MAPK9
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Official Full Name
MAPK9 mitogen-activated protein kinase 9
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Background
Stress-activated Protein Kinases (SAPKs) are strongly activated in response to adverse stimuli such as heat and osmotic shock, UV light and other DNA-damaging reagents, and inhibitors of protein synthesis. They are also activated strongly in response to agonists that are released or produced under conditions of stress, such as proinflammatory cytokines. The SAPK1/jnk family consists of 3 isoforms:SAPK1 alpha/jnk2; SAPK1 beta/jnk3; SAPK1 beta/jnk1. -
Synonyms
MAPK9; mitogen-activated protein kinase 9; PRKM9; JNK2; Jun kinase; p54a; SAPK; MAPK 9; MAP kinase 9; c-Jun kinase 2; c-Jun N-terminal kinase 2; stress-activated protein kinase 1a; stress-activated protein kinase JNK2; JNK2A; JNK2B; JNK-55; SAPK1a; JNK2BETA; p54aSAPK; JNK2ALPHA;
- Involved Pathway
- Protein Function
- Interacting Protein
- MAPK9 Related Signal Pathway
MAPK9 involved in several pathways and played different roles in them. We selected most pathways MAPK9 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAPK9 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| MAPK signaling pathway | MAPK12;CACNA1H;FGF2;FGF11;RAC1B;Fgf15;NTRK2;MAX;MAP2K2A |
| ErbB signaling pathway | RPS6KB2;SOS1;ERBB3B;ABL1;PAK2B;PAK1;AREGB;CAMK2A;PIK3R5 |
| Ras signaling pathway | Pdgfa&Pdgfb;FOXO4;PIK3CG;GAB2;PAK6;FGF3;GRB2;RELA;REL |
| cAMP signaling pathway | BDNF;LIPE;CREB3L3;MAPK9;GABBR1;ACOX1;PDE4C;PIK3CA;ARAP3 |
| FoxO signaling pathway | FOXG1A;AKT2L;RAG2;MAPK14A;GRM1;PIK3R3;TNFSF10;TGFB1A;CDKN1BB |
| Sphingolipid signaling pathway | TNF;PLD1;CERS5;PRKCB;GAB2;RELA;S1PR5;KRAS;ACER1 |
| Protein processing in endoplasmic reticulum | HSP90B1;DNAJC5G;UBQLN4;CAPN2B;TUSC3;MAP2K7;DNAJB1B;BAK1;SAR1B |
| Wnt signaling pathway | SFRP1A;DAAM2;NKD2B;PORCNL;DVL3A;WNT9B;PRKACBB;RAC3B;RAC2 |
| Osteoclast differentiation | LILRA2;PIK3R5;FCGR3B;STAT1;LILRB2;IL1A;TGFBR2;FYN;GAB2 |
| Focal adhesion | PTK2AA;COL24A1;LAMB3;LAMB4;PRKCA;CAPN2A;CAPN2;PTEN;PDGFA |
| Toll-like receptor signaling pathway | IFNA12;MAP2K2B;IFNA6;IL-8;PIK3R3B;CCL3L3;IFNA14;IFNA10;TLR4BB |
| NOD-like receptor signaling pathway | MAPK14A;IL6;RELA;TNF;NLRP1;IL18;NFKBIAA;IL8L2;CASPA |
| RIG-I-like receptor signaling pathway | MAPK14A;Ifna15;MAPK9;TMEM173;MAPK14B;MAPK10;TNF;TRADD;IFNA4 |
| T cell receptor signaling pathway | CDC42;CD3G;MAP2K7;TNF;GRAPA;PPP3CB;PAK7;MAPK13;MAP3K7 |
| Fc epsilon RI signaling pathway | MAP2K2;LCP2;PLA2G4B;MAPK1;AKT1;GAB2;MAPK11;PIK3R3;INPP5D |
| TNF signaling pathway | MAPK3;TRADD;NFKBIA;PIK3R1;MAPK10;MAPK13;IL6;MMP9;ATF4 |
| Neurotrophin signaling pathway | MAPK3;NGFRAP1;ARHGDIB;MAPK7;SHC4;MAPK9;PIK3CD;MAPK12;SH2B1 |
| Retrograde endocannabinoid signaling | MAPK8;PRKCB;GABRG3;SLC17A7;Adcy4;GABRA5;GABRA4;GNG13;PTGS2 |
| Dopaminergic synapse | ITPR3;PPP2R1B;PPP2R3C;PPP2R2D;ITPR1;GNG3;GSK3A;PRKACG;COMT |
| Inflammatory mediator regulation of TRP channels | PRKACG;TRPV4;ASIC1;CYP2C55;PLA2G4D;PIK3CG;PLCB4;CYP2C38;ALOX12E |
| Insulin signaling pathway | PKLR;TRIP10A;INSRA;PPP1R3CA;PYGMA;SOCS3;ACACA;PIK3CA;PPP1CAB |
| GnRH signaling pathway | CALM3A;PRKACG;MAP2K1;CACNA1DA;MAP2K2;MAPK8B;NRAS;RAF1;MAPK9 |
| Progesterone-mediated oocyte maturation | HSP90AA1;CDC23;AKT1;MAD1L1;RAF1;SPDYA;PRKACBB;RPS6KA6;PIK3R2 |
| Prolactin signaling pathway | SOCS3;FOS;GRB2;INS1;MAP2K1;IRF1;SHC2;PPIB;SIRPA |
| Adipocytokine signaling pathway | AKT2L;PCK1;RXRB;RXRGA;IRS4;RXRG;G6PCA.1;G6PC2;PTPN11B |
| Type II diabetes mellitus | ADIPOQ;MAPK1;PIK3CD;SOCS2;SLC2A2;IRS2;PIK3R1;INSR;HKDC1 |
| Insulin resistance | SLC27A1B;MLXIPL;CRTC2;PRKCBB;CD36;PIK3CG;PPP1R3CB;MAPK9;RELA |
| Non-alcoholic fatty liver disease (NAFLD) | NDUFA1;INS1;NDUFC1;NDUFB5;LEP;PPARA;SREBF1;NDUFS5;GSK3B |
| Epithelial cell signaling in Helicobacter pylori infection | CDC42;NFKBIA;RELA;F11R;PTPN11;SRC;IKBKG;ATP6V1C2;PLCG1 |
| Shigellosis | MAPK8;U2AF1L4;PFN4;MAPK13;IKBKG;NFKBIB;ITGB1;RAC1;RELA |
| Salmonella infection | NOS2;ACTB1;IL-8;DYNC1I1;MYD88;MAPK12;MAPK9;TLR5B;WASB |
| Pertussis | IL1A;CASP7;NFKB1;C1QA;MAPK10;C4BPA;TRAF6;C4A;CALM2 |
| Chagas disease (American trypanosomiasis) | IL1B2;NFKB1;PLCB3;GNA15;MAPK10;Il2;PLCB1;PIK3CD;IL-8 |
| Toxoplasmosis | BIRC8;PIK3CB;PIK3CD;IKBKG;HSPA2;IFNGR2;CD40;MAPK12;GNAO1 |
| Tuberculosis | FADD;AKT2;FCGR3B;C3;CEBPG;ATP6V0C;TGFB2;IFNA7;CALM2 |
| Hepatitis C | IFN-a;TLR3;IFNA16;NR1H3;TRADD;OCLN;CLDN15;PIK3R3;NFKBIA |
| Hepatitis B | ELK1;TP53;IFNAR1;PRKCB;DDX3X;IKBKB;Fasl;TNF;RAF1 |
| Influenza A | IL12B;TNFRSF1A;MAP2K1;HLA-DQA2;IL18;BLA;ACTB;NXF3;IFNGR2 |
| Herpes simplex infection | EIF2S1B;MAPK8B;PTPN11A;SRPK1A;HNRPKL;MHC2DEB;JAK2A;SRSF3;TAF3 |
| Epstein-Barr virus infection | HLA-DRB5;PIK3CD;STAT3;PIK3R1;MAPK8;SFPI1;IL10RB;HLA-F;POLR3GL |
| Pathways in cancer | FGF8;EGLN3;CXCL12;RUNX1;MLH1;FH;FZD1;FGF5;RALB |
| Colorectal cancer | PIK3R1;TGFBR1;BAD;ARAF;SMAD4;RHOA;DCC;MSH2;PIK3CA |
| Pancreatic cancer | SMAD3;VEGFA;CDC42;BRAF;TP53;SMAD4;BCL2L1;TGFB3;MAP2K1 |
| Choline metabolism in cancer | SLC22A3;MAP2K2;MAPK10;PRKCG;PPAP2B;SLC44A1;FOS;SLC44A2;WASF3 |
MAPK9 has several biochemical functions, for example, ATP binding, JUN kinase activity, cysteine-type endopeptidase activator activity involved in apoptotic process. Some of the functions are cooperated with other proteins, some of the functions could acted by MAPK9 itself. We selected most functions MAPK9 had, and list some proteins which have the same functions with MAPK9. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | NLRP4C;CAMK2A;HELZ2;MOV10;CDK13;MAPK8B;HSPA8;RAF1B;SMC1AL |
| JUN kinase activity | MAPK9;MAPK8;ALPK2;MAPK10 |
| cysteine-type endopeptidase activator activity involved in apoptotic process | BAD;NLRP1;CARD8;PYCARD;BCL2L13;MAPK9;CASP1;CTSC;CTSH |
| mitogen-activated protein kinase kinase kinase binding | MARVELD3;MAPK9;MAP3K11;MAP4K2;CDC37;TRAF2;MAPK1;MAPK8IP3;MAP2K1 |
| protein binding | TTC23L;PSMD3;KIF22;CNTNAP4;BANF1;MAL2;FBXW7;TMEM171;UBE2G2 |
| transcription factor binding | NKX2-1;RNF4;WWP2;APBB2;PARP1;CD34;AHR;IGHMBP2;TFDP1B |
MAPK9 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAPK9 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAPK9.
ARRB2; ARRB1; WDR62; SF3B4; CEP44
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