Recombinant Human IL28RA protein, GST-tagged
|Product Overview :||Recombinant Human IL28RA(28-222aa) fused with GST tag was expressed in E. coli.|
- Gene Information
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|Description :||The protein encoded by this gene belongs to the class II cytokine receptor family. This protein forms a receptor complex with interleukine 10 receptor, beta (IL10RB). The receptor complex has been shown to interact with three closely related cytokines, including interleukin 28A (IL28A), interleukin 28B (IL28B), and interleukin 29 (IL29). The expression of all three cytokines can be induced by viral infection. The cells overexpressing this protein have been found to have enhanced responses to IL28A and IL29, but decreased response to IL28B. Three alternatively spliced transcript variants encoding distinct isoforms have been reported.|
|Source :||E. coli|
|Form :||Protein lyophilized in sterile PBS (58 mM Na2HPO4, 17 mM NaH2PO4, 68 mM NaCl, 100 mM GSH, pH 8.0) and 10% glycerol.|
|AA Sequence :||QNVTLLSQNFSVYLTWLPGLGNPQD VTYFVAYQSSPTRRRWREVEECAGT KELLCSMMCLKKQDLYNKFKGRVRT VSPSSKSPWVESEYLDYLFEVEPAP PVLVLTQTEEILSANATYQLPPCMP PLDLKYEVAFWKEGAGNKTLFPVTP HGQPVQITLQPAASEHHCLSARTIY TFSVPKYSKFSKPTCFLLEV|
|Storage :||Aliquot and store at -20 centigrade to -80 centigrade for up to 6 months. Avoid freeze thaw cycles.|
|Shipping :||The product is shipped with ice packs. Upon receipt, store it immediately at -20 centigrade to -80 centigrade.|
|Gene Name :||IL28RA interleukin 28 receptor, alpha (interferon, lambda receptor) [ Homo sapiens ]|
|Official Symbol :||IL28RA|
|Synonyms :||IL28RA; interleukin 28 receptor, alpha (interferon, lambda receptor); interleukin 28 receptor, alpha; interleukin-28 receptor subunit alpha; CRF2/12; IFNLR; IL 28R1; interferon lambda receptor 1; CRF2-12; IL-28RA; IL-28R-alpha; IFN-lambda-R1; IFN-lambda receptor 1; interleukin 28 receptor A; IL-28 receptor subunit alpha; interferon lambda, receptor 1; interleukin 28 alpha receptor; class II cytokine receptor CRF2/12; interleukin or cytokine receptor 2; cytokine receptor class-II member 12; cytokine receptor family 2 member 12; likely interleukin or cytokine receptor 2; LICR2; IFNLR1; IL-28R1;|
|Gene ID :||163702|
|mRNA Refseq :||NM_170743|
|Protein Refseq :||NP_734464|
|UniProt ID :||Q8IU57|
|Chromosome Location :||1p36.11|
|Pathway :||Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Jak-STAT signaling pathway, organism-specific biosystem; Jak-STAT signaling pathway, conserved biosystem;|
|Function :||contributes_to cytokine receptor activity; protein binding; receptor activity;|
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Q&As (6)Ask a question
IL-28RA can treat hepatitis B virus infection and is also used in the development of chronic hepatitis B.
IL-28RA can enhance the body's immune function, thereby inhibiting the growth and reproduction of pathogens.
At normal doses, IL-28RA has no significant adverse effects on humans.
Recombinant IL-28RA can effectively treat hepatitis B without causing significant side effects.
IL-28RA is suitable for clinical use and has been used in many medical facilities.
This protein can improve the body's resistance to disease.
Customer Reviews (3)Write a review
Its molecular weight and composition were determined by western blotting and mass spectrometry, and its binding activity to IL-28B and its activation ability to cell surface receptors were verified. -
To evaluate the expression system and production of recombinant IL-28RA protein to ensure its high quality expression and stability. In addition, it is also necessary to test its stability under different conditions, such as temperature, storage time, etc. -
The binding capacity of recombinant IL-28RA protein to IL-28B and the regulation of cell signal transduction pathways, such as JAK/STAT, were verified in cell experiments to evaluate its efficacy for immunomodulatory and antiviral effects. -
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