MAPK1 Protein


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Official Full Name mitogen-activated protein kinase 1
Background This gene encodes a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. One study also suggests that this protein acts as a transcriptional repressor independent of its kinase activity. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene.
Synonyms ERK; p38; p40; p41; ERK2; ERT1; ERK-2; MAPK2; PRKM1; PRKM2; P42MAPK; p41mapk; p42-MAPK; MAPK1; mitogen-activated protein kinase 1
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Human
    • Insect Cell
    • Insect Cells
    • Mammalian Cell
    • Tag :
    • C-Myc/DDK
    • Gly/Pro
    • GST
    • His
    • His/GST
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    • N-His
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human MAPK1-26227TH Recombinant Human MAPK1 protein E.coli N/A
    Human MAPK1-27H Biotinylated Recombinant Human ERK2, His-tagged E.coli His
    Human MAPK1-28697TH Recombinant Human MAPK1 E.coli N/A
    Human MAPK1-28700TH Recombinant Human MAPK1, His-tagged E.coli His
    Human MAPK1-308H Recombinant Human MAPK1, GST-tagged, Active E.coli GST
    Human MAPK1-37H Recombinant Human Mitogen-Activated Protein Kinase 1 E.coli N/A
    Human MAPK1-529H Recombinant Human Mitogen-activated protein kinase 1, His tagged E.coli His
    Human MAPK1-7267H Recombinant Human MAPK1, GST tagged Insect Cell GST
    Human MAPK1-896H Recombinant Human Mitogen-Activated Protein Kinase 1 Human N/A
    Human MAPK1-918H Recombinant Human MAPK1, GST-tagged Insect Cell GST
    Mouse Mapk1-482M Recombinant Mouse Mapk1, Gly & Pro tagged Insect Cell His
    Mouse Mapk1-638M Recombinant Mouse Mitogen-activated Protein Kinase 1, His-tagged E.coli His
    Mouse Mapk1-7394M Recombinant Mouse Mapk1, His & GST tagged Insect Cell His/GST
    Rat MAPK1-3571R Recombinant Rat MAPK1 Protein Mammalian Cell His
    Rat Mapk1-664R Recombinant Rat Mitogen Activated Protein Kinase 1, His-tagged E.coli His
    Chicken MAPK1-5726C Recombinant Chicken MAPK1 Mammalian Cell His
    Zebrafish MAPK1-9677Z Recombinant Zebrafish MAPK1 Mammalian Cell His
    Human MAPK1-692HCL Recombinant Human MAPK1 cell lysate Insect Cell N/A
    Mouse MAPK1-001MCL Recombinant Mouse MAPK1 cell lysate Insect Cell N/A
    Human MAPK1-2417H Recombinant Human MAPK1 Protein, His-tagged E.coli N-His
    Human MAPK1-2418H Recombinant Human MAPK1 Protein, His-tagged E.coli N-His
    Mouse Mapk1-482MAF488 Recombinant Mouse Mapk1 Protein, Gly/Pro-tagged, Alexa Fluor 488 conjugated Insect Cells Gly/Pro
    Mouse Mapk1-482MAF555 Recombinant Mouse Mapk1 Protein, Gly/Pro-tagged, Alexa Fluor 555 conjugated Insect Cells Gly/Pro
    Mouse Mapk1-482MAF647 Recombinant Mouse Mapk1 Protein, Gly/Pro-tagged, Alexa Fluor 647 conjugated Insect Cells Gly/Pro
    Mouse Mapk1-482MF Recombinant Mouse Mapk1 Protein, Gly/Pro-tagged, FITC conjugated Insect Cells Gly/Pro
    Human MAPK1-4934HF Recombinant Full Length Human MAPK1 Protein, GST-tagged E.coli GST
    Human MAPK1-5665HF Recombinant Full Length Human MAPK1 Protein, GST-tagged E.coli GST
    Human MAPK1-6912HF Recombinant Full Length Human MAPK1 Protein, GST-tagged E.coli GST
    Human MAPK1-7267HAF488 Recombinant Human MAPK1 Protein, GST-tagged, Alexa Fluor 488 conjugated Insect Cells GST
    Human MAPK1-7267HAF555 Recombinant Human MAPK1 Protein, GST-tagged, Alexa Fluor 555 conjugated Insect Cells GST
    Human MAPK1-7267HAF647 Recombinant Human MAPK1 Protein, GST-tagged, Alexa Fluor 647 conjugated Insect Cells GST
    Human MAPK1-7267HF Recombinant Human MAPK1 Protein, GST-tagged, FITC conjugated Insect Cells GST
    Mouse Mapk1-7394MAF488 Recombinant Mouse Mapk1 Protein, His/GST-tagged, Alexa Fluor 488 conjugated Insect Cells His/GST
    Mouse Mapk1-7394MAF555 Recombinant Mouse Mapk1 Protein, His/GST-tagged, Alexa Fluor 555 conjugated Insect Cells His/GST
    Mouse Mapk1-7394MAF647 Recombinant Mouse Mapk1 Protein, His/GST-tagged, Alexa Fluor 647 conjugated Insect Cells His/GST
    Mouse Mapk1-7394MF Recombinant Mouse Mapk1 Protein, His/GST-tagged, FITC conjugated Insect Cells His/GST
    Human MAPK1-048H Recombinant Human MAPK1 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
    Human MAPK1-052H Recombinant Human MAPK1 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
    Human MAPK1-2008H Recombinant Human MAPK1 Protein, GST-tagged E.coli GST
    Human MAPK1-385H Recombinant Human MAPK1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Mouse Mapk1-3937M Recombinant Mouse Mapk1 Protein, Myc/DDK-tagged HEK293T Myc/DDK

    MAPK1 involved in several pathways and played different roles in them. We selected most pathways MAPK1 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAPK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    ErbB signaling pathway PRKCBB; CAMK2D; NRAS; HRASA; RPS6KB1; PIK3CG; CAMK2A; RAF1B; PAK3; ELK1
    Ras signaling pathway KIT; PDGFB; KSR1; RASA4; GNG8; PLA2G10; RGL1; PLA2G2F; RRAS; PGF
    Rap signaling pathway PIK3R1; FGF14; VEGFC; NRAS; PDGFD; RAF1; Itgam&Itgb2; AKT1; CALM1; RAP1B
    cGMP-PKG signaling pathway NFATC4; INSR; CALML3; MAPK1; GNAQ; PPIF; ATP2B1; CREB3L3; GNA11; RGS2
    cAMP signaling pathway GNAI3; MAPK10; DRD1A; GRIA3; CALM4; GRIA1; GRIA2; CAMK2G; RRAS; RHOA
    Chemokine signaling pathway STAT1; GRB2; MAPK1; GSK3A; Ccl21a; JAK3; CXCL11; CXCR2; CCR5; GRK6
    HIF- signaling pathway IFNGR2; INS; IL6; STAT3; ERBB2; VEGFA; HK2; PIK3R2; PDHA1; PIK3R3
    FoxO signaling pathway RAF1B; PRKAB1B; SMAD3A; PRKAG3; PCK2; GRB2B; GABARAPL1; RAF1A; FOXO1B; BCL6A
    Sphingolipid signaling pathway PIK3R2; CERS5; PPP2R5C; GNAQ; GNAI2; OPRD1; NRAS; MAPK10; LASS1; MS4A2
    Phospholipase D signaling pathway DGKD; SOS1; DGKE; PIP5K1B; PLA2G4C; PLA2G4A; PLD1; PTK2B; PIK3R1; AVP
    Oocyte meiosis PPP2CB; CALM3A; YWHAZ; CDC16; ANAPC2; CALM3; CPEB4; SMC1A; PPP2R5E; PLK1
    mTOR signaling pathway RPS6KA1; PIK3CA; RRN3; RRAGCA; RPS6KB1B; TSC1; PIK3CD; BRAF; PRR5; STK11
    PIK-Akt signaling pathway FLT4; IL6; PDGFRB; IL2RG; TNN; GNG13; PKN1; HSP90AB1; LAMB4; IFNA12
    Adrenergic signaling in cardiomyocytes SCN4BA; ATP1A1B; PRKACG; PLN; ATP2B3B; CAMK2B1; ADCY1; PPP2R2B; ATP1A3A; MYL4
    Vascular smooth muscle contraction PLA2G2F; PPP1CC; CACNA1D; MYH11; ROCK2; CACNA1SB; AVPR1B; NPR1A; CALM1A; PPP1CBL
    Dorso-ventral axis formation PIWIL4; ETV7; EGFRA; NOTCH2; NOTCH3; MAPK1; SOS1; FMN2; CPEB3; CPEB1
    TGF-beta signaling pathway SKP1; GDF7; RHOAA; ACVR1BA; TGFBR1; TGFBR1B; BMPR1AA; IFNG1-2; SMAD9; GDF6A
    Axon guidance SEMA7A; L1CAM; PLXNA1; NCAN; NFATC3; PHB; EGF; DPYSL5A; DNM2; NCK1
    VEGF signaling pathway PTK2AA; MAPK12B; PTK2AB; PRKCB; RAC1A; AKT2; RAC3; MAPK3; PIK3R3; RAC2
    Osteoclast differentiation IKBKB; MITF; FOSL1; TNF; TAB2; CYBA; PIK3CG; ITGB3; PPP3CC; MAP2K6
    Focal adhesion ITGB7; BCAR1; ITGB4; RAF1; PIP5K1C; CAV2; MYL12B; LAMB1A; EGFRA; PIK3R3B
    Adherens junction YES1; ACP1; RHOAD; RHOAB; SMAD4; CDC42; CREBBP; TGFBR1B; EGFR; TCF7L2
    Gap junction ITPR3; GRM5; TUBA8L4; TUBA8; GRB2; PRKACAA; TUBA2; GNA15.4; PLCB3; ITPR1
    Signaling pathways regulating pluripotency of stem cells BMP4; WNT10B; IGF1; HRAS; HAND1; ACVR1B; INHBC; PIK3CD; KRAS; PCGF1
    Platelet activation SNAP23; PIK3R1; ACTG1; TBXAS1; FERMT3; RAP1A; SYK; FYN; ARHGEF12; MYLK2
    Toll-like receptor signaling pathway IFNPHI1; MAPK9; TRAF3; TLR7; MAP2K7; Ifna15; MAP2K2; IRAK1; IFNB; TLR2-1
    NOD-like receptor signaling pathway NAIP7; MAPK8B; IKBKB; MAPK10; MAPK9; PYDC1; CXCL1; NLRC4; CARD9; MAPK11
    Natural killer cell mediated cytotoxicity TNFSF10; ULBP1; BRAF; IFNA16; MAPK1; MAP2K2; IFNA12; SH2D1B; KIR2DL1; KRAS
    T cell receptor signaling pathway CD3E; CD3D; PAK3; NFATC1; PIK3CG; RAF1; TEC; CD3E; GSK3B; PIK3R3; PPP3CA
    B cell receptor signaling pathway PIK3CD; ACTR2; BCL2L11; MAP2K2; Cd79a, Cd79b; RASGRP3; NFKB1; PPP3R1; ARPC5; MAPK3
    Fc epsilon RI signaling pathway AKT2; PLCG2; PDPK1; PLCG1; PIK3CD; PLA2G4B; FYN; MAPK13; PIK3R2; FCER1G
    Fc gamma R-mediated phagocytosis LIMK1; PLA2G4A; PLA2G4F; FCGR1A; ARPC1A; WASF3; BIN1; PIK3R1; AKT2; CFL2
    TNF signaling pathway TNFAIP3; CASP8; ITCH; PGAM5; CREB3L3; DNM1L; BAG4; AKT1; MAPK8; PIK3CD
    Circadian entrainment PRKCG; PER3; GRIA3; GNAO1; GNAI1; PRKCA; GRIN2A; PLCB2; GNG4; GNAI3
    Long-term potentiation MAP2K2; PRKACG; CALM1; PRKCG; MAPK3; PPP3CA; RAF1; PPP3R1; PLCB2; GRIN1
    Neurotrophin signaling pathway CAMK2G; MAPKAPK2; BAD; MAP3K5; AKT2; Fasl; SHC4; PRKCD; NFKBIA; PIK3CD
    Retrograde endocannabinoid signaling ITPR3; GABRB1; MAPK13; GRM1; MAPK1; GABRA4; GABRR3; SLC17A6; GABRA1; GNB3
    Glutamatergic synapse PRKACB; GRIK4; GRIN3A; GNAO1; SLC1A2; GRIN3B; GRIK2; PLCB4; GRIA3; GNAQ
    Cholinergic synapse PLCB2; BCL2; GNG10; KCNQ5; PIK3CB; MAPK3; PIK3CD; GNGT1; GNG8; Adcy4
    Serotonergic synapse Casp3; MAPK1; TPH1; HTR4; ALOX15; PRKACB; HTR1F; HTR3B; HTR2B; GNAI2
    Long-term depression PRKG2; HRAS; MAPK3; GNAQ; RAF1; GRIA1; PPP2R1A; GNAS; PLCB2; BRAF
    Regulation of actin cytoskeleton RHOAB; MYL9B; MYL9A; ITGB5; ITGB2; ARPC5B; EZRB; INSRR; VCLA; MYLK4
    Insulin signaling pathway MAPK1; CALM3; PPP1CAA; RAF1; PPP1R3CA; PCK2; PDPK1B; PPP1CBL; PPP1R3C; PYGL
    GnRH signaling pathway CALM1B; GNRHR2; MMP14A; MAP2K2A; CALM3A; PLCB1; MAP2K3; MAPK7; GNAS; MMP14B
    Progesterone-mediated oocyte maturation CCNA1; FZR1; PLK1; MAD2L2; RAF1; CDC16; SPDYA; RPS6KA3; SPDYB; MAPK1
    Estrogen signaling pathway OPRM1; SHC1; ATF4; FOS; AKT1; CREB3L1; CALM1; GABBR2; SRC; PIK3CD
    Melanogenesis FZD6; a; CAMK2B1; GNAO1B; WNT3; CALM1B; KIT; RAF1; CALM1A; CAMK2D1
    Prolactin signaling pathway NFKB1; SRC; MAPK3; PIK3R5; MAPK13; RELA; SOCS2; SOCS3; NRAS; GALT
    Thyroid hormone signaling pathway MED12; ATP1A4; GATA4; EP300; MED14; PIK3CA; PLCG2; ATP2A2; CASP9; TP53
    Oxytocin signaling pathway MYLK3; PRKAA1; CAMK2A; CAMK2D; CAMK4; PRKAB2; CAMKK1; CACNB3; KCNJ14; PPP1R12B
    Type II diabetes mellitus CACNA1G; PRKCZ; TNF; IRS4; MAFA; PKM; PRKCE; PIK3R5; PKM2; SOCS4
    Aldosterone-regulated sodium reabsorption FXYD2; IRS1; PRKCG; PIK3R1; ATP1B3; KCNJ1; PIK3CB; INS; PRKCA; PRKCB
    Alzheimers disease ITPR3; TNF; CDK5R1; NDUFA12; ATP5F1; COX7A2; NDUFA13; COX7B2; NDUFB5; NDUFS3
    Prion diseases C1QA; PRKACG; Hc; FYN; HSPA5; NCAM1; HSPA1A; IL1A; C1QC; C8A
    Alcoholism HIST1H2AE; GNAI2; HDAC10; HDAC6; CREB5; GM14483; SHC1; SLC6A3; GRIN2A; HDAC7A
    Salmonella infection CDC42L; IL-8; CCL4; ARPC5LB; PFN2L; CCL3L1; MAPK12A; IL1A; RHOGD; RHOGC
    Pertussis IRF3; RHOA; C4A; ITGB2L; C1R; FOS; MAPK9; IL1A; C3; AMCF-II
    Leishmaniasis NFKBIA; FCGR2A; ELK1; HLA-DQA1; H2-AB1; H2-AA; ITGB2; PTPN6; MAPK3; ITGAM
    Chagas disease (American trypanosomiasis) TLR2; PIK3CB; MAPK1; TGFBR2; TICAM1; MAPK10; PIK3CA; GNAS; RELA; PPP2CA
    Toxoplasmosis IKBKG; TYK2; HLA-DRB5; Toxoplasma Gondii Microneme Protein MIC3; LAMA1; IRGM; BIRC2; IL10RA; HLA-DMB; HLA-DMA
    Tuberculosis PPP3CC; HLA-DOB; HLA-DQB1; SRC; H2-AA; CEBPG; TNF; TLR4; IFNA6; IL12A
    Hepatitis C IFNAR2; CLDN4; PPP2R2A; CLDN17; IFNA7; IRF3; TRAF3; IFNA6; EIF3E; PIAS1
    Influenza A HSPA2; MAPK9; KPNA1; OAS1A; CCL2; OAS2; Fasl; IL8L2; IFNA8; BLB2
    Pathways in cancer FGF22; PDGFB; TCEB1; ITGAV; NOS2; FGF9; GLI3; MSH6; GNG10; WNT3
    Viral carcinogenesis GTF2H1; GTF2A1L; SRF; PRKACB; HIST1H4A; C3; SCIN; UBR4; TBPL2; RAC1
    Proteoglycans in cancer CD63; CD44; FZD3; CAMK2G; CAV2; MSN; PTPN6; MTOR; FLNA; MAPK12
    MicroRNAs in cancer SPRY2; ERBB3; ABL1; MMP9; PLCG2; HNRNPK; EP300; RAF1; TPM1; HDAC4
    Colorectal cancer CCND1; APC; PIK3CA; MAP2K1; PIK3R2; RAC1; SMAD4; TGFBR2; FOS; TGFB2
    Renal cell carcinoma BRAF; MET; PIK3R1; MAP2K1; VEGFA; RAC1; ETS1; CUL2; MAP2K2; PAK1
    Pancreatic cancer SMAD2; RELA; PIK3R2; MAP2K1; PIK3R3; SMAD4; TGFB2; STAT1; TP53; RB1
    Endometrial cancer BRAF; ARAF; MLH1; TCF7L2; PIK3CA; AXIN2; PTEN; HRAS; PIK3R3; MAPK1
    Prostate cancer EP300; TCF7; IKBKB; NRAS; INSRR; GSK3B; HRAS; CCNE2; PIK3CG; HSP90B1
    Thyroid cancer TPM3; RET; KRAS; BRAF; HRAS; RXRB; LEF1; TP53; TCF7; PAX8
    Melanoma FGF1; HGF; FGF2; IGF1R; PDGFD; FGF14; MDM2; PTEN; BAD; FGF17
    Bladder cancer SRC; EGF; TP53; E2F3; MAPK1; BRAF; DAPK3; MMP1; TRP53; ARAF
    Chronic myeloid leukemia PIK3CG; MECOM; CTBP1; PIK3R2; SHC4; PIK3R1; RUNX1; TGFBR2; AKT1; RB1
    Acute myeloid leukemia PPARD; SOS1; FLT3; PIK3R2; PIK3CD; JUP; PIM2; RUNX1; SPI1; IKBKG
    Non-small cell lung cancer HRAS; BRAF; PIK3CA; RAF1; RXRG; RASSF1; SOS1; CCND1; MAP2K2; BAD
    Central carbon metabolism in cancer PDGFRB; HKDC1; PDHB; SLC2A1; KIT; PFKL; IDH1; G6PDX; TRP53; G6PD
    Choline metabolism in cancer SLC44A2; PDGFD; Pdgfa&Pdgfb; PDGFC; PLD1; PRKCG; TSC1; RAF1; MAPK8; PLA2G4D

    MAPK1 has several biochemical functions, for example, ATP binding, DNA binding, MAP kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MAPK1 itself. We selected most functions MAPK1 had, and list some proteins which have the same functions with MAPK1. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding NTRK3; STK33; PGS1; TEX14; DCLK1A; MAP4K6; KIF1B; UBA6; SPAST; KIF14
    MAP kinase activity MAPK15; MAPK6; MAPK12A; MAPK8A; MAPK12B; MAPK12; MAPK13; MAPK14; NLK2; MAPK11
    RNA polymerase II carboxy-terminal domain kinase activity CDK1; CDK12; CDK8; MAPK1; CDK13; CDK9; CDK7; CCNK
    mitogen-activated protein kinase kinase kinase binding STK38; TRAF2; TRAF6; MAPK1; MAPK9; MARVELD3; MAP2K1; TCF3; PPEF2; CDC37
    phosphatase binding SH3YL1; PPP1R36; DZIP3; SMAD2; MAPK1; SH2D4A; KIAA0649; SLC9A3R2; PPP1R37; PPP1R18
    phosphotyrosine binding CBLB; ZAP70; STAP1; SAMSN1; MAPK3; CBL; PTPN3; CBLC; MAPK1; LDLRAP1
    protein binding CD200R3; RNH1; NCOA5; MT1X; RIT1; SCAND1; APBB2; FBN2; GAGE8; TUBB4A
    protein serine/threonine kinase activity SNRKA; CDC42BPG; PAK4; HIPK1; CSNK1G3; MKNK2; MAPK8; TSSK6; PRKY; LMTK2
    transcription factor binding TP53; TFDP1; HDAC8; GPX3; TFAP2A; TAF7L; TBL1X; KAT2B; NKX2; NR0B2A

    MAPK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAPK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAPK1.


    Reverchon, M; Bertoldo, MJ; et al. CHEMERIN (RARRES2) Decreases In Vitro Granulosa Cell Steroidogenesis and Blocks Oocyte Meiotic Progression in Bovine Species. BIOLOGY OF REPRODUCTION 90:-(2014).

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