Recombinant Human MAPK9 Protein (M1-E364), His tagged
| Cat.No. : | MAPK9-1139H |
| Product Overview : | Recombinant Human 6His-TEV-JNK2(M1-E364) (D3K, C6V, S8N, Q14E, K203A, E204A, K250A, K251A) Protein was expressed in E. coli. |
- Specification
- Gene Information
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| Description : | Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as pro-inflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK9/JNK2. In turn, MAPK9/JNK2 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. In response to oxidative or ribotoxic stresses, inhibits rRNA synthesis by phosphorylating and inactivating the RNA polymerase 1-specific transcription initiation factor RRN3. Promotes stressed cell apoptosis by phosphorylating key regulatory factors including TP53 and YAP1. In T-cells, MAPK8 and MAPK9 are required for polarized differentiation of T-helper cells into Th1 cells. Upon T-cell receptor (TCR) stimulation, is activated by CARMA1, BCL10, MAP2K7 and MAP3K7/TAK1 to regulate JUN protein levels. Plays an important role in the osmotic stress-induced epithelial tight-junctions disruption. When activated, promotes beta-catenin/CTNNB1 degradation and inhibits the canonical Wnt signaling pathway. Participates also in neurite growth in spiral ganglion neurons. Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimer and plays a role in the regulation of the circadian clock. Phosphorylates POU5F1, which results in the inhibition of POU5F1's transcriptional activity and enhances its proteosomal degradation. |
| Source : | E. coli |
| Species : | Human |
| Tag : | His |
| Form : | Liquid |
| Protein Length : | M1-E364 |
| Endotoxin : | < 0.01 EU per μg of the protein |
| Purity : | 90% |
| Stability : | Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade. |
| Storage : | Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
| Storage Buffer : | Supplied as sterile 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol |
| Shipping : | It is shipped out with blue ice. |
| Gene Name : | MAPK9 mitogen-activated protein kinase 9 [ Homo sapiens (human) ] |
| Official Symbol : | MAPK9 |
| Synonyms : | MAPK9; mitogen-activated protein kinase 9; PRKM9; JNK2; Jun kinase; p54a; SAPK; MAPK 9; MAP kinase 9; c-Jun kinase 2; c-Jun N-terminal kinase 2; stress-activated protein kinase 1a; stress-activated protein kinase JNK2; JNK2A; JNK2B; JNK-55; SAPK1a; JNK2BETA; p54aSAPK; JNK2ALPHA; |
| Gene ID : | 5601 |
| mRNA Refseq : | NM_001135044 |
| Protein Refseq : | NP_001128516 |
| MIM : | 602896 |
| UniProt ID : | P45984 |
Products Types
| ◆ Recombinant Protein | ||
| MAPK9-2421H | Recombinant Human MAPK9 Protein, His-tagged | +Inquiry |
| MAPK9-5488H | Recombinant Human Mitogen-Activated Protein Kinase 9 | +Inquiry |
| MAPK9-1138H | Recombinant Human MAPK9 Protein (M1-E364), Tag Free | +Inquiry |
| Mapk9-3948M | Recombinant Mouse Mapk9 Protein, Myc/DDK-tagged | +Inquiry |
| MAPK9-3206H | Recombinant Human MAPK9 protein, His-SUMO-tagged | +Inquiry |
| ◆ Lysates | ||
| MAPK9-4485HCL | Recombinant Human MAPK9 293 Cell Lysate | +Inquiry |
| MAPK9-4486HCL | Recombinant Human MAPK9 293 Cell Lysate | +Inquiry |
| MAPK9-4487HCL | Recombinant Human MAPK9 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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