MTOR

  • Official Full Name

    mechanistic target of rapamycin (serine/threonine kinase)

  • Overview

    The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. The ANGPTL7 gene is located in an intron of this gene. [provided by RefSeq, Sep 2008]
  • Synonyms

    MTOR; mechanistic target of rapamycin (serine/threonine kinase); FRAP; FRAP1; FRAP2; RAFT1; RAPT1; serine/threonine-protein kinase mTOR; rapamycin target protein 1; mammalian target of rapamycin; rapamycin and FKBP12 target 1; FKBP-rapamycin associated protein; rapamycin associated protein FRAP2; FKBP12-rapamycin complex-associated protein 1; FK506 binding protein 12-rapamycin associated protein 2; FK506-binding protein 12-rapamycin complex-associated protein 1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Insect Cell
  • Mamanlian cells
  • Mammalian Cell
  • Sf21
  • Wheat Germ
  • Flag
  • Flag|His
  • His
  • His (Fc)
  • Avi
  • Myc
  • His|T7
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MTOR-42H Active Recombinant Human MTOR/RPTOR/MLST8 protein, FLAG/His-tagged Insect Cell Flag/His
Human MTOR-167H Active Recombinant Human MTOR(1362-end) Protein, N-Flag-tagged Sf21 Flag 1362-end
Human MTOR-523H Recombinant Human MTOR Mammalian Cell His
Human MTOR-156H Recombinant Human MTOR, MYC/DDK-tagged HEK293 Myc/DDK
Human MTOR-1820H Recombinant Human MTOR protein, His & T7-tagged E.coli His/T7 Ala2226~Val2488 (Accession # P42345)
Human MTOR-30254TH Recombinant Human MTOR Wheat Germ N/A 100 amino acids
Human MTOR-4068HCL Recombinant Human MTOR 293 Cell Lysate HEK293 N/A
Human MTOR-3539H-B Recombinant Human MTOR Protein Pre-coupled Magnetic Beads HEK293
Human MTOR-4973H Recombinant Human MTOR Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human MTOR-4396H Recombinant Human MTOR protein, His&Myc-tagged E.coli His&Myc 2012-2144aa
Human MTOR-22H Recombinant Human MTOR Protein, GST tagged E.coli
Human MTOR-4164H Recombinant Human MTOR Protein (Phe1720-Ala2020), N-His tagged E.coli N-His Phe1720-Ala2020
Human MTOR-4805HFL Recombinant Full Length Human MTOR, Flag-tagged Mamanlian cells Flag
Human MTOR-3539H Recombinant Human MTOR Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse MTOR-10215M Recombinant Mouse MTOR Protein Mammalian Cell His
Mouse Mtor-25M Recombinant Mouse Mtor protein, His-tagged E.coli His
Mouse Mtor-1798M Recombinant Mouse Mtor Protein, His-tagged E.coli N-His Ala2226-Val2488
Mouse Mtor-4222M Recombinant Mouse Mtor Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse MTOR-5792M Recombinant Mouse MTOR Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse MTOR-5792M-B Recombinant Mouse MTOR Protein Pre-coupled Magnetic Beads HEK293
Rat MTOR-3815R Recombinant Rat MTOR Protein Mammalian Cell His
Rat MTOR-3474R-B Recombinant Rat MTOR Protein Pre-coupled Magnetic Beads HEK293
Rat MTOR-3474R Recombinant Rat MTOR Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish MTOR-4634Z Recombinant Zebrafish MTOR Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource
  • MTOR Related Signal Pathway

MTOR involved in several pathways and played different roles in them. We selected most pathways MTOR participated on our site, such as ErbB signaling pathway, HIF- signaling pathway, Phospholipase D signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MTOR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
ErbB signaling pathwayERBB4A;MAP2K2A;ARAF;PAK7;AREG;MAP2K1;MAP2K4A;KRAS;CAMK2D2
HIF- signaling pathwayRELA;Trf;PRKCA;IFNGR1;HK3;STAT3;NOS2;INS1;CAMK2D
Phospholipase D signaling pathwayGRM6;TSC2;CYTH1;GRB2;PIK3CG;Adcy4;HRAS;SHC4;AVPR2
mTOR signaling pathwayRPTOR;PRKCB;IRS1;PIK3R3;AKT2;ULK1;EIF4E1C;TSC1B;PIK3CG
PIK-Akt signaling pathwayPIK3CB;KRAS;Fasl;EIF4E1B;MLST8;ITGA2;PRL;LPAR5;SOS1
AMPK signaling pathwayCAMKK2;CREB3L4;SCD5;PIK3R3;Scd2;CPT1A;EIF4EBP1;PFKFB2;PPP2R5D
Jak-STAT signaling pathwayIL21;STAT1;EPOR;IFNGR1;IL27RA;NT5C3;TP-1;Il2;IL7R
Insulin signaling pathwayRHOQ;KRAS;PRKAG3;SOS1;RAF1;PPP1R3C;PRKAR1B;HRASA;PPP1R3CB
Thyroid hormone signaling pathwayRHEB;PLCB2;PLCG2;PRKCB;RXRG;KRAS;BMP4;TSC2;RXRB
Adipocytokine signaling pathwayPTPN11A;PRKAG1;JAK2;ACSL1B;LEPR;G6PC;PTPN11B;CAMKK1;AKT2
Type II diabetes mellitusSOCS2;PRKCZ;PDX1;PIK3CB;MAPK1;MTOR;HK1;INS2;MAPK8
Insulin resistancePTEN;NFKBIA;RPS6KA6;PIK3CG;PRKAG3;PRKAB1A;G6PC;PTPN11A;PPP1R3C
Pathways in cancerMTOR;NFKB1;MMP9;PIK3CB;FZD9;EP300;LAMC2;FZD8;PTGER3
Proteoglycans in cancerPTPN6;PTK2;IGF1R;PPP1R12C;TNF;MAP2K2;WNT5B;FGFR1;HSPG2
MicroRNAs in cancerCYP24A1;PDGFRA;SERPINB5;TRIM71;Pdgfa&Pdgfb;PRKCG;HDAC4;RPTOR;PIK3CA
GliomaRAF1;NRAS;PIK3CB;MAPK3;PLCG1;CALML5;BRAF;MAP2K1;PTEN
Prostate cancerTCF7L2;NFKBIA;RAF1;MAP2K2;CASP9;TRP53;CREB3L1;NDRG1;GSK3B
Acute myeloid leukemiaIKBKG;AKT3;MAPK3;STAT3;JUP;TCF7L2;PIK3CB;RUNX1T1;EIF4EBP1
Central carbon metabolism in cancerFGFR1;SLC1A5;PIK3CB;PKM2;AKT2;PFKM;PIK3CG;HK1;RAF1
Choline metabolism in cancerPLCG1;MAPK9;PDGFA;PDGFRB;RAC2;WASF1;EIF4EBP1;PIK3CB;RPS6KB1

MTOR has several biochemical functions, for example, ATP binding, RNA polymerase III type 1 promoter DNA binding, RNA polymerase III type 2 promoter DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MTOR itself. We selected most functions MTOR had, and list some proteins which have the same functions with MTOR. You can find most of the proteins on our site.

Function Related Protein
ATP bindingMELK;TOR1L1;KIF3CB;CHD4A;CAMK2A;TP53;NRBP1;KIF1B;PRKDC
RNA polymerase III type 1 promoter DNA bindingMAF1;RPTOR;MTOR
RNA polymerase III type 2 promoter DNA bindingMTOR;MAF1;RPTOR
RNA polymerase III type 3 promoter DNA bindingMAF1;MTOR;RPTOR
TFIIIC-class transcription factor bindingRPTOR;MTOR
drug bindingCYP4B1;DRD4;SIGMAR1;CHRNB3;CHRNA7;CHRNB4;PYGB;UGT1A7;PPP3CB
kinase activityMAP4K6;LRRK2;PRKCBB;CDK5;AKT3A;PRKAR2AA;CAMK2B1;MKNK2B;PKLR
phosphoprotein bindingAPTX;PITX2;IGF2R;FKBP4;URI1;PKD2;GPRIN1;RB1;LYN
protein bindingARIH1;JAM3B;KRTAP2-3;KHDC1B;SERPINB8;PLOD3;UFD1L;MAP3K2;RPL23
protein dimerization activityPIP;SLC4A11;GRIN2A;MGAA;TWIST1B;MYCH;TFE3B;KIF9;PEX3
protein domain specific bindingESRRA;ERCC1;CHMP1B;NDE1;PTPN11;NR0B2;FAF1;DVL2;HIST1H4J
protein serine/threonine kinase activityFASTK;MAP2K4;SBK1;MAPK14;RIOK1;BMPR2A;MAP2K1;CAMK1GB;ACVR1BA
ribosome bindingEIF2S1A;ERI1;EIF6;EIF2S1B;MTRF1;NARG1;IGHMBP2;SBDS;RPN2

MTOR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MTOR here. Most of them are supplied by our site. Hope this information will be useful for your research of MTOR.

RPTOR

Research Area

Related articles

Knuth, A; Liu, L; et al. Placenta Growth Factor Induces Invasion and Activates p70 during Rapamycin Treatment in Trophoblast Cells. AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY 73:330-340(2015).
Gargalionis, AN; Korkolopoulou, P; et al. Polycystin-1 and polycystin-2 are involved in the acquisition of aggressive phenotypes in colorectal cancer. INTERNATIONAL JOURNAL OF CANCER 136:1515-1527(2015).
  • Reviews
  • Q&As

Customer Reviews (3)

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Reviews
12/27/2020

    With its reliable performance and consistent results, the MTOR protein provides researchers with the confidence and accuracy required for successful experimentation.

    02/16/2019

      The MTOR protein stands out as a protein of exceptional quality, perfectly suited to meet the experimental needs of researchers.

      12/01/2016

        One remarkable aspect of working with the MTOR protein is the excellent technical support provided by its manufacturer.

        Q&As (5)

        Ask a question
        How does dysregulation of the MTOR pathway contribute to the development of certain diseases? 01/01/2022

        Dysregulation of the MTOR pathway has been linked to various diseases, including cancer, metabolic disorders, and neurological conditions.

        How does the MTOR pathway influence the response to immunotherapy in cancer treatment? 04/19/2021

        Activation of the MTOR pathway can impair the response to immunotherapy by promoting immunosuppressive mechanisms within the tumor microenvironment.

        What are the mechanisms through which the MTOR pathway contributes to drug resistance in cancer? 01/24/2020

        The enhancement of drug efflux pumps, increased repair of DNA damage, and the promotion of cancer stem cell survival are some of the mechanisms by which the MTOR pathway contributes to drug resistance.

        How can the knowledge of the MTOR pathway be leveraged to develop novel cancer therapies? 02/28/2019

        Understanding the molecular mechanisms of the MTOR pathway can aid in the development of targeted therapies that specifically inhibit its activity, thereby improving cancer treatment outcomes.

        What are the implications of MTOR pathway dysregulation in metabolic disorders? 08/28/2018

        Dysregulation of the MTOR pathway has been linked to metabolic disorders such as obesity, diabetes, and insulin resistance, highlighting its role in metabolic homeostasis.

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