• Official Full Name

    interleukin 28 receptor alpha

  • Background

    The protein encoded by this gene belongs to the class II cytokine receptor family. This protein forms a receptor;complex with interleukine 10 receptor, beta (IL10RB). The receptor complex has been shown to interact with three;closely related cytokines, including interleukin 28A (IL28A), interleukin 28B (IL28B), and interleukin 29 (IL29). The;expression of all three cytokines can be induced by viral infection. The cells overexpressing this protein have been;found to have enhanced responses to IL28A and IL29, but decreased response to IL28B. Three alternatively spliced;transcript variants encoding distinct isoforms have been reported.
  • Synonyms

    IL28RA; interleukin 28 receptor alpha; interleukin-28 receptor subunit alpha; IL-28RA; IL-28R-alpha; IFN-lambda R1; IL-28 receptor subunit alpha; interferon lambda receptor 1; interferon-lambda receptor 1; class II cytokine receptor 12; cytokine receptor class-II member 12; cytokine receptor family 2 member 12; IFNLR1; CRF2-12;
    • Type:
    • Recombinant Proteins
    • Protein Pre-coupled Magnetic Beads
    • Species :
    • Human
    • Mouse
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Mammalian cells
    • Wheat Germ
    • Tag :
    • Fc
    • GST
    • His
    • His (Fc)
    • Avi
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human IL28RA-841H Recombinant Human IL28RA Mammalian Cell His
    Human IL28RA-601H Recombinant Human Interleukin 28 Receptor, Alpha (interferon, lambda receptor) E.coli N/A
    Human IL28RA-3151H Recombinant Human IL28RA Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Human IL28RA-49H Recombinant Human IL28RA protein, GST-tagged E.coli GST
    Human IL28RA-3151H-B Recombinant Human IL28RA Protein Pre-coupled Magnetic Beads HEK293
    Human IL28RA-5659H Active Recombinant Human Interleukin 28 Receptor, Alpha (interferon, lambda receptor), Fc-tagged Mammalian cells Fc
    Human IL28RA-5201H Recombinant Human IL28RA Protein, GST-tagged Wheat Germ GST
    Mouse Il28ra-74M-B Recombinant Mouse Il28ra Protein Pre-coupled Magnetic Beads HEK293
    Mouse Il28ra-74M Recombinant Mouse Il28ra Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Mouse Il28ra-5658M Active Recombinant Mouse Interleukin 28 Receptor Alpha, Fc-tagged Mammalian cells Fc
    • Involved Pathway
    • Protein Function
    • Interacting Protein
    • IL28RA Related Articles

    IL28RA involved in several pathways and played different roles in them. We selected most pathways IL28RA participated on our site, such as Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Type III interferon signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL28RA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interactionCSF2;FLT3LG;TNFRSF14;CX3CR1;IL26;CCR9A;PRL;Ifna15;BMP7B
    Jak-STAT signaling pathwaySOCS1A;GH1;BCL2;SOCS3;IL6ST;IFNA5;AOX3L1;IRX1;Il23a; Il12b
    Type III interferon signalingIL28RA;IRX1;IL10RB

    IL28RA has several biochemical functions, for example, cytokine receptor activity, contributes_to cytokine receptor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL28RA itself. We selected most functions IL28RA had, and list some proteins which have the same functions with IL28RA. You can find most of the proteins on our site.

    Function Related Protein
    cytokine receptor activityF3;CRFB17;IL13RA1;IL12RB2;PRLRA;GHRA;IL20RA;CSF3R;IL1RL1
    contributes_to cytokine receptor activityIRX1;IL28RA;CD44
    protein bindingDBF4B;C7orf31;ANAPC4;CISH;NTRK1;FTSJ3;MPP2;ERRFI1;TOX4

    IL28RA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL28RA here. Most of them are supplied by our site. Hope this information will be useful for your research of IL28RA.


    Egli, A; Santer, DM; et al. IL-28B is a Key Regulator of B- and T-Cell Vaccine Responses against Influenza. PLOS PATHOGENS 10:-(2014).
    • Q&As
    • Reviews

    Q&As (6)

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    Which types of hepatitis B can IL-28RA be treated? 11/12/2022

    IL-28RA can treat hepatitis B virus infection and is also used in the development of chronic hepatitis B.

    What is the action mechanism of IL-28RA in vivo? 06/22/2022

    IL-28RA can enhance the body's immune function, thereby inhibiting the growth and reproduction of pathogens.

    Does IL-28RA have an effect on human body? 07/14/2021

    At normal doses, IL-28RA has no significant adverse effects on humans.

    IL-28ra in a role in the treatment of hepatitis b is what? 03/19/2021

    Recombinant IL-28RA can effectively treat hepatitis B without causing significant side effects.

    Is IL-28RA suitable for clinical treatment? 07/16/2020

    IL-28RA is suitable for clinical use and has been used in many medical facilities.

    Can IL-28RA improve the body's resistance to disease? 01/14/2019

    This protein can improve the body's resistance to disease.

    Customer Reviews (3)

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      Its molecular weight and composition were determined by western blotting and mass spectrometry, and its binding activity to IL-28B and its activation ability to cell surface receptors were verified. -


        To evaluate the expression system and production of recombinant IL-28RA protein to ensure its high quality expression and stability. In addition, it is also necessary to test its stability under different conditions, such as temperature, storage time, etc. -


          The binding capacity of recombinant IL-28RA protein to IL-28B and the regulation of cell signal transduction pathways, such as JAK/STAT, were verified in cell experiments to evaluate its efficacy for immunomodulatory and antiviral effects. -

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