Recombinant Human Human MAP3K7 MAP3K7-30308TH

Recombinant Human Human MAP3K7


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Recombinant Human Human MAP3K7

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Cat.No. : MAP3K7-30308TH Optional Service: Optional requirements on this protein
Product Overview : Recombinant fragments, corresponding to amino acids 1-303 of Human TAK1and 437-504 of Human TAB1, linked by a small peptide , with an N-terminal proprietary tag expressed in a Baculovirus infected Sf9 cell expression system, MWt 74kDa.
Description : The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
Biological activity : The Specific activity of MAP3K7-30308TH was determined to be 10 nmol/min/mg.
Form : Liquid
Storage buffer : Preservative: NoneConstituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, pH 7.5
Storage : Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Gene Name : MAP3K7 mitogen-activated protein kinase kinase kinase 7 [ Homo sapiens ]
Official Symbol : MAP3K7
Synonyms : MAP3K7; mitogen-activated protein kinase kinase kinase 7; TAK1; MEKK7;
Gene ID : 6885
mRNA Refseq : NM_003188
Protein Refseq : NP_003179
MIM : 602614
Uniprot ID : O43318
Chromosome Location : 6q15
Pathway : Activated TLR4 signalling, organism-specific biosystem; Adaptive Immune System, organism-specific biosystem; Adherens junction, organism-specific biosystem; Adherens junction, conserved biosystem; B Cell Receptor Signaling Pathway, organism-specific biosystem;
Function : ATP binding; MAP kinase kinase activity; MAP kinase kinase kinase activity; kinase activity; magnesium ion binding;
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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