MUC2
-
Official Full Name
mucin 2, oligomeric mucus/gel-forming
-
Overview
Mucins are high molecular weight glycoproteins which constitute the major component of the mucus layer that protects the gastric epithelium from chemical and mechanical aggressions. In humans, at least 14 mucin genes have been identified that code for the -
Synonyms
MUC2; mucin 2, oligomeric mucus/gel-forming; mucin 2, intestinal/tracheal; mucin-2; intestinal mucin-2; mucin-like protein; MLP; SMUC; MUC-2;
- Recombinant Proteins
- Native Proteins
- Human
- Mouse
- Pig
- Rat
- E.coli
- Pig
- Yeast
- GST
- His
- His|SUMO
- N/A
- N
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | MUC2-1515H |
Recombinant Human MUC2 Protein, GST tagged
|
E.coli | GST | ||
| Human | MUC2-285H | Recombinant Human MUC2 protein, His-tagged | E.coli | His | ||
| Human | MUC2-3254H | Recombinant Human MUC2 protein, His-tagged | E.coli | His | 36-240aa |
|
| Human | MUC2-1466H | Recombinant Human MUC2 Protein (36-240 aa), His-tagged | Yeast | His | 36-240 aa |
|
| Human | MUC2-672H | Recombinant Human MUC2 Protein (36-240 aa), His-SUMO-tagged | E.coli | His/SUMO | 36-240 aa |
|
| Human | MUC2-155H | Recombinant Human MUC2 Protein, GST-tagged | E.coli | GST | 4958-5180 aa |
|
| Human | MUC2-4626H | Recombinant Human MUC2 Protein (Ala4770-Ala5169), N-His tagged | E.coli | N-His | Ala4770-Ala5169 |
|
| Mouse | Muc2-689M | Recombinant Mouse Muc2 protein, His-tagged | E.coli | His | Ala27~Asn110 (Accession# Q80Z19) |
|
| Mouse | Muc2-691M | Recombinant Mouse Muc2 protein, His-tagged | E.coli | His | Val1294~Pro1442 (Accession# Q80Z19) |
|
| Mouse | Muc2-690M | Recombinant Mouse Muc2 protein, His-tagged | E.coli | His | Asn652~Glu735 (Accession# Q80Z19) |
|
| Rat | Muc2-1803R | Recombinant Rat Muc2 Protein, His-tagged | E.coli | N-His | Val33-Ala601 |
|
| Pig | MUC2-1146P | Recombinant Pig MUC2 Protein, His-tagged | E.coli | N-His | Val36-Cys351 |
|
| Pig | MUC2-28P | Native Pig Mucin 2 (MUC2) Protein | Pig | N/A |
- Involved Pathway
- Protein Function
- Interacting Protein
- MUC2 Related Articles
MUC2 involved in several pathways and played different roles in them. We selected most pathways MUC2 participated on our site, such as Vibrio cholerae infection, Amoebiasis, which may be useful for your reference. Also, other proteins which involved in the same pathway with MUC2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Vibrio cholerae infection | ATP6V1E1;ATP6V1F;PLCG2;PRKACB;KDELR1;ATP6V1E2;PRKACA;ATP6V0B;ATP6V1A |
| Amoebiasis | IL1B;ARG1;IL12A;PIK3R1;COL4A1;ITGAM;LAMB3;CXCL1;COL5A1 |
MUC2 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MUC2 itself. We selected most functions MUC2 had, and list some proteins which have the same functions with MUC2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | FMNL3;KLKB1;IFI35;PRDM1;CIZ1;ING5;ATG4A;ADRM1;SNX10 |
MUC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MUC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of MUC2.
MLH1; CFTR
- Q&As
- Reviews
Q&As (6)
Ask a questionThe transcriptional regulation of MUC2 protein is regulated by a variety of signaling pathways and transcription factors, including methylation modification in the MUC2 promoter region, and regulation of transcription factors GATA4 and KLF4.
Yes, mutations in the MUC2 protein have been found to be associated with hereditary myxous enteropathy (HM), a rare intestinal disease caused primarily by mutations in the MUC2 protein that result in loss of function of the mucus layer.
MUC2 protein is involved in intestinal immune regulation by influencing intestinal microbes, regulating inflammatory response and antigen presentation, helping to maintain intestinal immune balance.
The shear variant of the MUC2 protein may have an important impact on its mucus layer formation and stability. Different shear variants may affect their adhesion and resistance to degradation.
Abnormal expression and functional defects of the MUC2 protein may lead to increased retention of microorganisms and harmful substances in the intestine, triggering intestinal inflammatory responses such as intestinal mucosal inflammation and destruction of the mucus layer.
By forming a mucus layer, MUC2 protein provides a protective barrier to the gut against harmful microorganisms, toxins and other external irritants from entering the intestinal mucosa.
Customer Reviews (3)
Write a reviewIt was observed that the expression level was high enough to meet the experimental requirements.
The use of this protein found high purity and no significant impurities.
Relatively active and able to efficiently perform the required biological activity experiments.
Ask a Question for All MUC2 Products
Required fields are marked with *
My Review for All MUC2 Products
Required fields are marked with *
