Recombinant Human LOXL4 protein, His-tagged

• Cat.No.: LOXL4-2158H
• Product Overview: Recombinant Human LOXL4(570-756) fused with His tag at C-terminal was expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 570-756 a.a.
• Description: This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family.
• Form: 9 mM Na2HPO4/KH2PO4 pH 7.4, 124 mM KCl, 2.4 mM KCl and 10% glycerol
• Molecular Mass: 23 kDa
• Purity: ≥90%
• Applications: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
• Stability: >6 months at –80 centigrade. Avoid freeze/thaw cycles. Storing diluted enzyme is not recommended, if necessary, use carrier protein (BSA 0.1 – 0.5%).
• Concentration: 0.33 mg/ml

Gene Information

• Gene Name: LOXL4 lysyl oxidase-like 4 [ Homo sapiens ]
• Official Symbol: LOXL4
• Synonyms: LOXL4; lysyl oxidase-like 4; lysyl oxidase homolog 4; FLJ21889; LOXC; lysyl oxidase related C; lysyl oxidase-like protein 4; lysyl oxidase-like 4 pseudogene; lysyl oxidase-related protein C
• Gene ID: 84171
• mRNA Refseq: NM_032211
• Protein Refseq: NP_115587
• MIM: 607318
• UniProt ID: Q96JB6
• Chromosome Location: 10q24
• Function: copper ion binding; metal ion binding; oxidoreductase activity; protein binding; protein-lysine 6-oxidase activity; scavenger receptor activity