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Official Full Name mitogen-activated protein kinase 1
Background This gene encodes a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. One study also suggests that this protein acts as a transcriptional repressor independent of its kinase activity. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene.
Synonyms ERK; p38; p40; p41; ERK2; ERT1; ERK-2; MAPK2; PRKM1; PRKM2; P42MAPK; p41mapk; p42-MAPK; MAPK1; mitogen-activated protein kinase 1
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Human
    • Insect Cell
    • Mammalian Cell
    • Tag :
    • C-Myc/DDK
    • GST
    • His
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human MAPK1-048H Recombinant Human MAPK1 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
    Human MAPK1-052H Recombinant Human MAPK1 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
    Human MAPK1-2008H Recombinant Human MAPK1 Protein, GST-tagged E.coli GST
    Human MAPK1-26227TH Recombinant Human MAPK1 protein E.coli N/A
    Human MAPK1-27H Biotinylated Recombinant Human ERK2, His-tagged E.coli His
    Human MAPK1-28697TH Recombinant Human MAPK1 E.coli N/A
    Human MAPK1-28700TH Recombinant Human MAPK1, His-tagged E.coli His
    Human MAPK1-308H Recombinant Human MAPK1, GST-tagged, Active E.coli GST
    Human MAPK1-37H Recombinant Human Mitogen-Activated Protein Kinase 1 E.coli N/A
    Human MAPK1-385H Recombinant Human MAPK1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human MAPK1-529H Recombinant Human Mitogen-activated protein kinase 1, His tagged E.coli His
    Human MAPK1-692HCL Recombinant Human MAPK1 cell lysate Insect Cell N/A
    Human MAPK1-7267H Recombinant Human MAPK1, GST tagged Insect Cell GST
    Human MAPK1-896H Recombinant Human Mitogen-Activated Protein Kinase 1 Human N/A
    Human MAPK1-918H Recombinant Human MAPK1, GST-tagged Insect Cell GST
    Mouse MAPK1-001MCL Recombinant Mouse MAPK1 cell lysate Insect Cell N/A
    Mouse Mapk1-3937M Recombinant Mouse Mapk1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Mouse Mapk1-482M Recombinant Mouse Mapk1, Gly & Pro tagged Insect Cell His
    Mouse Mapk1-638M Recombinant Mouse Mitogen-activated Protein Kinase 1, His-tagged E.coli His
    Mouse Mapk1-7394M Recombinant Mouse Mapk1, His & GST tagged Insect Cell His/GST
    Rat MAPK1-3571R Recombinant Rat MAPK1 Protein Mammalian Cell His
    Rat Mapk1-664R Recombinant Rat Mitogen Activated Protein Kinase 1, His-tagged E.coli His
    Chicken MAPK1-5726C Recombinant Chicken MAPK1 Mammalian Cell His
    Zebrafish MAPK1-9677Z Recombinant Zebrafish MAPK1 Mammalian Cell His

    MAPK1 involved in several pathways and played different roles in them. We selected most pathways MAPK1 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAPK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathway MAP2K4B; FGF1; CACNG2A; GNA12; TRP53; CACNA1D; ARRB1; PLA2G4AA; RRAS2; FGF8A
    ErbB signaling pathway MAPK8A; PIK3CA; SHC3; SHC1; MAPK8; MAPK1; RPS6KB1B; PTK2AB; AKT2; PAK2B
    Ras signaling pathway FGFR3; CALM1; PIK3CD; STK4; ARF6; PLD2; FGF20; CALM4; RGL1; FGF13
    Rap signaling pathway PRKCB; MAPK11; PFN3; RASGRP3; MLLT4; LPAR5; RRAS; ANGPT1; FGF3; RALB
    cGMP-PKG signaling pathway PPP3R2; CALM4; PIK3R5; SLC25A31; ATP1B1; KCNMB4; SLC25A6; BNP; INS; LOC100328615
    cAMP signaling pathway HTR4; RHOA; RAC3; PIK3CA; HCAR2; BRAF; MAPK9; PPARA; RAP1A; GPR119
    Chemokine signaling pathway RAC2; ROCK2; CXCL6; Ccl27a; CCR8; CCL3; CCL8; CXCL11; CXCR6; CCL17
    HIF- signaling pathway ENO2; PLCG2; HK3; PFKFB3; HMOX1; ANGPT2; VHL; CUL2; RELA; PIK3R5
    FoxO signaling pathway CDKN1BB; FOXO1; S1PR1; CDKN1BA; IRS2; BNIP3; FOXG1; MAPK8; SMAD2; PCK1
    Sphingolipid signaling pathway MAPK8; FYN; PPP2R3C; HRAS; SPTLC1; LASS2; PIK3CB; PIK3CD; ACER1; PRKCG
    Phospholipase D signaling pathway RALB; CXCR2; GNA12; PLCB2; GRM7; GAB1; GRM5; PLCB3; AKT1; Kitl
    Oocyte meiosis BTRC; INS1; PPP1CAA; SMC1AL; MAPK1; RPS6KA1; IGF1R; PPP2R5C; FBXW11B; Ar
    mTOR signaling pathway CAB39; RRAGCA; CAB39L; MLST8; TSC1A; RB1CC1; PIK3R3B; PRKCG; IRS1; MAPK3
    PIK-Akt signaling pathway PIK3CD; BRCA1; COL24A1; PPP2CA; LAMA3; PRKCA; LAMA2; FIGF; PIK3CG; CRTC2
    Adrenergic signaling in cardiomyocytes CACNG4; MYL4; CALML3; SCN1BA; PPP2R3A; PIK3R2; CREM; CALM3B; CACNA1DA; MAPK11
    Vascular smooth muscle contraction MLCK2; GNA11; ADORA2AA; BRAF; GNA12; ARAF; CALD1; MAP2K2A; PRKACBB; PPP1R12A
    Dorso-ventral axis formation CPEB3; MAPK1; SPIRE2; KRAS; PIWIL2; CPEB1; SOS1; ETV6; PIWIL1; ETS1
    TGF-beta signaling pathway MAPK1; BMPR1B; AMH; GDF5; NODAL; BMP7; CUL1; SMAD2; ID1; RPS6KB2
    Axon guidance KCNQ2; NETO2; ARPC5; PPP3CA; ARHGEF28; COL4A5; FRS2A; ITGB1; RND1L; NFATC4
    VEGF signaling pathway RAC3A; RAF1A; PLA2G4A; PTGS2; PLA2G4C; NOS3; PLA2G4AA; SRC; MAPKAPK2; RAF1B
    Osteoclast differentiation LILRB1; SOCS3; PIK3CB; IL1B; TNFRSF11B; PIK3CG; IFNB1; MAPK13; IKBKG; LILRB4
    Focal adhesion ITGAV; CCND1; CDC42; VAV1; ITGA2B; THBS3; RHOAD; TNK2; THBS4B; PPP1CBL
    Adherens junction CSNK2A1; ACTB; CTNNA2; RAC1B; ACTN3; CSNK2B; VCLA; ACTB1; PVRL1; ACTG1
    Signaling pathways regulating pluripotency of stem cells FZD3; TCF3; PIK3CD; MAP2K1; JARID2; LEFTY2; MAPK1; OTX1; NANOG; FZD7
    Platelet activation ACTG1; GP1BB; SRC; FGA; PRKACG; PPP1CC; GUCY1A3; PLA2G4A; MAPK3; F2RL3
    Toll-like receptor signaling pathway MAP2K2B; IFNA5; TRAF3; TLR5; RAC1B; TLR4BB; MAPK10; IFNA12; TLR1LB; SPP1
    NOD-like receptor signaling pathway RIPK2; TRIP6; CASP1; NFKBIA; Ccl12; IKBKB; HSP90AA1.2; NFKBIAA; BIRC2; PSTPIP1A
    Natural killer cell mediated cytotoxicity SHC1; KIR3DL2; KIR2DS4; GM-CSF; HLA-C; CD247; LCP2; MICA; RAET1D; VAV3
    T cell receptor signaling pathway EVLB; PLCG1; PTPN6; PAK3; MAPK12; PIK3CB; CD3E; CD3D; LCP2; MAPK1; GRAP2
    B cell receptor signaling pathway RAC1; NEDD9; IFITM1; DAPP1; TTC6; INPPL1; PPP3R2; SYK; PRKCB; PLCG2
    Fc epsilon RI signaling pathway AKT2; TNF; RAC2; MAP2K4; PIK3CD; IL4; GRB2; MAPK9; MAPK3; PLA2G4D
    Fc gamma R-mediated phagocytosis PIP5K1B; PAK1; ASAP2; PTPRC; PPAP2A; PIK3CD; ARPC5L; CFL1; GAB2; RPS6KB2
    TNF signaling pathway CXCL2; VCAM1; MAP3K5; NFKB1; MAP3K14; RELA; MAP2K6; BIRC2; MAP2K7; CXCL3
    Circadian entrainment RYR2; GUCY1A3; GNG5; CAMK2G; KCNJ3; MTNR1B; CALM2; RPS6KA5; GRIN1; GNG11
    Long-term potentiation PRKACB; ITPR1; ITPR3; MAP2K2; PRKCG; CAMK2G; PLCB3; BRAF; RPS6KA3; CALM2
    Neurotrophin signaling pathway CALM2; BDNF; RIPK2; PLCG1; MAP2K1; SHC2; SH2B2; GRB2; NFKBIA; CALML3
    Retrograde endocannabinoid signaling MAPK10; GABRR1; PLCB2; SLC17A7; GABRG2; SLC17A6; MAPK8; MAPK1; Adcy4; GNG2
    Glutamatergic synapse SLC38A2; GRIK2; PRKACG; DLGAP1; PRKACB; GRIN3B; GRIK3; GNGT2; GRIN3A; GNB3
    Cholinergic synapse GNG11; AKT2; KCNJ2; GNG10; PIK3R2; CHRM4; GNG5; GNB1; PLCB4; MAPK1
    Serotonergic synapse GABRB2; GNAS; CYP2C39; GNG12; GNB3; ALOX12E; GNG8; MAPK1; MAP2K1; ITPR1
    Long-term depression GRID2; KRAS; PLA2G4A; NRAS; LYN; ITPR3; GRIA2; MAPK1; CRHR1; PLCB1
    Regulation of actin cytoskeleton RHOAA; FGD1; ROCK1; SOS1; FGF19; PPP1R12C; PIP4K2B; MSNA; LIMK1A; FGD3
    Insulin signaling pathway CALM3; PRKAG3; GSK3AA; MAPK8B; SHC3; PTPRF; GRB2B; IKBKB; MAPK9; PIK3CD
    GnRH signaling pathway RAF1; RAF1A; MAP2K7; MMP14; CACNA1DA; PLA2G4C; MAPK8B; GNRH1; MAP2K2; CALM4
    Progesterone-mediated oocyte maturation INS2; CPEB1B; IGF1R; RPS6KA2; HSP90AA1.1; CDC16; MAPK14A; HSP90AA1.2; RPS6KA6; KRAS
    Estrogen signaling pathway GPR30; HSPA1L; KCNJ3; ESR1; PLCB4; KCNJ9; KCNJ6; FKBP4; HRAS; CREB3L3
    Melanogenesis CALM1B; WNT7A; KITA; TYR; PRKACA; WNT8A; WNT2; PLCB1; WNT4A; WNT11B
    Prolactin signaling pathway PIK3R3; CSH; PRLR; PIK3CD; RAF1; PIK3R5; TNFSF11; PIK3R1; FOXO3; SOCS7
    Thyroid hormone signaling pathway PFKFB2; MED30; PIK3R2; SLC16A2; GSK3B; NCOR1; ATP1B1; FOXO1; ATP1B4; KAT2A
    Oxytocin signaling pathway MYL6B; CACNG1; CALML5; CACNB2; NRAS; HRAS; GNAQ; CAMK2G; ITPR3; NPR1
    Type II diabetes mellitus INS-IGF2; ADIPOQ; TNF; MAFA; INS2; CACNA1G; PIK3R5; PKM; HK2; MTOR
    Aldosterone-regulated sodium reabsorption INS1; MAPK3; PIK3CD; SCNN1B; ATP1A3; MAPK1; PIK3CA; ALPHA-ENAC; PIK3CG; ATP1A2
    Alzheimers disease COX7A2L; ATP5J; CALML3; PSENEN; CASP9; RYR3; CALM2; GRIN1; MME; BID
    Prion diseases HSPA5; STIP1; PRNP; NCAM2; C5; IL1A; PRKACG; HSPA1A; C9; LOC100033925
    Shigellosis ARPC5L; ITGA5; SRC; ELMO1; MAPK12; MAPK11; MAPK9; RAC1; DIAPH1; MAPK8
    Salmonella infection RILP; IL18; PKN2; WASLA; TLR4; MAPK11; NOS2; WASF1; RAC1B; TLR5
    Pertussis GM5077; C3; NOS2; GNAI3; C2; C4BPA; IRF1; CXCL6; IRAK4; NLRP3
    Leishmaniasis STAT1; MAPK3; MAP3K7; HLA-DRB5; NOS2; IRAK1; ITGA4; ITGB2; ITGAM; IL1B
    Chagas disease (American trypanosomiasis) CCL3L3; PLCB3; IL6; GNAI1; PIK3CD; TGFBR1; PIK3R2; PPP2CA; IL12B; GNAI3
    Toxoplasmosis TGFB3; HLA-DRB1; CD40; BIRC2; HLA-DRA; TAB2; IL12A; NFKBIB; TYK2; PPIF
    Tuberculosis ATP6AP1; HLA-DRB1; VDR; CAMK2D; CD209C; NFYB; TGFB3; MAPK11; IRAK2; FCGR2A
    Hepatitis B TICAM2; IFN-a; TGFB2; TLR3; BCL2; MAPK8; RB1; MAP2K1; IFNA12; CASP8
    Influenza A TLR3; AGFG1; IL18; VDAC1; NLRP3; PYCARD; TRIM25; IL33; SOCS3; HLA-DRB4
    Pathways in cancer NOS2; CCNE2; ARNT; GNAI3; NFKBIA; GNG12; TRAF4; FAS; EPAS1; PTCH1
    Viral carcinogenesis SCRIB; PKM2; HIST1H4B; HDAC1; HIST1H2BA; PIK3CA; RHOA; CREB3L1; HDAC3; HIST1H2BF
    Proteoglycans in cancer CBLC; SLC9A1; ACTG1; MAP2K2; ROCK1; PIK3R5; ITPR3; IGF1R; MMP2; WNT3
    MicroRNAs in cancer APC2; PDCD4; DDIT4; TP53; RHOA; NOTCH4; MCL1; EZR; Casp3; ZFPM2
    Colorectal cancer APC; DCC; FOS; RHOA; PIK3R3; RAF1; PIK3CB; APC2; BIRC5; BCL2
    Renal cell carcinoma EPAS1; RBX1; PDGFB; HIF1A; PIK3CG; ARAF; KRAS; RAF1; PAK7; EGLN2
    Pancreatic cancer TGFA; STAT1; RAC2; SMAD3; PIK3CA; BRAF; TGFBR1; RAD51; PIK3R2; IKBKG
    Endometrial cancer CTNNA2; PIK3CD; BRAF; ILK; HRAS; AKT1; APC; AKT2; TCF7; TRP53
    Prostate cancer FGFR2; BRAF; INS1; AKT1; CPN1; IGF1; ARAF; GSK3B; KRAS; TCF7
    Thyroid cancer TCF7L2; NCOA4; TPR; PAX8; TRP53; RXRA; PPARG; MAP2K1; TCF7; MAP2K2
    Melanoma BRAF; PIK3R2; FGF4; FGF18; MAPK3; PIK3CD; FGF10; TRP53; PDGFA; FGF12
    Bladder cancer TP53; E2F3; RPS6KA5; DAPK1; MAP2K1; HRAS; TRP53; SRC; UPK3A; TYMP
    Chronic myeloid leukemia CBLC; CBL; PIK3R1; AKT2; TP53; RB1; AKT1; SMAD3; TGFB2; MDM2
    Acute myeloid leukemia PIK3R3; GRB2; AKT3; PIK3R1; RUNX1; MAPK3; CCND1; JUP; PIK3R2; PIK3CD
    Non-small cell lung cancer KRAS; ERBB2; PRKCG; NRAS; PDPK1; PRKCA; PIK3CG; CASP9; AKT1; RXRA
    Central carbon metabolism in cancer PDGFRA; SIRT6; PIK3R5; PGAM1; PIK3R1; PKM2; PDGFRB; HRAS; PDHA2; NTRK1
    Choline metabolism in cancer AKT1; HIF1A; LYPLA1; PDGFC; SLC44A2; CHKB; MAPK8; MAPK1; PIK3CG; SOS1

    MAPK1 has several biochemical functions, for example, ATP binding, DNA binding, MAP kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MAPK1 itself. We selected most functions MAPK1 had, and list some proteins which have the same functions with MAPK1. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding ACLYA; MAP4K5; PIK3CB; CDKL3; STK38L; FBXO18; TARS2; MAP3K8; GRK5; XRCC3
    DNA binding Rhox5; FBXL19; HIST4H4; FOXC1A; ZNF530; HIST1H2BG; PIAS4; SCML2; EOMES; TCEB3B
    MAP kinase activity MAPK14A; MAPK11; MAPK12A; MAPK12; MAPK14; NLK1; MAPK13; MAPK1; MAPK8A; NLK
    RNA polymerase II carboxy-terminal domain kinase activity CDK1; CCNK; MAPK1; CDK12; CDK8; CDK7; CDK13; CDK9
    mitogen-activated protein kinase kinase kinase binding TRAF6; MAP2K1; MAPK1; PPEF2; STK38; MAP4K2; CDC37; MARVELD3; MAPK8IP3; TCF3
    phosphatase binding DLG1; SH3RF2; SPRED1; TRPC4AP; PPARA; PPP1R35; MAPK1; WNK1; SYTL2; PPP1R21
    phosphotyrosine binding MAPK1; ZAP70; ACP2; CBL; CBLC; SAMSN1; PTPN3; SHC1; FGR; MAPK3
    protein binding ASGR1; DIP2A; NDRG1; RHOB; H3F3C; BFSP2; SETD2; TNK1; ADPRH; C1GALT1C1
    protein serine/threonine kinase activity TTK; MKNK1; STK32A; RIOK1; UHMK1; CAMK2D2; PHKG1B; CDK11B; SLC14A2; PINK1
    transcription factor binding APBB1; KEAP1; NR0B2A; TFDP1B; BPTF; JUNB; E2F1; NEUROD1; INSIG2; GATA4

    MAPK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAPK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAPK1.


    Reverchon, M; Bertoldo, MJ; et al. CHEMERIN (RARRES2) Decreases In Vitro Granulosa Cell Steroidogenesis and Blocks Oocyte Meiotic Progression in Bovine Species. BIOLOGY OF REPRODUCTION 90:-(2014).

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