• Official Full Name

    mitogen-activated protein kinase kinase 1

  • Overview

    The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development. [provided by RefSeq, Jul 2008]
  • Synonyms

    MAP2K1; mitogen-activated protein kinase kinase 1; CFC3; MEK1; MKK1; MAPKK1; PRKMK1; dual specificity mitogen-activated protein kinase kinase 1; MEK 1; MAPKK 1; MAPK/ERK kinase 1; ERK activator kinase 1; protein kinase, mitogen-activated, kinase 1 (MAP kinase kinase 1);

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Cell & Tissue Lysates
  • Assay Kits
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Insect (sf21)
  • Insect Cell
  • Insect Cells
  • Mammalian Cell
  • Mammalian cells
  • Sf9 Insect Cell
  • DDK
  • Flag
  • Gly
  • Pro
  • GST
  • His
  • His (Fc)
  • Avi
  • His|GST
  • His|MBP
  • Myc
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MAP2K1-2568H Active Recombinant Human MAP2K1, His-tagged Insect Cell His
Human MAP2K1-175H Active Recombinant Human MAP2K1, GST-tagged E.coli GST
Human MAP2K1-343H Recombinant Human MAP2K1 Mammalian Cell His
Human MAP2K1-639H Recombinant Human MAP2K1 protein, His-tagged E.coli His
Human MAP2K1-596H Recombinant Human MAP2K1, His-tagged Sf9 Insect Cell His
Human MAP2K1-1034H Recombinant Human Mitogen-Activated Protein Kinase Kinase 1, GST-tagged E.coli GST
Human MAP2K1-1033H Recombinant Human Mitogen-Activated Protein Kinase Kinase 1, GST-tagged Sf9 Insect Cell GST
Human MAP2K1-167H Recombinant Human v protein, MYC/DDK-tagged HEK293 Myc/DDK
Human MAP2K1-62H Recombinant Human MAP2K1 protein, Flag-tagged, Biotinylated Insect Cell Flag
Human MAP2K1-1035H Recombinant Human Mitogen-Activated Protein Kinase Kinase 1, His-tagged Sf9 Insect Cell His
Human MAP2K1-299H Recombinant Human MAP2K1 protein, His/MBP-tagged E.coli His/MBP
Human MAP2K1-300H Recombinant Human MAP2K1 protein, His/MBP-tagged E.coli His/MBP
Human MAP2K1-2723HF Active Recombinant Full Length Human MAP2K1 Protein, GST-tagged Insect (sf21) GST
Human MAP2K1-8116HF Active Recombinant Full Length Human MAP2K1 Protein, GST-tagged E.coli GST
Human MAP2K1-3929HF Active Recombinant Full Length Human MAP2K1 Protein, GST-tagged Insect (sf21) GST
Human MAP2K1-234HFL Recombinant Full Length Human MAP2K1 Protein, C-Flag-tagged Mammalian cells Flag
Human MAP2K1-2354HF Active Recombinant Full Length Human MAP2K1 Protein, GST-tagged Insect (sf21) GST
Human MAP2K1-3430H-B Recombinant Human MAP2K1 Protein Pre-coupled Magnetic Beads HEK293
Human MAP2K1-9955HF Active Recombinant Full Length Human MAP2K1 Protein, DDK-tagged, Biotinylated Insect (sf21) DDK
Human MAP2K1-5001H Recombinant Human MAP2K1 Protein (Leu54-Val369), N-His tagged E.coli N-His
Human MAP2K1-5481HF Active Recombinant Full Length Human MAP2K1 Protein, GST-tagged Insect (sf21) GST
Human MAP2K1-3430H Recombinant Human MAP2K1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Map2k1-1032M Active Recombinant Mouse Map2k1 protein, GST-tagged E.coli GST
Mouse Map2k1-666M Active Recombinant Mouse Map2k1, GST-tagged E.coli GST
Mouse Map2k1-1032H Recombinant Mouse Mitogen-Activated Protein Kinase Kinase 1, GST-tagged E.coli GST
Mouse Map2k1-1350M Recombinant Mouse Map2k1, His & GST tagged Insect Cell His/GST
Mouse MAP2K1-483M Recombinant Mouse MAP2K1, Gly & Pro tagged Insect Cell His
Mouse MAP2K1-001MCL Recombinant Mouse MAP2K1 cell lysate Insect Cell N/A
Mouse MAP2K1-483MAF488 Recombinant Mouse Map2k1 Protein, Gly/Pro-tagged, Alexa Fluor 488 conjugated Insect Cells Gly/Pro
Mouse Map2k1-3920M Recombinant Mouse Map2k1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse MAP2K1-1310M Recombinant Mouse MAP2K1 protein(Met1-Ile393), His&GST-tagged Insect Cells N-His&GST
Mouse Map2k1-1350MAF488 Recombinant Mouse Map2k1 Protein, His/GST-tagged, Alexa Fluor 488 conjugated Insect Cells His/GST
Mouse Map2k1-1350MAF555 Recombinant Mouse Map2k1 Protein, His/GST-tagged, Alexa Fluor 555 conjugated Insect Cells His/GST
Mouse Map2k1-1350MF Recombinant Mouse Map2k1 Protein, His/GST-tagged, FITC conjugated Insect Cells His/GST
Mouse MAP2K1-483MAF555 Recombinant Mouse Map2k1 Protein, Gly/Pro-tagged, Alexa Fluor 555 conjugated Insect Cells Gly/Pro
Mouse MAP2K1-1307M Recombinant Mouse MAP2K1 protein(Met1-Ile393) Insect Cells N/A
Mouse Map2k1-1350MAF647 Recombinant Mouse Map2k1 Protein, His/GST-tagged, Alexa Fluor 647 conjugated Insect Cells His/GST
Mouse MAP2K1-483MAF647 Recombinant Mouse Map2k1 Protein, Gly/Pro-tagged, Alexa Fluor 647 conjugated Insect Cells Gly/Pro
Mouse MAP2K1-483MF Recombinant Mouse Map2k1 Protein, Gly/Pro-tagged, FITC conjugated Insect Cells Gly/Pro
Rat MAP2K1-3559R Recombinant Rat MAP2K1 Protein Mammalian Cell His
Rat MAP2K1-3215R-B Recombinant Rat MAP2K1 Protein Pre-coupled Magnetic Beads HEK293
Rat MAP2K1-3215R Recombinant Rat MAP2K1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque MAP2K1-2663R Recombinant Rhesus monkey MAP2K1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque MAP2K1-2483R-B Recombinant Rhesus Macaque MAP2K1 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque MAP2K1-2483R Recombinant Rhesus Macaque MAP2K1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish MAP2K1-12591Z Recombinant Zebrafish MAP2K1 Mammalian Cell His
Chicken MAP2K1-1266C Recombinant Chicken MAP2K1 Mammalian Cell His
Kit-1614 MEK1 Kinase Binding Assay Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Map2k1 Related Signal Pathway

Map2k1 involved in several pathways and played different roles in them. We selected most pathways Map2k1 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Map2k1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MAPK signaling pathwayFGF8;IL1R1;FGF13;FLNC;FGF17;FGF1A;MOS;TGFBR1A;PPP3R1
Ras signaling pathwayKSR2;PLA2G2D;PLA2G12B;PLA2G4D;MAP2K1;PAK2;EFNA4;GAB1;PLA2G12A
cGMP-PKG signaling pathwayPRKG1;AKT2;CALML3;SLC8A2;SLC25A31;KCNMB4;ATF4;PPP3R1;CREB5
Chemokine signaling pathwayCCL3L3;CDC42;CCR8;GNB2;CCL3;GNG13;SHC2;FGR;ROCK2
FoxO signaling pathwaySMAD3;CCNG2;MAP2K2;TGFB3;RAF1;KLF2;SGK2;SKP2;RAG2
Sphingolipid signaling pathwayDEGS1;RAC3;NOS3;PPP2R2D;PRKCG;AKT1;CERS4;PPP2R5D;PLD1
Phospholipase D signaling pathwayPDGFA;CYTH1;RALGDS;AKT1;PIK3R1;CYTH3;AVPR1A;PLCG2;GAB1
PIK-Akt signaling pathwayGNB3;Ifna11;COL6A6;NGF;G6PC;TSC2;GNG10;PIK3CD;TP53
Vascular smooth muscle contractionPRKCE;KCNMA1A;CYP4A14;MAPK3;KCNMB1;KCNMB2;ROCK2A;CALM3A;ROCK2
Dorso-ventral axis formationSPIRE2;ETS2;KRAS;CPEB3;PIWIL1;CPEB2;EGFRA;MAP2K1;NOTCH4
Osteoclast differentiationOSCAR;FCGR2B;IL1A;NFATC2;LILRB5;FYN;MAPK11;NFKB2;LILRA2
Signaling pathways regulating pluripotency of stem cellsWNT3A;SMAD3;SMAD2;FZD5;ACVR2B;WNT2B;FGFR4;WNT1;TCF3
Toll-like receptor signaling pathwayCCL3;CD40;IFNB;IL6;TLR1LA;IFNA6;TOLLIP;IL12B;MAPK1
Natural killer cell mediated cytotoxicityPIK3R1;PRF1;IFNGR1;ITGB2L;FCGR3B;FASLG;SYK;IFNA13;PPP3R1
T cell receptor signaling pathwayCD8A;NFATC3;MAPK3;VAV1;CD28;PIK3CG;GRAP2;HRAS;PDCD1
B cell receptor signaling pathwayBTK;PIK3CB;HDAC5;IFITM1;DUSP4;HRAS;LILRB3;BCL2L11;PLCG2
Fc epsilon RI signaling pathwayRAC3;AKT2;VAV1;PIK3CA;MAPK9;IL13;FCER1A;RAF1;PLA2G4F
Fc gamma R-mediated phagocytosisGSN;PLA2G6;WASL;DOCK2;MAPK1;cgr2b;PLD1;FCGR2B;PLA2G4A
Long-term potentiationBRAF;CALM3;CALM2;ITPR3;ATF4;PLCB1;PPP3CB;RAF1;PPP3R1
Neurotrophin signaling pathwayCALM4;TP73;CALM2;MAP2K5;PIK3R3;GSK3B;ATF4;PLCG2;PTPN11
Cholinergic synapseKCNQ2;Adcy4;CREB3;CREB5;BCL2;CREB3L3;CHRNA4;ITPR3;ATF4
Serotonergic synapseTRPC1;GNB2;CYP2C38;MAPK3;PLA2G4C;ALOX8;HTR4;GNG4;RAF1
Regulation of actin cytoskeletonGNA12A;MAP2K2;ITGA5;MSNB;PPP1R12A;WASLB;F2R;ROCK2B;MAPK1
Insulin signaling pathwayPPP1R3C;GYS2;TRIP10;HRASB;RPS6KB1;PPP1R3B;FOXO1B;IRS1;PDPK1
Progesterone-mediated oocyte maturationIGF1RB;GNAI1;ARAF;SPDYA;INS2;PRKACBB;PRKACAB;RPS6KA3B;MAPK9
Estrogen signaling pathwayPRKACG;PIK3R5;CALM3;CALM1;NOS3;PLCB4;MAPK3;PRKCD;CREB3L3
Prolactin signaling pathwayINS2;STAT1;SOCS7;CCND2;PRL;STAT3;SRC;CCND1;MAPK9
Thyroid hormone signaling pathwayGSK3B;PIK3R1;MED4;THRA;HIF1A;MED27;RXRA;ATP1A4;PLCD4
Oxytocin signaling pathwayMYLK3;PPP3CA;CAMK2D;RYR1;CACNG7;CACNA2D1;PIK3R3;GNAI3;NOS3
Prion diseasesC8A;Hc;C8G;PRKACB;C6;C5;PRKACG;HSPA1A;C7
Pathways in cancerCCNA1;GNGT2;FGF22;GNAI2;NKX3-1;STK36;LPAR2;WNT7B;IL-8
Proteoglycans in cancerPPP1CA;IGF2;SDC2;IGF1R;AKT1;CD63;WNT9B;RPS6;TFAP4
Renal cell carcinomaGAB1;AHA-1;HGF;PDGFB;PAK1;PIK3R5;AKT1;PIK3R1;ARAF
Pancreatic cancerAKT1;STAT1;PIK3R5;MAPK10;MAPK9;TRP53;RAC2;SMAD4;PIK3CB
Endometrial cancerGRB2;CASP9;BAD;PIK3R5;ARAF;PIK3R1;APC;MAP2K2;TRP53
Chronic myeloid leukemiaTGFB1;TGFB3;PIK3R5;MAPK3;TGFBR1;CBLC;PIK3CA;AKT2;CCND1
Non-small cell lung cancerARAF;PIK3R1;RXRA;MAPK1;NRAS;PIK3R2;TP53;AKT1;CCND1
Central carbon metabolism in cancerMAPK3;AKT2;SIRT3;G6PDX;AKT1;PDK1;HK3;PIK3CG;PDHB
Choline metabolism in cancerRAC1;DGKD;SOS1;PIP5K1B;RHEB;PIK3CA;PRKCG;PLA2G4D;WASF2

Map2k1 has several biochemical functions, for example, ATP binding, MAP kinase kinase activity, Ras GTPase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Map2k1 itself. We selected most functions Map2k1 had, and list some proteins which have the same functions with Map2k1. You can find most of the proteins on our site.

Function Related Protein
MAP kinase kinase activityMAP2K3;MAPKAPK5;MAP2K1;MAP2K2A;MAPK10;MAPK14;MAP3K9;MAP2K6;ALPK2
mitogen-activated protein kinase kinase kinase bindingMAPK8IP3;MAP3K11;PPEF2;TRAF2;MAP2K1;CDC37;TCF3;TRAF6;STK38
protein C-terminus bindingPEX16;PQBP1;MAP2K1;PFKM;HOMER3;PPP2CB;SDCBP;DYNLL1;CD2AP
protein N-terminus bindingMNAT1;MAU2;LACRT;TDRD7;ERCC4;KCNB1;MECP2;VPS25;STX1A
protein bindingFBXO2;POLR2J;USP10;TESK1;PLIN1;NR3C1;HMGB2;PRADC1;CCDC130
protein serine/threonine kinase activator activityCDK5R1;LTF;STK4;STK3;ALS2;MAP2K1;IGF2;SPRY2;MAP2K2
protein serine/threonine kinase activityRPS6KA1;STK11;PHKG1B;STK36;RPS6KB2;RPS6KA4;STK32C;MASTL;MYLK4
protein serine/threonine/tyrosine kinase activityTTK;AURKA;DSTYK;RPS6KB1;TNK2;AURKC;RPS6KA1;TESK1;AURKB
protein tyrosine kinase activityTNK2;KITA;Aatk;BTK;SHC1;ABL2;MAP2K7;MAP2K2;SRC
receptor signaling protein tyrosine phosphatase activity

Map2k1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Map2k1 here. Most of them are supplied by our site. Hope this information will be useful for your research of Map2k1.


  • Q&As
  • Reviews

Q&As (5)

Ask a question
Are there ongoing clinical trials targeting MAP2K1? 01/12/2023

Yes, there are clinical trials exploring the efficacy and safety of MAP2K1 inhibitors in various cancers and other diseases.

Are there diagnostic tests specifically targeting MAP2K1 in clinical practice? 01/10/2023

Some diagnostic tests may analyze MAP2K1 mutations, especially in the context of cancer, to inform treatment decisions.

What diagnostic applications does MAP2K1 have in cancer detection? 09/30/2019

MAP2K1 mutations can serve as biomarkers in cancer diagnostics, aiding in the identification and classification of tumors.

How does MAP2K1 contribute to drug resistance in cancer treatment? 06/14/2019

MAP2K1 mutations can be associated with resistance to certain cancer therapies, making it important to understand its role in treatment response.

Are there targeted therapies based on MAP2K1 in cancer treatment? 02/17/2016

Yes, MAP2K1 inhibitors are being explored as targeted therapies in cancer treatment, aiming to block the abnormal signaling associated with MAP2K1 mutations.

Customer Reviews (3)

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    The unmatched performance of the MAP2K1 protein in both ELISA assays and protein electron microscopy structure analysis showcases its versatility and reliability in various experimental settings.


      The MAP2K1 protein finds extensive utility in protein electron microscopy structure analysis.


        With its exceptional specificity and sensitivity, it enables precise and reliable detection of target molecules, making it a valuable tool in the field of diagnostic and research applications.

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