MUC2

  • Official Full Name

    mucin 2, oligomeric mucus/gel-forming

  • Overview

    Mucins are high molecular weight glycoproteins which constitute the major component of the mucus layer that protects the gastric epithelium from chemical and mechanical aggressions. In humans, at least 14 mucin genes have been identified that code for the
  • Synonyms

    MUC2; mucin 2, oligomeric mucus/gel-forming; mucin 2, intestinal/tracheal; mucin-2; intestinal mucin-2; mucin-like protein; MLP; SMUC; MUC-2;

  • Recombinant Proteins
  • Native Proteins
  • Human
  • Mouse
  • Pig
  • Rat
  • E.coli
  • Pig
  • Yeast
  • GST
  • His
  • His|SUMO
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MUC2-1515H Recombinant Human MUC2 Protein, GST tagged E.coli GST
Human MUC2-285H Recombinant Human MUC2 protein, His-tagged E.coli His
Human MUC2-3254H Recombinant Human MUC2 protein, His-tagged E.coli His 36-240aa
Human MUC2-1466H Recombinant Human MUC2 Protein (36-240 aa), His-tagged Yeast His 36-240 aa
Human MUC2-672H Recombinant Human MUC2 Protein (36-240 aa), His-SUMO-tagged E.coli His/SUMO 36-240 aa
Human MUC2-155H Recombinant Human MUC2 Protein, GST-tagged E.coli GST 4958-5180 aa
Human MUC2-4626H Recombinant Human MUC2 Protein (Ala4770-Ala5169), N-His tagged E.coli N-His Ala4770-Ala5169
Mouse Muc2-689M Recombinant Mouse Muc2 protein, His-tagged E.coli His Ala27~Asn110 (Accession# Q80Z19)
Mouse Muc2-691M Recombinant Mouse Muc2 protein, His-tagged E.coli His Val1294~Pro1442 (Accession# Q80Z19)
Mouse Muc2-690M Recombinant Mouse Muc2 protein, His-tagged E.coli His Asn652~Glu735 (Accession# Q80Z19)
Rat Muc2-1803R Recombinant Rat Muc2 Protein, His-tagged E.coli N-His Val33-Ala601
Pig MUC2-1146P Recombinant Pig MUC2 Protein, His-tagged E.coli N-His Val36-Cys351
Pig MUC2-28P Native Pig Mucin 2 (MUC2) Protein Pig N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

MUC2 involved in several pathways and played different roles in them. We selected most pathways MUC2 participated on our site, such as Vibrio cholerae infection, Amoebiasis, which may be useful for your reference. Also, other proteins which involved in the same pathway with MUC2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Vibrio cholerae infectionATP6V1H;SEC61G;ATP6V1A;PDIA4;ATP6V0C;PRKACG;ATP6V1E1;ATP6V0E1;ATP6V1C1
AmoebiasisCTSG;ARG2;SERPINB9;AASS;ITGAM;TLR4;ACTN4;RELA;COL4A1

MUC2 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MUC2 itself. We selected most functions MUC2 had, and list some proteins which have the same functions with MUC2. You can find most of the proteins on our site.

Function Related Protein
protein bindingSLC4A1AP;ACMSD;DOK1;CRLF1;SEC22A;SEPT3;DNAJC28;MRPL11;TAF9

MUC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MUC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of MUC2.

MLH1; CFTR

Research Area

Related articles

Vo, DTN; Nakayama, T; et al. Progression risk assessments of individual non-invasive gastric neoplasms by genomic copy-number profile and mucin phenotype. BMC MEDICAL GENOMICS 8:-(2015).
Cserni, G; et al. Reversed polarity of the glandular epithelial cells in micropapillary carcinoma of the large intestine and the EMA/MUC1 immunostain. PATHOLOGY 46:527-532(2014).
  • Q&As
  • Reviews

Q&As (6)

Ask a question
What is the transcriptional regulation mechanism of MUC2 protein? 12/21/2019

The transcriptional regulation of MUC2 protein is regulated by a variety of signaling pathways and transcription factors, including methylation modification in the MUC2 promoter region, and regulation of transcription factors GATA4 and KLF4.

Are mutations in the MUC2 protein associated with hereditary myxous bowel disease? 10/02/2019

Yes, mutations in the MUC2 protein have been found to be associated with hereditary myxous enteropathy (HM), a rare intestinal disease caused primarily by mutations in the MUC2 protein that result in loss of function of the mucus layer.

What is the role of the MUC2 protein in intestinal immunoregulation? 03/17/2019

MUC2 protein is involved in intestinal immune regulation by influencing intestinal microbes, regulating inflammatory response and antigen presentation, helping to maintain intestinal immune balance.

How does the shear variant of the MUC2 protein affect its function? 01/13/2019

The shear variant of the MUC2 protein may have an important impact on its mucus layer formation and stability. Different shear variants may affect their adhesion and resistance to degradation.

What is the relationship between MUC2 protein and intestinal inflammation? 01/02/2019

Abnormal expression and functional defects of the MUC2 protein may lead to increased retention of microorganisms and harmful substances in the intestine, triggering intestinal inflammatory responses such as intestinal mucosal inflammation and destruction of the mucus layer.

How does MUC2 protein function in the intestinal mucosal barrier? 01/02/2019

By forming a mucus layer, MUC2 protein provides a protective barrier to the gut against harmful microorganisms, toxins and other external irritants from entering the intestinal mucosa.

Customer Reviews (3)

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Reviews
11/10/2020

    It was observed that the expression level was high enough to meet the experimental requirements.

    05/08/2020

      The use of this protein found high purity and no significant impurities.

      01/31/2020

        Relatively active and able to efficiently perform the required biological activity experiments.

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