Recombinant Human GDF11 protein

• Cat.No.: GDF11-01H
• Product Overview: Recombinant Human GDF11 was expressed in E. coli.

Specification

• Description: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein plays a role in the development of the nervous and other organ systems, and may regulate aging.
• Source: E. coli
• Species: Human
• Form: 20mM Tris-HCl, 200 mM NaCl, pH7.4, 2Mm DTT
• Molecular Mass: ~13 kDa
• AA Sequence: NLGLDCDEHSSESRCCRYPLTVDFE AFGWDWIIAPKRYKANYCSGQCEYM FMQKYPHTHLVQQANPRGSAGPCCT PKMSPINMLYFNDKQQIIYGKIPGM VVDRCGCS
• Purity: > 95% as determined by SDS-PAGE
• Storage: Short Term Storage (1 week) at +4 centigrade, Long Term Storage(3 months) at -20 centigrade to -80 centigrade. Avoid freeze/thaw cycles.
• Concentration: 0.1 mg/ml

Gene Information

• Gene Name: GDF11 growth differentiation factor 11 [ Homo sapiens ]
• Official Symbol: GDF11
• Synonyms: GDF11; growth differentiation factor 11; growth/differentiation factor 11; BMP 11; GDF-11; bone morphogenetic protein 11; BMP11; BMP-11
• Gene ID: 10220
• mRNA Refseq: NM_005811
• Protein Refseq: NP_005802
• MIM: 603936
• UniProt ID: O95390
• Chromosome Location: 12q13.13
• Function: cytokine activity; growth factor activity

Reviews

04/19/2022

The repeatability of GDF11 is very good, which can ensure the reliability of the experimental results, and also facilitate the subsequent research and application.

05/23/2020

After using GDF11, my experimental results are more stable and reliable, and also convenient for subsequent data analysis.

03/09/2020

The band intensity of GDF11 in Western blot was high, which improved the signal-to-noise ratio of the experiment.

Q&As

Can GDF11 protein be used to treat some diseases with stem cell therapy?

The protein can be used to treat some diseases through stem cell therapy, such as using the promoter of GDF11 to activate the self-renewal and regenerative ability of stem cells.

What diseases can GDF11 protein be used as a therapeutic target?

GDF11 protein can be used as a therapeutic target for a variety of diseases such as muscular dystrophy, osteoporosis, cardiovascular diseases and neurodegenerative diseases.

What is the role of GDF11 protein on bone growth?

GDF11 protein inhibits the differentiation of well-developed chondrocytes in bone growth plates into osteoblasts, thereby inhibiting bone growth.

Can GDF11 protein be intervened with drugs?

The GDF11 protein can be intervened by means of drugs, such as using soluble GDF11 receptors to increase the activity of the GDF11 signaling pathway.

Does GDF11 protein promote muscle growth?

In young animals, GDF11 promotes muscle growth, but in older adults and mice, its effect is not significant.

Does GDF11 protein drive neuroblast production and growth?

This protein promotes the production and growth of neuroblasts and also plays an important role in the differentiation and function of neural stem cells.