Recombinant Human Human MAP3K7
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Cat.No. : | MAP3K7-30308TH Optional Service: Optional requirements on this protein |
Product Overview : | Recombinant fragments, corresponding to amino acids 1-303 of Human TAK1and 437-504 of Human TAB1, linked by a small peptide , with an N-terminal proprietary tag expressed in a Baculovirus infected Sf9 cell expression system, MWt 74kDa. |
Description : | The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. |
Biological activity : | The Specific activity of MAP3K7-30308TH was determined to be 10 nmol/min/mg. |
Form : | Liquid |
Storage buffer : | Preservative: NoneConstituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, pH 7.5 |
Storage : | Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles. |
Gene Name : | MAP3K7 mitogen-activated protein kinase kinase kinase 7 [ Homo sapiens ] |
Official Symbol : | MAP3K7 |
Synonyms : | MAP3K7; mitogen-activated protein kinase kinase kinase 7; TAK1; MEKK7; |
Gene ID : | 6885 |
mRNA Refseq : | NM_003188 |
Protein Refseq : | NP_003179 |
MIM : | 602614 |
Uniprot ID : | O43318 |
Chromosome Location : | 6q15 |
Pathway : | Activated TLR4 signalling, organism-specific biosystem; Adaptive Immune System, organism-specific biosystem; Adherens junction, organism-specific biosystem; Adherens junction, conserved biosystem; B Cell Receptor Signaling Pathway, organism-specific biosystem; |
Function : | ATP binding; MAP kinase kinase activity; MAP kinase kinase kinase activity; kinase activity; magnesium ion binding; |
◆ Recombinant Protein
Map3k7-3932M | Recombinant Mouse Map3k7 Protein, Myc/DDK-tagged | +Inquiry |
MAP3K7-3566R | Recombinant Rat MAP3K7 Protein | +Inquiry |
MAP3K7-82H | Recombinant Human MAP3K7 protein, Flag-tagged, Biotinylated | +Inquiry |
MAP3K7-2518H | Recombinant Human MAP3K7 protein, His-tagged | +Inquiry |
MAP3K7-2890Z | Recombinant Zebrafish MAP3K7 | +Inquiry |
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◆ Lysates
MAP3K7-1056HCL | Recombinant Human MAP3K7 cell lysate | +Inquiry |
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MAP1LC3AMAP1LC3BMAP1LC3B2Map2k1MAP2K2MAP2K3MAP2K6Map3k1MAP3K14MAP3K2MAP3K3MAP3K5MAP3K8MAP4K5MAP2K4MAP3K6MAP2K5MAP2K7MAP3K11MAP4K4MAP4K2MAP4K1MAP1SMap2MAP3K13MAP3K15MAP3K4MAP3K7MAP3K7IP1MAP4MAP3K10MAP3K9MAP1AMAP1BMAP7MAP4K3MAP3K12MAP1LC3CMAP6D1MAP7D1MAP9MAP6MAP2K1IP1MAP7D2MAP7D3
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