-2519H Recombinant Human GAPDH protein, His-tagged E.coli His Gly2-Glu335
Human GAPDH-231H Recombinant Human GAPDH protein, T7/His-tagged E.coli T7/His
Human GAPDH-117H Recombinant Human GAPDH, GST-tagged Wheat Germ GST
Human GAPDH-9157H Recombinant Human GAPDH, His-tagged E.coli His
Human GAPDH-6024HCL Recombinant Human GAPDH 293 Cell Lysate HEK293 N/A
Human GAPDH-5133H Recombinant Human GAPDH protein, GST-tagged E.coli GST 3-335aa
Human GAPDH-180HF Recombinant Full Length Human GAPDH Protein, GST-tagged In Vitro Cell Free System GST 1 a.a. - 335 a.a.
Human GAPDH-62H Native Human Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) Human Heart N/A
Human GAPDH-014H Recombinant Human GAPDH Protein(Met 1-Glu 335), His-tagged E.coli N-His Met 1-Glu 335
Human GAPDH-2191H Recombinant Human GAPDH Protein, His-tagged E.coli N-His Gly2-Val324
Human GAPDH-15HFL Recombinant Full Length Human GAPDH Protein, C-Flag-tagged Mammalian cells Flag
Human GAPDH-2941H Recombinant Human GAPDH protein, His-SUMO-tagged E.coli His-SUMO 2-335aa
Human GAPDH-2961H Recombinant Human GAPDH Protein (Met1-Glu335), C-His tagged E.coli C-His Met1-Glu335
Human GAPDH-4150H Recombinant Human GAPDH Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human GAPDH-045H Recombinant Human GAPDH Protein, His-tagged E.coli His
Human GAPDH-959H Recombinant Human GAPDH Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human GAPDH-959H-B Recombinant Human GAPDH Protein Pre-coupled Magnetic Beads HEK293
Human GAPDH-2544H Recombinant Human GAPDH protein(11-330 aa), C-His-tagged E.coli C-His 11-330 aa
Mouse Gapdh-21M Active Recombinant Mouse Gapdh protein, His-tagged (Bioactivity Validated) E.coli His
Mouse Gapdh-505M Recombinant Mouse Gapdh protein(Met1-Glu333), His-tagged E.coli N-His Met1-Glu333
Mouse Gapdh-3150M Recombinant Mouse Gapdh Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat GAPDH-2476R Recombinant Rat GAPDH Protein Mammalian Cell His
Rat GAPDH-2132R Recombinant Rat GAPDH Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Gapdh-1562R Recombinant Rat Gapdh Protein, His-tagged E.coli N-His Gly56-Phe284
Rat GAPDH-2132R-B Recombinant Rat GAPDH Protein Pre-coupled Magnetic Beads HEK293
Rabbit GAPDH-126R Active Native Rabbit GAPDH Rabbit N/A
Chinese hamster GAPDH-2940C Recombinant Chinese hamster GAPDH protein, His-tagged E.coli His 2-333aa
Rhesus Macaque GAPDH-1812R Recombinant Rhesus monkey GAPDH Protein, His-tagged Mammalian Cell His
Rhesus Macaque GAPDH-1633R-B Recombinant Rhesus Macaque GAPDH Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque GAPDH-1633R Recombinant Rhesus Macaque GAPDH Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish GAPDH-6540Z Recombinant Zebrafish GAPDH Mammalian Cell His
Chicken GAPDH-5878C Recombinant Chicken GAPDH Mammalian Cell His
Chicken GAPDH-517C Recombinant Chicken GAPDH Protein (2-333 aa), His-tagged E.coli His 2-333 aa
Kit-2216 GAPDH Activity Assay Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

GAPDH involved in several pathways and played different roles in them. We selected most pathways GAPDH participated on our site, such as Glycolysis / Gluconeogenesis, Metabolic pathways, Carbon metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with GAPDH were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Glycolysis / GluconeogenesisGAPDHS;PDHA1B;PFKMB;GM5506;PFKL;PKLR;ADH7;ALDH9A1B;PFKP
Metabolic pathwaysIDH1;AZIN2;TREH;HADH;PTGS2A;ALPP;HSD3B6;HDC;SPTLC2A
Carbon metabolismSDHB;PKMA;AMT;TKTL2;ME1;ACSS1;IDH3A;RGN;ECHS1
Biosynthesis of amino acidsTKTL1;TPI1;PGK2;ENO2;ACO2;TKTB;GOT1;TAT;SDS
HIF- signaling pathwayHIF1A;INSR;NOS2;PDHB;SERPINE1;Il6ra;TLR4;TFRC;MKNK1
Alzheimers diseaseCALM1;APAF1;FAS;NDUFB4;PPP3CA;GRIN2C;NDUFB3;ATP2A2;MME

GAPDH has several biochemical functions, for example, NAD binding, NADP binding, glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GAPDH itself. We selected most functions GAPDH had, and list some proteins which have the same functions with GAPDH. You can find most of the proteins on our site.

Function Related Protein
NAD bindingSORD;GPD1B;LDHB;ME3;GPD1;HPGD;NDUFS2;HSD11B2;CYB5R3
NADP bindingNNT;GAPDHS;CAT;MIOX;NOS3;GAPDH;CRYZL1;SPR;NOS1
glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activityGAPDH;GAPDHS
identical protein bindingMRFAP1L1;KRTAP10-5;CSNK2B;JMJD6;KHDC1A;TRIM55;MIEF1;ST13;CLDN9
microtubule bindingPRNP;KIF23;MACF1;MAPRE1A;LRPPRC;TRIM54;FES;CHD4;DPYSL5
peptidyl-cysteine S-nitrosylase activity
protein bindingHSP90AA1;HPS6;GPI1;FAM13C;CREB3L3;DBNL;ERC2;ASUN;HOXA1

GAPDH has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GAPDH here. Most of them are supplied by our site. Hope this information will be useful for your research of GAPDH.

EGFR; S100A8; PREP; PCNA

Research Area

Related articles

Bil-Lula, I; Sochocka, M; et al. Adenovirus Type 9 Enhances Differentiation and Decreases Cytokine Release from Preadipocytes. JOURNAL OF MEDICAL VIROLOGY 87:230-239(2015).
Upadhyaya, B; Tian, XL; et al. Expression and distribution of thiol-regulating enzyme glutaredoxin 2 (GRX2) in porcine ocular tissues. EXPERIMENTAL EYE RESEARCH 130:58-65(2015).
  • Reviews
  • Q&As

Customer Reviews (3)

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Reviews
07/14/2022

    Customer service was patient, prompt and accurate in answering my queries.

    11/26/2021

      High protein concentration, good quality, worth buying!

      01/02/2021

        The product brochure is very detailed and has comprehensive basic information about the GAPDH protein.

        Q&As (5)

        Ask a question
        Is GAPDH expression stable across tissues? 08/12/2022

        GAPDH is highly expressed in all tissues with relatively stable expression and is often used as an internal reference protein.

        What diseases has GAPDH been closely associated with the study of? 07/14/2022

        GAPDH is closely related to the study of hepatocellular carcinoma and can be used as one of the indicators for the diagnosis of hepatocellular carcinoma.

        What is the relationship between GAPDH and HDAC1? 01/25/2022

        GAPDH binds to HDAC1.

        What are the biological functions of GAPDH? 01/01/2022

        GAPDH binds to matrix proteins, regulates host immune responses, and plays a role in pathogen virulence and surface localization, among others.

        What are the effects of affecting protein expression of GAPDH? 03/05/2021

        Interference with GAPDH protein expression results in telomere shortening.

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