map2k1

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map2k1

Official Full Name mitogen-activated protein kinase kinase 1
Background The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development. [provided by RefSeq, Jul 2008]
Synonyms MAP2K1; mitogen-activated protein kinase kinase 1; CFC3; MEK1; MKK1; MAPKK1; PRKMK1; dual specificity mitogen-activated protein kinase kinase 1; MEK 1; MAPKK 1; MAPK/ERK kinase 1; ERK activator kinase 1; protein kinase, mitogen-activated, kinase 1 (MAP kinase kinase 1)
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Insect Cell
    • Mammalian Cell
    • Sf9 Insect Cell
    • Tag :
    • Flag
    • GST
    • His
    • MBP
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human MAP2K1-1033H Recombinant Human Mitogen-Activated Protein Kinase Kinase 1, GST-tagged Sf9 Insect Cell GST
    Human MAP2K1-1034H Recombinant Human Mitogen-Activated Protein Kinase Kinase 1, GST-tagged E.coli GST
    Human MAP2K1-1035H Recombinant Human Mitogen-Activated Protein Kinase Kinase 1, His-tagged Sf9 Insect Cell His
    Human MAP2K1-167H Recombinant Human v protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human MAP2K1-175H Recombinant Human MAP2K1, GST-tagged E.coli GST
    Human MAP2K1-2568H Recombinant Human MAP2K1, His-tagged Insect Cell His
    Human MAP2K1-299H Recombinant Human MAP2K1 protein, His/MBP-tagged E.coli His/MBP
    Human MAP2K1-300H Recombinant Human MAP2K1 protein, His/MBP-tagged E.coli His/MBP
    Human MAP2K1-343H Recombinant Human MAP2K1 Mammalian Cell His
    Human MAP2K1-596H Recombinant Human MAP2K1, His-tagged Sf9 Insect Cell His
    Human MAP2K1-62H Recombinant Human MAP2K1 protein, Flag-tagged, Biotinylated Insect Cell Flag
    Human MAP2K1-639H Recombinant Human MAP2K1 protein, His-tagged E.coli His
    Mouse MAP2K1-001MCL Recombinant Mouse MAP2K1 cell lysate Insect Cell N/A
    Mouse Map2k1-1032H Recombinant Mouse Mitogen-Activated Protein Kinase Kinase 1, GST-tagged E.coli GST
    Mouse Map2k1-1032M Recombinant Mouse Map2k1 protein, GST-tagged E.coli GST
    Mouse Map2k1-1350M Recombinant Mouse Map2k1, His & GST tagged Insect Cell His/GST
    Mouse Map2k1-3920M Recombinant Mouse Map2k1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Mouse MAP2K1-483M Recombinant Mouse MAP2K1, Gly & Pro tagged Insect Cell His
    Mouse Map2k1-666M Recombinant Mouse Map2k1, GST-tagged E.coli GST
    Rat MAP2K1-3559R Recombinant Rat MAP2K1 Protein Mammalian Cell His
    Rhesus Macaque MAP2K1-2663R Recombinant Rhesus monkey MAP2K1 Protein, His-tagged Mammalian Cell His
    Chicken MAP2K1-1266C Recombinant Chicken MAP2K1 Mammalian Cell His
    Zebrafish MAP2K1-12591Z Recombinant Zebrafish MAP2K1 Mammalian Cell His
    Kit-1614 MEK1 Kinase Binding Assay Kit N/A

    map2k1 involved in several pathways and played different roles in them. We selected most pathways map2k1 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with map2k1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathway Pdgfa&Pdgfb; RPS6KA6; TGFB1; NFKB2; MAPK10; PDGFAB; TGFB3; RAC3; TAB2; CACNA1DA
    ErbB signaling pathway KRAS; PLCG2; NRAS; PIK3CA; PAK6; RAF1; ABL2; RPS6KB1B; CAMK2B1; CBLB
    Ras signaling pathway GNG2; PRKCB; PLCG1; PLA2G10; PDGFRB; PRKCG; PLA2G12A; STK4; PRKACG; FGF2
    Rap signaling pathway PIK3CD; MAGI1; RASGRP3; GNAO1; Pdgfa&Pdgfb; PIK3CG; VEGFC; PRKCG; PRKCI; LPAR4
    cGMP-PKG signaling pathway RGS2; AGTR1A; VDAC2; ATP2B4; MAPK3; NFATC3; PDE3A; PIK3R2; CALM3; ATP2A3
    cAMP signaling pathway PIK3R2; GPR119; HTR6; PIK3CA; PAK1; CAMK2G; PPP1CA; PIK3CB; ATP1B4; GPR81
    Chemokine signaling pathway CCL2; PARD3; GNG10; STAT5B; CX3CR1; STAT2; IKBKG; GNB1; GNG2; PLCB1
    HIF- signaling pathway VHL; NOX3; ALDOA; PGK1; IGF1; PDHB; SERPINE1; HKDC1; FLT1; BCL2
    FoxO signaling pathway PRKAB1B; G6PC3; GADD45AB; STAT3; GABARAPL2; TGFB3; PRKAB2; GRB2B; FOXO1A; MAPK11
    Sphingolipid signaling pathway DEGS1; PLCB3; ROCK2; MAP2K1; BDKRB2; CERS4; MAPK8; FYN; NOS3; TRAF2
    Phospholipase D signaling pathway MS4A2; RALGDS; LPAR4; Kitl; PIK3R2; RRAS2; AGTR1B; AGPAT4; F2R; PTPN11
    Oocyte meiosis CALML5; PPP1CBL; YWHAB; PPP2R1A; PPP3R1; IGF1R; AURKA; SPDYB; MOS; SLKA
    PIK-Akt signaling pathway TNN; COL6A5; ITGA10; TCL1B4; PPP2R5B; PRLR; FGF3; CCND1; TEK; FGFR1
    Vascular smooth muscle contraction GNA12; PPP1R12C; PLA2G2D; ACTG2; PRKCG; MYLK3; EDNRAA; PTGIR; PPP1R12A; PLA2G4D
    Dorso-ventral axis formation NOTCH3; ETS2; GRB2; ETV6; NOTCH1B; CPEB1B; SPIRE1A; CPEB3; NOTCH4; NOTCH2
    VEGF signaling pathway KRAS; HRASA; MAPK11; PRKCG; PTGS2; MAPKAPK2; MAPK3; CDC42L2; PIK3CA; SH2D2A
    Osteoclast differentiation LILRA3; IKBKG; PLCG2; CYLD; TREM2; SOCS1; IFNB1; MAPK8; RELB; NCF4
    Focal adhesion PAK4; ITGB7; RHOAB; PIK3R3B; BADB; COL11A1A; TNN; ITGA1; Pdgfa&Pdgfb; PAK2B
    Gap junction GNAI2; PRKACBA; TUBA1B; GNAIA; ADCY1B; TUBB2B; TUBA3D; GJA1; PDGFRB; PRKCBA
    Signaling pathways regulating pluripotency of stem cells SETDB1; FZD5; SMAD2; ZIC3; LIF; TBX3; PCGF5; FZD1; ESX1; RAF1
    Toll-like receptor signaling pathway IRAK4; CASP8; PIK3R3A; MAP2K2B; TLR1LA; IFNA21; TLR8; IFNA6; AKT3A; IFNA5
    Natural killer cell mediated cytotoxicity SHC3; MAPK1; KIR2DL1; IFNA4; KLRC2; HLA-A; LCK; KIR2DS5; GRB2; PIK3R2
    T cell receptor signaling pathway PIK3R3; LCP2; PAK6; CD4; CABIN1; NCK2; PPP3R1; DEF6A; CD28; PRKCQ
    B cell receptor signaling pathway CR2; CRK; SYK; CD81; CRKL; GSK3B; PIK3CA; INPP5D; PPP3CA; ITPR2
    Fc epsilon RI signaling pathway PIK3CA; MAPK13; MS4A2; MAP2K1; PIK3R1; PLA2G4D; MAPK8; GRB2; PIK3R5; SYK
    Fc gamma R-mediated phagocytosis CDC42; GSN; PRKCA; AMPH; INPP5D; PLA2G4A; PIK3R1; VAV3; WASF1; NCF1
    TNF signaling pathway TRAF5; VEGFC; MAGI2; MMP9; PGAM5; PTGS2; MMP3; PIK3R5; MAPK13; PIK3CD
    Long-term potentiation GRIN2A; MAPK3; MAP2K1; PPP1CB; GRIN2B; CALM3; PPP1CC; PPP1R1A; ITPR1; RAF1
    Neurotrophin signaling pathway CALM4; BRAF; MAP2K7; ARHGDIG; KIDINS220; CAMK2B; RHOA; MAPK12; SH2B2; NFKB1
    Cholinergic synapse KCNQ5; CREB3L3; CAMK2A; GNG10; CREB3L2; PLCB1; KCNJ2; CAMK4; SLC5A7; GNG2
    Serotonergic synapse APP; HTR1F; GNB1; ALOX12E; CYP2C37; ITPR3; GNAO1; HTR3C; CYP2J5; GNAI1
    Long-term depression ITPR1; PLCB2; GUCY1B3; GRIA3; PRKG1; GNA12; RAF1; CRHR1; PRKCB; PLA2G4A
    Regulation of actin cytoskeleton LIMK2; RAC3; ARHGEF7; ABI2A; PAK2B; ITGAX; FGF1; INS; FGF13B; MLCK2
    Insulin signaling pathway PRKAR2B; PHKA2; PPP1R3CA; HRASA; TSC2; PRKAR2AA; PHKA1; FBP1B; PIK3CA; PIK3R1
    GnRH signaling pathway PLA2G4C; Adcy4; GNRH1; LHBETA1; PRKCDA; GNRHR; CDC42L; PLA2G4D; MMP2; CDC42
    Progesterone-mediated oocyte maturation RPS6KAL; RPS6KA3A; INS; PRKACAA; ADCY1B; RAF1; CPEB1; HSP90AB1; IGF1; PIK3R5
    Estrogen signaling pathway CREB5; HSPA1B; ITPR1; GNAI1; PIK3CG; FKBP4; ATF6B; CALML3; AKT1; SRC
    Melanogenesis KITB; PLCB2; PRKACAA; TYRP1; PLCB3; CAMK2G; KITLG; PLCB4; RAF1B; MITF
    Prolactin signaling pathway PRLR; TNFSF11; SOCS3; SHC4; FOXO3; INS1; SOS1; CCND2; CCND1; SHC3
    Thyroid hormone signaling pathway PRKCB; RHEB; HRAS; ATP2A2; RCAN1; ATP1A1; MED13L; RAF1; PLCB2; PFKFB2
    Oxytocin signaling pathway PRKAG3; CAMKK2; MAP2K1; PRKAA1; MAPK1; PPP3CB; GNAI1; CALML5; PPP1R12C; ITPR3
    Prion diseases CCL5; C6; SOD1; FYN; LOC100033925; C1QA; C1QC; IL1B; C1QB; IL1A
    Alcoholism HIST1H2BH; HIST1H3E; SLC6A3; HIST1H2BI; GRIN3A; GNG13; HIST1H2AJ; HIST1H2AB; H3F3C; MAPK3
    Hepatitis B MAP3K1; CCNA2; BCL2; TRP53; BAD; IKBKG; SMAD3; ATF4; STAT5B; CCNE1
    Influenza A NFKBIA; IFNA17; MAPK3; BMA1; RAF1; CASP1; LOC780933; PRSS1; IFNAR2; DNAJC3
    Pathways in cancer HSP90AB1; Kitl; F2RL3; ARHGEF12; FGF4; PIK3R1; RALGDS; FZD10; STAT1; ITGB1
    Proteoglycans in cancer ITGAV; PIK3R3; AKT2; WNT7A; COL21A1; MAP2K1; SOS1; MAPK13; TLR4; PRKCB
    MicroRNAs in cancer BRCA1; MAP2K1; TNXB; UBE2I; RPS6KA5; ERBB3; SOS1; HOXD10; MMP9; CDCA5
    Colorectal cancer PIK3R5; MSH2; TGFBR1; AXIN1; PIK3R2; CASP9; MAPK3; SMAD4; AXIN2; TRP53
    Renal cell carcinoma EGLN1; EGLN2; PAK2; MAP2K2; PIK3CB; RAF1; PAK7; NRAS; PIK3R3; VEGFA
    Pancreatic cancer STAT1; TP53; PIK3R5; PIK3CG; MAPK10; RALGDS; PIK3CB; TRP53; TGFBR2; PIK3R3
    Endometrial cancer PIK3R2; AXIN1; TCF7L2; AKT1; PIK3R3; PIK3CB; PIK3R1; AXIN2; CCND1; TRP53
    Glioma MAP2K2; CALML5; PIK3R3; CAMK2B; SOS1; CALML3; GRB2; PDGFA; AKT1; TRP53
    Prostate cancer PIK3CB; PIK3R3; NFKB1; CREB3L2; CCND1; MDM2; PTEN; TCF7L2; INS; CPN1
    Thyroid cancer MAPK3; RET; TCF7; LEF1; PAX8; RXRB; CCND1; HRAS; NTRK1; TFG
    Melanoma IGF1R; NRAS; PDGFRB; FGF8; FGF7; CDH1; FGF22; BAD; PIK3R2; PIK3CD
    Bladder cancer UPK3A; RASSF1; RPS6KA5; FGFR3; MAPK1; CCND1; CXCL8; CDKN2A; TRP53; KRAS
    Chronic myeloid leukemia RB1; HDAC2; KRAS; BCR; MAP2K1; CBLB; MECOM; PIK3R5; STAT5A; HRAS
    Acute myeloid leukemia RELA; PIK3R1; NFKB1; PPARD; CCNA1; STAT5A; IKBKG; MAPK3; EIF4EBP1; PML
    Non-small cell lung cancer FOXO3; PDPK1; EML4; RARB; PLCG1; PIK3CB; TP53; RXRG; MAP2K2; ERBB2
    Central carbon metabolism in cancer PIK3R2; RAF1; PDHA1; PFKL; PDK1; PFKP; NTRK1; GLS2; PIK3R1; PKM
    Choline metabolism in cancer PLD1; PRKCA; SLC44A2; DGKB; RAC2; RPS6KB1; PDGFRA; RAC1; GPCPD1; MAP2K1

    map2k1 has several biochemical functions, for example, ATP binding, MAP kinase kinase activity, Ras GTPase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by map2k1 itself. We selected most functions map2k1 had, and list some proteins which have the same functions with map2k1. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding TIE1; DMPK; CDK8; HK1; RAD54L; TMEM38A; UBE2Q2; TTF2; ASNA1; NMRK1
    MAP kinase kinase activity MAP3K20; MAPKAPK5; ALPK2; MAP2K6; MAP2K2B; MAP3K9; MAPK10; PAK3; SBK3; MAP2K7
    Ras GTPase binding MAP2K1; RAP1GAP; RAPGEF4; MLLT4; RAPGEF6; MAPKAP1; RASGRP3; RGL3; RIN1; RAP1A
    mitogen-activated protein kinase kinase kinase binding DUSP19; MAPK1; CDC42; MAPK8IP3; MAPK9; MAP2K1; MAP3K11; TRAF6; CDC37; MAP4K2
    protein C-terminus binding SIAH1; FBLN1; PROP1; KSR1; VGLL3; ATXN2; SDCBP; PFKM; PEX12; VTA1
    protein N-terminus binding MEN1; TRP53; ERCC5; UNC13A; SMARCC1; TGFB1; NCOR2; ZWINT; PDLIM5; EXOC5
    protein binding DSTN; COA5; HSD17B12; LENG1; COMMD8; SART1; RAB11B; HBP1; CCDC148; HDAC2
    protein kinase activity FASTKD2; WEE2; CSNK1E; PAK2; PLK2B; JAK2A; PINK1; DCLK3; TNIKA; EPHA4B
    protein serine/threonine kinase activator activity MAP2K2; CDK5R1; MAP2K1; IGF2; ALS2; CALM2; CAB39; CALM1; FAM20A; PARP16
    protein serine/threonine kinase activity SMG1; NEK1; MKNK2; TNNI3K; DCLK1; MYO3B; MASTL; NLK2; AURKA; ATM
    protein serine/threonine/tyrosine kinase activity AURKC; PRKCG; PRKACA; DYRK1AA; DYRK1B; CLK4; DYRK3; TNK2; DYRK4; TESK1
    protein tyrosine kinase activity JAK1; TNK1; PTK2BB; ERBB2; PTK2AA; SHC1; DYRK3; ERBB4; EPHA4B; PTK7
    receptor signaling protein tyrosine phosphatase activity MAP2K1

    map2k1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with map2k1 here. Most of them are supplied by our site. Hope this information will be useful for your research of map2k1.

    BRAF

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