IL28RA

  • Official Full Name

    interleukin 28 receptor alpha

  • Overview

    The protein encoded by this gene belongs to the class II cytokine receptor family. This protein forms a receptor;complex with interleukine 10 receptor, beta (IL10RB). The receptor complex has been shown to interact with three;closely related cytokines, including interleukin 28A (IL28A), interleukin 28B (IL28B), and interleukin 29 (IL29). The;expression of all three cytokines can be induced by viral infection. The cells overexpressing this protein have been;found to have enhanced responses to IL28A and IL29, but decreased response to IL28B. Three alternatively spliced;transcript variants encoding distinct isoforms have been reported.

  • Synonyms

    IL28RA;interleukin 28 receptor alpha;interleukin-28 receptor subunit alpha;IL-28RA;IL-28R-alpha;IFN-lambda R1;IL-28 receptor subunit alpha;interferon lambda receptor 1;interferon-lambda receptor 1;class II cytokine receptor 12;cytokine receptor class-II member 12;cytokine receptor family 2 member 12;IFNLR1;CRF2-12

Recombinant Proteins

  • Mouse
  • Human
  • Mammalian Cells
  • E.coli
  • HEK293
  • Wheat Germ
  • Fc
  • GST
  • Non
  • His
  • Avi

    Involved Pathway

    IL28RA involved in several pathways and played different roles in them. We selected most pathways IL28RA participated on our site, such as Cytokine-cytokine receptor interaction,Jak-STAT signaling pathway,Type III interferon signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL28RA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Jak-STAT signaling pathway SOCS4,TP-1,IL12BA,STAT2,IFNGR1,Il6ra,IFNG,IFNA16,STAT4,PIAS1
    Type III interferon signaling IRX1,IL10RB
    Cytokine-cytokine receptor interaction CCL21,IL9,TNFSF14,PRLR,CSF2,KITA,IFNW1,IFNA3,IL1B,Fasl

    Protein Function

    IL28RA has several biochemical functions, for example, cytokine receptor activity,contributes_to cytokine receptor activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL28RA itself. We selected most functions IL28RA had, and list some proteins which have the same functions with IL28RA. You can find most of the proteins on our site.

    Function Related Protein
    contributes_to cytokine receptor activity CD44,IRX1
    protein binding GNMT,VRK1,HIST2H4A,HDAC2,NDUFAF1,SIRT6,TRIM6,SOX6,GOSR2,SART3
    cytokine receptor activity CRFB6,Il4ra,GHR,IL4R.1,F3,PRLRA,LIFRA,IL20RA,F3A,IL1RL1

    Interacting Protein

    IL28RA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL28RA here. Most of them are supplied by our site. Hope this information will be useful for your research of IL28RA.

    LSM8

    Resources

    References

    • Egli, A; Santer, DM; et al. IL-28B is a Key Regulator of B- and T-Cell Vaccine Responses against Influenza. PLOS PATHOGENS 10:-(2014).

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