| Description : |
This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. |
| Source : |
In Vitro Cell Free System |
| Species : |
Human |
| Tag : |
GST |
| Form : |
50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
| Molecular Mass : |
110.9 kDa |
| Protein Length : |
756 amino acids |
| AA Sequence : |
MAWSPPATLF LFLLLLGQPP PSRPQSLGTT KLRLVGPESK PEEGRLEVLH QGQWGTVCDD NFAIQEATVA CRQLGFEAAL TWAHSAKYGQ GEGPIWLDNV RCVGTESSLD QCGSNGWGVS DCSHSEDVGV ICHPRRHRGY LSETVSNALG PQGRRLEEVR LKPILASAKQ HSPVTEGAVE VKYEGHWRQV CDQGWTMNNS RVVCGMLGFP SEVPVDSHYY RKVWDLKMRD PKSRLKSLTN KNSFWIHQVT CLGTEPHMAN CQVQVAPARG KLRPACPGGM HAVVSCVAGP HFRPPKTRPQ RKGSWAEEPR VRLRSGAQVG EGRVEVLMNR QWGTVCDHRW NLISASVVCR QLGFGSAREA LFGARLGQGL GPIHLSEVRC RGYERTLSDC PALEGSQNGC QHENDAAVRC NVPNMGFQNQ VRLAGGRIPE EGLLEVQVEV NGVPRWGSVC SENWGLTEAM VACRQLGLGF AIHAYKETWF WSGTPRAQEV VMSGVRCSGT ELALQQCQRH GPVHCSHGGG RFLAGVSCMD SAPDLVMNAQ LVQETAYLED RPLSQLYCAH EENCLSKSAD HMDWPYGYRR LLRFSTQIYN LGRTDFRPKT GRDSWVWHQC HRHYHSIEVF THYDLLTLNG SKVAEGHKAS FCLEDTNCPT GLQRRYACAN FGEQGVTVGC WDTYRHDIDC QWVDITDVGP GNYIFQVIVN PHYEVAESDF SNNMLQCRCK YDGHRVWLHN CHTGNSYPAN AELSLEQEQR LRNNLI |
| Applications : |
Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array |
| Storage : |
Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
