IL28RA

  • Official Full Name

    interleukin 28 receptor alpha

  • Overview

    The protein encoded by this gene belongs to the class II cytokine receptor family. This protein forms a receptor;complex with interleukine 10 receptor, beta (IL10RB). The receptor complex has been shown to interact with three;closely related cytokines, including interleukin 28A (IL28A), interleukin 28B (IL28B), and interleukin 29 (IL29). The;expression of all three cytokines can be induced by viral infection. The cells overexpressing this protein have been;found to have enhanced responses to IL28A and IL29, but decreased response to IL28B. Three alternatively spliced;transcript variants encoding distinct isoforms have been reported.
  • Synonyms

    IL28RA; interleukin 28 receptor alpha; interleukin-28 receptor subunit alpha; IL-28RA; IL-28R-alpha; IFN-lambda R1; IL-28 receptor subunit alpha; interferon lambda receptor 1; interferon-lambda receptor 1; class II cytokine receptor 12; cytokine receptor class-II member 12; cytokine receptor family 2 member 12; IFNLR1; CRF2-12;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • E.coli
  • HEK293
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Fc
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

IL28RA involved in several pathways and played different roles in them. We selected most pathways IL28RA participated on our site, such as Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Type III interferon signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL28RA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cytokine-cytokine receptor interactionIL2RGA;IL8L2;TNFSF14;CCL2;CXCR4B;CX3CL1;CCL26;INHBC;IL6ST
Jak-STAT signaling pathwayHRASB;STAM2;PTPN2B;GHRA;IFNB1;PIK3R3;PRL;IFNB;MYCB
Type III interferon signalingIL10RB;IL28RA;IRX1

IL28RA has several biochemical functions, for example, cytokine receptor activity, contributes_to cytokine receptor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL28RA itself. We selected most functions IL28RA had, and list some proteins which have the same functions with IL28RA. You can find most of the proteins on our site.

Function Related Protein
cytokine receptor activityIRX1;F3;LIFRB;IL15RA;IL12RB1;GHR;F3A;FLT3;CRFB12
contributes_to cytokine receptor activityIL28RA;IRX1;CD44
protein bindingCD72;DGKQ;MIB1;PSMB4;PSMC1;NLRP2;HILPDA;HOXB6;EXOSC2

IL28RA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL28RA here. Most of them are supplied by our site. Hope this information will be useful for your research of IL28RA.

LSM8

Research Area

Related articles

Egli, A; Santer, DM; et al. IL-28B is a Key Regulator of B- and T-Cell Vaccine Responses against Influenza. PLOS PATHOGENS 10:-(2014).
  • Q&As
  • Reviews

Q&As (6)

Ask a question
Which types of hepatitis B can IL-28RA be treated? 11/12/2022

IL-28RA can treat hepatitis B virus infection and is also used in the development of chronic hepatitis B.

What is the action mechanism of IL-28RA in vivo? 06/22/2022

IL-28RA can enhance the body's immune function, thereby inhibiting the growth and reproduction of pathogens.

Does IL-28RA have an effect on human body? 07/14/2021

At normal doses, IL-28RA has no significant adverse effects on humans.

IL-28ra in a role in the treatment of hepatitis b is what? 03/19/2021

Recombinant IL-28RA can effectively treat hepatitis B without causing significant side effects.

Is IL-28RA suitable for clinical treatment? 07/16/2020

IL-28RA is suitable for clinical use and has been used in many medical facilities.

Can IL-28RA improve the body's resistance to disease? 01/14/2019

This protein can improve the body's resistance to disease.

Customer Reviews (3)

Write a review
Reviews
10/04/2020

    Small harm to the human body, high safety.

    08/08/2020

      The detection method is very sensitive and can be detected in small quantities.

      01/14/2019

        It is very stable and does not denature even at low temperatures.

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