GATA2

  • Official Full Name

    GATA binding protein 2

  • Overview

    This gene encodes a member of the GATA family of zinc-finger transcription factors that are named for the consensus nucleotide sequence they bind in the promoter regions of target genes. The encoded protein plays an essential role in regulating transcription of genes involved in the development and proliferation of hematopoietic and endocrine cell lineages. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]
  • Synonyms

    GATA2; GATA binding protein 2; DCML; IMD21; NFE1B; MONOMAC; endothelial transcription factor GATA-2;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Arg
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human GATA2-28983TH Recombinant Human GATA2 Wheat Germ N/A 102 amino acids
Human GATA2-136H Recombinant Human GATA2 protein, Arginine-tagged E.coli Arg
Human GATA2-476H Recombinant Human GATA2 Protein, His-tagged E.coli His Pro175~Gly480
Human GATA2-28285TH Recombinant Human GATA2 Wheat Germ N/A 480 amino acids
Human GATA2-6013HCL Recombinant Human GATA2 293 Cell Lysate HEK293 N/A
Human GATA2-4745H Recombinant Human GATA2 Protein, GST-tagged Wheat Germ GST
Human GATA2-181HF Recombinant Full Length Human GATA2 Protein In Vitro Cell Free System 480 amino acids
Human GATA2-962H-B Recombinant Human GATA2 Protein Pre-coupled Magnetic Beads HEK293
Human GATA2-962H Recombinant Human GATA2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human GATA2-602H Recombinant Human GATA2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human GATA2-1252HFL Recombinant Full Length Human GATA2 Protein, C-Flag-tagged Mammalian cells Flag
Human GATA2-5465HF Recombinant Full Length Human GATA2 Protein, GST-tagged In Vitro Cell Free System GST 480 amino acids
Human GATA2-2792H Recombinant Human GATA2 Protein (Pro175-Gly480), His tagged E.coli His Pro175-Gly480
Mouse GATA2-6223M Recombinant Mouse GATA2 Protein Mammalian Cell His
Mouse Gata2-477M Recombinant Mouse Gata2 Protein, His-tagged E.coli His Thr117~Arg338
Mouse GATA2-3482M-B Recombinant Mouse GATA2 Protein Pre-coupled Magnetic Beads HEK293
Mouse Gata2-3160M Recombinant Mouse Gata2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse GATA2-3482M Recombinant Mouse GATA2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Chicken GATA2-1186C Recombinant Chicken GATA2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

GATA2 involved in several pathways and played different roles in them. We selected most pathways GATA2 participated on our site, such as Adipogenesis, Factors involved in megakaryocyte development and platelet production, HIF-1-alpha transcription factor network, which may be useful for your reference. Also, other proteins which involved in the same pathway with GATA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
AdipogenesisBSCL2;CREB1;EPAS1B;CTNNB1;CFD;CEBPD;NDN;NRIP1;EGR2B
Factors involved in megakaryocyte development and platelet productionKIF4A;H3F3B.1;MAFF;MYB;HBG1;MAFG;AKAP1;KIF11;HBBE2
HIF-1-alpha transcription factor networkPLIN2;CITED2;COPS5;ADM;ENG;NDRG1;NPM1;EGLN3;GATA2
HemostasisDOCK7;F3B;DGKQ;GNA13B;KIF4;BA2;ANXA2A;GATA2A;ANXA2
IL-3 Signaling PathwaySPI1B;CISH;GNB2L1;GATA2;GATA1;KCNIP3;GATA2A;GATA1A;PILRB
Regulation of Androgen receptor activitySRY;HOXB13;SMARCE1;APPBP2;GATA2;TRIM24;NR0B1;NR2C2;KAT7
SIDS Susceptibility PathwaysMAP2;CHRFAM7A;MECP2;PHOX2A;POU2F2;DEAF1;MBD1;ECE1;CC2D1A
Signaling events mediated by HDAC Class IGATA1;SIRT4;SIRT2;MXD1;SIRT7;GATA2;NR2C1;WDR77;SIRT5

GATA2 has several biochemical functions, for example, C2H2 zinc finger domain binding, RNA polymerase II distal enhancer sequence-specific DNA binding, RNA polymerase II regulatory region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GATA2 itself. We selected most functions GATA2 had, and list some proteins which have the same functions with GATA2. You can find most of the proteins on our site.

Function Related Protein
C2H2 zinc finger domain bindingLEF1;WT1;EHMT1;TAF9;GATA1;EBF1;THAP7;GATA2;HMGA2
RNA polymerase II distal enhancer sequence-specific DNA bindingRUVBL2;RELA;ARID3B;MED12;NFATC1;ESRRB;CREB1;NFE2L2;BACH1A
RNA polymerase II regulatory region sequence-specific DNA bindingZFY2;CUX2;ZNF256;MSX1;SOX13;HOXD9;ATF4B1;ATF2;PKNOX2
RNA polymerase II transcription factor bindingTRP53;GATA3;MTA2;GSK3B;GFI1B;GATA2;TRPS1;MEF2A;TBX3
chromatin bindingAAAS;SUPT5H;SKIL;KDM1A;DHX30;HESX1;KLF6A;COQ7;STAT5B
enhancer sequence-specific DNA bindingGATA1;HMGB2;GATA2;KLF6A;TBX19;GATA5;KLF7B;GATA4;SOX11
protein bindingSPRR3;PPP3CA;IGF2BP3;UHRF1;HPN;DNAJC11;SH2D2A;POLG;POLB
transcription factor activity, sequence-specific DNA bindingBATF3;HSF5;NR2F6;ZNF461;PBX3B;E2F4;SIX2;SOX1;KLF11
transcription factor bindingARNT;PPRC1;IFI16;PURA;CDK9;TRP53;HEY1;TAF7;ARID5A
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific bindingTLX1;OTX2;CREB3L1;JUN;NFAT5;MZF1;BATF;KLF4;TFE3
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific bindingPKNOX1;ESRRG;MAFK;CSRNP3;BHLHA15;OVOL2;SOHLH1;LEF1;MYOG
zinc ion bindingSOLH;S100A8;GM757;TRIM59;NR1H3;CAD;RNF115;RNF24;SETDB2

GATA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GATA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of GATA2.

Lmo2; PSMA3; TRIM23; KRTAP10-9; PRR20C; GOLGA2

Research Area

Related articles

Plymate, SR; Bhatt, RS; et al. Taxane Resistance in Prostate Cancer Mediated by AR-Independent GATA2 Regulation of IGF2. CANCER CELL 27:158-159(2015).
Chou, J; Lutskiy, M; et al. Presence of hypogammaglobulinemia and abnormal antibody responses in GATA2 deficiency. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 134:223-226(2014).
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