Recombinant Human GAPDH Protein, Myc/DDK-tagged, C13 and N15-labeled
Cat.No. : | GAPDH-4150H |
Product Overview : | GAPDH MS Standard C13 and N15-labeled recombinant protein (NP_002037) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells. |
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Description : | This gene encodes a member of the glyceraldehyde-3-phosphate dehydrogenase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. The product of this gene catalyzes an important energy-yielding step in carbohydrate metabolism, the reversible oxidative phosphorylation of glyceraldehyde-3-phosphate in the presence of inorganic phosphate and nicotinamide adenine dinucleotide (NAD). The encoded protein has additionally been identified to have uracil DNA glycosylase activity in the nucleus. Also, this protein contains a peptide that has antimicrobial activity against E. coli, P. aeruginosa, and C. albicans. Studies of a similar protein in mouse have assigned a variety of additional functions including nitrosylation of nuclear proteins, the regulation of mRNA stability, and acting as a transferrin receptor on the cell surface of macrophage. Many pseudogenes similar to this locus are present in the human genome. Alternative splicing results in multiple transcript variants. |
Source : | HEK293 |
Species : | Human |
Tag : | Myc&DDK |
Molecular Mass : | 36.1 kDa |
AA Sequence : | MGKVKVGVNGFGRIGRLVTRAAFNS GKVDIVAINDPFIDLNYMVYMFQYD STHGKFHGTVKAENGKLVINGNPIT IFQERDPSKIKWGDAGAEYVVESTG VFTTMEKAGAHLQGGAKRVIISAPS ADAPMFVMGVNHEKYDNSLKIISNA SCTTNCLAPLAKVIHDNFGIVEGLM TTVHAITATQKTVDGPSGKLWRDGR GALQNIIPASTGAAKAVGKVIPELN GKLTGMAFRVPTANVSVVDLTCRLE KPAKYDDIKKVVKQASEGPLKGILG YTEHQVVSSDFNSDTHSSTFDAGAG IALNDHFVKLISWYDNEFGYSNRVV DLMAHMASKETRTRPLEQKLISEED LAANDILDYKDDDDKV |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 3 months from receipt of products under proper storage and handling conditions. |
Storage : | Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
Concentration : | 50 μg/mL as determined by BCA |
Storage Buffer : | 100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
Gene Name : | GAPDH glyceraldehyde-3-phosphate dehydrogenase [ Homo sapiens (human) ] |
Official Symbol : | GAPDH |
Synonyms : | GAPDH; glyceraldehyde-3-phosphate dehydrogenase; GAPD; aging-associated gene 9 protein; peptidyl-cysteine S-nitrosylase GAPDH; G3PD; MGC88685; |
Gene ID : | 2597 |
mRNA Refseq : | NM_002046 |
Protein Refseq : | NP_002037 |
MIM : | 138400 |
UniProt ID : | P04406 |
Products Types
◆ Recombinant Protein | ||
GAPDH-2132R | Recombinant Rat GAPDH Protein, His (Fc)-Avi-tagged | +Inquiry |
GAPDH-5453C | Recombinant Chicken GAPDH protein, MBP&His-Avi-tagged, Biotinylated | +Inquiry |
Gapdh-505M | Recombinant Mouse Gapdh protein(Met1-Glu333), His-tagged | +Inquiry |
GAPDH-1633R | Recombinant Rhesus Macaque GAPDH Protein, His (Fc)-Avi-tagged | +Inquiry |
GAPDH-2544H | Recombinant Human GAPDH protein(11-330 aa), C-His-tagged | +Inquiry |
◆ Native Protein | ||
GAPDH-126R | Active Native Rabbit Glyceraldehyde-3-phosphate Dehydrogenase | +Inquiry |
GAPDH-62H | Native Human Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) | +Inquiry |
◆ Lysates | ||
GAPDH-6024HCL | Recombinant Human GAPDH 293 Cell Lysate | +Inquiry |
◆ Assay kits | ||
Kit-2216 | GAPDH Activity Assay Kit | +Inquiry |
Related Gene
Not For Human Consumption!
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Customer Reviews (3)
Write a reviewCustomer service was patient, prompt and accurate in answering my queries.
High protein concentration, good quality, worth buying!
The product brochure is very detailed and has comprehensive basic information about the GAPDH protein.
Q&As (5)
Ask a questionGAPDH is highly expressed in all tissues with relatively stable expression and is often used as an internal reference protein.
GAPDH is closely related to the study of hepatocellular carcinoma and can be used as one of the indicators for the diagnosis of hepatocellular carcinoma.
GAPDH binds to HDAC1.
GAPDH binds to matrix proteins, regulates host immune responses, and plays a role in pathogen virulence and surface localization, among others.
Interference with GAPDH protein expression results in telomere shortening.
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