Recombinant Human MAPK1 Protein, MYC/DDK-tagged, C13 and N15-labeled

• Cat.No.: MAPK1-048H
• Product Overview: MAPK1 MS Standard C13 and N15-labeled recombinant protein (NP_620407) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: This gene encodes a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. One study also suggests that this protein acts as a transcriptional repressor independent of its kinase activity. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene.
• Source: HEK293
• Species: Human
• Tag: Myc&DDK
• Molecular Mass: 41.4 kDa
• AA Sequence: MAAAAAAGAGPEMVRGQVFDVGPRY TNLSYIGEGAYGMVCSAYDNVNKVR VAIKKISPFEHQTYCQRTLREIKIL LRFRHENIIGINDIIRAPTIEQMKD VYIVQDLMETDLYKLLKTQHLSNDH ICYFLYQILRGLKYIHSANVLHRDL KPSNLLLNTTCDLKICDFGLARVAD PDHDHTGFLTEYVATRWYRAPEIML NSKGYTKSIDIWSVGCILAEMLSNR PIFPGKHYLDQLNHILGILGSPSQE DLNCIINLKARNYLLSLPHKNKVPW NRLFPNADSKALDLLDKMLTFNPHK RIEVEQALAHPYLEQYYDPSDEPIA EAPFKFDMELDDLPKEKLKELIFEE TARFQPGYRSTRTRPLEQKLISEED LAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: MAPK1 mitogen-activated protein kinase 1 [ Homo sapiens (human) ]
• Official Symbol: MAPK1
• Synonyms: MAPK1; mitogen-activated protein kinase 1; ERK; ERK-2; ERK2; ERT1; MAPK2; p38; p40; p41; p41mapk; p42-MAPK; P42MAPK; PRKM1; PRKM2; mitogen-activated protein kinase 1; MAP kinase 1; MAP kinase 2; MAPK 2; extracellular signal-regulated kinase 2; mitogen-activated protein kinase 2; protein tyrosine kinase ERK2; EC 2.7.11.24
• Gene ID: 5594
• mRNA Refseq: NM_138957
• Protein Refseq: NP_620407
• MIM: 176948
• UniProt ID: P28482

Reviews

03/24/2022

Whether it be troubleshooting issues, offering experimental guidance, or addressing any concerns, the manufacturer's technical support ensures that researchers have a reliable and knowledgeable resource to rely on.

03/26/2021

In addition to its scientific merits, the manufacturer of MAPK1 protein stands out for its outstanding technical support.

03/11/2020

The company provides a dedicated team of experts who are readily available to assist researchers throughout their experimental journey.

Q&As

Can MAPK1 be used as a biomarker for cancer diagnosis?

MAPK1 expression and activity levels can be used as biomarkers to assess cancer risk and prognosis.

How can MAPK1 be targeted in drug development for non-cancer conditions?

MAPK1 inhibitors are being explored for potential use in non-cancer conditions, such as heart disease and neurodegenerative disorders.

In what other clinical conditions is MAPK1 relevant?

MAPK1 is also implicated in various other diseases, including cardiovascular diseases and neurological disorders.

Are there targeted therapies that inhibit MAPK1 for cancer treatment?

Yes, there are targeted therapies that aim to inhibit MAPK1, especially in cases where MAPK1 is overactive in cancer cells.

Can MAPK1 be used for personalized medicine approaches?

Yes, by assessing the MAPK1 status in a patient's cells, healthcare providers can develop personalized treatment plans.