Recombinant Human TAK1-TAB1, GST-tagged, Active

Cat.No. : TAK1-TAB1-440H
Product Overview : Recombinant human proteins TAK1 (1-303) and TAB1 (437-end), linked by a small peptide (DFGGGGG), were expressed by baculovirus inSf9insect cells using an N-terminal GST tag. MW = 74 kDa.
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Cat. No. : TAK1-TAB1-440H
Description : TAK1 is a serine/threonine protein kinase that mediates signaling by TGFβ and morphogenetic protein (BMP). In response to IL-1, TAK1 forms a kinase complex with TAB1 and this complex is required for the activation of nuclear factor kappa B (NfκB). TAK1 can also activate MAPK8/JNK and MAP2K4/MKK4 and thus play a role in the cell response to environmental stress. Tak1 is essential for thymocyte development and activation and deletion of TAK1 prevents maturation of single-positive thymocytes displaying CD4 or CD8. Thymocytes lacking TAK1 fail to activate NfκB and JNK and are prone to apoptosis upon stimulation.
Source : Sf9 insect cells using baculovirus.
Sequence : TAK1 (1-303) and TAB1 (437-end)), linked by a small peptide (DFGGGGG).
Applications : Kinase Assay, Western Blot.
Storage And Stability : Store product at -70℃. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Gene Name : MAP3K7 mitogen-activated protein kinase kinase kinase 7 [ Homo sapiens ],MAP3K7IP1 mitogen-activated protein kinase kinase kinase 7 interacting protein 1 [ Homo sapiens ]
Synonyms : MAP3K7; mitogen-activated protein kinase kinase kinase 7; TAK1; MEKK7; TGF1a; TGF-beta activated kinase 1; transforming growth factor-beta-activated kinase 1; EC; OTTHUMP00000016870; OTTHUMP00000016871; OTTHUMP00000016872; OTTHUMP00000016873; TGF-beta-activated kinase 1; TAB1; 3"-Tab1; MGC57664; MAP3K7IP1; mitogen-activated protein kinase kinase kinase 7 interacting protein 1; TAK1-binding protein 1; transforming growth factor beta-activated kinase-binding protein 1; Mitogen-activated protein kinase kinase kinase 7-interacting protein 1; TGF-beta-activated kinase 1-binding protein 1
Gene ID : 688510454
mRNA Refseq : NM_003188NM_006116
Protein Refseq : NP_003179NP_006107
MIM : 602614602615
UniProt ID : O43318Q15750
Chromosome Location : 6q16.1-q16.322q13.1
Pathway : Adherens junction; MAPK signaling pathway; NOD-like receptor signaling pathway; RIG-I-like receptor signaling pathway; T cell receptor signaling pathway; Toll-like receptor signaling pathway; Wnt signaling pathway
Function : ATP binding; MAP kinase kinase activity; MAP kinase kinase kinase activity; magnesium ion binding; nucleotide binding; protein binding; protein serine/threonine kinase activity; protein tyrosine kinase activity; transferase activity; catalytic activity; kinase activator activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.


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