Recombinant Human MTOR Protein, GST tagged

• Cat.No.: MTOR-22H
• Product Overview: Recombinant Human MTOR Protein with GST tag was expressed in E. coli.

Specification

• Description: The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This kinase is a component of two distinct complexes, mTORC1, which controls protein synthesis, cell growth and proliferation, and mTORC2, which is a regulator of the actin cytoskeleton, and promotes cell survival and cell cycle progression. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. Inhibitors of mTOR are used in organ transplants as immunosuppressants, and are being evaluated for their therapeutic potential in SARS-CoV-2 infections. Mutations in this gene are associated with Smith-Kingsmore syndrome and somatic focal cortical dysplasia type II. The ANGPTL7 gene is located in an intron of this gene.
• Source: E. coli
• Species: Human
• Molecular Mass: 38.4 kDa
• AA Sequence: MSPILGYWKIKGLVQPTRLLLEYLE EKYEEHLYERDEGDKWRNKKFELGL EFPNLPYYIDGDVKLTQSMAIIRYI ADKHNMLGGCPKERAEISMLEGAVL DIRYGVSRIAYSKDFETLKVDFLSK LPEMLKMFEDRLCHKTYLNGDHVTH PDFMLYDALDVVLYMDPMCLDAFPK LVCFKKRIEAIPQIDKYLKSSKYIA WPLQGWQATFGGGDHPPKSDLVPRG SELIRVAILWHEMWHEGLEEASRLY FGERNVKGMFEVLEPLHAMMERGPQ TLKETSFNQAYGRDLMEAQEWCRKY MKSGNVKDLTQAWDLYYHVFRRISK Q
• Purity: > 80% by SDS-PAGE
• Storage: Store it at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Concentration: 2.5 mg/mL
• Storage Buffer: PBS, pH 7.4

Gene Information

• Gene Name: MTOR mechanistic target of rapamycin (serine/threonine kinase) [ Homo sapiens (human) ]
• Official Symbol: MTOR
• Synonyms: MTOR; mechanistic target of rapamycin (serine/threonine kinase); FK506 binding protein 12 rapamycin associated protein 1, FRAP, FRAP1, FRAP2; serine/threonine-protein kinase mTOR; dJ576K7.1 (FK506 binding protein 12 rapamycin associated protein 1); FK506 binding protein 12 rapamycin associated protein 2; FKBP rapamycin associated protein; FKBP12 rapamycin complex associated protein 1; FLJ44809; mammalian target of rapamycin; RAFT1; rapamycin and FKBP12 target 1; rapamycin associated protein FRAP2; rapamycin target protein; RAPT1; rapamycin target protein 1; FKBP-rapamycin associated protein; FKBP12-rapamycin complex-associated protein 1; FK506 binding protein 12-rapamycin associated protein 1; FK506 binding protein 12-rapamycin associated protein 2; FK506-binding protein 12-rapamycin complex-associated protein 1; FRAP; FRAP1; FRAP2
• Gene ID: 2475
• mRNA Refseq: NM_004958
• Protein Refseq: NP_004949
• MIM: 601231
• UniProt ID: P42345

Reviews

12/27/2020

With its reliable performance and consistent results, the MTOR protein provides researchers with the confidence and accuracy required for successful experimentation.

02/16/2019

The MTOR protein stands out as a protein of exceptional quality, perfectly suited to meet the experimental needs of researchers.

12/01/2016

One remarkable aspect of working with the MTOR protein is the excellent technical support provided by its manufacturer.

Q&As

How does dysregulation of the MTOR pathway contribute to the development of certain diseases?

Dysregulation of the MTOR pathway has been linked to various diseases, including cancer, metabolic disorders, and neurological conditions.

How does the MTOR pathway influence the response to immunotherapy in cancer treatment?

Activation of the MTOR pathway can impair the response to immunotherapy by promoting immunosuppressive mechanisms within the tumor microenvironment.

What are the mechanisms through which the MTOR pathway contributes to drug resistance in cancer?

The enhancement of drug efflux pumps, increased repair of DNA damage, and the promotion of cancer stem cell survival are some of the mechanisms by which the MTOR pathway contributes to drug resistance.

How can the knowledge of the MTOR pathway be leveraged to develop novel cancer therapies?

Understanding the molecular mechanisms of the MTOR pathway can aid in the development of targeted therapies that specifically inhibit its activity, thereby improving cancer treatment outcomes.

What are the implications of MTOR pathway dysregulation in metabolic disorders?

Dysregulation of the MTOR pathway has been linked to metabolic disorders such as obesity, diabetes, and insulin resistance, highlighting its role in metabolic homeostasis.