Official Full Name | mitogen-activated protein kinase kinase 1 |
Background | The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development. [provided by RefSeq, Jul 2008] |
Synonyms | MAP2K1; mitogen-activated protein kinase kinase 1; CFC3; MEK1; MKK1; MAPKK1; PRKMK1; dual specificity mitogen-activated protein kinase kinase 1; MEK 1; MAPKK 1; MAPK/ERK kinase 1; ERK activator kinase 1; protein kinase, mitogen-activated, kinase 1 (MAP kinase kinase 1); |
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Map2k1 involved in several pathways and played different roles in them. We selected most pathways Map2k1 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Map2k1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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MAPK signaling pathway | FGF16; PRKACBA; RPS6KAL; FGF1A; GADD45AA; MAPK3; CACNG7; C11orf52; RPS6KA3A; RAP1AB |
ErbB signaling pathway | PTK2; ERBB3A; PRKCB; AKT2; PRKCBA; AKT3A; MTOR; PIK3CA; EGFRA; RPS6KB1 |
Ras signaling pathway | PDGFA; FGF11; SHC2; HRAS; FGF13; RAB5C; PLA2G4F; EFNA4; PIK3R2; NRAS |
Rap signaling pathway | MLLT4; FGF3; SRC; CALM2; CDC42; MAGI1; PLCB2; PFN3; KITLG; FGF18 |
cGMP-PKG signaling pathway | MYH7; PIK3R3; GNAI3; IRS1; PIK3CG; PPP3R2; KCNMB3; CREB3L3; PIK3CA; GNA12 |
cAMP signaling pathway | GRIA3; ACOX3; CAMK2G; GRIN2D; HTR1E; EP300; FSHR; FOS; BRAF; ATP1A3 |
Chemokine signaling pathway | ELMO1; CXCR2; RAP1B; CXCL5; PLCB4; GNG5; PIK3R2; ADRBK1; CCL6; CCL4 |
HIF- signaling pathway | ANGPT2; PLCG2; EGLN1; ERBB2; HK1; MKNK2; PDHA1; SLC2A1; IFNG; IL6 |
FoxO signaling pathway | AKT2; CCNB2; RAF1B; TGFB1A; PIK3CA; PLK3; MAP2K1; PCK1; IRS4; PIK3CD |
Sphingolipid signaling pathway | PPP2R2A; NSMAF; LASS4; SPHK1; PPP2CA; HRAS; CERS2; RELA; SMPD1; PIK3R1 |
Phospholipase D signaling pathway | PIK3R3; AVPR2; IL-8; PPAP2B; RRAS; PIK3R1; PIP5K1C; RHOA; KITLG; Kitl |
Oocyte meiosis | RPS6KA1; CALML3; PPP3R1; CALM; CPEB1A; SGOL1; INSB; INS1; YWHABL; CDC27 |
PIK-Akt signaling pathway | ITGA2; FGF8; IRS1; TSC1; GNG3; IL2RG; Ifna15; CCNE1; VWF; CREB3L1 |
Vascular smooth muscle contraction | PRKACB; MAPK1; ADORA2AB; CACNA1SA; NPR1; NPR2; RAF1; CACNA1DA; CALM2; MYLK |
Dorso-ventral axis formation | ETV6; CPEB1A; SPIRE1A; PPP1R2P9; SOS1; ETV7; NOTCH2; GRB2B; ETS1; SPIRE1 |
VEGF signaling pathway | PPP3CCA; MAPK3; PXNA; PLA2G4A; PPP3CC; MAP2K1; CDC42L; PTK2AB; PPP3R1B; PPP3R1 |
Osteoclast differentiation | PIK3CG; TGFBR1; MAP2K7; ITGB3; TGFB2; MAPK9; TNFRSF1A; TNFRSF11B; IL1R1; LILRB1 |
Focal adhesion | RAPGEF1; MYL12B; PAK3; THBS4B; COL2A1B; ITGB1A; BRAF; SHC3; PARVG; AKT1 |
Gap junction | HTR2C; GNAQ; GNAS; TUBA2; TUBA3A; HTR2B; TUBB6; SRC; TUBA1A; GNA11A |
Signaling pathways regulating pluripotency of stem cells | INHBE; WNT3; LHX5; FZD7; PCGF3; MYF5; BMI1; PIK3R1; PIK3CA; BMPR1A |
Toll-like receptor signaling pathway | STAT1A; IL12BA; CD80; MAP2K2; CCL4L1; NFKB1; IL12A; Ifna11; CXCL11; MAP2K4B |
Natural killer cell mediated cytotoxicity | HLA-E; KIR3DL2; Fasl; HLA-G; ITGB2L; IFNGR2; KIR2DL3; RAC3; FASLG; PIK3R3 |
T cell receptor signaling pathway | FOS; PIK3CG; IL5; MUC1; CD8B1; CD8A; GRAPA; GRB2; RHOA; PAK7 |
B cell receptor signaling pathway | NFATC2; NFKBIB; RAC2; RAC3; CSK; MAP2K1; CTNNB2; PDK2B; PIK3R2; IFITM1 |
Fc epsilon RI signaling pathway | SYK; MAPK1; BTK; PLA2G4A; MAP2K3; MAP2K4; AKT1; MAP2K6; HRAS; IL13 |
Fc gamma R-mediated phagocytosis | PLA2G4F; ARPC1A; DOCK2; INPP5D; MYO10; WASL; PIK3CA; PLA2G6; LIMK1; WASF3 |
TNF signaling pathway | MAP3K5; BAG4; BIRC3; VCAM1; MAP3K7; LIF; PIK3R2; MAPK12; PIK3R5; IKBKG |
Long-term potentiation | GRIN2C; RAP1A; NRAS; PPP1CC; PRKACG; MAP2K2; ITPR1; PRKACA; CALM4; GRM5 |
Neurotrophin signaling pathway | MAPK12; Fasl; AKT1; PTPN11; PIK3R3; NFKBIB; RPS6KA1; ARHGDIB; MAP2K1; ZFP110 |
Cholinergic synapse | PRKCA; PIK3R3; PRKACB; PIK3R1; ATF4; NRAS; CHRM5; GNGT2; GNGT1; BCL2 |
Serotonergic synapse | CYP2C39; ITPR3; KCNN2; GNG10; CYP2C50; PRKCB; GNB3; SLC18A1; HTR6; CYP2D10 |
Long-term depression | PRKCG; PLCB4; PPP2CA; GNA11; GRM1; GNAI1; CRHR1; GRIA1; RYR1; GRID2 |
Regulation of actin cytoskeleton | ITGB4; PIP5K2; PDGFD; ITGB2L; GNA12A; DIAPH1; ARPC5A; PIK3R3B; GSNB; EZRB |
Insulin signaling pathway | RHEB; PPARGC1A; PPP1CAB; PHKG2; PDPK1B; CALM2B; GSK3B; RPTOR; FLOT1B; FLOT2A |
GnRH signaling pathway | CALM3; CALM2B; MAP2K4; ADCY2B; MAPK14A; ADCY1B; CALML3; PRKACB; CAMK2D2; CGNRH-R |
Progesterone-mediated oocyte maturation | MAPK14B; RAF1; CCNA2; GNAIA; PDE3B; CPEB1A; ANAPC4; CCNB3; ADCY1B; PIK3R3B |
Estrogen signaling pathway | HSPA1L; FOS; RAF1; PLCB2; ATF6B; MAP2K2; HSPA1A; GNAO1; CALM2; MMP9 |
Melanogenesis | MAP2K2B; KIT; WNT8A; GNAI1; KITLG; PLCB2; TCF7L1A; WNT8B; FZD7A; FZD10 |
Prolactin signaling pathway | SOCS6; LHB; STAT1; SOCS3; MAPK10; ESR2; KRAS; TH; INS1; STAT3 |
Thyroid hormone signaling pathway | SIN3A; STAT1; DIO2; PLCB3; NOTCH4; ATP1B4; SLC2A1; TRP53; HDAC3; NOTCH2 |
Oxytocin signaling pathway | PPP1R12A; PIK3CA; RAF1; CAMK2B; CACNA2D3; SRC; PIK3R3; PIK3CD; MYL6; MAP2K1 |
Prion diseases | NCAM1; C8B; BAX; CASP12; C6; NCAM2; Hc; MAPK1; MAP2K1; SOD1 |
Alcoholism | GM14477; CALM3; GNAS; H2AFB2; H2AFV; HIST1H2BH; GNAI3; H2AFB3; HIST2H2AA4; SHC2 |
Hepatitis B | EGR2; IKBKB; NFKBIA; GRB2; FAS; TGFB3; ATF4; CXCL8; IFNA6; TLR3 |
Influenza A | CASP1; TLR3; IVNS1ABP; PABPN1L; IRF9; MAPK8; NFKBIA; HSPA1L; IL8L1; NXF2 |
Pathways in cancer | FOS; WNT8B; FGF17; CKS2; MAPK8; CCND1; BIRC5; LAMA2; AGTR1B; WNT7A |
Proteoglycans in cancer | NANOG; PPP1CC; FAS; FLNC; PRKACG; WNT10B; CBLC; PRKACB; PPP1CB; PPP1R12A |
MicroRNAs in cancer | BCL2; TNXB; ERBB3; PTGS2; HMGA2; ABL1; MCL1; SOX4; PDGFRA; BAK1 |
Colorectal cancer | MAPK9; BAX; TGFB1; PIK3R3; MAPK1; TGFB3; PIK3R2; AKT2; PIK3R1; CYCS |
Renal cell carcinoma | FLCN; EGLN1; VHL; TGFB1; MAPK1; TGFB3; KRAS; FH1; PIK3CD; RAC1 |
Pancreatic cancer | PIK3R5; TGFB1; AKT1; STAT3; SMAD2; PLD1; RELA; IKBKG; RAF1; SMAD4 |
Endometrial cancer | KRAS; PIK3R1; AKT2; PIK3CB; APC; BAD; TCF7L2; ERBB2; PIK3R5; PDPK1 |
Glioma | PLCG1; CALM2; PIK3CB; TP53; PLCG2; PIK3CD; RB1; AKT2; SHC2; PRKCG |
Prostate cancer | HSP90AA1; RAF1; IKBKB; HSP90AB1; SPINK1; MDM2; ARAF; PDGFD; PDPK1; SRD5A2 |
Thyroid cancer | TFG; NTRK1; HRAS; TPM3; TP53; NCOA4; MAP2K1; TPR; MAPK1; CCDC6 |
Melanoma | FGF12; NRAS; RB1; PDGFRB; TRP53; MAPK3; PIK3R5; FGF20; FGF22; AKT1 |
Bladder cancer | MAP2K1; RB1; RAF1; HRAS; E2F3; THBS1; EGF; TYMP; MYC; KRAS |
Chronic myeloid leukemia | SHC4; NRAS; RAF1; MAPK1; MAPK3; PTPN11; CRK; TRP53; SHC3; PIK3CD |
Acute myeloid leukemia | RAF1; CCNA1; KRAS; STAT5B; PIM2; MAPK3; CEBPA; RPS6KB2; BRAF; RUNX1T1 |
Non-small cell lung cancer | MAPK3; RAF1; FOXO3; TGFA; HRAS; RXRG; BAD; KRAS; PIK3R2; AKT1 |
Central carbon metabolism in cancer | NTRK3; AKT2; PTEN; PFKP; PIK3CD; PDHB; PKM2; GLS2; HK1; PIK3R3 |
Choline metabolism in cancer | PIK3CD; DGKZ; MAPK10; HRAS; PIK3R3; DGKD; SLC22A5; PIK3R2; RALGDS; DGKQ |
Map2k1 has several biochemical functions, for example, ATP binding, MAP kinase kinase activity, Ras GTPase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Map2k1 itself. We selected most functions Map2k1 had, and list some proteins which have the same functions with Map2k1. You can find most of the proteins on our site.
Function | Related Protein |
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ATP binding | MCM4; MYLK3; ATP7B; DCLK2; TLK1B; MTPAP; Ckmm; CDC34B; P2RX4B; PCCB |
MAP kinase kinase activity | MAP3K9; MAP2K2; MAP2K2A; MAP3K14; MAP2K2B; MAP2K1; MAP2K7; MAPKAPK5; MAP2K3; MAP2K6 |
Ras GTPase binding | RIN1; RAP1A; SH3BP4; RGL3; MLLT4; PLCE1; MAP2K1; RAPGEF6; MAPKAP1; CIB1 |
mitogen-activated protein kinase kinase kinase binding | TCF3; MAP3K11; CDC37; MAPK1; MAPK8IP3; PPEF2; TRAF2; DUSP19; STK38; MARVELD3 |
protein C-terminus binding | ZBTB16; CSK; PABPC1; YWHAB; DGKZ; PFKM; CALCOCO1; ERCC3; ATP2A2; KPNA3 |
protein N-terminus binding | TP53; MECP2; ZWINT; STXBP1; NBN; SERPINB1A; RPS21; MAP2K1; YWHAQ; PEX5 |
protein binding | IRS1; RPGRIP1; NOL6; KCNE1; FAM158A; PELO; HTR1B; SF3B2; TMEM14C; ASB7 |
protein kinase activity | EPHA4B; EPHB4A; CDC7; ACVR1L; MAPK14A; PRKAG1; PKN1B; HIPK3A; TRIOA; MAP3K1 |
protein serine/threonine kinase activator activity | ALS2; FAM20A; CALM2; MAP2K2; STRADA; SPRY2; STK3; CDK5R1; CALM1; PARP16 |
protein serine/threonine kinase activity | CDKL5; FAM20C; GRK1A; BMPR1BB; EIF2AK3; MAPK12A; ERN1; MAPK14; PAK2; SMOK3A |
protein serine/threonine/tyrosine kinase activity | MAP2K1; TESK2; PRKACA; CLK2; RPS6KA1; PRKCG; SGK1; AURKB; RPS6KA2; DYRK1AA |
protein tyrosine kinase activity | CLK3; NEK1; FES; LYN; ERBB4A; CSF1RA; PTK2AA; TESK1; PTK2B; FGFR1B |
receptor signaling protein tyrosine phosphatase activity | MAP2K1 |
Map2k1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Map2k1 here. Most of them are supplied by our site. Hope this information will be useful for your research of Map2k1.
BRAF
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