Recombinant Human GRN protein, His-tagged

• Cat.No.: GRN-726H
• Product Overview: Recombinant Human GRN protein(NP_002078.1)(Met1-Leu593), fused with His tag, was expressed in HEK293.

Specification

• Source: HEK293
• Species: Human
• Tag: His
• Form: Lyophilized from sterile PBS, pH 7.4Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
• Molecular Mass: The secreted recombinant human Progranulin comprises 587 amino acids with a predicted molecular mass of 63.2 kDa. As a result of glycosylation, rhGRN migrates as an approximately 93.3 kDa band in SDS-PAGE under reducing conditions.
• Protein length: Met1-Leu593
• Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method
• Purity: > 95 % as determined by SDS-PAGE
• Storage: Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents.

Gene Information

• Gene Name: GRN granulin [ Homo sapiens ]
• Official Symbol: GRN
• Synonyms: GRN; granulin; granulins; CLN11; PCDGF; PGRN; progranulin; acrogranin; proepithelin; granulin-epithelin; PC cell-derived growth factor; GEP; GP88; PEPI
• Gene ID: 2896
• mRNA Refseq: NM_002087
• Protein Refseq: NP_002078
• MIM: 138945
• UniProt ID: P28799

Reviews

06/16/2022

The outstanding quality of proteins lies in their strong biological activity and their high purity during production, which is really rare.

04/30/2022

Application of this protein enables researchers to conduct research in more fields and broadens the horizon of scientific research.

06/29/2019

This protein has a short half-life, high clearance rate, and high safety and efficacy.

Q&As

Are there have any relationship between GRN protein and TDP-43 protein?

There is an interaction between GRN protein and TDP-43 protein, and together they are involved in the development of neurodegenerative diseases.

Why does GRN protein play a role in neuroprotection?

GRN protein is involved in neuroprotection by regulating cell survival, apoptosis, inflammatory response and other pathways. It may work by promoting neuronal survival, suppressing inflammatory responses, and more.

What is the diagnostic significance of GRN protein in neurodegenerative diseases?

Abnormal expression of GRN protein is related to neurodegenerative diseases, and detecting the expression level of GRN protein or gene mutation can help diagnose these diseases and provide reference for treatment and prognosis assessment.

What is the role of GRN protein in Alzheimer's disease?

The role of GRN protein in Alzheimer's disease is not fully understood, but studies have shown that it is involved in the metabolism and clearance of β-amyloid, which may have an important impact on the pathological process.

Are there transcription factors involved in the regulation of GRN protein expression?

Yes, some transcription factors have been found to regulate the expression of GRN proteins, including CREB, SMAD, etc.

Which role of GRN protein in prefrontal dementia?

GRN protein plays an important role in prefrontal dementia. It is involved in the survival and maintenance of nerve cells, and its deletion or mutation may lead to degenerative loss of nerve cells.