MAPK1

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MAPK1

Official Full Name mitogen-activated protein kinase 1
Background This gene encodes a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. One study also suggests that this protein acts as a transcriptional repressor independent of its kinase activity. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene.
Synonyms ERK; p38; p40; p41; ERK2; ERT1; ERK-2; MAPK2; PRKM1; PRKM2; P42MAPK; p41mapk; p42-MAPK; MAPK1; mitogen-activated protein kinase 1
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Human
    • Insect Cell
    • Mammalian Cell
    • Tag :
    • C-Myc/DDK
    • GST
    • His
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human MAPK1-048H Recombinant Human MAPK1 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
    Human MAPK1-052H Recombinant Human MAPK1 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
    Human MAPK1-2008H Recombinant Human MAPK1 Protein, GST-tagged E.coli GST
    Human MAPK1-26227TH Recombinant Human MAPK1 protein E.coli N/A
    Human MAPK1-27H Biotinylated Recombinant Human ERK2, His-tagged E.coli His
    Human MAPK1-28697TH Recombinant Human MAPK1 E.coli N/A
    Human MAPK1-28700TH Recombinant Human MAPK1, His-tagged E.coli His
    Human MAPK1-308H Recombinant Human MAPK1, GST-tagged, Active E.coli GST
    Human MAPK1-37H Recombinant Human Mitogen-Activated Protein Kinase 1 E.coli N/A
    Human MAPK1-385H Recombinant Human MAPK1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human MAPK1-529H Recombinant Human Mitogen-activated protein kinase 1, His tagged E.coli His
    Human MAPK1-692HCL Recombinant Human MAPK1 cell lysate Insect Cell N/A
    Human MAPK1-7267H Recombinant Human MAPK1, GST tagged Insect Cell GST
    Human MAPK1-896H Recombinant Human Mitogen-Activated Protein Kinase 1 Human N/A
    Human MAPK1-918H Recombinant Human MAPK1, GST-tagged Insect Cell GST
    Mouse MAPK1-001MCL Recombinant Mouse MAPK1 cell lysate Insect Cell N/A
    Mouse Mapk1-3937M Recombinant Mouse Mapk1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Mouse Mapk1-482M Recombinant Mouse Mapk1, Gly & Pro tagged Insect Cell His
    Mouse Mapk1-638M Recombinant Mouse Mitogen-activated Protein Kinase 1, His-tagged E.coli His
    Mouse Mapk1-7394M Recombinant Mouse Mapk1, His & GST tagged Insect Cell His/GST
    Rat MAPK1-3571R Recombinant Rat MAPK1 Protein Mammalian Cell His
    Rat Mapk1-664R Recombinant Rat Mitogen Activated Protein Kinase 1, His-tagged E.coli His
    Chicken MAPK1-5726C Recombinant Chicken MAPK1 Mammalian Cell His
    Zebrafish MAPK1-9677Z Recombinant Zebrafish MAPK1 Mammalian Cell His

    MAPK1 involved in several pathways and played different roles in them. We selected most pathways MAPK1 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAPK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathway MAPKAPK5; IL1A; MAP3K11; PDGFRB; MAP4K3; GADD45BA; RAC2; PPP3CC; NFATC3; TNFRSF1A
    ErbB signaling pathway PIK3R2; NCK2B; CAMK2G1; HRAS; RPS6KB1; GSK3AA; STAT5B; PIK3R5; RAF1; HRASB
    Ras signaling pathway MAPK1; CALM2; VEGFA; FGF10; FGF4; GNG12; FOXO4; HGF; MLLT4; PDGFA
    Rap signaling pathway NRAS; FGF22; MET; ITGB2L; ACTG1; FGF9; RAP1GAP; LAT; FGF19; LPAR5
    cGMP-PKG signaling pathway SLC25A4; INSR; NPR2; MYLK4; FXYD2; ATP2B1; MYLK; CREB3L2; ATP1A1; NOS3
    cAMP signaling pathway HCN2; MLLT4; MAPK9; PIK3R5; MAPK10; CNGA3; NFKBIA; RAC1; PLN; NFKB1
    Chemokine signaling pathway AKT2; RAP1B; GNAI3; CCR9; BRAF; SHC4; AMCF-II; CXCR3; PRKACB; RELA
    HIF- signaling pathway PIK3CB; EPO; CAMK2G; VEGFA; PIK3R1; PRKCG; SLC2A1; ALDOA; TCEB1; IFNGR1
    FoxO signaling pathway SGK2A; PIK3CB; AKT2L; STAT3; MAPK13; FOXG1; SGK2; HOMER1B; CCNB2; SGK3
    Sphingolipid signaling pathway PPP2CA; LOC100328615; KRAS; SPTLC1; GAB2; RAF1; TNFRSF1A; TRP53; TNF; LASS4
    Phospholipase D signaling pathway PIK3CA; HRAS; CYTH4; AVP; PLCB3; SHC3; PLD2; DGKZ; INS; DNM3
    Oocyte meiosis MAD2L1; PPP2R5EA; PTTG2; FBXO5; PPP2R5A; CAMK2G; SMC3; CUL1B; CPEB1B; INS
    mTOR signaling pathway PIK3R5; RRAGC; EIF4BA; VEGFAA; RPTOR; PDPK1B; PRKCG; RPS6KB1; TSC1B; RPS6KA3A
    PIK-Akt signaling pathway PIK3CG; MET; LPAR4; FGF4; FLT4; YWHAZ; GNG3; TNN; PTK2; PHLPP1
    Adrenergic signaling in cardiomyocytes CACNB3A; MAPK11; CREB3L3A; CREB3L4; TPM4B; PIK3CG; RPS6KA5; SCN1B; ADRa1A; AGTR1A
    Vascular smooth muscle contraction GNA13A; PPP1CAB; MYL9A; PLA2G4D; PRKACAB; PPP1R14AB; CALM3B; PLCB1; PLA2G1B; GNA12
    Dorso-ventral axis formation NOTCH1A; ETS2; CPEB1; GRB2; ETV6; CPEB4; MAPK1; NOTCH4; SPIRE1; NOTCH1B
    TGF-beta signaling pathway SMAD2; CUL1A; INHBB; SKP1; BAMBIA; RBL1; TFDP1; MYCB; BMP7A; ZFYVE16
    Axon guidance EPHA6; NETO2; SEMA4C; DPYSL4; SEMA3A; GFRA1; HRAS; SPTBN1; RANBP9; NFATC2
    VEGF signaling pathway PLCG1; MAPK14A; RAC2; HSPB1; MAP2K2; MAPK12; BAD; MAPKAPK3; PPP3R1B; PIK3R2
    Osteoclast differentiation AKT1; MAP3K14; MAPK8; SOCS1; NCF1; FCGR4; CAMK4; TREM2; LILRB2; LILRB1
    Focal adhesion RAF1A; ACTN3B; CAV2; FYNB; SHC1; RAF1; BAD; MYLK; IGF1RA; LAMC2
    Adherens junction CDC42L; NLK2; WASF2; CREBBP; CSNK2A1; ACP1; WASLB; LMO7A; BAIAP2; TCF7
    Gap junction GRM5; GNAS; GRB2B; LPAR1; TUBA8L4; GRB2A; TUBB2; CX43; PDGFB; PRKG1
    Signaling pathways regulating pluripotency of stem cells OTX1; WNT4; AKT2; BMP4; WNT10B; WNT16; PIK3CG; FZD3; ID4; NRAS
    Platelet activation PRKCZ; FCER1G; ITGB1; F2RL3; MYLK4; PPP1R12A; AKT1; PPP1CC; ITGA2; COL27A1
    Toll-like receptor signaling pathway TICAM2; IRF7; NFKB1; MAPK14A; IFNA4; IFNA8; RELA; FOS; CD80; SPP1
    NOD-like receptor signaling pathway IL6; PYDC1; LOC100033925; PSTPIP1; MAPK8; SGUT1; HSP90AA1.1; MAPK8A; PYCARD; IL-8
    Natural killer cell mediated cytotoxicity PPP3R2; H60a; IFNA5; IFNA1; SYK; FCGR3B; Ifna11; FCGR4; ITGB2L; PRKCB
    T cell receptor signaling pathway FOS; CD40LG; PAK1; MAPK11; LCK; DEF6A; DBNLB; PPP3R1; CD8A; MAPK1
    B cell receptor signaling pathway PIK3CD; ARPC3; FCGR2B; PDK2; CD79B; ARPC4; cgr2b; NFKB1; MAPK4; NFATC3
    Fc epsilon RI signaling pathway GRB2; PLCG1; IL13; MAPK1; HRAS; PDPK1; VAV3; NRAS; RAC2; LYN
    Fc gamma R-mediated phagocytosis PPAP2C; PRKCA; ASAP1; NCF1; PRKCE; PIK3CD; GSN; VAV2; WASF2; PLA2G4D
    TNF signaling pathway RIPK1; CCL2; RPS6KA5; ITCH; LTA; MLKL; MAP2K3; CASP10; NFKB1; MAP3K7IP3
    Circadian entrainment PER1; GRIA3; Adcy4; AKR1C1; MAPK3; RYR1; PRKCG; PRKACG; GRIN2C; PLCB2
    Long-term potentiation CAMK4; PPP3CB; MAPK3; PLCB1; CALML5; PRKACA; CALM3; RPS6KA1; PPP3CA; GRIN2B
    Neurotrophin signaling pathway MAPKAPK2; FOXO3; IKBKB; PIK3R1; KRAS; MAPK9; PIK3R5; ATF4; MAGED1; ARHGDIG
    Retrograde endocannabinoid signaling GABRA2; SLC17A8; GABRD; GRM5; SLC17A7; PRKACA; MAPK13; GNG5; GNG2; FAAH
    Glutamatergic synapse ADRBK2; PPP3CA; GRM8; GNG10; GRIN2A; GLS2; GNG11; GRIK2; GNAS; GRM5
    Cholinergic synapse GNA11; NRAS; PLCB2; KCNQ2; CREB3L1; ATF4; CREB3L3; CHRNA7; CAMK2B; KCNQ4
    Serotonergic synapse PLA2G4F; GNB4; ITPR1; GNG2; KCNN2; GNB3; CYP2C50; GNG10; KCND2; ALOX15
    Long-term depression GNAQ; MAPK3; NOS1; RYR1; GNAO1; GRM1; ITPR1; PLCB4; GNAZ; GUCY1A3
    Regulation of actin cytoskeleton CHRM5B; PFN2; ROCK2A; ACTN3; KRAS; ROCK2; FGFR1A; FGF10; FGF13A; WASLB
    Insulin signaling pathway INSB; PIK3R1; HRAS; MAP2K1; RAF1; SHC1; CALM2B; PRKAB1; PPP1R3DA; HRASA
    GnRH signaling pathway MAP2K3; CACNA1DA; PRKACA; CACNA1D; GNRHR2; HBEGFA; PRKCBA; GNRH1; ADCY2B; PLA2G4C
    Progesterone-mediated oocyte maturation MAD2L1; GNAIA; CDC23; PRKACG; RPS6KA3; RPS6KA6; AKT3A; PDE3B; RAF1A; SPDYA
    Estrogen signaling pathway NOS3; HSPA2; HSPA1B; GABBR2; HSP90AB1; SHC3; SP1; GABBR1; PIK3R5; CALM4
    Melanogenesis TYRP1; WNT3A; CALML3; FZD3; EDNRBA; KITA; WNT1; EDNRB2; WNT5A; GNA11A
    Prolactin signaling pathway INS1; MAPK11; STAT3; KRAS; NRAS; ELF5; MAPK8; MAP2K1; SOCS7; SOCS3
    Thyroid hormone signaling pathway PFKFB2; BAD; ATP1A3; SLC2A1; MED12L; MAP2K2; RCAN2; DIO3; MAPK1; SRC
    Oxytocin signaling pathway CALM4; MYLK4; CACNA2D2; CCND1; MYLK2; PLA2G4D; FOS; PIK3CA; CACNG7; CAMK2A
    Type II diabetes mellitus IRS1; PRKCZ; MAPK8; HK2; PIK3R3; SOCS2; INSR; PIK3R2; PIK3CG; HK3
    Aldosterone-regulated sodium reabsorption PIK3R1; IGF1; INSR; ATP1B1; SGK1; ATP1A1; ATP1A4; SCNN1B; ATP1A2; SLC9A3R2
    Alzheimers disease CDK5R1; AKR1C1; BACE1; NCSTN; NDUFA1; COX5B; NDUFB11; PLCB2; NDUFA8; EIF2AK3
    Prion diseases STIP1; IL1B; C8A; PRKACB; C1QC; C8G; ELK1; MAP2K1; C1QB; PRNP
    Alcoholism GNG11; SLC18A1; HIST1H2AB; HIST1H4N; CREB3L3; HIST1H2BP; CAMK4; BRAF; HAT1; SLC18A2
    Shigellosis ATG5; UBE2D2; ELMO1; U2AF1L4; ITGB1; MAPK8; MAPK10; WAS; MAPK13; NFKBIA
    Salmonella infection MYH9; IFNGR1; RHOGB; TJP1; DYNC2H1; NLRC4; NOS2B; KLC1A; WASB; IL-8
    Pertussis IL-8; C1QA; CD14; IL6; C5; CALM4; MAPK3; IL12B; CXCL5; C1R
    Leishmaniasis PTGS2; IL1B; MARCKSL1; IL12B; HLA-DRB3; NOS2; ITGAM; MAPK3; H2-AB1; MAPK11
    Chagas disease (American trypanosomiasis) IL12A; TLR9; ACE; BDKRB2; CASP8; MAPK9; IL10; GNAI1; NFKB1; MYD88
    Toxoplasmosis HSPA1L; LDLR; Toxoplasma Gondii Microneme Protein MIC3; LAMC2; HLA-DPB1; MAPK1; MYD88; LAMA3; H2-AB1; Toxoplasma Gondii Dense Granule Protein 7
    Tuberculosis TGFB3; RAF1; MAPK9; CALM1; IL23; IFNA14; ATP6V0B; Ifna15; HLA-DQA2; CEBPG
    Hepatitis C IL-8; IFNA4; NFKBIA; TRAF6; SCARB1; DDX58; MAPK8; SOS1; TYK2; IFN-a
    Hepatitis B IFNA16; PIK3CB; FADD; IFNAR1; IL-8; EGR2; RELA; MAP2K4; IFNA1; BCL2
    Influenza A TMPRSS13; IFNA13; HSPA8; CCL5; HLA-DOB; ICAM1; BMA2; PRKCA; DDX58; HNRNPUL1
    Pathways in cancer ARNT; PLCG1; GNG5; SMAD3; FGF6; ITGB1; PLCB2; FOS; HSP90AA1; CBLB
    Viral carcinogenesis POLB; HIST1H4G; GTF2H4; IRF3; HIST1H4J; H2BFWT; GTF2H3; YWHAH; CASP8; GTF2B
    Proteoglycans in cancer FGFR1; FZD3; TRP53; RRAS; PRKCB; PAK1; ITGB1; MAPK3; PPP1R12B; TWIST2
    MicroRNAs in cancer BAK1; Casp3; PLCG2; SOS1; MARCKS; TIMP3; ITGA5; MAPK1; HMGA2; PDGFB
    Colorectal cancer MAPK10; RAC1; LEF1; RAC3; APC; CASP9; ARAF; CYCS; TGFBR2; TRP53
    Renal cell carcinoma GAB1; CDC42; FH; EPAS1; TGFB3; PAK2; PIK3CG; AKT2; MET; FH1
    Pancreatic cancer PIK3CA; TGFA; MAPK10; PIK3R5; RAC2; RB1; BAD; RALGDS; TGFB2; MAPK9
    Endometrial cancer PIK3CD; PIK3R1; TCF7L2; CDH1; AXIN2; ERBB2; BAD; AKT2; MAPK3; LEF1
    Glioma PIK3CD; MAPK1; PLCG1; PRKCA; CALM2; CAMK2G; AKT1; TRP53; PDGFA; PIK3R3
    Prostate cancer TGFA; MDM2; INS1; PIK3CD; HRAS; BCL2; TCF7L2; SPINK1; SPRY1; GSTP1
    Thyroid cancer TRP53; RXRG; RXRB; LEF1; PPARG; CDH1; TCF7; NRAS; PAX8; TP53
    Melanoma KRAS; MET; PDGFD; FGF4; PTEN; FGF9; PDGFB; PIK3CA; MAP2K1; AKT2
    Bladder cancer NRAS; VEGFA; FGFR3; ERBB2; CCND1; TP53; DAPK1; MAPK3; ARAF; EGF
    Chronic myeloid leukemia MAP2K1; AKT1; CTBP2; ABL1; MAPK1; PIK3R5; SMAD3; CBLC; PIK3CA; RAF1
    Acute myeloid leukemia MYC; SFPI1; BRAF; JUP; TCF7; MAP2K2; FLT3; TCF7L2; CCNA1; PIK3CG
    Non-small cell lung cancer PLCG1; RARB; PIK3CB; ERBB2; RXRG; BAD; ARAF; RXRA; PIK3R2; TRP53
    Central carbon metabolism in cancer MAP2K2; LDHA; PFKL; MAPK3; MAPK1; NTRK3; IDH1; TP53; PDGFRA; ERBB2
    Choline metabolism in cancer MAP2K2; SLC22A3; SLC22A5; DGKE; Pdgfa&Pdgfb; MAPK3; MAPK1; PIK3R5; MAPK10; SLC22A2

    MAPK1 has several biochemical functions, for example, ATP binding, DNA binding, MAP kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MAPK1 itself. We selected most functions MAPK1 had, and list some proteins which have the same functions with MAPK1. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding CHEK2; KIAA1804; AK7; MB21D1; ACTB1; ABCB6A; CAD; RECQL4; P2RX4; ICK
    DNA binding TOPORS; MKXA; PRM2; RPP21; MYEF2; HMG20B; MCM6L; ZNF280D; FOXB1A; PCGF2
    MAP kinase activity NLK2; MAPK14A; MAPK8A; MAPK8B; MAPK6; MAPK14; NLK1; MAPK4; MAPK15; MAPK7
    RNA polymerase II carboxy-terminal domain kinase activity CDK1; CCNK; CDK7; MAPK1; CDK9; CDK12; CDK13; CDK8
    mitogen-activated protein kinase kinase kinase binding MAP4K2; PPEF2; CDC42; TCF3; MAP2K1; DUSP19; CDC37; TRAF6; STK38; MAPK1
    phosphatase binding CRY2; SH2D4A; CTSC; CSRNP2; MAPK3; SLC9A3R1; DLG1L; PPP1R26; SMAD3; PPP1R35
    phosphotyrosine binding GRB2; PTPN3; ACP2; MAPK1; ZAP70; SAMSN1; MAPK3; FGR; CBLC; LDLRAP1
    protein binding MICAL1; SILV; LMO4; TRPC2; MPZL1L; AMY1A; TPD52; MAP3K7IP3; SPTAN1; MTMR4
    protein serine/threonine kinase activity NEK10; RIOK1; TRPM6; STK38L; PRKAA2; MYLK4; PDK3; EIF2AK3; BMPR2A; SBK1
    transcription factor binding DIP2BA; TFAP2A; VDRA; BPTF; TRP53; KAT6B; MED6; DNMT1; CHCHD2; IFT172

    MAPK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAPK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAPK1.

    PTPN7; RPS6KA3; DUSP1; MAPK14

    Liszka, L; et al. DUCTAL ADENOCARCINOMA OF THE PANCREAS USUALLY RETAINED SMAD4 AND p53 PROTEIN STATUS AS WELL AS EXPRESSION OF EPITHELIAL-TO-MESENCHYMAL TRANSITION MARKERS AND CELL CYCLE REGULATORS AT THE STAGE OF LIVER METASTASIS. POLISH JOURNAL OF PATHOLOGY 65:100-112(2014).
    Reverchon, M; Bertoldo, MJ; et al. CHEMERIN (RARRES2) Decreases In Vitro Granulosa Cell Steroidogenesis and Blocks Oocyte Meiotic Progression in Bovine Species. BIOLOGY OF REPRODUCTION 90:-(2014).

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