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Recombinant Human GDF11 Protein, His-tagged

Cat.No. : GDF11-280H
Product Overview : Recombinant Human GDF11(Thr138~Asn386) fused with His tag at N-terminal was expressed in E. coli.
  • Specification
  • Gene Information
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Description : This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein plays a role in the development of the nervous and other organ systems, and may regulate aging.
Source : E. coli
Species : Human
Tag : His
Form : 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.
Molecular Mass : 31.88kDa
Protein length : Thr138~Asn386
Endotoxin : <1.0EU per 1ug (determined by the LAL method)
Purity : > 90%
Applications : Positive Control; Immunogen; SDS-PAGE; WB.
If bio-activity of the protein is needed, please check active protein
Stability : The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
Reconstitution : Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.
Gene Name : GDF11 growth differentiation factor 11 [ Homo sapiens ]
Official Symbol : GDF11
Synonyms : GDF11; growth differentiation factor 11; growth/differentiation factor 11; BMP 11; GDF-11; bone morphogenetic protein 11; BMP11; BMP-11;
Gene ID : 10220
mRNA Refseq : NM_005811
Protein Refseq : NP_005802
MIM : 603936
UniProt ID : O95390

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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Can GDF11 protein be used to treat some diseases with stem cell therapy? 12/25/2019

The protein can be used to treat some diseases through stem cell therapy, such as using the promoter of GDF11 to activate the self-renewal and regenerative ability of stem cells.

What diseases can GDF11 protein be used as a therapeutic target? 12/13/2019

GDF11 protein can be used as a therapeutic target for a variety of diseases such as muscular dystrophy, osteoporosis, cardiovascular diseases and neurodegenerative diseases.

What is the role of GDF11 protein on bone growth? 12/10/2019

GDF11 protein inhibits the differentiation of well-developed chondrocytes in bone growth plates into osteoblasts, thereby inhibiting bone growth.

Can GDF11 protein be intervened with drugs? 12/02/2019

The GDF11 protein can be intervened by means of drugs, such as using soluble GDF11 receptors to increase the activity of the GDF11 signaling pathway.

Does GDF11 protein promote muscle growth? 10/10/2019

In young animals, GDF11 promotes muscle growth, but in older adults and mice, its effect is not significant.

Does GDF11 protein drive neuroblast production and growth? 09/29/2019

This protein promotes the production and growth of neuroblasts and also plays an important role in the differentiation and function of neural stem cells.

Customer Reviews (3)

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Reviews
04/19/2022

    The repeatability of GDF11 is very good, which can ensure the reliability of the experimental results, and also facilitate the subsequent research and application.

    05/23/2020

      After using GDF11, my experimental results are more stable and reliable, and also convenient for subsequent data analysis.

      03/09/2020

        The band intensity of GDF11 in Western blot was high, which improved the signal-to-noise ratio of the experiment.

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