GATA2 Protein

GATA2

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GATA2

Official Full Name GATA binding protein 2
Background This gene encodes a member of the GATA family of zinc-finger transcription factors that are named for the consensus nucleotide sequence they bind in the promoter regions of target genes. The encoded protein plays an essential role in regulating transcription of genes involved in the development and proliferation of hematopoietic and endocrine cell lineages. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]
Synonyms GATA2; GATA binding protein 2; DCML; IMD21; NFE1B; MONOMAC; endothelial transcription factor GATA-2;
    • Species :
    • Chicken
    • Human
    • Mouse
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • Arg
    • GST
    • His
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human GATA2-136H Recombinant Human GATA2 protein, Arginine-tagged E.coli Arg
    Human GATA2-28285TH Recombinant Human GATA2 Wheat Germ N/A
    Human GATA2-28983TH Recombinant Human GATA2 Wheat Germ N/A
    Human GATA2-4745H Recombinant Human GATA2 Protein, GST-tagged Wheat Germ GST
    Human GATA2-476H Recombinant Human GATA2 Protein, His-tagged E.coli His
    Human GATA2-6013HCL Recombinant Human GATA2 293 Cell Lysate HEK293 N/A
    Human GATA2-602H Recombinant Human GATA2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Mouse Gata2-3160M Recombinant Mouse Gata2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Mouse Gata2-477M Recombinant Mouse Gata2 Protein, His-tagged E.coli His
    Mouse GATA2-6223M Recombinant Mouse GATA2 Protein Mammalian Cell His
    Chicken GATA2-1186C Recombinant Chicken GATA2 Mammalian Cell His

    GATA2 involved in several pathways and played different roles in them. We selected most pathways GATA2 participated on our site, such as Adipogenesis, Factors involved in megakaryocyte development and platelet production, HIF-1-alpha transcription factor network, which may be useful for your reference. Also, other proteins which involved in the same pathway with GATA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Adipogenesis BMP3; MIXL1; DVL1; GDF10; NR2F1; MBNL1; DDIT3; NRIP1; CDKN1A; E2F4
    Factors involved in megakaryocyte development and platelet production MGC173646; GATA2; CENPE; HBE1; EHD1; AKAP1B; ZFPM1; SH2B3; KIF9; KLC3
    HIF-1-alpha transcription factor network GATA2; PLIN2; CP; CITED2; NDRG1; COPS5; ENG; NPM1; ADM; EGLN3
    Hemostasis NADL1.1; KIFC1; KIF26A; KIF2C; SLC7A6; CXADR; HBBE2; SLC16A1; HBB-BH1; STXBP3
    IL-3 Signaling Pathway SPI1B; GNB2L1; BIRC5A; GATA2A; GSK3AB; KCNIP3B; GATA2; KCNIP3; GATA1A; BMX
    Regulation of Androgen receptor activity SENP1; APPBP2; NR0B1; SMARCE1; SRY; TRIM24; NR2C1; GATA2; HOXB13; SMARCA2
    SIDS Susceptibility Pathways IL1RN; RUNX3; LMX1B; ECE1; PHOX2A; KCNQ1; MBD1; SNTA1; SP3; CREM
    Signaling events mediated by HDAC Class I GATA1; WDR77; PRMT5; SIRT4; NR2C1; SIRT2; SIRT7; MXD1; FKBP3; SIRT5

    GATA2 has several biochemical functions, for example, C2H2 zinc finger domain binding, RNA polymerase II distal enhancer sequence-specific DNA binding, RNA polymerase II regulatory region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GATA2 itself. We selected most functions GATA2 had, and list some proteins which have the same functions with GATA2. You can find most of the proteins on our site.

    Function Related Protein
    C2H2 zinc finger domain binding EHMT1; THAP7; GATA2; GATA1; LEF1; U2AF2; EHMT2; HMGA2; WT1; EBF1
    RNA polymerase II distal enhancer sequence-specific DNA binding NFATC1; MEOX2; GATA2; RUVBL2; MIXL1; NR1H4; H3F3B; NR2F6; SIX3; NFE2L1
    RNA polymerase II regulatory region sequence-specific DNA binding DBP; RELB; RARA; RARG; ZNF549; RXRA; ATF4B2; CREBBP; CGGBP1; GLIS1
    RNA polymerase II transcription factor binding GATA5; MKX; GATA2B; ZFPM2; GATA3; MIXL1; TAL1; T; Ar; GATA2A
    chromatin binding HMG20A; TDRD3; MEF2C; RDBP; TOX4; ZMYND11; HINFP; POU1F1; TPR; GABPA
    enhancer sequence-specific DNA binding SOX9; GATA1; ATF2; TFAP2B; FOXN4; YY1; LMO4; TWIST1B; GATA5; GATA3
    protein binding CYBRD1; BCL2L2; FKBP1B; BRPF1; ITGB1; POLRMT; VPS54; TFG; KRTAP19-7; FAM124B
    transcription factor activity, sequence-specific DNA binding ZFP354B; MYCH; HOXC5; POU2F2; NR1I3; PPARD; NFIL3; STAT4; ZBTB25; ETS2
    transcription factor binding SOX10; MECP2; NR0B1; CDK9; TRAPPC2; FOS; TMEM173; NCOR2; FOXA3; FIGLA
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding PITX1; DDIT3; FOS; TFAP2C; TFAM; CTCFL; GLI2; PGR; MTF1; MEIS1
    transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding LEF1; SOX17; EAF2; BARHL1B; FEZF2; MAFGA; BARX2; FOXC1; CREB3L3; MYOG
    zinc ion binding RORC; GFI1AA; PCGF2; RXRGB; ITGB1BP2; ISL2A; LNX2B; MSL2B; MYRIP; TRIM35-39

    GATA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GATA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of GATA2.

    Lmo2; PSMA3; TRIM23; KRTAP10-9; PRR20C; GOLGA2

    Plymate, SR; Bhatt, RS; et al. Taxane Resistance in Prostate Cancer Mediated by AR-Independent GATA2 Regulation of IGF2. CANCER CELL 27:158-159(2015).
    Chou, J; Lutskiy, M; et al. Presence of hypogammaglobulinemia and abnormal antibody responses in GATA2 deficiency. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 134:223-226(2014).

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