MAPK1

  • Official Full Name

    mitogen-activated protein kinase 1

  • Background

    This gene encodes a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. One study also suggests that this protein acts as a transcriptional repressor independent of its kinase activity. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene.
  • Synonyms

    ERK; p38; p40; p41; ERK2; ERT1; ERK-2; MAPK2; PRKM1; PRKM2; P42MAPK; p41mapk; p42-MAPK; MAPK1; mitogen-activated protein kinase 1;
    • Type:
    • Recombinant Proteins
    • Cell & Tissue Lysates
    • Protein Pre-coupled Magnetic Beads
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Human
    • Insect Cell
    • Insect Cells
    • Mammalian Cell
    • Tag :
    • C
    • Myc
    • DDK
    • Flag
    • His
    • Gly
    • Pro
    • GST
    • His (Fc)
    • Avi
    • His|GST
    • Myc|DDK
    • N/A
    • N
    • No tag
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Chicken MAPK1-5726C Recombinant Chicken MAPK1 Mammalian Cell His
    Human MAPK1-27H Biotinylated Recombinant Human ERK2, His-tagged E.coli His
    Human MAPK1-37H Recombinant Human Mitogen-Activated Protein Kinase 1 E.coli N/A
    Human MAPK1-918H Recombinant Human MAPK1, GST-tagged Insect Cell GST
    Human MAPK1-7267H Recombinant Human MAPK1, GST tagged Insect Cell GST
    Human MAPK1-26227TH Active Recombinant Human MAPK1 protein E.coli N/A
    Human MAPK1-896H Recombinant Human Mitogen-Activated Protein Kinase 1 Human N/A
    Human MAPK1-28700TH Recombinant Human MAPK1, His-tagged E.coli His
    Human MAPK1-308H Recombinant Human MAPK1, GST-tagged, Active E.coli GST
    Human MAPK1-28697TH Recombinant Human MAPK1 E.coli N/A
    Human MAPK1-529H Recombinant Human Mitogen-activated protein kinase 1, His tagged E.coli His
    Human MAPK1-2008H Recombinant Human MAPK1 Protein, GST-tagged E.coli GST
    Human MAPK1-048H Recombinant Human MAPK1 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
    Human MAPK1-692HCL Recombinant Human MAPK1 cell lysate Insect Cell N/A
    Human MAPK1-052H Recombinant Human MAPK1 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
    Human MAPK1-2417H Recombinant Human MAPK1 Protein, His-tagged E.coli N-His
    Human MAPK1-2418H Recombinant Human MAPK1 Protein, His-tagged E.coli N-His
    Human MAPK1-385H Recombinant Human MAPK1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human MAPK1-7267HAF488 Recombinant Human MAPK1 Protein, GST-tagged, Alexa Fluor 488 conjugated Insect Cells GST
    Human MAPK1-7267HAF555 Recombinant Human MAPK1 Protein, GST-tagged, Alexa Fluor 555 conjugated Insect Cells GST
    Human MAPK1-1361H-B Recombinant Human MAPK1 Protein Pre-coupled Magnetic Beads HEK293
    Human MAPK1-7267HAF647 Recombinant Human MAPK1 Protein, GST-tagged, Alexa Fluor 647 conjugated Insect Cells GST
    Human MAPK1-1361H Recombinant Human MAPK1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Human MAPK1-7267HF Recombinant Human MAPK1 Protein, GST-tagged, FITC conjugated Insect Cells GST
    Human MAPK1-1080H Recombinant Human MAPK1 Protein (M1-S360), Tag Free E.coli No tag
    Human MAPK1-1081H Recombinant Human MAPK1 Protein (M1-S360), Flag/His tagged E.coli Flag/His
    Human MAPK1-2577H Recombinant Human MAPK1 protein, GST-tagged E.coli GST
    Mouse Mapk1-3937M Recombinant Mouse Mapk1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Mouse Mapk1-7394MAF647 Recombinant Mouse Mapk1 Protein, His/GST-tagged, Alexa Fluor 647 conjugated Insect Cells His/GST
    Mouse Mapk1-482MF Recombinant Mouse Mapk1 Protein, Gly/Pro-tagged, FITC conjugated Insect Cells Gly/Pro
    Mouse Mapk1-7394MAF488 Recombinant Mouse Mapk1 Protein, His/GST-tagged, Alexa Fluor 488 conjugated Insect Cells His/GST
    Mouse Mapk1-7394MAF555 Recombinant Mouse Mapk1 Protein, His/GST-tagged, Alexa Fluor 555 conjugated Insect Cells His/GST
    Mouse Mapk1-7394MF Recombinant Mouse Mapk1 Protein, His/GST-tagged, FITC conjugated Insect Cells His/GST
    Mouse Mapk1-482MAF647 Recombinant Mouse Mapk1 Protein, Gly/Pro-tagged, Alexa Fluor 647 conjugated Insect Cells Gly/Pro
    Mouse Mapk1-482MAF488 Recombinant Mouse Mapk1 Protein, Gly/Pro-tagged, Alexa Fluor 488 conjugated Insect Cells Gly/Pro
    Mouse MAPK1-001MCL Recombinant Mouse MAPK1 cell lysate Insect Cell N/A
    Mouse Mapk1-7394M Recombinant Mouse Mapk1, His & GST tagged Insect Cell His/GST
    Mouse Mapk1-482MAF555 Recombinant Mouse Mapk1 Protein, Gly/Pro-tagged, Alexa Fluor 555 conjugated Insect Cells Gly/Pro
    Mouse Mapk1-482M Recombinant Mouse Mapk1, Gly & Pro tagged Insect Cell His
    Mouse Mapk1-638M Recombinant Mouse Mitogen-activated Protein Kinase 1, His-tagged E.coli His
    Rat MAPK1-3227R Recombinant Rat MAPK1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Rat MAPK1-3227R-B Recombinant Rat MAPK1 Protein Pre-coupled Magnetic Beads HEK293
    Rat Mapk1-664R Recombinant Rat Mitogen Activated Protein Kinase 1, His-tagged E.coli His
    Rat MAPK1-3571R Recombinant Rat MAPK1 Protein Mammalian Cell His
    Zebrafish MAPK1-9677Z Recombinant Zebrafish MAPK1 Mammalian Cell His
    • Involved Pathway
    • Protein Function
    • Interacting Protein
    • MAPK1 Related Articles
    • MAPK1 Related Signal Pathway

    MAPK1 involved in several pathways and played different roles in them. We selected most pathways MAPK1 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAPK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathwayGRB2A;TGFB3;IL1R2;PPM1AA;PRKACBA;PRKACG;ZAK;NTRK1;FGF14
    ErbB signaling pathwayGAB1;ERBB2;NRG1;SRC;MAP2K4A;MAP2K2A;PAK2;CAMK2A;PIK3CD
    Ras signaling pathwayRRAS2;ANGPT2;SHOC2;INS;TEK;Fgf15;RASA4;FGF5;BAD
    Rap signaling pathwayVEGFA;MAPK11;PARD6B;RALGDS;MAPK3;FGF13;PFN3;CALM4;CALM2
    cGMP-PKG signaling pathwayIRS4;SLC25A5;OPRD1;LOC100328615;VDAC1;ATP1A2;VASP;CREB3L2;MEF2B
    cAMP signaling pathwayPPP1CB;HTR1A;BDNF;MAPK10;GIPR;PLD1;CNGA3;RAP1A;PRKACB
    Chemokine signaling pathwayVAV1;PTK2;AMCF-II;IKBKB;CXCL10;RAC2;PF4;LOC100033925;PLCB3
    HIF- signaling pathwayPRKCG;IL6R;HK1;TCEB2;PDHB;PDHA2;ENO3;IL6;HIF1A
    FoxO signaling pathwaySGK2B;KLF2B;PRKAB1B;SMAD3;PRKAG3;CCND2A;INS2;FBXO25;CCNB2
    Sphingolipid signaling pathwayPIK3R5;DEGS1;PPP2R5C;TRP53;PTEN;PLCB2;AKT1;MAPK11;PIK3CD
    Phospholipase D signaling pathwayLPAR4;DNM3;PIK3R5;GRB2;GAB1;RALB;DGKD;INSR;IL-8
    Oocyte meiosisMOS;PGR;IGF1RB;CPEB1A;CALM1A;PTTG1;PPP1CC;CAMK2B;INSB
    mTOR signaling pathwayRPS6KA6;CAB39;RPS6KA3A;PIK3R5;PRKAA2;PIK3CB;EIF4E2RS1;ULK2;RICTOR
    PIK-Akt signaling pathwaySTK11;LAMB4;SGK3;PKN2;FLT4;IFNA13;GH1;KRAS;CCND1
    Adrenergic signaling in cardiomyocytesCAMK2B;CREB5;CALM2A;CREM;PRKACAA;TNNC1A;CALM2;CACNA1DA;CALM4
    Vascular smooth muscle contractionKCNMB1;CALM1;PLCB2;NPR1;RHOAB;PRKCQ;PRKCBA;ROCK2A;PLCB1
    Dorso-ventral axis formationETV6;CPEB4;SOS1;EGFRA;PIWIL4;KRAS;FMN2;SPIRE1;GRB2
    TGF-beta signaling pathwayBMP7B;BMP8B;PITX2;NDR1;TGFBR1A;ID2B;ID2A;GDF6;TGFB2
    Axon guidancePAK2;KBTBD7;DUSP9;HBEGF;ABLIM3;EFNB2A;RGMA;ARPC3;DUSP6
    VEGF signaling pathwayRAC2;PRKCBB;PRKCB;VEGFAB;PLCG1;MAPKAPK3;VEGFA;RAF1;PTGS2B
    Osteoclast differentiationNOX3;MAPK1;MAP3K7;LILRA2;PIK3CG;TGFB1;IL1A;FCGR2C;LILRA5
    Focal adhesionITGB3B;BRAF;ITGA3B;PDGFAB;CAV3;PRKCBA;ITGB4;RHOB;BCL2A
    Adherens junctionCTNNB1;CTNND1;RHOAD;SMAD3A;ACTB2;SNAI1;ERBB2;IGF1RB;MAPK3
    Gap junctionDRD1B;PDGFA;CX43;PRKACAA;TUBB2A;TUBA7L;TUBA8L;HTR2B;GNA11B
    Signaling pathways regulating pluripotency of stem cellsAKT2;WNT7B;LIFR;WNT2B;WNT3A;FGFR2;APC;ZIC3;BMPR2
    Platelet activationPRKACG;ARHGEF12;PIK3R2;FCER1G;PLCB3;PRKG1;PLCB2;PIK3CA;MYLK3
    Toll-like receptor signaling pathwayPIK3R5;MAPK10;TLR3;TNF;MAPK1;LBP;PIK3R3A;FADD;SPP1
    NOD-like receptor signaling pathwayCASP8;BIRC3;HSP90AA1.1;MAPK8;MAPK14A;MAPK3;TAB3;CASPA;IL8L2
    Natural killer cell mediated cytotoxicityFCGR3B;FCER1G;PPP3R1;FASLG;ARAF;PTPN6;BID;IFNA21;PRKCG
    T cell receptor signaling pathwayMAP3K7;MAPK11;TNF;DLG1;CBLC;IL5;PIK3CB;LCK;EVLB
    B cell receptor signaling pathwayBANK1;ACTR2;CRK;MAP4K1;GSK3B;PPP3R1;NEDD9;DOK1;PLEKHA1
    Fc epsilon RI signaling pathwayFYN;FCER1A;VAV1;RAF1;PIK3R2;PIK3CB;LAT;MS4A2;SOS1
    Fc gamma R-mediated phagocytosisPLD1;VAV2;FCGR2B;PRKCA;DOCK2;AMPH;HCK;PPAP2B;MARCKSL1
    TNF signaling pathwayMMP9;IKBKB;IKBKG;PIK3CB;MAGI2;SOCS3;MAP3K5;VCAM1;TRAF5
    Circadian entrainmentGNB2;NOS1AP;CALM1;GUCY1B3;FOS;MTNR1A;RYR2;GNB3;GNAO1
    Long-term potentiationRAF1;MAP2K1;GRIN2D;ATF4;GRIA2;PPP1CB;RAP1A;ARAF;CALML3
    Neurotrophin signaling pathwayTRAF6;MAPK12;PIK3CD;CDC42;MAPKAPK2;IRAK1;NTRK1;PLCG1;RPS6KA2
    Retrograde endocannabinoid signalingMAPK3;GNG11;GABRP;GABRA6;GRIA2;GNG3;SLC17A6;GABRA5;PRKACA
    Glutamatergic synapseGNAI1;GRIK5;GRIA2;GNAI3;GRIN3A;GNG3;GNGT2;GRIK1;GLUL
    Cholinergic synapsePRKACA;GNB4;AKT1;CHRM1;GNAO1;KCNQ1;CAMK2B;ATF4;CHRNB4
    Serotonergic synapsePRKACA;HTR3B;HTR3E;PLA2G4C;GNG12;GNG2;CYP4X1;TPH2;ALOX15B
    Long-term depressionPRKCG;NRAS;PLA2G4A;ITPR3;PLCB4;BRAF;GNAQ;GRID2;PPP2CA
    Regulation of actin cytoskeletonRRAS;FN1A;MYLK;GSNB;ITGA8;ARHGEF4;FGF19;MAP2K1;INSRR
    Insulin signaling pathwayINS1;EIF4E1C;PPP1R3CB;PIK3CB;IRS1;PHKG1;MAPK8B;EXOC7;PPP1CB
    GnRH signaling pathwayPRKCBB;CAMK2D2;PRKCA;ADCY1B;CALM1A;MAP2K6;GNRHR;CAMK2G;PLCB1
    Progesterone-mediated oocyte maturationINS;IGF1R;CPEB1B;HSP90AA1.2;PGR;RPS6KA6;CDC27;FZR1A;CDC25C
    Estrogen signaling pathwayKRAS;GNAI2;HSP90AB1;PLCB4;Adcy4;FOS;KCNJ9;PIK3CA;CALM4
    MelanogenesisFzd4;GNA15.4;DVL3A;WNT7AA;CALM3B;KITLG;Kitl;CREB3L3A;MITFA
    Prolactin signaling pathwayMAPK11;MAPK3;TNFRSF11A;SOCS3;PRP2;AKT1;ESR2;PRLR;SOCS1
    Thyroid hormone signaling pathwayMED12L;RXRG;GATA4;BMP4;STAT1;MAPK3;HIF1A;HDAC3;ESR1
    Oxytocin signaling pathwayRHOA;PRKACB;PIK3CD;PRKAG2;NFATC2;MAP2K1;PPP1CC;PIK3R5;ITPR3
    Type II diabetes mellitusSOCS2;MAPK1;PKM2;MAPK10;IRS4;PIK3CB;HKDC1;CACNA1G;HK3
    Aldosterone-regulated sodium reabsorptionATP1A3;ATP1A1;PIK3CG;HSD11B2;ATP1B2;PIK3R3;IGF1;SCNN1B;SCNN1G
    Alzheimers diseaseGSK3B;PPP3CB;SDHA;CDK5R1;NDUFS2;UQCRC1;GRIN1;UQCR10;NDUFB2
    Prion diseasesNCAM2;C1QB;C9;CCL5;IL6;MAPK3;C1QA;CASP12;C1QC
    AlcoholismCREB5;SLC18A1;HIST2H3C1;HIST3H2A;GNGT1;HIST1H3E;HIST1H2AL;HIST1H3H;HIST1H2AB
    ShigellosisITGA5;ELMO2;U2AF1L4;ROCK1;PFN4;U2AF1;ITGB1;ATG5;MAPK8
    Salmonella infectionKLC1A;ROCK2;LBP;RHOGC;IFNGR2;CXCL2;CXCL1;IFNG1-2;KLC4
    PertussisCALML3;RHOA;ITGB2;Il23a; Il12b;NLRP3;ITGB1;ITGAM;C1QB;MAPK11
    LeishmaniasisHLA-DQA1;NCF1;NFKB1;FCGR2A;IFNGR1;TAB2;Itgam&Itgb2;TRAF6;MAPK11
    Chagas disease (American trypanosomiasis)GNAI3;NFKB1;PIK3CG;PPP2R2D;CALR;IL6;MAPK8;SMAD3;MAPK12
    ToxoplasmosisHLA-DRB4;LAMB2;NOS2;NFKBIA;AKT1;LDLR;GNAO1;LAMB1;HLA-DQB1
    TuberculosisITGB2L;H2-AB1;CLEC7A;CLEC4M;KSR1;CLEC4E;CALM3;BAD;BCL2
    Hepatitis CPPP2CB;LDLR;BRAF;SOCS3;CLDN16;NFKBIA;NR1H3;IFNA4;IFNA5
    Hepatitis BFADD;TGFB1;APAF1;PIK3CD;PIK3R1;SMAD4;EGR3;PRKCA;IFNA14
    Influenza AMAP2K4;AKT2;FAS;MAPK9;RAE1;HLA-DOA;NXF3;Ccl12;IFNA5
    Pathways in cancerFGF8;FH1;FGFR3;MAPK10;IGF1;MSH2;ARNT;MAP2K2;ITGA2
    Viral carcinogenesisHIST1H2BK;GTF2E1;EP300;PRKACA;ATF4;PKM2;H2-Q10;VDAC3;HDAC1
    Proteoglycans in cancerIGF2;FGF2;PLCG1;RRAS2;PPP1R12A;WNT10B;SMAD2;ARHGEF1;ARHGEF12
    MicroRNAs in cancerPDGFRB;BMF;HOXD10;CCNG1;PIK3R2;UBE2I;TRIM71;DNMT3B;ZEB1
    Colorectal cancerPIK3R2;PIK3CB;MAPK3;MLH1;TGFBR1;TCF7;BCL2;PIK3CD;MSH6
    Renal cell carcinomaARAF;SOS1;RAPGEF1;RAP1B;PTPN11;PIK3CA;VHL;AHA-1;MAPK3
    Pancreatic cancerTP53;NFKB1;RELA;IKBKG;MAPK9;TGFBR2;VEGFA;RAC3;BCL2L1
    Endometrial cancerAKT1;TCF7L2;ERBB2;MLH1;PIK3R2;LEF1;CTNNA2;PIK3CD;BRAF
    GliomaMTOR;PIK3R1;CALML3;SOS1;KRAS;PRKCA;CALM2;CAMK2D;BRAF
    Prostate cancerACTL6B;IKBKG;HSP90AB1;AKT2;PIK3CB;INS1;BAD;RELA;IKBKB
    Thyroid cancerTCF7;TCF7L2;CCND1;LEF1;MAP2K1;TRP53;BRAF;TPR;TP53
    MelanomaFGF3;FGF7;AKT2;IGF1R;PDGFC;AKT1;PDGFB;RB1;NRAS
    Bladder cancerMYC;MAPK3;THBS1;CDH1;ERBB2;DAPK1;EGF;RAF1;MAPK1
    Chronic myeloid leukemiaCTBP2;KRAS;BRAF;PIK3CB;BCL2L1;IKBKB;TP53;NFKBIA;BCR
    Acute myeloid leukemiaIKBKG;TCF7;SPI1;MYC;PIK3CG;RELA;PIK3R1;CEBPA;STAT5B
    Non-small cell lung cancerPIK3R2;RXRA;CCND1;PIK3R5;FOXO3;PLCG1;MAP2K2;ARAF;RARB
    Central carbon metabolism in cancerPTEN;HK1;PIK3R1;RET;PIK3R5;NTRK3;PIK3CG;PDHA1;C12orf5
    Choline metabolism in cancerPDGFB;RAC1;Pdgfa&Pdgfb;PDGFC;PLA2G4A;PPAP2A;MTOR;DGKB;RALGDS

    MAPK1 has several biochemical functions, for example, ATP binding, DNA binding, MAP kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MAPK1 itself. We selected most functions MAPK1 had, and list some proteins which have the same functions with MAPK1. You can find most of the proteins on our site.

    Function Related Protein
    ATP bindingKIFC2;TESK2;ABCD3B;PFKFB2A;EPB42;CARKD;Adcy4;ACTC1A;PEO1
    DNA bindingAHDC1;RAD51L1;FOXE3;POLA1;ASCL1B;VEPH1;NKX2.4B;CRY1;GCM1
    MAP kinase activityMAPK8B;MAPK1;NLK;MAPK7;MAPK12A;MAPK14B;MAPK8A;MAPK11;MAPK12
    RNA polymerase II carboxy-terminal domain kinase activityCDK13;CCNK;CDK9;CDK1;CDK8;CDK7;CDK12;MAPK1
    mitogen-activated protein kinase kinase kinase bindingTRAF2;STK38;MAP3K11;MAP2K1;MAPK8IP3;CDC42;TRAF6;PPEF2;MAPK9
    phosphatase bindingCRY2;CARHSP1;PPP1R37;SYTL2;TPRN;CHCHD3;TRPC4AP;PPP1R18;PPP1R35
    phosphotyrosine bindingGRB2;STAP1;PTPN3;LDLRAP1;MAPK3;FGR;SAMSN1;ZAP70;CBL
    protein bindingSEC31A;PEBP1;MAD2L2;PCNP;R3HDM2;TMEM190;NLGN4Y;COQ9;WBP11
    protein serine/threonine kinase activityPAK1;PBK;RPS6KA2;PIM1;RAF1;NEK8;EIF2AK3;PAK6;SMOK3A
    transcription factor bindingARHGEF2;HDAC7;RNF19A;POU5F1;DACT2;PPP1R13B;C1QBP;PIAS2;SOX8

    MAPK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAPK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAPK1.

    PTPN7; RPS6KA3; DUSP1; MAPK14

    Liszka, L; et al. DUCTAL ADENOCARCINOMA OF THE PANCREAS USUALLY RETAINED SMAD4 AND p53 PROTEIN STATUS AS WELL AS EXPRESSION OF EPITHELIAL-TO-MESENCHYMAL TRANSITION MARKERS AND CELL CYCLE REGULATORS AT THE STAGE OF LIVER METASTASIS. POLISH JOURNAL OF PATHOLOGY 65:100-112(2014).
    Reverchon, M; Bertoldo, MJ; et al. CHEMERIN (RARRES2) Decreases In Vitro Granulosa Cell Steroidogenesis and Blocks Oocyte Meiotic Progression in Bovine Species. BIOLOGY OF REPRODUCTION 90:-(2014).
    • Q&As
    • Reviews

    Q&As (0)

    Ask a question

    Customer Reviews (0)

    Write a review

    Ask a Question for All MAPK1 Products

    Required fields are marked with *

    My Review for All MAPK1 Products

    Required fields are marked with *

    logo

    Stay Updated on the
    Latest Bioscience Trends

    Copyright © 2023 Creative BioMart. All Rights Reserved.

    Terms and Conditions        Privacy Policy