Active Recombinant Human Interleukin 28 Receptor, Alpha (interferon, lambda receptor), Fc-tagged IL28RA-5659H

Active Recombinant Human Interleukin 28 Receptor, Alpha (interferon, lambda receptor), Fc-tagged


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Active Recombinant Human Interleukin 28 Receptor, Alpha (interferon, lambda receptor), Fc-tagged

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Cat.No. : IL28RA-5659H Optional Service: Optional requirements on this protein
Product Overview : RecombinantHuman IL28RA protein was expressed in Murine myeloma cell line with the Fcpart of Human IgG1 Pro100-Lys330 (C-terminus) and Human IL28RAArg21-Ala228 (N-terminus).
Description : IL28RA isa type I transmembrane glycoprotein that is the cytokine receptor family 2member 12 (CRF2-12). It pairs with the IL-10 receptor β subunit (IL-10 Rβ,CRF2-4) to form the IL-28 R. Each subunit of this receptor can interact withthe interferon-like cytokines (type III interferons) IL-28A (IFN-λ2), IL-28B(IFN-λ3) or IL-29 (IFN-λ1). Human IL28RA cDNA encodes a 520 amino acid (aa)protein with a 20 aa signal peptide, a 208 aa extracellular domain (ECD) witha fibronectin type III motif and four potential N-glycosylation sites, a 21aa transmembrane sequence, and a proline-rich and acidic 271 aa cytoplasmicdomain.
Source : Mammalian cells
Form : Lyophilizedfrom a 0.2 μm filtered solution in PBS.
N-terminalSequence : Arg21
MolecularWeight : 50.2 kDa (monomer)
Activity : Measuredby its binding ability in a functional ELISA. In a 100 μL reaction mixturecontaining rhIL28RA/FcChimera at 1 μg/mL and rhIL-28A dilutions at 1-1000 ng/mL, the concentrationof rhIL-28A that produces 50% of the optimal binding response is found to beapproximately 40-200 ng/mL.
Endotoxin Level : <1.0EU per 1μg of the protein by the LAL method.
SDS-PAGE : 65-75kDa, reducing conditions.
Purity : >95%,by SDS-PAGE under reducing conditions and visualized by silver stain.
Reconstitution : 100 μg/mLin sterile PBS
Storage : Use amanual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70°C as supplied. 1month, 2 to 8°C under sterile conditions after reconstitution. 3 months, -20 to-70°C under sterile conditions after reconstitution.
Renderingbased on PDB OG4. :

Gene Name : IL28RA interleukin 28receptor, alpha (interferon, lambda receptor) [ Homo sapiens ]
Official Symbol : IL28RA
Synonyms : IL28RA; interleukin28 receptor, alpha (interferon, lambda receptor); IFNLR; LICR2;IFNLR1; CRF2/12; IL-28R1; interleukin-28 receptor subunit alpha; CRF2-12;IL-28RA; IL-28R-alpha; IFN-lambda-R1; IFN-lambda receptor 1; interleukin 28receptor A; IL-28 receptor subunit alpha; interferon lambda receptor 1;interferon lambda, receptor 1; class II cytokine receptor CRF2/12;interleukin or cytokine receptor 2; cytokine receptor class-II member 12;cytokine receptor family 2 member 12; likely interleukin or cytokine receptor2
Gene ID : 163702
mRNA Refseq : NM_173064
Protein Refseq : NP_775087
MIM : 607404
UniProt ID : Q8IU57
Chromosome Location : 1p36.11
Pathway : Cytokine-cytokinereceptor interaction; Jak-STAT signaling pathway
Function : contributes_to cytokinereceptor activity; protein binding; receptor activity
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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