Recombinant Human MAPK1, GST-tagged, Active

• Cat.No.: MAPK1-308H
• Product Overview: Recombinant full-length human ERK2 was expressed byE. coliusing an N-terminal GST tag. MW=68kDa.

Specification

• Cat. No.: MAPK1-308H
• Description: ERK2 is a protein serine/threonine kinase that is a member of the extracellular signal-regulated kinases (ERKs) which are activated in response to numerous growth factors and cytokines. Activation of ERK2 requires both tyrosine and threonine phosphorylation that is mediated by MEK. ERK2 is ubiquitously distributed in tissues with the highest expression in heart, brain and spinal cord. Activated ERK2 translocates into the nucleus where it phosphorylates various transcription factors.
• Source: E. coli.
• Sequence: Full-length.
• Applications: Kinase Assay, Western Blot.
• Storage And Stability: Store product at –70^oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Information

• Gene Name: MAPK1 mitogen-activated protein kinase 1 [ Homo sapiens ]
• Synonyms: MAPK1; mitogen-activated protein kinase 1; ERK; p38; p40; p41; ERK2; ERT1; MAPK2; PRKM1; PRKM2; P42MAPK; p41mapk; p42-MAPK; MAP kinase 2; Mitogen-activated protein kinase 2; Extracellular signal-regulated kinase 2; OTTHUMP00000174492; MAP kinase 2; protein tyrosine kinase ERK2
• Gene ID: 5594
• mRNA Refseq: NM_002745
• Protein Refseq: NP_002736
• MIM: 176948
• UniProt ID: P28482
• Chromosome Location: 22q11.2; 22q11.21
• Pathway: Acute myeloid leukemia; Adherens junction; Alzheimer"s disease; Axon guidance; cell receptor signaling pathway; Bladder cancer; Chemokine signaling pathway; Chronic myeloid leukemia; Dorso-ventral axis formation; Colorectal cancer; Endometrial cancer; ErbB signaling pathway; Fc epsilon RI signaling pathway; Fc gamma R-mediated phagocytosis; Focal adhesion; Gap junction; Glioma; GnRH signaling pathway; Insulin signaling pathway
• Function: ATP binding; MAP kinase 2 activity; mitogen-activated protein kinase kinase kinase binding; nucleotide binding; phosphotyrosine binding; protein binding; protein serine/threonine kinase activity; transferase activity

Reviews

03/24/2022

Whether it be troubleshooting issues, offering experimental guidance, or addressing any concerns, the manufacturer's technical support ensures that researchers have a reliable and knowledgeable resource to rely on.

03/26/2021

In addition to its scientific merits, the manufacturer of MAPK1 protein stands out for its outstanding technical support.

03/11/2020

The company provides a dedicated team of experts who are readily available to assist researchers throughout their experimental journey.

Q&As

Can MAPK1 be used as a biomarker for cancer diagnosis?

MAPK1 expression and activity levels can be used as biomarkers to assess cancer risk and prognosis.

How can MAPK1 be targeted in drug development for non-cancer conditions?

MAPK1 inhibitors are being explored for potential use in non-cancer conditions, such as heart disease and neurodegenerative disorders.

In what other clinical conditions is MAPK1 relevant?

MAPK1 is also implicated in various other diseases, including cardiovascular diseases and neurological disorders.

Are there targeted therapies that inhibit MAPK1 for cancer treatment?

Yes, there are targeted therapies that aim to inhibit MAPK1, especially in cases where MAPK1 is overactive in cancer cells.

Can MAPK1 be used for personalized medicine approaches?

Yes, by assessing the MAPK1 status in a patient's cells, healthcare providers can develop personalized treatment plans.