GATA2
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Official Full Name
GATA binding protein 2
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Background
This gene encodes a member of the GATA family of zinc-finger transcription factors that are named for the consensus nucleotide sequence they bind in the promoter regions of target genes. The encoded protein plays an essential role in regulating transcription of genes involved in the development and proliferation of hematopoietic and endocrine cell lineages. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009] -
Synonyms
GATA2; GATA binding protein 2; DCML; IMD21; NFE1B; MONOMAC; endothelial transcription factor GATA-2;
- Involved Pathway
- Protein Function
- Interacting Protein
- GATA2 Related Articles
- GATA2 Related Research Area
GATA2 involved in several pathways and played different roles in them. We selected most pathways GATA2 participated on our site, such as Adipogenesis, Factors involved in megakaryocyte development and platelet production, HIF-1-alpha transcription factor network, which may be useful for your reference. Also, other proteins which involved in the same pathway with GATA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Adipogenesis | CREB1;CYP26A1;PIANP;EGR2;KLF7A;E2F1;MEF2AA;BMP3;EBF1 |
| Factors involved in megakaryocyte development and platelet production | GATA1;KIF3B;NFE2;DOCK6;KIFC1;DOCK9;ZFPM1;IRF1B;HBG2 |
| HIF-1-alpha transcription factor network | TFF3;ENG;CP;NPM1;GATA2;ADM;PLIN2;COPS5;NDRG1 |
| Hemostasis | RHOGA;CAP1;SERPINB8;HBBE3;F13A1B;GRB7;CXADR;ESAMA;CFD |
| IL-3 Signaling Pathway | KCNIP3;SPI1B;GATA2A;GATA1;CISH;BMX;GATA1A;PILRB;GSK3AB |
| Regulation of Androgen receptor activity | NR2C1;KAT7;NR2C2;SRY;APPBP2;SENP1;SMARCA2;TRIM24;GATA2 |
| SIDS Susceptibility Pathways | CTCF;MBD1;POU2F2;CHRFAM7A;KCNH2;CREM;KCNJ8;ECE1;RUNX3 |
| Signaling events mediated by HDAC Class I | NR2C1;PRMT5;TFCP2;MXD1;GATA2;SIRT2;FKBP3;WDR77;SIRT7 |
GATA2 has several biochemical functions, for example, C2H2 zinc finger domain binding, RNA polymerase II distal enhancer sequence-specific DNA binding, RNA polymerase II regulatory region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GATA2 itself. We selected most functions GATA2 had, and list some proteins which have the same functions with GATA2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| C2H2 zinc finger domain binding | WT1;HMGA2;GATA2;EBF1;GATA1;LEF1;EHMT2;U2AF2;EHMT1 |
| RNA polymerase II distal enhancer sequence-specific DNA binding | REL;BACH1A;GZF1;HNRNPC;CREB1;NR5A2;SFPI1;SIX3;FLI1 |
| RNA polymerase II regulatory region sequence-specific DNA binding | DBP;MYOG;SNAI1;GLIS1;RXRA;PHF21B;CREB3;SATB1;TBX20 |
| RNA polymerase II transcription factor binding | MTA2;DHX9;WWP2;ID4;SPOP;KDM1A;Ar;ZFPM2A;GSC |
| chromatin binding | TMPOA;SMARCD1;UBTF;ZMYND11;FOXO1;ARX;TOX4;WHSC1;EGR2 |
| enhancer sequence-specific DNA binding | GATA2;MYT1;SOX11;LDB1;ATF2;HMGB2;ISL1;XBP1;TFAP2B |
| protein binding | DYNC1LI1;CDKN2B;LIMK1;RHPN1;CTNNA3;STX7;ATRNL1;MAPK3;RASSF2 |
| transcription factor activity, sequence-specific DNA binding | ETS2;TGIF1;MYCB;RERE;ZFP28;PRDM1;Ar;FOXJ1B;WNT5A |
| transcription factor binding | CXXC5;DAXX;PARK7;NEUROD1;RNF222;ERCC3;PPARGC1A;MDFI;DR1 |
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | NFATC3;POU1F1;ESR1;NKX2-8;PATZ1;MYC;MITF;MYOCD;OTX1 |
| transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding | MAFGA;MAFF;MYOCD;ATF1;CREBBP;MAFBA;EAF2;HOXD8;ATF3 |
| zinc ion binding | ISL1L;GATA1A;PRICKLE2B;NAPEPLD;CAD;APOBEC2A;TRIM39;CPA2;TRAF4 |
GATA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GATA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of GATA2.
Lmo2; PSMA3; TRIM23; KRTAP10-9; PRR20C; GOLGA2
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