MTOR
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Official Full Name
mechanistic target of rapamycin (serine/threonine kinase)
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Overview
The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. The ANGPTL7 gene is located in an intron of this gene. [provided by RefSeq, Sep 2008] -
Synonyms
MTOR; mechanistic target of rapamycin (serine/threonine kinase); FRAP; FRAP1; FRAP2; RAFT1; RAPT1; serine/threonine-protein kinase mTOR; rapamycin target protein 1; mammalian target of rapamycin; rapamycin and FKBP12 target 1; FKBP-rapamycin associated protein; rapamycin associated protein FRAP2; FKBP12-rapamycin complex-associated protein 1; FK506 binding protein 12-rapamycin associated protein 2; FK506-binding protein 12-rapamycin complex-associated protein 1;
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- MTOR Related Signal Pathway
MTOR involved in several pathways and played different roles in them. We selected most pathways MTOR participated on our site, such as ErbB signaling pathway, HIF- signaling pathway, Phospholipase D signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MTOR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| ErbB signaling pathway | PRKCBA;NRG1;PIK3CA;PAK6B;RAF1;CAMK2B1;AKT2L;CAMK2D1;NCK2B |
| HIF- signaling pathway | PLCG1;Trf;PRKCA;PIK3CB;TIMP1;MTOR;NFKB1;EIF4E2;NOX3 |
| Phospholipase D signaling pathway | FYN;GNA12;ARF6;RALGDS;RRAS;MAP2K1;AGTR1A;PLD1;PLCG1 |
| mTOR signaling pathway | VEGFA;PIK3R1;MTOR;EIF4E1C;RRAGD;RPS6KA3;PIK3R5;RPS6KA3B;RB1CC1 |
| PIK-Akt signaling pathway | ITGA6;ITGA5;PDGFRA;LPAR6;IFNA21;IL7;PPP2R5A;MAP2K1;IL2RA |
| AMPK signaling pathway | ACACA;PPP2R5A;FOXO3;RPS6KB2;ADIPOQ;PPP2R5E;CRTC2;Scd1;CCND1 |
| Jak-STAT signaling pathway | IL20RA;IFNA13;IFNA7;LIF;PRP2;Ifnl2;STAT1;IFNL3;IL23R |
| Insulin signaling pathway | CALM2A;SOCS4;TSC1;PDPK1B;FBP2;PRKAG1;PDPK1;PIK3R3;SOS1 |
| Thyroid hormone signaling pathway | TP53;NCOR1;STAT1;MED1;MAP2K1;TBC1D4;TSC2;MED14;FXYD2 |
| Adipocytokine signaling pathway | ACACB;ACSBG2;NFKB1;TNFRSF1A;LEP;PPARAB;PRKAA2;RXRGA;STAT3 |
| Type II diabetes mellitus | PRKCD;INS-IGF2;SOCS1;PIK3CD;HK3;INSR;IRS2;IRS1;INS2 |
| Insulin resistance | PRKCDA;TNF;MLXIPL;MAPK9;TNFRSF1A;MAPK8A;IKBKB;MAPK8;PPARA |
| Pathways in cancer | FGF6;ARHGEF12;CASP9;WNT7B;NOS2;RET;CSF1R;TRAF2;FZD5 |
| Proteoglycans in cancer | CAV1;IGF1;PLCG2;ROCK2;IGF1R;TP53;PRKCB;HRAS;GAB1 |
| MicroRNAs in cancer | ZFPM2;PTEN;EZR;NOTCH4;ERBB2;BMF;HOXD10;NOTCH2;SOS1 |
| Glioma | RB1;PIK3CG;CAMK2G;HRAS;PDGFRB;MAP2K1;SHC3;PIK3R5;CAMK2A |
| Prostate cancer | SMARCD1;KRAS;PIK3R3;MTOR;PDGFD;PIK3R2;FGFR1;TP53;TCF7 |
| Acute myeloid leukemia | EIF4EBP1;CEBPA;PIK3R5;RPS6KB1;GRB2;BRAF;KIT;TCF7;SPI1 |
| Central carbon metabolism in cancer | IDH1;FGFR1;PDK1;PIK3R2;TP53;PDHB;PIK3R5;NRAS;PIK3CD |
| Choline metabolism in cancer | PLD1;PLA2G4C;TSC2;SLC22A2;PIK3CG;CHKA;PRKCB;RPS6KB2;PRKCG |
MTOR has several biochemical functions, for example, ATP binding, RNA polymerase III type 1 promoter DNA binding, RNA polymerase III type 2 promoter DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MTOR itself. We selected most functions MTOR had, and list some proteins which have the same functions with MTOR. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | MAT2A;ABCC12;NRBP2;NOD1;TEC;DDX3;CSNK1DB;DARS;RUNX2A |
| RNA polymerase III type 1 promoter DNA binding | MTOR;RPTOR;MAF1 |
| RNA polymerase III type 2 promoter DNA binding | RPTOR;MTOR;MAF1 |
| RNA polymerase III type 3 promoter DNA binding | MAF1;RPTOR;MTOR |
| TFIIIC-class transcription factor binding | MTOR;RPTOR |
| drug binding | TOP2A;UGT1A7;CHRNB2;CHKA;ADRB2;FOLR2;PIGC;PYGL;CHRNB4 |
| kinase activity | UCKL1A;PKN1B;PKMA;PDK2B;PKMYT1;BCR;CSF1RA;SBK3;DCLK3 |
| phosphoprotein binding | RRAGA;LRP11;IGF2R;PAFAH1B1;DPYS;GPRIN1;MTOR;CACNB2;APTX |
| protein binding | RNF183;FAM114A1;RPSA;PAX9;DYRK2;RPS26;SPOP;KLB;GPR19 |
| protein dimerization activity | NEUROG1;HNF1A;TFAP2C;OLIG3;HES4;ATP6V1C2;HER2;NCOA3;MXI1 |
| protein domain specific binding | YWHAZ;WNT1;CHMP1B;UNC13A;CHMP2A;WNT3;CASKIN1;VAPA;NCK1 |
| protein serine/threonine kinase activity | CDC42BPG;SYK;SMOK3A;SMG1;MAP2K2A;CSNK1G2A;VRK3;MAPKAPK2;MAP4K4 |
| ribosome binding | ETF1;SEC61B;HSPA5;PPP1R2P9;MTRF1L;CPEB4;ETF1A;EIF2S1A;OLA1 |
MTOR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MTOR here. Most of them are supplied by our site. Hope this information will be useful for your research of MTOR.
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Customer Reviews (3)
Write a reviewWith its reliable performance and consistent results, the MTOR protein provides researchers with the confidence and accuracy required for successful experimentation.
The MTOR protein stands out as a protein of exceptional quality, perfectly suited to meet the experimental needs of researchers.
One remarkable aspect of working with the MTOR protein is the excellent technical support provided by its manufacturer.
Q&As (5)
Ask a questionDysregulation of the MTOR pathway has been linked to various diseases, including cancer, metabolic disorders, and neurological conditions.
Activation of the MTOR pathway can impair the response to immunotherapy by promoting immunosuppressive mechanisms within the tumor microenvironment.
The enhancement of drug efflux pumps, increased repair of DNA damage, and the promotion of cancer stem cell survival are some of the mechanisms by which the MTOR pathway contributes to drug resistance.
Understanding the molecular mechanisms of the MTOR pathway can aid in the development of targeted therapies that specifically inhibit its activity, thereby improving cancer treatment outcomes.
Dysregulation of the MTOR pathway has been linked to metabolic disorders such as obesity, diabetes, and insulin resistance, highlighting its role in metabolic homeostasis.
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