Recombinant Human MAPK9 Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: MAPK9-2746H
• Product Overview: MAPK9 MS Standard C13 and N15-labeled recombinant protein (NP_620709) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase targets specific transcription factors, and thus mediates immediate-early gene expression in response to various cell stimuli. It is most closely related to MAPK8, both of which are involved in UV radiation induced apoptosis, thought to be related to the cytochrome c-mediated cell death pathway. This gene and MAPK8 are also known as c-Jun N-terminal kinases. This kinase blocks the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells. Studies of this gene's mouse counterpart suggest a key role in T-cell differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported.
• Source: HEK293
• Species: Human
• Tag: Myc&DDK
• Molecular Mass: 48.1 kDa
• AA Sequence: MSDSKCDSQFYSVQVADSTFTVLKR YQQLKPIGSGAQGIVCAAFDTVLGI NVAVKKLSRPFQNQTHAKRAYRELV LLKCVNHKNIISLLNVFTPQKTLEE FQDVYLVMELMDANLCQVIHMELDH ERMSYLLYQMLCGIKHLHSAGIIHR DLKPSNIVVKSDCTLKILDFGLART ACTNFMMTPYVVTRYYRAPEVILGM GYKENVDIWSVGCIMAEMVLHKVLF PGRDYIDQWNKVIEQLGTPSAEFMK KLQPTVRNYVENRPKYPGIKFEELF PDWIFPSESERDKIKTSQARDLLSK MLVIDPDKRISVDEALRHPYITVWY DPAEAEAPPPQIYDAQLEEREHAIE EWKELIYKEVMDWEERSKNGVVKDQ PSDAAVSSNATPSQSSSINDISSMS TEQTLASDTDSSLDASTGPLEGCRT RTRPLEQKLISEEDLAANDILDYKD DDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: MAPK9 mitogen-activated protein kinase 9 [ Homo sapiens (human) ]
• Official Symbol: MAPK9
• Synonyms: MAPK9; mitogen-activated protein kinase 9; PRKM9; JNK2; Jun kinase; p54a; SAPK; MAPK 9; MAP kinase 9; c-Jun kinase 2; c-Jun N-terminal kinase 2; stress-activated protein kinase 1a; stress-activated protein kinase JNK2; JNK2A; JNK2B; JNK-55; SAPK1a; JNK2BETA; p54aSAPK; JNK2ALPHA
• Gene ID: 5601
• mRNA Refseq: NM_139070
• Protein Refseq: NP_620709
• MIM: 602896
• UniProt ID: P45984