LOXL4

  • Official Full Name

    lysyl oxidase-like 4

  • Overview

    This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. [provided by RefSeq, Jul 2008]
  • Synonyms

    LOXL4; lysyl oxidase-like 4; LOXC; lysyl oxidase homolog 4; lysyl oxidase related C; lysyl oxidase-like protein 4; lysyl oxidase-like 4 pseudogene; lysyl oxidase-related protein C;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Human
  • Mouse
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Insect Cell
  • Wheat Germ
  • Yeast
  • FLAG
  • GST
  • His
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human LOXL4-28220TH Recombinant Human LOXL4 N/A
Human LOXL4-2158H Recombinant Human LOXL4 protein, His-tagged E.coli His
Human LOXL4-194H Recombinant Human LOXL4 protein, GST-tagged Insect Cell GST 492-end
Human LOXL4-2157H Recombinant Human LOXL4 protein, GST-tagged Wheat Germ GST
Human LOXL4-2159H Recombinant Human LOXL4 protein, FLAG-tagged Insect Cell FLAG
Human LOXL4-4676HCL Recombinant Human LOXL4 293 Cell Lysate HEK293 N/A
Human LOXL4-4705H Recombinant Human LOXL4 protein, His-tagged E.coli His 25-756aa
Human LOXL4-577HF Recombinant Full Length Human LOXL4 Protein, GST-tagged In Vitro Cell Free System GST 756 amino acids
Human LOXL4-280H Recombinant Human LOXL4 Protein, His-tagged E.coli His Gly399~Pro552
Human LOXL4-5209H Recombinant Human LOXL4 Protein (Gly399-Pro552), His tagged E.coli His Gly399-Pro552
Mouse LOXL4-2020M Recombinant Mouse LOXL4 Protein (26-757 aa), His-tagged Yeast His 26-757 aa
Mouse LOXL4-2001M Recombinant Mouse LOXL4 Protein (26-757 aa), His-tagged E.coli His 26-757 aa
Mouse Loxl4-1742M Recombinant Mouse Loxl4 Protein, His-tagged E.coli N-His Pro534-Ser737
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

LOXL4 involved in several pathways and played different roles in them. We selected most pathways LOXL4 participated on our site, such as Assembly of collagen fibrils and other multimeric structures, Collagen formation, Crosslinking of collagen fibrils, which may be useful for your reference. Also, other proteins which involved in the same pathway with LOXL4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Assembly of collagen fibrils and other multimeric structuresBMP1B;COL11A1B;DST;BMP1;PCOLCE;CTSS;COL1A2;COL6A1;TLL2
Collagen formationLOXL1;COL4A3;ADAMTS2;COL8A2;COL9A3;COL17A1A;CTSL1;COL6A3;PPIB
Crosslinking of collagen fibrilsLOXL3;BMP1B;LOXL4;LOXL2;ABHD1;PCOLCE;TLL1;BMP1;LOXL1
Elastic fibre formationLTBP3;LOX;ABHD1;BMP10;MFAP1;ITGB3A;LOXL4;EFEMP1;MFAP3
Extracellular matrix organizationMFAP1;F11R.2;ADAM15;MMP8;CTSD;ADAMTS3;PCOLCE2;CTS7;ADAM8

LOXL4 has several biochemical functions, for example, copper ion binding, protein binding, protein-lysine 6-oxidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by LOXL4 itself. We selected most functions LOXL4 had, and list some proteins which have the same functions with LOXL4. You can find most of the proteins on our site.

Function Related Protein
copper ion bindingLOXL3;PRNPA;LOXL3B;SLC11A2;S100A12;PAM;LOXL5A;SNAI3;SNCA
protein bindingCENPI;GEM;WHSC2;ILKAP;ZNF350;RYR1B;ABCC2;C7orf59;SORBS2
protein-lysine 6-oxidase activityLOXL2A;LOXL2;LOXL3;ABHD1;LOXL2B;LOXL4;LOX;POLR1B
scavenger receptor activityTMPRSS15;CCBP2;VTNA;TMPRSS4;LOXL2;LOXL4;PRSS12;LGALS3BPA;MARCO

LOXL4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LOXL4 here. Most of them are supplied by our site. Hope this information will be useful for your research of LOXL4.

TRIP13; KDM1A; PRMT6; SUV39H1; APOE; LONP1; RAD23A; CDC37; EXOC6; ECSIT; MAST1

Research Area

  • Reviews
  • Q&As

Customer Reviews (3)

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Reviews
07/27/2021

    The catalytic activity of LOXL4 is very powerful, and it can easily realize chemical reactions that are otherwise difficult to carry out, which has high application potential.

    11/03/2020

      This stability of LOXL4 is very strong, and its structure and function remain stable even after multiple uses or storage, providing strong support for long-term experiments and applications.

      09/29/2019

        The production process of LOXL4 pays great attention to environmental protection, from the selection of raw materials to the production process reflects the concept of green production.

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