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Official Full Name mitogen-activated protein kinase kinase kinase 7
Background The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
Synonyms MAP3K7; mitogen-activated protein kinase kinase kinase 7; TAK1; MEKK7; TGF-beta activated kinase 1; TGF-beta-activated kinase 1; transforming growth factor-beta-activated kinase 1; TGF1a; MAP; MAP3K; mitogen-activated protein kinase 7
    • Species :
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • HEK293T
    • Insect Cell
    • Mammalian Cell
    • Sf9 Insect Cell
    • Tag :
    • Flag
    • GST
    • His
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human MAP3K7-1056HCL Recombinant Human MAP3K7 cell lysate N/A
    Human MAP3K7-30308TH Recombinant Human Human MAP3K7 N/A
    Human MAP3K7-4095H Recombinant Human MAP3K7 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human MAP3K7-82H Recombinant Human MAP3K7 protein, Flag-tagged, Biotinylated Insect Cell Flag
    Human TAK1-TAB1-440H Recombinant Human TAK1-TAB1, GST-tagged, Active Sf9 Insect Cell GST
    Mouse Map3k7-3932M Recombinant Mouse Map3k7 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Rat MAP3K7-3566R Recombinant Rat MAP3K7 Protein Mammalian Cell His
    Zebrafish MAP3K7-2890Z Recombinant Zebrafish MAP3K7 Mammalian Cell His

    map3k7 involved in several pathways and played different roles in them. We selected most pathways map3k7 participated on our site, such as MAPK signaling pathway, NF-kappa B signaling pathway, AMPK signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with map3k7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathway MAP2K1; PTPN7; HRASA; TRP53; NTRK1; TGFBR2; PPP3CA; MEF2CB; HSPB1; MINK1
    NF-kappa B signaling pathway RELA; TRIM25; BIRC2; MAP3K14; TNFRSF13C; LY96; BLNK; ICAM1; TNFRSF1A; PIAS4
    AMPK signaling pathway CCNA1; Scd2; SIRT1; CPT1C; CREB3L3; GYS2; PFKFB4; PFKL; CREB1; CFTR
    Wnt signaling pathway WNT7A; WNT2B; TCF7L2; MAPK8B; SKP1; TP53; PPARDB; MYCB; FOSL1A; RAC1
    Osteoclast differentiation AKT2; MAPK11; CYLD; MAP2K6; LCK; RAC1; PIK3R5; GAB2; IKBKB; MAP2K1
    Adherens junction WASLA; PVRL2; RHOAB; MLLT4; RHOAD; LMO7; WASF1; SMAD3; WASL; FYNB
    Toll-like receptor signaling pathway IL8L1; CCL5; TLR8; CASP8; IL-8; IFNPHI3; MAPK3; IFNA2; TLR5; AKT1
    NOD-like receptor signaling pathway MAPK12B; IL8L1; CARD18; TAB3; TRIP6; CARD8; CASP1; SGUT1; Ccl12; NLRP3
    RIG-I-like receptor signaling pathway RNF125; ATG12; IFNPHI1; OTUD5A; IL-8; MAPK14A; MAPK8B; NLRX1; IFNA1; ISG15
    T cell receptor signaling pathway GRAPA; CARD11; MUC1; MAP3K14; PPP3R1; CD8A; CD28; Il2; CD3D; PAK2
    TNF signaling pathway TNFAIP3; SELE; Ccl12; DNM1L; TRADD; MAP3K7; TNFRSF1A; CREB5; CXCL5; CREB3L3
    Leishmaniasis MAPK13; ITGA4; Itgam&Itgb2; ITGB2L; FCGR2C; HLA-DQA1; CR1; HLA-DQA2; IFNGR1; HLA-DRA
    Toxoplasmosis IL10RA; TNFRSF1A; LY96; H2-AA; BIRC3; CASP8; LAMB2; XIAP; MAP3K7; PIK3CB
    Measles PIK3CD; AKT1; IL6; FCGR2B; DOK1; IFNAR2; IL2RG; EIF2AK2; CD3E; NFKB1
    Herpes simplex infection NXF3; HLA-DMA; IFNA21; HNRPK; SRSF1; BLA; MAPK8; IFNA4; IFNA10; SRSF9
    Epstein-Barr virus infection PSMD7; YWHAG; HLA-C; TBPL1; DDX58; NFKBIA; MDM2; PSMC3; ENTPD3; SYK

    map3k7 has several biochemical functions, for example, DNA binding, protein C-terminus binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by map3k7 itself. We selected most functions map3k7 had, and list some proteins which have the same functions with map3k7. You can find most of the proteins on our site.

    Function Related Protein
    DNA binding RUNX2A; ALX3; DMRT2B; ZFAND5; MXTX2; HOXC8A; HMX3; ZNF689; ZFP36L3; IRX4A
    protein C-terminus binding SHANK2; VTA1; ERCC4; CTGF; PEX1; VGLL1; YWHAB; DLG4; AXIN1; VPS4A
    protein binding DPF2; NDP; NADSYN1; ADAMTS3; CCKBR; DHRS1; FDX1L; PID1; RBMX; PDK3
    protein heterodimerization activity SOX32; BMP6; INHA; MEF2C; HIST2H2L; NAE1; TWIST1; HIST1H2BH; LTC4S; H2AFZ
    transcription cofactor activity MXD1; NMI; FAM48A; MED17; ZNF212; CREB1; ZNF763; LDB2B; SUPT20H; TMF1
    transcription factor activity, sequence-specific DNA binding ONECUT3; ZNF79; CNOT8; NFE2; ATOH8; POU4F3; RNF4; ZFP551; PHF1; ZNF500

    map3k7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with map3k7 here. Most of them are supplied by our site. Hope this information will be useful for your research of map3k7.


    Szili, D; Banko, Z; et al. TGF beta Activated Kinase 1 (TAK1) at the Crossroad of B Cell Receptor and Toll-Like Receptor 9 Signaling Pathways in Human B Cells. PLOS ONE 9:-(2014).
    Kennedy, RB; Ovsyannikova, IG; et al. Multigenic control of measles vaccine immunity mediated by polymorphisms in measles receptor, innate pathway, and cytokine genes. VACCINE 30:2159-2167(2012).

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