Map2k1 Protein

Map2k1

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Map2k1

Official Full Name mitogen-activated protein kinase kinase 1
Background The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development. [provided by RefSeq, Jul 2008]
Synonyms MAP2K1; mitogen-activated protein kinase kinase 1; CFC3; MEK1; MKK1; MAPKK1; PRKMK1; dual specificity mitogen-activated protein kinase kinase 1; MEK 1; MAPKK 1; MAPK/ERK kinase 1; ERK activator kinase 1; protein kinase, mitogen-activated, kinase 1 (MAP kinase kinase 1)
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Insect (sf21)
    • Insect Cell
    • Insect Cells
    • Mammalian Cell
    • Sf9 Insect Cell
    • Tag :
    • BTN
    • Flag
    • Gly/Pro
    • GST
    • His
    • His/GST
    • MBP
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human MAP2K1-175H Active Recombinant Human MAP2K1, GST-tagged E.coli GST
    Human MAP2K1-2568H Active Recombinant Human MAP2K1, His-tagged Insect Cell His
    Mouse Map2k1-1032M Active Recombinant Mouse Map2k1 protein, GST-tagged E.coli GST
    Mouse Map2k1-666M Active Recombinant Mouse Map2k1, GST-tagged E.coli GST
    Human MAP2K1-1033H Recombinant Human Mitogen-Activated Protein Kinase Kinase 1, GST-tagged Sf9 Insect Cell GST
    Human MAP2K1-1034H Recombinant Human Mitogen-Activated Protein Kinase Kinase 1, GST-tagged E.coli GST
    Human MAP2K1-1035H Recombinant Human Mitogen-Activated Protein Kinase Kinase 1, His-tagged Sf9 Insect Cell His
    Human MAP2K1-167H Recombinant Human v protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human MAP2K1-299H Recombinant Human MAP2K1 protein, His/MBP-tagged E.coli His/MBP
    Human MAP2K1-300H Recombinant Human MAP2K1 protein, His/MBP-tagged E.coli His/MBP
    Human MAP2K1-343H Recombinant Human MAP2K1 Mammalian Cell His
    Human MAP2K1-596H Recombinant Human MAP2K1, His-tagged Sf9 Insect Cell His
    Human MAP2K1-62H Recombinant Human MAP2K1 protein, Flag-tagged, Biotinylated Insect Cell Flag
    Human MAP2K1-639H Recombinant Human MAP2K1 protein, His-tagged E.coli His
    Mouse Map2k1-1032H Recombinant Mouse Mitogen-Activated Protein Kinase Kinase 1, GST-tagged E.coli GST
    Mouse Map2k1-1350M Recombinant Mouse Map2k1, His & GST tagged Insect Cell His/GST
    Mouse MAP2K1-483M Recombinant Mouse MAP2K1, Gly & Pro tagged Insect Cell His
    Rat MAP2K1-3559R Recombinant Rat MAP2K1 Protein Mammalian Cell His
    Rhesus Macaque MAP2K1-2663R Recombinant Rhesus monkey MAP2K1 Protein, His-tagged Mammalian Cell His
    Chicken MAP2K1-1266C Recombinant Chicken MAP2K1 Mammalian Cell His
    Zebrafish MAP2K1-12591Z Recombinant Zebrafish MAP2K1 Mammalian Cell His
    Mouse MAP2K1-001MCL Recombinant Mouse MAP2K1 cell lysate Insect Cell N/A
    Mouse Map2k1-1350MAF488 Recombinant Mouse Map2k1 Protein, His/GST-tagged, Alexa Fluor 488 conjugated Insect Cells His/GST
    Mouse Map2k1-1350MAF555 Recombinant Mouse Map2k1 Protein, His/GST-tagged, Alexa Fluor 555 conjugated Insect Cells His/GST
    Mouse Map2k1-1350MAF647 Recombinant Mouse Map2k1 Protein, His/GST-tagged, Alexa Fluor 647 conjugated Insect Cells His/GST
    Mouse Map2k1-1350MF Recombinant Mouse Map2k1 Protein, His/GST-tagged, FITC conjugated Insect Cells His/GST
    Human MAP2K1-2354HF Recombinant Full Length Human MAP2K1 Protein, GST-tagged Insect (sf21) GST
    Human MAP2K1-2723HF Recombinant Full Length Human MAP2K1 Protein, GST-tagged Insect (sf21) GST
    Human MAP2K1-3929HF Recombinant Full Length Human MAP2K1 Protein, GST-tagged Insect (sf21) GST
    Mouse MAP2K1-483MAF488 Recombinant Mouse Map2k1 Protein, Gly/Pro-tagged, Alexa Fluor 488 conjugated Insect Cells Gly/Pro
    Mouse MAP2K1-483MAF555 Recombinant Mouse Map2k1 Protein, Gly/Pro-tagged, Alexa Fluor 555 conjugated Insect Cells Gly/Pro
    Mouse MAP2K1-483MAF647 Recombinant Mouse Map2k1 Protein, Gly/Pro-tagged, Alexa Fluor 647 conjugated Insect Cells Gly/Pro
    Mouse MAP2K1-483MF Recombinant Mouse Map2k1 Protein, Gly/Pro-tagged, FITC conjugated Insect Cells Gly/Pro
    Human MAP2K1-5481HF Recombinant Full Length Human MAP2K1 Protein, GST-tagged Insect (sf21) GST
    Human MAP2K1-8116HF Recombinant Full Length Human MAP2K1 Protein, GST-tagged E.coli GST
    Human MAP2K1-9955HF Recombinant Full Length Human MAP2K1 Protein, BTN-tagged Insect (sf21) BTN
    Mouse Map2k1-3920M Recombinant Mouse Map2k1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Kit-1614 MEK1 Kinase Binding Assay Kit N/A

    Map2k1 involved in several pathways and played different roles in them. We selected most pathways Map2k1 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Map2k1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathway TNFRSF1A; FGF2; FGFR1; TGFBR1A; CACNG7A; FGF11A; ZAK; SRFA; NR4A1; FGF20
    ErbB signaling pathway GSK3B; AREGB; MAP2K2; NRG2B; CBLB; MAP2K4; NRAS; SHC1; MAPK1; RPS6KB2
    Ras signaling pathway FIGF; RAB5B; GRIN2A; GAB1; MAPK8; REL; FGF6; Kitl; RASGRP3; MLLT4
    Rap signaling pathway PIK3R1; ANGPT1; ITGB2L; KITLG; FGF1; PDGFRB; SKAP1; FGF16; RAP1GAP; PFN3
    cGMP-PKG signaling pathway ATP2A2; ATP2A1; ATP1B4; IRS1; ITPR1; ATP2B1; IRS2; PPP3CC; PIK3CG; PIK3R5
    cAMP signaling pathway GLI1; GNAI1; LOC100328615; CAMK2D; VAV3; OXTR; LIPE; MAP2K2; PIK3R3; PPARA
    Chemokine signaling pathway CCL14; ROCK2; GNG12; PTK2; CXCL11; PLCB4; GM13306; PLCB1; CCR8; CXCL16
    HIF- signaling pathway RPS6KB1; PFKFB3; RPS6KB2; PIK3CG; PIK3CD; BCL2; CAMK2A; ENO2; SERPINE1; EIF4E2
    FoxO signaling pathway MDM2; PIK3R5; SKP2; SGK2; MAPK8B; MAPK14A; AKT2L; SGK2A; PRKAA1; RAG2
    Sphingolipid signaling pathway MAPK3; PPP2R2C; SGPP2; PRKCE; ROCK2; S1PR4; LOC100328615; RAC2; AKT1; NSMAF
    Phospholipase D signaling pathway GRM5; RALB; PLCG1; INS2; DGKD; AGTR1A; GRM2; PIK3CB; AGPAT3; PIP5K1C
    Oocyte meiosis PPP1CB; SLK; CAMK2B1; ANAPC13; PPP2R5B; PPP3R2; CALM3B; FBXW11; CPEB3; ESPL1
    PIK-Akt signaling pathway PPP2R3C; THBS1; IL2RG; FIGF; ITGA2; PRLR; GNG5; ATF4; PTEN; SGK1
    Vascular smooth muscle contraction GNA15.1; RAF1; KCNMB2; ACTG2; PPP1CAB; CALM3B; CACNA1SA; KCNMA1A; ADORA2AB; CACNA1SB
    Dorso-ventral axis formation CPEB1A; GRB2A; FMN2; ETS2; SPIRE1; EGFRA; GRB2; PIWIL4; SPIRE2; ETV6
    VEGF signaling pathway CDC42L2; RAC3; PIK3R3A; VEGFA; PTGS2; PIK3CD; NOS3; PIK3R5; MAP2K1; VEGFAA
    Osteoclast differentiation RELB; PPARG; LILRB5; LILRA2; PIK3R2; MAP3K14; PIK3CG; FOS; FCGR3B; SIRPG
    Focal adhesion PIK3R3A; ITGAV; VEGFAB; PRKCB; SRC; PARVA; PRKCBB; BADB; VAV2; COL2A1
    Gap junction TUBA4L; GNA11B; PDGFD; TUBB2B; TUBA8L; PRKG1; TUBA1C; PRKACBA; TUBA7L; SRC
    Signaling pathways regulating pluripotency of stem cells BMPR1B; BMP2; WNT2; WNT4; SKIL; ID2; HESX1; LIFR; SOX2; IL6ST
    Toll-like receptor signaling pathway CD14; PIK3R1; RAC1A; TRAF3; CXCL9; IFNA21; IFNA16; PIK3R3B; IFNA2; CCL4L2
    Natural killer cell mediated cytotoxicity IFNA6; PIK3CB; IFNA21; TNFRSF10A; NCR3; MAPK3; NFATC1; FASLG; MICB; PPP3R2
    T cell receptor signaling pathway PIK3R5; PIK3CD; MAPK12; MAPK3; DLG1; CD3E; AKT1; SHB; PIK3R1; PAK1
    B cell receptor signaling pathway CTNNB2; RELA; PDPK1A; MAP2K2; ARPC4; SOS1; PPP3CC; NRAS; LAT2; LIME1
    Fc epsilon RI signaling pathway MS4A2; PLA2G4F; RAC2; PLA2G4B; RAC3; PIK3CG; MAP2K1; RAC1; GRB2; MAPK8
    Fc gamma R-mediated phagocytosis NCF1; PPAP2A; PLCG2; PPAP2B; SPHK2; MARCKSL1; SCIN; PRKCE; MAPK3; ASAP2
    TNF signaling pathway FAS; LIF; CFLAR; CASP10; MAPK1; PGAM5; CREB3L1; IL1B; BIRC2; Ccl12
    Long-term potentiation PPP3CB; ATF4; PPP3CC; PRKACG; GRIA2; RPS6KA1; PLCB2; RPS6KA3; PPP1R1A; PLCB1
    Neurotrophin signaling pathway PIK3R1; PIK3CB; MAPK12; NRAS; RPS6KA5; ARHGDIA; MAPK3; SH2B3; SHC2; KRAS
    Cholinergic synapse PIK3R5; CHRNA6; PIK3R2; SLC5A7; GNG11; PIK3R3; GNG12; ITPR1; GNB1; KCNJ2
    Serotonergic synapse APP; HTR2B; GNB3; KCNN2; GNG4; HTR2A; PTGS1; CYP2J6; MAPK3; GNG8
    Long-term depression LYN; PLCB2; PPP1R17; PRKCG; CRH; GNAI1; GRID2; GNAQ; GRM1; PLCB4
    Regulation of actin cytoskeleton MAP2K2; GNA12; PIP5K1B; PIK3CB; INS1; BAIAP2A; APC2; ROCK2; MAP2K2A; ITGA4
    Insulin signaling pathway RAF1B; PPP1CBL; PYGL; INSR; RPS6KB1; CBL; SOS1; CALM3; FASN; PRKACAA
    GnRH signaling pathway MAP3K1; CAMK2D2; PRKCD; CDC42; GNRH2; MAP2K4; PRKCA; GNA11B; MAP2K6; HRAS
    Progesterone-mediated oocyte maturation MOS; PIK3R3A; PIK3R5; ANAPC1; Adcy4; ANAPC4; CPEB3; PIK3R3B; MAPK11; PIK3R1
    Estrogen signaling pathway Adcy4; ESR2; CREB3L3; PIK3R3; OPRM1; KRAS; PLCB3; PIK3CD; PRKCD; MAPK1
    Melanogenesis RAF1B; FZD7; KITLGB; PLCB3; CAMK2B1; ADCY1B; CREB3L3; FZD5; CALML3; WNT9A
    Prolactin signaling pathway SOCS5; MAPK1; INS; PIK3R5; PRLR; LHCGR; INS2; STAT5A; SOCS7; PRP2
    Thyroid hormone signaling pathway MDM2; PIK3R1; RCAN2; PDPK1; EP300; MAPK3; ITGAV; MED24; PLN; NCOA1
    Oxytocin signaling pathway PLA2G4F; ITPR1; CALM4; GNAI1; MAPK1; RAF1; MAP2K5; PIK3R3; TRPM2; RHOA
    Prion diseases LAMC1; IL1B; IL1A; C1QA; NOTCH1; MAPK1; LOC100033925; MAP2K1; PRKACB; BAX
    Alcoholism HIST3H2BB-PS; HIST1H2BD; GM14477; NTRK2; ATF2; GNAI2; CALML3; HDAC8; ATF4; H3F3A
    Hepatitis B RB1; BIRC5; IFNA8; IFNA10; CREB3L2; IFNA13; TBK1; FASLG; CYCS; SMAD4
    Influenza A PIK3R2; HLA-DRB4; HNRNPUL1; IL-8; IL12B; IRF9; MAP2K2; TRIM25; IFNA21; PIK3CG
    Pathways in cancer LAMC2; PIK3CB; TGFA; KRAS; MAPK9; NFKB1; FGF1; GSTP1; SLC2A1; CTBP2
    Proteoglycans in cancer ITPR1; WNT3A; CD63; MDM2; PIK3R1; HCLS1; PPP1R12B; SDC4; ITPR3; KRAS
    MicroRNAs in cancer SLC45A3; NOTCH1; ITGA5; MMP9; CCNE2; CYP24A1; RECK; ABCB1A; PLCG1; DDIT4
    Colorectal cancer MSH2; MLH1; AKT2; APC; TGFBR1; PIK3R1; PIK3CB; PIK3R5; RHOA; SMAD3
    Renal cell carcinoma TGFB1; FLCN; SOS1; PIK3CD; SLC2A1; PIK3R2; PIK3R5; EPAS1; PAK7; ARAF
    Pancreatic cancer TGFA; PIK3CD; PLD1; RAC2; STAT3; IKBKB; PIK3R2; PIK3R5; RAC1; MAPK1
    Endometrial cancer APC; APC2; ARAF; PTEN; PIK3CD; SOS1; TRP53; PIK3R3; TCF7; NRAS
    Glioma CALM1; SHC2; PIK3R2; MAPK1; PRKCB; SOS1; TP53; KRAS; CALML5; PDGFRA
    Prostate cancer IKBKB; SMARCC2; HSP90B1; PIK3CG; MAP4K1; SMARCD1; GSK3B; CREB5; CREB3L1; RB1
    Thyroid cancer TP53; PPARG; NTRK1; CCDC6; LEF1; HRAS; MAP2K2; TCF7; MAPK3; TFG
    Melanoma HGF; BRAF; MITF; PDGFRA; MDM2; PDGFA; FGFR1; FGF10; PIK3CB; ARAF
    Bladder cancer MYC; DAPK1; E2F1; EGF; TYMP; RPS6KA5; MMP1A; BRAF; MDM2; MMP9
    Chronic myeloid leukemia CBLB; AKT2; MAPK1; MECOM; TGFBR1; ABL1; CTBP2; GAB2; RUNX1; TGFBR2
    Acute myeloid leukemia PML; CEBPA; STAT3; SOS1; AKT1; KIT; RPS6KB2; PIK3R3; MAP2K2; NFKB1
    Non-small cell lung cancer PRKCG; ERBB2; AKT1; PLCG1; MAPK1; MAP2K1; PRKCA; BAD; PIK3CG; PLCG2
    Central carbon metabolism in cancer PIK3CA; MAP2K1; HKDC1; PFKM; TRP53; KIT; MAP2K2; PIK3CD; KRAS; PIK3CB
    Choline metabolism in cancer SLC22A3; PPAP2A; PRKCB; PLA2G4D; DGKA; PDGFRA; RAC2; PDGFD; MTOR; LYPLA1

    Map2k1 has several biochemical functions, for example, ATP binding, MAP kinase kinase activity, Ras GTPase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Map2k1 itself. We selected most functions Map2k1 had, and list some proteins which have the same functions with Map2k1. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding DDX43; PIP5K1B; PDPK1B; DDX55; MAPKAPK5; NPR2; DCAKD; PAK1; HSPA5; FANCM
    MAP kinase kinase activity PAK3; MAP3K14; MAP2K7; MAP2K2A; MAPK14; MAPKAPK5; MAP2K2B; ALPK2; MAP2K1; MAP2K2
    Ras GTPase binding RAP1GAP; RIN1; RAPGEF6; RGL3; RAPGEF4; SPHK2; RASGRP3; MLLT4; SH3BP4; RAP1A
    mitogen-activated protein kinase kinase kinase binding MAP2K1; CDC37; MAPK1; TCF3; MAP3K11; DUSP19; MAP4K2; MARVELD3; MAPK9; TRAF2
    protein C-terminus binding PDZD3; DGKZ; DLG4; PPP1R9B; KCNIP3; ITGB3BP; ERCC2; SNTG1; TRP53; MLLT4
    protein N-terminus binding BIRC2; APTX; PEX5; SUV39H1; SERPINB1A; KCNQ2; EXOC4; RND2; GTF2H2; SMARCA4
    protein binding RRAD; ZP3; C1GALT1C1; C1orf65; AGR2; SPANXD; SCMH1; SPSB3; YAP1; NRSN1
    protein kinase activity STK24B; RIPK3; STK4; CDK9; CCL5; CSNK2A2A; CDK11A; OXSR1B; GRK1B; ERBB3A
    protein serine/threonine kinase activator activity IGF2; MAP2K2; STK4; CALM3; CAB39; LTF; ALS2; STK3; CALM2; CALM1
    protein serine/threonine kinase activity MAPK11; AURKB; AURKA; GRK7A; PRKDC; TSSK4; MAP4K6; PRKCA; PASK; RIPK1
    protein serine/threonine/tyrosine kinase activity RPS6KA1; RPS6KA2; RPS6KB1; PRKACA; DSTYK; PRKAA2; AURKB; PRKCG; TESK1; DYRK1AA
    protein tyrosine kinase activity LCK; CLK4; FYNB; TTK; KITA; CSF1RA; KIT; BCR; FES; JAK3
    receptor signaling protein tyrosine phosphatase activity MAP2K1

    Map2k1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Map2k1 here. Most of them are supplied by our site. Hope this information will be useful for your research of Map2k1.

    BRAF

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