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Recombinant Human MAPK1 Protein, MYC/DDK-tagged

Cat.No. : MAPK1-385H
Product Overview : Recombinant human MAPK1 protein, fused to MYC/DDK tag at C-terminus, was expressed in HEK293.
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Description : This gene encodes a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. One study also suggests that this protein acts as a transcriptional repressor independent of its kinase activity. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene. [provided by RefSeq, Jan 2014].
Source : HEK293
Species : Human
Tag : Myc&DDK
Form : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
Molecular Mass : 41.2 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration : >50 ug/mL as determined by microplate BCA method
Gene Name : mitogen-activated protein kinase 1 [ Homo sapiens ]
Official Symbol : MAPK1
Synonyms : ERK; ERK-2; ERK2; ERT1; MAPK2; p38; p40; p41; p41mapk; p42-MAPK; P42MAPK; PRKM1; PRKM2
Gene ID : 5594
mRNA Refseq : NM_002745.4
Protein Refseq : NP_002736.3
MIM : 176948
UniProt ID : P28482

Not For Human Consumption!

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03/24/2022

    Whether it be troubleshooting issues, offering experimental guidance, or addressing any concerns, the manufacturer's technical support ensures that researchers have a reliable and knowledgeable resource to rely on.

    03/26/2021

      In addition to its scientific merits, the manufacturer of MAPK1 protein stands out for its outstanding technical support.

      03/11/2020

        The company provides a dedicated team of experts who are readily available to assist researchers throughout their experimental journey.

        Q&As (5)

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        Can MAPK1 be used as a biomarker for cancer diagnosis? 12/28/2021

        MAPK1 expression and activity levels can be used as biomarkers to assess cancer risk and prognosis.

        How can MAPK1 be targeted in drug development for non-cancer conditions? 11/03/2021

        MAPK1 inhibitors are being explored for potential use in non-cancer conditions, such as heart disease and neurodegenerative disorders.

        In what other clinical conditions is MAPK1 relevant? 01/12/2020

        MAPK1 is also implicated in various other diseases, including cardiovascular diseases and neurological disorders.

        Are there targeted therapies that inhibit MAPK1 for cancer treatment? 10/27/2018

        Yes, there are targeted therapies that aim to inhibit MAPK1, especially in cases where MAPK1 is overactive in cancer cells.

        Can MAPK1 be used for personalized medicine approaches? 08/19/2017

        Yes, by assessing the MAPK1 status in a patient's cells, healthcare providers can develop personalized treatment plans.

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