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MAP3K7

  • Official Full Name

    mitogen-activated protein kinase kinase kinase 7

  • Overview

    The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
  • Synonyms

    MAP3K7; mitogen-activated protein kinase kinase kinase 7; TAK1; MEKK7; TGF-beta activated kinase 1; TGF-beta-activated kinase 1; transforming growth factor-beta-activated kinase 1; TGF1a; MAP; MAP3K; mitogen-activated protein kinase 7;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Insect Cell
  • Mammalian Cell
  • Sf9 Insect Cell
  • Flag
  • GST
  • His
  • Fc
  • Avi
  • Myc
  • DDK
  • Non
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MAP3K7-82H Recombinant Human MAP3K7 protein, Flag-tagged, Biotinylated Insect Cell Flag 1-303;437-504
Human MAP3K7-30308TH Recombinant Human Human MAP3K7 Non 1-303;437-504
Human TAK1-TAB1-440H Recombinant Human TAK1-TAB1, GST-tagged, Active Sf9 Insect Cell GST 1-303;437-end
Human MAP3K7-1056HCL Recombinant Human MAP3K7 cell lysate Non
Human MAP3K7-2518H Recombinant Human MAP3K7 protein, His-tagged E.coli His 1-291 aa
Human MAP3K7-4095H Recombinant Human MAP3K7 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc&DDK
Human MAP3K7-5124H Recombinant Human MAP3K7 Protein (Glu30-Thr285), N-His tagged E.coli His Glu30-Thr285
Mouse Map3k7-3932M Recombinant Mouse Map3k7 Protein, Myc/DDK-tagged HEK293T Myc&DDK
Rat MAP3K7-3566R Recombinant Rat MAP3K7 Protein Mammalian Cell His
Rat MAP3K7-3222R Recombinant Rat MAP3K7 Protein, His (Fc)-Avi-tagged HEK293 His&Fc&Avi
Rat MAP3K7-3222R-B Recombinant Rat MAP3K7 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish MAP3K7-2890Z Recombinant Zebrafish MAP3K7 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource
  • MAP3K7 Related Signal Pathway

MAP3K7 involved in several pathways and played different roles in them. We selected most pathways MAP3K7 participated on our site, such as MAPK signaling pathway, NF-kappa B signaling pathway, AMPK signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAP3K7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MAPK signaling pathwayPPM1AA;NTRK1;CACNG1A;MAP2K3;FGF3;RELA;HSC70;MAP2K5;MEF2C
NF-kappa B signaling pathwayLRDD;CD40;IRAK1;RIPK1;CCL21B;MAP3K7IP3;RELB;PTGS2;TRAF3
AMPK signaling pathwayCREB3L1;G6PC;AKT1;EIF4EBP1;PFKFB4;RAB11B;FOXO1;HNF4A;ACACA
Wnt signaling pathwayTCF7;CAMK2G;WNT2;BTRC;CAMK2D2;PRKCB;DAAM1;CAMK2D1;PPP3CA
Osteoclast differentiationFCGR3;IL1B;TGFBR2;MITF;PIK3CA;LILRA4;CYBB;MAPK12;CYBA
Adherens junctionYES1;FYNB;SRC;SMAD2;PTPRFB;ACTN1;ERBB2;WAS;FARP2
Toll-like receptor signaling pathwayMAP2K2;PIK3R3B;TAB2;MAPK3;IRAK4;TBK1;CCL4L2;MAPK8A;RAC1A
NOD-like receptor signaling pathwayIL1B;MAPK12B;CXCL1;SUGT1;NLRP1;ERBB2IP;MAPK14A;IL8L2;CCL5
RIG-I-like receptor signaling pathwayIL12B;IFNA21;IFNA2;SIKE1;IFNW1;MAPK13;MAPK8;ATG5;MAPK9
T cell receptor signaling pathwayNFKBIA;AKT2;EVLB;RELA;GRAP2;PRKCQ;NFKBIE;HRAS;PPP3R2
TNF signaling pathwayIL6;MAP3K14;LIF;IL15;PIK3CD;FAS;ICAM1;CASP8;VEGFC
LeishmaniasisTAB2;NFKBIB;MAPK12;TGFB3;PTPN6;STAT1;IFNG;IFNGR2;HLA-DRB1
ToxoplasmosisIL10RA;HLA-DQA2;HSPA1A;ALOX5;RELA;IFNG;TAB2;LDLR;HLA-DRB3
MeaslesEIF2AK4;PIK3R2;IFNA7;TNFSF10;IFNA12;TNFRSF10A;STAT5A;TYK2;IL1B
Herpes simplex infectionSOCS3;HLA-DRB1;IKBKG;Ccl12;SRSF3;C3;IL6;HNRPK;Casp3
Epstein-Barr virus infectionTYK2;HSPA2;TNFAIP3;POLR1C;POLR2G;YWHAB;POLR2B;PRKACG;PSMC2

MAP3K7 has several biochemical functions, for example, DNA binding, protein C-terminus binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAP3K7 itself. We selected most functions MAP3K7 had, and list some proteins which have the same functions with MAP3K7. You can find most of the proteins on our site.

Function Related Protein
DNA bindingHIST2H2BB;THAP10;ZNF511;FOXP1A;HIST1H2BH;FLI1;MYCLA;RBM5;CROP
protein C-terminus bindingJAK2;PPP2CB;ERCC4;C11orf60;ECM1;TFCP2;CACNA1B;PHB;TJP2
protein bindingADCK5;RPGRIP1L;PTPN2;DVL3;UBE2O;ZSCAN21;TSHZ3;SERPINF2;PLAA
protein heterodimerization activityH3F3B;JAM2A;ADORA1;LTC4S;PDGFA;SOX9;POLA1;OSTB;SNX6
transcription cofactor activityZNF212;MED16;MED30;MED17;TFDP2;MAX;NSD1;PHF21A;MED12
transcription factor activity, sequence-specific DNA bindingZFP518A;EHF;MAFGA;ZNF317;NR2F6B;SALL4;RXRA;PKNOX1;L3MBTL4

MAP3K7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAP3K7 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAP3K7.

TAB2; MAPK8IP1; MAP2K7; TRAF6

Research Area

Related articles

Szili, D; Banko, Z; et al. TGF beta Activated Kinase 1 (TAK1) at the Crossroad of B Cell Receptor and Toll-Like Receptor 9 Signaling Pathways in Human B Cells. PLOS ONE 9:-(2014).
Kennedy, RB; Ovsyannikova, IG; et al. Multigenic control of measles vaccine immunity mediated by polymorphisms in measles receptor, innate pathway, and cytokine genes. VACCINE 30:2159-2167(2012).
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