Recombinant Human LOXL4

• Cat.No.: LOXL4-28220TH
• Product Overview: Recombinant fragment, corresponding to amino acids 500-756 of Human LOXL4 expressed in a baculovirus-infected Sf9 cell expression system; 257 amino acids, MWt 31kDa.

Specification

• Description: This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family.
• Form: Liquid
• Storage buffer: Preservative: NoneConstituents: 20% Glycerol, 0.05% Tween 20, 3mM DTT, 25mM Tris HCl, 100mM Sodium chloride, pH 8.0
• Storage: Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles.

Gene Information

• Gene Name: LOXL4 lysyl oxidase-like 4 [ Homo sapiens ]
• Official Symbol: LOXL4
• Synonyms: LOXL4; lysyl oxidase-like 4; lysyl oxidase homolog 4; FLJ21889; LOXC
• Gene ID: 84171
• mRNA Refseq: NM_032211
• Protein Refseq: NP_115587
• MIM: 607318
• Uniprot ID: Q96JB6
• Chromosome Location: 10q24
• Function: copper ion binding; metal ion binding; oxidoreductase activity; oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor; protein binding