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Official Full Name growth differentiation factor 2
Background Growth differentiation factor 2 (GDF2) also known as bone morphogenetic protein (BMP)-9 is a protein that in humans is encoded by the GDF2 gene. GDF2 belongs to the transforming growth factor beta superfamily. GDF2 has a role in inducing and maintaining the ability of embryonic basal forebrain cholinergic neurons (BFCN) to respond to a neurotransmitter called acetylcholine; BFCN are important for the processes of learning, memory and attention.[2] GDF2 is also important for the maturation of BFCN. Another role of GDF2 has been recently suggested. GDF2 is a potent inducer of hepcidin (a cationic peptide that has a antimicrobial properties) in liver cells (hepatocytes) and can regulate iron metabolism.[3] The physiological receptor of GDF2 is thought to be activin receptor-like kinase 1, ALK1 (also called ACVRL1), an endothelial-specific type I receptor of the TGF-beta receptor family. GDF2 is one of the most potent BMPs to induce orthotopic bone formation in vivo. BMP3, a blocker of most BMPs seems not to affect GDF2.
Synonyms BMP-9; BMP9; GDF2; growth differentiation factor 2; GDF-2; bone morphogenetic protein 9; growth/differentiation factor 2; Human BMP9 ELISA KIT; Human; BMP9 ELISA KIT; ELISA KIT; BMP9 ELISA; KIT; ELISA
    • Species :
    • Chicken
    • Human
    • Mouse
    • Zebrafish
    • Source :
    • CHO
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Yeast
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human GDF2-1823H Recombinant Human GDF2 Protein (300-429 aa), His-tagged Yeast His
    Human GDF2-13209H Recombinant Human GDF2, His-tagged E.coli His
    Human GDF2-211H Recombinant Human Growth Differentiation Factor 2, His-tagged E.coli His
    Human GDF2-27488TH Recombinant Human GDF2 protein CHO N/A
    Human GDF2-4823H Recombinant Human GDF2 Protein, GST-tagged Wheat Germ GST
    Human GDF2-5970HCL Recombinant Human GDF2 293 Cell Lysate HEK293 N/A
    Mouse Gdf2-1852M Recombinant Mouse Gdf2 protein, His-tagged E.coli His
    Mouse Gdf2-274M Recombinant Mouse Gdf2 protein, His-tagged E.coli His
    Mouse Gdf2-276M Recombinant Mouse Gdf2 CHO N/A
    Mouse GDF2-6286M Recombinant Mouse GDF2 Protein Mammalian Cell His
    Chicken GDF2-6982C Recombinant Chicken GDF2 Mammalian Cell His
    Zebrafish GDF2-7666Z Recombinant Zebrafish GDF2 Mammalian Cell His

    gdf2 involved in several pathways and played different roles in them. We selected most pathways gdf2 participated on our site, such as ALK1 signaling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with gdf2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    ALK1 signaling events CSNK2B; ACVRL1; FKBP1A; GDF2

    gdf2 has several biochemical functions, for example, cytokine activity, growth factor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by gdf2 itself. We selected most functions gdf2 had, and list some proteins which have the same functions with gdf2. You can find most of the proteins on our site.

    Function Related Protein
    cytokine activity LIF; BMP6; IFNL3; BMP15; TNF; GM13279; IL18; Ifna15; Ccl27a; GM13288
    growth factor activity Kitl; PDGFA; GH1; PDGFAB; NRG2; FGF10B; IL5; OSGIN1; GDF10B; FGF20A
    protein binding ASB9; CHEK1; MIS12; NAT2; LCP2; ATP5B; RNF144B; RYK; WDR11; C16orf87
    transforming growth factor beta receptor binding GDF2; GDF11; GDF9; BMP4; SPAW; BMP5; NDR1; LFT1; BMP7A; AMH

    gdf2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with gdf2 here. Most of them are supplied by our site. Hope this information will be useful for your research of gdf2.

    Srinivasan, C; Siddiqui, A; et al. Stability characterization and appearance of particulates in a lyophilized formulation of a model peptide hormone-human secretin. INTERNATIONAL JOURNAL OF PHARMACEUTICS 481:104-113(2015).
    Li, YJ; El Mozen, LA; et al. Transforming growth factor beta 3 involved in the pathogenesis of synovial chondromatosis of temporomandibular joint. SCIENTIFIC REPORTS 5:-(2015).


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