Recombinant Human MAPK1 Protein, MYC/DDK-tagged, C13 and N15-labeled
Cat.No. : | MAPK1-048H |
Product Overview : | MAPK1 MS Standard C13 and N15-labeled recombinant protein (NP_620407) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells. |
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Description : | This gene encodes a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. One study also suggests that this protein acts as a transcriptional repressor independent of its kinase activity. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene. |
Source : | HEK293 |
Species : | Human |
Tag : | Myc&DDK |
Molecular Mass : | 41.4 kDa |
AA Sequence : | MAAAAAAGAGPEMVRGQVFDVGPRY TNLSYIGEGAYGMVCSAYDNVNKVR VAIKKISPFEHQTYCQRTLREIKIL LRFRHENIIGINDIIRAPTIEQMKD VYIVQDLMETDLYKLLKTQHLSNDH ICYFLYQILRGLKYIHSANVLHRDL KPSNLLLNTTCDLKICDFGLARVAD PDHDHTGFLTEYVATRWYRAPEIML NSKGYTKSIDIWSVGCILAEMLSNR PIFPGKHYLDQLNHILGILGSPSQE DLNCIINLKARNYLLSLPHKNKVPW NRLFPNADSKALDLLDKMLTFNPHK RIEVEQALAHPYLEQYYDPSDEPIA EAPFKFDMELDDLPKEKLKELIFEE TARFQPGYRSTRTRPLEQKLISEED LAANDILDYKDDDDKV |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 3 months from receipt of products under proper storage and handling conditions. |
Storage : | Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
Concentration : | 50 μg/mL as determined by BCA |
Storage Buffer : | 100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
Gene Name : | MAPK1 mitogen-activated protein kinase 1 [ Homo sapiens (human) ] |
Official Symbol : | MAPK1 |
Synonyms : | MAPK1; mitogen-activated protein kinase 1; ERK; ERK-2; ERK2; ERT1; MAPK2; p38; p40; p41; p41mapk; p42-MAPK; P42MAPK; PRKM1; PRKM2; mitogen-activated protein kinase 1; MAP kinase 1; MAP kinase 2; MAPK 2; extracellular signal-regulated kinase 2; mitogen-activated protein kinase 2; protein tyrosine kinase ERK2; EC 2.7.11.24 |
Gene ID : | 5594 |
mRNA Refseq : | NM_138957 |
Protein Refseq : | NP_620407 |
MIM : | 176948 |
UniProt ID : | P28482 |
Products Types
◆ Recombinant Protein | ||
Mapk1-3937M | Recombinant Mouse Mapk1 Protein, Myc/DDK-tagged | +Inquiry |
MAPK1-052H | Recombinant Human MAPK1 Protein, MYC/DDK-tagged, C13 and N15-labeled | +Inquiry |
MAPK1-385H | Recombinant Human MAPK1 Protein, MYC/DDK-tagged | +Inquiry |
MAPK1-2008H | Recombinant Human MAPK1 Protein, GST-tagged | +Inquiry |
MAPK1-7267H | Recombinant Human MAPK1 protein(Met1-Ser360), GST-tagged | +Inquiry |
◆ Lysates | ||
MAPK1-692HCL | Recombinant Human MAPK1 cell lysate | +Inquiry |
MAPK1-001MCL | Recombinant Mouse MAPK1 cell lysate | +Inquiry |
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Not For Human Consumption!
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Customer Reviews (3)
Write a reviewWhether it be troubleshooting issues, offering experimental guidance, or addressing any concerns, the manufacturer's technical support ensures that researchers have a reliable and knowledgeable resource to rely on.
In addition to its scientific merits, the manufacturer of MAPK1 protein stands out for its outstanding technical support.
The company provides a dedicated team of experts who are readily available to assist researchers throughout their experimental journey.
Q&As (5)
Ask a questionMAPK1 expression and activity levels can be used as biomarkers to assess cancer risk and prognosis.
MAPK1 inhibitors are being explored for potential use in non-cancer conditions, such as heart disease and neurodegenerative disorders.
MAPK1 is also implicated in various other diseases, including cardiovascular diseases and neurological disorders.
Yes, there are targeted therapies that aim to inhibit MAPK1, especially in cases where MAPK1 is overactive in cancer cells.
Yes, by assessing the MAPK1 status in a patient's cells, healthcare providers can develop personalized treatment plans.
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