GDF2

  • Official Full Name

    growth differentiation factor 2

  • Overview

    Growth differentiation factor 2 (GDF2) also known as bone morphogenetic protein (BMP)-9 is a protein that in humans is encoded by the GDF2 gene. GDF2 belongs to the transforming growth factor beta superfamily. GDF2 has a role in inducing and maintaining the ability of embryonic basal forebrain cholinergic neurons (BFCN) to respond to a neurotransmitter called acetylcholine; BFCN are important for the processes of learning, memory and attention.[2] GDF2 is also important for the maturation of BFCN. Another role of GDF2 has been recently suggested. GDF2 is a potent inducer of hepcidin (a cationic peptide that has a antimicrobial properties) in liver cells (hepatocytes) and can regulate iron metabolism.[3] The physiological receptor of GDF2 is thought to be activin receptor-like kinase 1, ALK1 (also called ACVRL1), an endothelial-specific type I receptor of the TGF-beta receptor family. GDF2 is one of the most potent BMPs to induce orthotopic bone formation in vivo. BMP3, a blocker of most BMPs seems not to affect GDF2.
  • Synonyms

    BMP-9; BMP9; GDF2; growth differentiation factor 2; GDF-2; bone morphogenetic protein 9; growth/differentiation factor 2; Human BMP9 ELISA KIT; Human; BMP9 ELISA KIT; ELISA KIT; BMP9 ELISA; KIT; ELISA;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • CHO
  • E. coli
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Yeast
  • C
  • His
  • GST
  • His (Fc)
  • Avi
  • His(N
  • ter)
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human GDF2-27488TH Active Recombinant Human GDF2 protein CHO N/A
Human GDF2-211H Recombinant Human Growth Differentiation Factor 2, His-tagged E.coli His
Human GDF2-13209H Recombinant Human GDF2, His-tagged E.coli His
Human GDF2-5970HCL Recombinant Human GDF2 293 Cell Lysate HEK293 N/A
Human GDF2-019H Active Recombinant Human GDF2 Protein E. coli
Human GDF2-5235HF Recombinant Full Length Human GDF2 Protein, GST-tagged In Vitro Cell Free System GST
Human GDF2-4823H Recombinant Human GDF2 Protein, GST-tagged Wheat Germ GST
Human GDF2-38H Recombinant Human GDF2 protein, His-tagged E.coli His
Human GDF2-4269H Recombinant Human GDF2 protein, His-tagged Yeast His
Human GDF2-104H Recombinant Active Human GDF2 Protein, His-tagged(N-ter) E.coli His(N-ter)
Human GDF2-1823H Recombinant Human GDF2 Protein (300-429 aa), His-tagged Yeast His
Human GDF2-119H Active Recombinant Human GDF2 Protein (Ser320-Arg429), N-His tagged, Animal-free, Carrier-free E.coli N-His
Human GDF2-0370H Recombinant Human GDF2 protein, His-tagged HEK293 His
Human GDF2-0775H Recombinant Human GDF2 Protein (Ser320-Arg429), C-His tagged Mammalian cells C-His
Human GDF2-3535H Recombinant Human GDF2 Protein (Ser320-Arg429), N-His tagged E.coli N-His
Mouse Gdf2-276M Active Recombinant Mouse Gdf2 CHO N/A
Mouse Gdf2-274M Recombinant Mouse Gdf2 protein, His-tagged E.coli His
Mouse GDF2-6286M Recombinant Mouse GDF2 Protein Mammalian Cell His
Mouse Gdf2-1852M Recombinant Mouse Gdf2 protein, His-tagged E.coli His
Mouse GDF2-3519M Recombinant Mouse GDF2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse GDF2-3519M-B Recombinant Mouse GDF2 Protein Pre-coupled Magnetic Beads HEK293
Rat Gdf2-373R Recombinant Rat Gdf2 Protein, His-tagged E.coli N-His
Zebrafish GDF2-7666Z Recombinant Zebrafish GDF2 Mammalian Cell His
Chicken GDF2-6982C Recombinant Chicken GDF2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • GDF2 Related Articles
  • GDF2 Related Gene Family
  • GDF2 Related Research Area

GDF2 involved in several pathways and played different roles in them. We selected most pathways GDF2 participated on our site, such as ALK1 signaling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with GDF2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
ALK1 signaling eventsACVRL1;CSNK2B;FKBP1A;GDF2

GDF2 has several biochemical functions, for example, cytokine activity, growth factor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GDF2 itself. We selected most functions GDF2 had, and list some proteins which have the same functions with GDF2. You can find most of the proteins on our site.

Function Related Protein
cytokine activityPRL7D1;WNT5A;LEFTY2;LTB;CCL20A.3;IL22;VEGFA;Ccl12;IFNA4
growth factor activityGDF9;MDK;CECR1;TYMP;CLCF1;GSDF;IL10;EPGN;FGF10A
protein bindingCAPNS2;PYYA;AKAP5;TMEM218;KCNS2;CLEC4G;CEP68;ZBED4;P2RX7
transforming growth factor beta receptor bindingLRG1;GDF10;LFT1;MSTNA;INHBA;BMP7A;NODAL;MSTN;BMP7B

GDF2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GDF2 here. Most of them are supplied by our site. Hope this information will be useful for your research of GDF2.

Srinivasan, C; Siddiqui, A; et al. Stability characterization and appearance of particulates in a lyophilized formulation of a model peptide hormone-human secretin. INTERNATIONAL JOURNAL OF PHARMACEUTICS 481:104-113(2015).
Li, YJ; El Mozen, LA; et al. Transforming growth factor beta 3 involved in the pathogenesis of synovial chondromatosis of temporomandibular joint. SCIENTIFIC REPORTS 5:-(2015).
TGF
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