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Recombinant Mouse Grn protein, His & T7-tagged

Cat.No. : Grn-7848M
Product Overview : Recombinant Mouse Grn aa. (Cys31~Leu269 (Accession # P28798)) fused with N-terminal His & T7 tag was produced in E. coli cells.
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  • Gene Information
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Source : E. coli
Species : Mouse
Tag : His & T7
Form : Freeze-dried powder
Molecular Mass : Predicted Molecular Mass: 29.2kDa.
Protein length : Cys31~Leu269 (Accession # P28798)
Endotoxin : <1.0EU per 1ug (determined by the LAL method)
Purity : >95%
Characteristic : The isoelectric point is 6.3.
Applications : SDS-PAGE; WB; ELISA; IP.
Stability : The thermal stability is described by the loss rate of the target protein. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. (Referring from China Biological Products Standard, which was calculated by the Arrhenius equation.) The loss of this protein is less than 5% within the expiration date under appropriate storage condition.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
Storage Buffer : Supplied as lyophilized form in PBS, pH7.4, containing 5% sucrose, 0.01% sarcosyl.
Reconstitution : Reconstitute in sterile PBS, pH7.2-pH7.4.
Gene Name : Grn granulin [ Mus musculus (house mouse) ]
Official Symbol : Grn
Synonyms : PLCB4; phospholipase C beta 4; ARCND2; PI-PLC; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4; 1-phosphatidyl-D-myo-inositol-4,5-bisphosphate; PLC-beta-4; dJ1119D9.2 (Phopholipase C, beta 4 (1-Phosphatidylinositol-4,5-Bisphosphate Phosphodiesterase Beta 4)); inositoltrisphosphohydrolase; monophosphatidylinositol phosphodiesterase; phosphoinositidase C; phosphoinositide phospholipase C-beta-4; triphosphoinositide phosphodiesterase
Gene ID : 14824
mRNA Refseq : NM_008175.4
Protein Refseq : NP_032201.2
UniProt ID : P28798

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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Are there have any relationship between GRN protein and TDP-43 protein? 11/04/2019

There is an interaction between GRN protein and TDP-43 protein, and together they are involved in the development of neurodegenerative diseases.

Why does GRN protein play a role in neuroprotection? 07/21/2019

GRN protein is involved in neuroprotection by regulating cell survival, apoptosis, inflammatory response and other pathways. It may work by promoting neuronal survival, suppressing inflammatory responses, and more.

What is the diagnostic significance of GRN protein in neurodegenerative diseases? 06/17/2019

Abnormal expression of GRN protein is related to neurodegenerative diseases, and detecting the expression level of GRN protein or gene mutation can help diagnose these diseases and provide reference for treatment and prognosis assessment.

What is the role of GRN protein in Alzheimer's disease? 05/05/2019

The role of GRN protein in Alzheimer's disease is not fully understood, but studies have shown that it is involved in the metabolism and clearance of β-amyloid, which may have an important impact on the pathological process.

Are there transcription factors involved in the regulation of GRN protein expression? 02/26/2019

Yes, some transcription factors have been found to regulate the expression of GRN proteins, including CREB, SMAD, etc.

Which role of GRN protein in prefrontal dementia? 02/08/2019

GRN protein plays an important role in prefrontal dementia. It is involved in the survival and maintenance of nerve cells, and its deletion or mutation may lead to degenerative loss of nerve cells.

Customer Reviews (3)

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Reviews
06/16/2022

    The outstanding quality of proteins lies in their strong biological activity and their high purity during production, which is really rare.

    04/30/2022

      Application of this protein enables researchers to conduct research in more fields and broadens the horizon of scientific research.

      06/29/2019

        This protein has a short half-life, high clearance rate, and high safety and efficacy.

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