Recombinant Human MAP3K7 cell lysate
Cat.No. : | MAP3K7-1056HCL |
- Specification
- Gene Information
- Related Products
Description : | The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. |
Species : | Human |
Size : | 100 ul |
Storage Buffer : | 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue) |
Applications : | Western Blot; |
Gene Name : | MAP3K7 mitogen-activated protein kinase kinase kinase 7 [ Homo sapiens ] |
Official Symbol : | MAP3K7 |
Synonyms : | MAP3K7; mitogen-activated protein kinase kinase kinase 7; TAK1; MEKK7; TGF-beta activated kinase 1; TGF-beta-activated kinase 1; transforming growth factor-beta-activated kinase 1; TGF1a; |
Gene ID : | 6885 |
mRNA Refseq : | NM_003188 |
Protein Refseq : | NP_003179 |
MIM : | 602614 |
UniProt ID : | O43318 |
Chromosome Location : | 6q15 |
Pathway : | Activated TLR4 signalling, organism-specific biosystem; Activation of NF-kappaB in B Cells, organism-specific biosystem; Adaptive Immune System, organism-specific biosystem; Adherens junction, organism-specific biosystem; Adherens junction, conserved biosystem; B Cell Receptor Signaling Pathway, organism-specific biosystem; BCR signaling pathway, organism-specific biosystem; |
Function : | ATP binding; MAP kinase kinase kinase activity; kinase activity; magnesium ion binding; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; |
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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