GATA2
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Official Full Name
GATA binding protein 2 -
Overview
This gene encodes a member of the GATA family of zinc-finger transcription factors that are named for the consensus nucleotide sequence they bind in the promoter regions of target genes. The encoded protein plays an essential role in regulating transcription of genes involved in the development and proliferation of hematopoietic and endocrine cell lineages. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009] -
Synonyms
GATA2;GATA binding protein 2;DCML;IMD21;NFE1B;MONOMAC;endothelial transcription factor GATA-2
Recombinant Proteins
- Chicken
- Human
- Mouse
- Mammalian Cells
- E.coli
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- His
- Non
- Flag
- DDK
- Myc
- Avi
- Fc
- GST
Involved Pathway
GATA2 involved in several pathways and played different roles in them. We selected most pathways GATA2 participated on our site, such as Adipogenesis,Factors involved in megakaryocyte development and platelet production,HIF-1-alpha transcription factor network, which may be useful for your reference. Also, other proteins which involved in the same pathway with GATA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Adipogenesis | PIANP,NAMPT,MIXL1,CTNNB1,MEF2B,GDF10,SPOCK1,CEBPA,EBF1,EPAS1B |
| Factors involved in megakaryocyte development and platelet production | KIFC1,KIF3A,RACGAP1,PHF21A,GATA1A,EHD1,CABLES1,AKAP1B,KIF2A,CABLES2 |
| Regulation of Androgen receptor activity | SPDEF,KAT7,SENP1,TRIM24,APPBP2,SMARCE1,HOXB13,SRY,SMARCA2,NR2C1 |
| IL-3 Signaling Pathway | GATA2A,BIRC5A,KCNIP3B,BMX,PILRB,GSK3AB,GNB2L1,CISH,SPI1B,GATA1 |
| SIDS Susceptibility Pathways | DLX2,TPPP,CDCA7L,TPH2,KCNH2,PLP1,SCN3B,PHOX2B,LMX1B,MBD1 |
| Signaling events mediated by HDAC Class I | SIRT5,SIRT7,PRMT5,SIRT4,FKBP3,NR2C1,GATA1,TFCP2,MXD1,SIRT2 |
| Hemostasis | Alb,NADL1.1,HMG20B,GRB14,SCG3,SLC7A8A,BA1L,CEACAM1,CABLES1,CFHL4 |
| HIF-1-alpha transcription factor network | CITED2,ADM,TFF3,COPS5,ENG,PLIN2,NPM1,CP,NDRG1,EGLN3 |
Protein Function
GATA2 has several biochemical functions, for example, C2H2 zinc finger domain binding,RNA polymerase II distal enhancer sequence-specific DNA binding,RNA polymerase II regulatory region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GATA2 itself. We selected most functions GATA2 had, and list some proteins which have the same functions with GATA2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| enhancer sequence-specific DNA binding | TWIST1B,YY1,TBX19,GATA5,KLF7B,ISL1,KLF6A,ATF2,SOX9,LDB1 |
| transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding | MAF,IRF2,MYOG,DLX2,GABPA,PPARG,MAFG,EP300,FOXO3,TRP53 |
| protein binding | RAD52,TRIM2,UTF1,CHAC1,NBR1,TUBG1,RAB21,COPRS,SNX15,RGS3 |
| zinc ion binding | TRIM35-22,RNF187,DYTN,MARCH7,RBM4.1,ZCCHC2,ADAM9,LIMK2,RECQL4,ALPI |
| RNA polymerase II regulatory region sequence-specific DNA binding | PAX9,H2AFY,NHLH2,NME2,SUV39H1,STOX1,EOMES,ALX4,ETV7,HES6 |
| transcription factor binding | RBFOX2,HMGB1,GTF2B,SMAD3,ARRB1,HYAL1,NLK,HDAC3,ERCC3,NAB1 |
| RNA polymerase II distal enhancer sequence-specific DNA binding | NR5A1,NFE2L1,CREB1,CDX2,T,SFPI1,SPI1,ESRRB,MEOX2,NFATC1 |
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | NRL,CEBPZ,FOXJ2,NR2E1,GLIS2,NR4A1,NR5A2,JUN,MYB,PAX5 |
| chromatin binding | FOXO1,TFAM,RBPJL,PROP1,HMGB2,SIRT6,MEIS3,ADNP,HOXD13,NOC3L |
Interacting Protein
GATA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GATA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of GATA2.
Lmo2;PSMA3;TRIM23;KRTAP10-9;PRR20C;GOLGA2
Resources
Research Area
Transcription Factors in the Akt PathwayHematopoietic Stem Cell Markers
Cancer Stem Cell Transcription Factors
Hematopoietic Stem Cell Transcription Factors and Regulators
Neural Stem Cell Markers
Pluripotent Stem Cell Transcription Factors
Related Services
Related Products
References
- Plymate, SR; Bhatt, RS; et al. Taxane Resistance in Prostate Cancer Mediated by AR-Independent GATA2 Regulation of IGF2. CANCER CELL 27:158-159(2015).
- Chou, J; Lutskiy, M; et al. Presence of hypogammaglobulinemia and abnormal antibody responses in GATA2 deficiency. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 134:223-226(2014).
