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Official Full Name mitogen-activated protein kinase kinase kinase 7
Background The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
Synonyms MAP3K7; mitogen-activated protein kinase kinase kinase 7; TAK1; MEKK7; TGF-beta activated kinase 1; TGF-beta-activated kinase 1; transforming growth factor-beta-activated kinase 1; TGF1a; MAP; MAP3K; mitogen-activated protein kinase 7
    • Species :
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293T
    • Insect Cell
    • Mammalian Cell
    • Sf9 Insect Cell
    • Tag :
    • Flag
    • GST
    • His
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human MAP3K7-2518H Recombinant Human MAP3K7 protein, His-tagged E.coli His
    Human MAP3K7-1056HCL Recombinant Human MAP3K7 cell lysate N/A
    Human MAP3K7-30308TH Recombinant Human Human MAP3K7 N/A
    Human MAP3K7-4095H Recombinant Human MAP3K7 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human MAP3K7-82H Recombinant Human MAP3K7 protein, Flag-tagged, Biotinylated Insect Cell Flag
    Human TAK1-TAB1-440H Recombinant Human TAK1-TAB1, GST-tagged, Active Sf9 Insect Cell GST
    Mouse Map3k7-3932M Recombinant Mouse Map3k7 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Rat MAP3K7-3566R Recombinant Rat MAP3K7 Protein Mammalian Cell His
    Zebrafish MAP3K7-2890Z Recombinant Zebrafish MAP3K7 Mammalian Cell His

    MAP3K7 involved in several pathways and played different roles in them. We selected most pathways MAP3K7 participated on our site, such as MAPK signaling pathway, NF-kappa B signaling pathway, AMPK signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAP3K7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathway TAB2; DUSP8A; GADD45AB; CACNB2; NLK1; MRAS; CACNB1; CACNA2D2; FGF5; ARRB2B
    NF-kappa B signaling pathway RELA; LTA; ZAP70; LTB; BCL10; LBP; BIRC3; BTK; MAP3K7IP3; CD40LG
    AMPK signaling pathway EEF2K; PDPK1; PPP2R2B; PFKFB3; PPP2R1A; PIK3CG; CAB39L; FASN; PRKAA1; ADIPOR1
    Wnt signaling pathway DAAM1B; CAMK2B; MAPK9; PRKACBA; CSNK1A1L; CXXC4; TCF7; WNT7AA; VANGL1; NFATC4
    Osteoclast differentiation MAPK8; MITF; LILRA5; AKT1; FCGR3A; FHL2; FOSL2; MAPK11; IFNGR2; CALCR
    Adherens junction PARD3; RAC2; CDC42L2; RHOAB; CTNNB1; SRC; WAS; MAPK1; CTNNA3; RAC3A
    Toll-like receptor signaling pathway TLR5; IRF7; NFKBIA; PIK3CB; AKT3A; RELA; FOS; MAP2K4A; STAT1B; MAP2K2B
    NOD-like receptor signaling pathway NAIP7; MAPK8; MAPK14B; MAP3K7; PSTPIP1A; IL18; NFKBIAB; CCL2; NAIP1; CXCL8B.3
    RIG-I-like receptor signaling pathway TANK; NT5C3; RELA; IKBKE; RIPK1; OTUD5; DAK; Ifna15; RNF207B; NFKBIAB
    T cell receptor signaling pathway IL5; IL4; GRAP2; SOS1; PIK3R3; KRAS; MAPK13; CBLC; PRKCQ; CDC42
    TNF signaling pathway PIK3R1; TNFAIP3; Casp3; TAB2; MAPK10; CASP10; PIK3CB; TRAF2; PIK3R3; BIRC3
    Leishmaniasis IRAK4; MAPK13; TNF; PRKCB; FCGR2A; IL4; STAT1; ITGA4; ITGB2; IL12B
    Measles FCGR2B; TLR4; AKT1; PIK3CB; TP73; CCND1; HSPA1B; CD28; IL12A; RAB9A
    Herpes simplex infection POLR2A; HLA-B; TAF6L; HLA-DPA1; Casp3; SOCS3B; BLB1; EEF1D; CASP8; LOC100033925
    Epstein-Barr virus infection PIK3CG; MAPK13; PIK3R2; EIF2AK2; CD38; PSMD11; CSNK2A2; MAP2K6; MDM2; HSPA1L

    MAP3K7 has several biochemical functions, for example, DNA binding, protein C-terminus binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAP3K7 itself. We selected most functions MAP3K7 had, and list some proteins which have the same functions with MAP3K7. You can find most of the proteins on our site.

    Function Related Protein
    DNA binding HMGB3B; PBX1B; ARNTL; ZFP746; SETDB1B; ZFP146; ZBED4; SOX12; POLG; LIG3
    protein C-terminus binding ERCC3; MAP2K1; SHANK3; LCK; FBLN1; BLOC1S2A; TJP2; TOP2B; SNX17; TRP53
    protein binding INTS7; GIP; Cd24a; RAB7; ELAVL1; SRP14; EDC3; IRX1; IFI6; CD3E
    protein heterodimerization activity CASP8; TENM3; FLOT2; ALX1; ENO3; HNF1A; ARNT; ALG2; Itgam&Itgb2; PDX1
    transcription cofactor activity PIR; ZNF865; CALCOCO1; NMI; WDR75; ZMYND11; MED12; MED1; NRG1; TFB2M
    transcription factor activity, sequence-specific DNA binding TGIF2; RBPJL; IRF2; FOXN2; EGR3; ZSCAN12; PLAGX; ZFP11; MNX2B; MAX

    MAP3K7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAP3K7 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAP3K7.


    Szili, D; Banko, Z; et al. TGF beta Activated Kinase 1 (TAK1) at the Crossroad of B Cell Receptor and Toll-Like Receptor 9 Signaling Pathways in Human B Cells. PLOS ONE 9:-(2014).
    Kennedy, RB; Ovsyannikova, IG; et al. Multigenic control of measles vaccine immunity mediated by polymorphisms in measles receptor, innate pathway, and cytokine genes. VACCINE 30:2159-2167(2012).

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