MAP3K7
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Official Full Name
mitogen-activated protein kinase kinase kinase 7 -
Overview
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. -
Synonyms
MAP3K7;mitogen-activated protein kinase kinase kinase 7;TAK1;MEKK7;TGF-beta activated kinase 1;TGF-beta-activated kinase 1;transforming growth factor-beta-activated kinase 1;TGF1a;MAP;MAP3K;mitogen-activated protein kinase 7
Recombinant Proteins
- Human
- Zebrafish
- Rat
- Mouse
- E.coli
- Mammalian Cells
- Insect Cells
- Sf9 Cells
- HEK293
- HeLa
- His
- Non
- Flag
- GST
- Avi
- Fc
- DDK
- Myc
Involved Pathway
MAP3K7 involved in several pathways and played different roles in them. We selected most pathways MAP3K7 participated on our site, such as MAPK signaling pathway,NF-kappa B signaling pathway,AMPK signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAP3K7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Osteoclast differentiation | LILRA2,PLCG2,NFATC2,FCGR4,LILRB1,PIK3R3,TGFB2,FOSB,FCGR3A,TGFBR2 |
| MAPK signaling pathway | RAC3B,CACNG7,NLK2,MAPK1,MAP2K3,FGF6,PLA2G4C,CACNB4A,PPP3CCB,CACNA1SB |
| Toll-like receptor signaling pathway | IL12BA,PIK3R5,TLR4BB,NFKBIA,CRFB2,PIK3CA,STAT1B,IFNPHI1,RIPK1,IL1B |
| NF-kappa B signaling pathway | TICAM2,BCL2A1A,LY96,PRKCQ,IL-8,TNFSF13B,PIDD1,CCL19,PLAU,VCAM1 |
| NOD-like receptor signaling pathway | NFKBIAB,TAB2,TRAF6,PYDC1,CASP5,CARD8,CASPA,NAIP6,NAIP1,NLRC4 |
| RIG-I-like receptor signaling pathway | NFKBIAA,SIKE1,IRF3,IFNA3,MAPK10,IL8L2,IFNA2,IL-8,IFNB1,IKBKG |
| T cell receptor signaling pathway | CD3E,PIK3R3,MAPK1,NCK1,PPP3CC,RAF1,PDCD1,NFATC2,SLA1,FOS |
| Toxoplasmosis | HLA-DRB5,HSPA2,MAPK13,IRAK1,HLA-DPB1,TLR4,IRGM1,HLA-DOB,PIK3R3,LAMC2 |
| Wnt signaling pathway | PPP3R1B,AXIN1,SKP1,NFATC3,FOSL1A,RAC3B,FBXW11,WNT11B,TLE3A,SERPINF1 |
Protein Function
MAP3K7 has several biochemical functions, for example, DNA binding,protein C-terminus binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAP3K7 itself. We selected most functions MAP3K7 had, and list some proteins which have the same functions with MAP3K7. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription factor activity, sequence-specific DNA binding | TFE3,HNF1BA,GRHL2,MYCS,ARNT,CBFB,WT1B,FOSL2,MTA3,ATF1 |
| protein C-terminus binding | TNNI3K,PHB,SDCBP2,TOP2A,CD2AP,STIP1,ITPR1,PHB2,DYNLL1,KCNK3 |
| protein binding | AMMECR1,LMLN,MLH3,POLG2,CCDC106,COLQ,SDC4,BBS5,PDS5B,NR1D2 |
| protein heterodimerization activity | IRAK1,TIMELESS,TTR,TAL1,UBXN6,HYPM,ZBTB1,LIFR,HIST1H3C,APOA2 |
| DNA binding | DNA2,NR0B2A,ZFP319,ZKSCAN17,H2AFY,CDT1,MIER1,MLL1,HOXA13,HIST1H4C |
| transcription cofactor activity | MED13,PRKCBP1L,MAX,ZNF671,LDB1A,TAF13,SLC26A3,PSMC5,NFKBIZ,LDB1B |
Interacting Protein
MAP3K7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAP3K7 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAP3K7.
TAB2;MAPK8IP1;MAP2K7;TRAF6
MAP3K7 Related Signal Pathway
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References
- Szili, D; Banko, Z; et al. TGF beta Activated Kinase 1 (TAK1) at the Crossroad of B Cell Receptor and Toll-Like Receptor 9 Signaling Pathways in Human B Cells. PLOS ONE 9:-(2014).
- Kennedy, RB; Ovsyannikova, IG; et al. Multigenic control of measles vaccine immunity mediated by polymorphisms in measles receptor, innate pathway, and cytokine genes. VACCINE 30:2159-2167(2012).
