GDF11

  • Official Full Name

    growth differentiation factor 11

  • Overview

    The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in mice and Xenopus suggest that this protein is involved in mesodermal formation and neurogenesis during embryonic development.
  • Synonyms

    GDF11; growth differentiation factor 11; growth/differentiation factor 11; BMP 11; GDF-11; bone morphogenetic protein 11; BMP11; BMP-11;

  • Recombinant Proteins
  • GMP Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Human/Mouse/Rat
  • Mouse
  • Rat
  • Zebrafish
  • E. coli
  • E.coli
  • HEK293
  • Human Cell
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • C
  • His
  • GST
  • His (Fc)
  • Avi
  • His(C
  • ter)
  • SUMO
  • Met
  • N/A
  • Tag Free
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human GDF11-1078H Active Recombinant Human GDF11 E.coli Met
Human GDF11-38H Active Recombinant Human GDF11, His-tagged E.coli His
Human GDF11-242 Recombinant Human Growth Differentiation Factor 11 E.coli N/A
Human GDF11-01H Recombinant Human GDF11 protein E.coli N/A
Human GDF11-137HG Active GMP Recombinant Human GDF11 Protein E.coli N/A
Human GDF11-280H Recombinant Human GDF11 Protein, His-tagged E.coli His
Human GDF11-155H Recombinant Human GDF11 Protein Human Cell
Human GDF11-103H Recombinant Active Human GDF11 Protein, His-tagged(C-ter) E.coli His(C-ter)
Human GDF11-4820H Recombinant Human GDF11 Protein, GST-tagged Wheat Germ GST
Human GDF11-2952H Recombinant Human GDF11 protein, His-SUMO-tagged E.coli His-SUMO
Human GDF11-3395H Recombinant Human GDF11 Protein (Asn299-Ser407) Mammalian cells Tag Free
Human GDF11-281H Recombinant Human GDF11 Protein, His-tagged E.coli His
Human GDF11-046H Active Recombinant Human GDF11 Protein E. coli
Human GDF11-07H Active Recombinant Human GDF11 Protein (Asn299-Ser407), C-His tagged, Animal-free, Carrier-free E.coli C-His
Mouse GDF11-1079M Active Recombinant Mouse GDF11 E.coli Met
Mouse Gdf11-108M Active Recombinant Mouse Gdf11 protein E.coli N/A
Mouse GDF11-6284M Recombinant Mouse GDF11 Protein Mammalian Cell His
Mouse GDF11-3518M Recombinant Mouse GDF11 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse GDF11-3518M-B Recombinant Mouse GDF11 Protein Pre-coupled Magnetic Beads HEK293
Mouse Gdf11-282M Recombinant Mouse Gdf11 Protein, His-tagged E.coli N/A
Rat Gdf11-1080R Active Recombinant Rat Gdf11 protein E.coli N/A
Rat Gdf11-283R Recombinant Rat Gdf11 Protein, His-tagged E.coli His
Human/Mouse/Rat GDF11-104H Active Recombinant Human/Mouse/Rat GDF11 Protein E.coli
Human/Mouse/Rat GDF11-105H Active Recombinant Human/Mouse/Rat GDF11 Protein E.coli
Zebrafish GDF11-12223Z Recombinant Zebrafish GDF11 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • GDF11 Related Gene Family

GDF11 involved in several pathways and played different roles in them. We selected most pathways GDF11 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with GDF11 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

GDF11 has several biochemical functions, for example, cytokine activity, growth factor activity, transforming growth factor beta receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GDF11 itself. We selected most functions GDF11 had, and list some proteins which have the same functions with GDF11. You can find most of the proteins on our site.

Function Related Protein
cytokine activityIFNA7;WNT2;IL17D;LTA;LEFTY2;FAM3C;IL13;MSTNB;INHBAA
growth factor activityNRG3;FGF18A;INHBAA;HBEGFA;GDF5;JAG1;BMP3;WISP3;LFT1
transforming growth factor beta receptor bindingINHBA;SPAW;NODAL;BMP5;NDR1;BMP7;GDF5;BMP2B;TGFBR3

GDF11 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GDF11 here. Most of them are supplied by our site. Hope this information will be useful for your research of GDF11.

ACVR2B; Acvr1b; Tgfbr1; Acvr1c; WFIKKN2; WFIKKN1

TGF
  • Q&As
  • Reviews

Q&As (6)

Ask a question
Can GDF11 protein be used to treat some diseases with stem cell therapy? 12/25/2019

The protein can be used to treat some diseases through stem cell therapy, such as using the promoter of GDF11 to activate the self-renewal and regenerative ability of stem cells.

What diseases can GDF11 protein be used as a therapeutic target? 12/13/2019

GDF11 protein can be used as a therapeutic target for a variety of diseases such as muscular dystrophy, osteoporosis, cardiovascular diseases and neurodegenerative diseases.

What is the role of GDF11 protein on bone growth? 12/10/2019

GDF11 protein inhibits the differentiation of well-developed chondrocytes in bone growth plates into osteoblasts, thereby inhibiting bone growth.

Can GDF11 protein be intervened with drugs? 12/02/2019

The GDF11 protein can be intervened by means of drugs, such as using soluble GDF11 receptors to increase the activity of the GDF11 signaling pathway.

Does GDF11 protein promote muscle growth? 10/10/2019

In young animals, GDF11 promotes muscle growth, but in older adults and mice, its effect is not significant.

Does GDF11 protein drive neuroblast production and growth? 09/29/2019

This protein promotes the production and growth of neuroblasts and also plays an important role in the differentiation and function of neural stem cells.

Customer Reviews (3)

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Reviews
04/19/2022

    The repeatability of GDF11 is very good, which can ensure the reliability of the experimental results, and also facilitate the subsequent research and application.

    05/23/2020

      After using GDF11, my experimental results are more stable and reliable, and also convenient for subsequent data analysis.

      03/09/2020

        The band intensity of GDF11 in Western blot was high, which improved the signal-to-noise ratio of the experiment.

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