Active Recombinant Mouse Interleukin 28 Receptor Alpha, Fc-tagged
Cat.No. : | Il28ra-5658M |
Product Overview : | RecombinantMouse Il28ra protein was expressed in Murine myeloma celllinewith the Fc part of Mouse IgG2A Glu98-Lys330 (C-terminus) and MouseIl28ra Arg21-Ala227 (N-terminus). |
- Specification
- Gene Information
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Cat. No. : | Il28ra-5658M |
Description : | Il28ra isa type I transmembrane glycoprotein that is cytokine receptor family 2 member12 (CRF2-12). It pairs with the IL-10 receptor β subunit (IL-10 Rβ, CRF2-4)to form the IL-28 R. Each subunit of this receptor can interact with theinterferon-like cytokines (type III interferons) IL-28A (IFN-λ2), IL-28B(IFN-λ3) and IL-29 (IFN-λ1). Mouse IL 28A and IL-28B share 97% amino acid(aa) identity rodents do not express IL-29. Mouse Il28ra cDNA encodes a 535 aaprotein with a 20 aa signal peptide, a 207 aa extracellular domain (ECD) witha fibronectin type III motif and four potential N-glycosylation sites, a 21 aatransmembrane sequence, and a proline-rich and acidic 287 aa cytoplasmicdomain. |
Source : | Mammalian cells |
Form : | Lyophilizedfrom a 0.2 μm filtered solution in PBS. |
N-terminalSequence : | Arg21 |
MolecularWeight : | 50.6 kDa (monomer) |
Activity : | Measuredby its binding ability in a functional ELISA. 1 μg/mL of rm Il28ra FcChimera was mixed with serially diluted rmIL-28B. Following incubation, the Il28ra rmIL-28Bcomplex was captured in a goat anti-mFc-coated plate. Bound IL-28B wasmeasured using biotinylated goat anti-mIL-28B. The concentration of rmIL-28Bthat produces 50% of the optimal binding was found to be approximately 0.7-3.5μg/mL. |
Endotoxin Level : | <1.0EU per 1μg of the protein by the LAL method. |
SDS-PAGE : | 62-70kDa, reducing conditions. |
Purity : | >95%,by SDS-PAGE under reducing conditions and visualized by silver stain. |
Reconstitution : | 200 μg/mLin sterile PBS |
Storage : | Use amanual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70°C as supplied. 1month, 2 to 8°C under sterile conditions after reconstitution. 3 months, -20 to-70°C under sterile conditions after reconstitution. |
Gene Name : | Il28ra interleukin 28 receptoralpha [ Mus musculus ] |
Official Symbol : | Il28ra |
Synonyms : | Il28ra; interleukin28 receptor alpha; IFNLR1; CRF2-12; interleukin-28 receptor subunit alpha;IL-28RA; IL-28R-alpha; IFN-lambda R1; IL-28 receptor subunit alpha;interferon lambda receptor 1; interferon-lambda receptor 1; class II cytokinereceptor 12; cytokine receptor class-II member 12; cytokine receptor family 2member 12 |
Gene ID : | 242700 |
mRNA Refseq : | NM_174851 |
Protein Refseq : | NP_777276 |
UniProt ID : | Q3URN4 |
Chromosome Location : | 4 |
Pathway : | Cytokine-cytokinereceptor interaction; Jak-STAT signaling pathway |
Function : | cytokine receptoractivity; receptor activity |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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