OLIG2

  • Official Full Name

    oligodendrocyte lineage transcription factor 2

  • Overview

    This gene encodes a basic helix-loop-helix transcription factor which is expressed in oligodendroglial tumors of the brain. The protein is an essential regulator of ventral neuroectodermal progenitor cell fate. The gene is involved in a chromosomal translocation t(14;21)(q11.2;q22) associated with T-cell acute lymphoblastic leukemia. Its chromosomal location is within a region of chromosome 21 which has been suggested to play a role in learning deficits associated with Down syndrome.
  • Synonyms

    OLIG2; oligodendrocyte lineage transcription factor 2; oligodendrocyte transcription factor 2;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • SUMO
  • Myc
  • DDK
  • N/A
  • T7|His
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human OLIG2-28318TH Active Recombinant Human OLIG2, GST-tagged Wheat Germ GST
Human OLIG2-185H Recombinant Human OLIG2 protein, T7/His-tagged E.coli T7/His
Human OLIG2-38H Recombinant Human OLIG2, GST-tagged E.coli GST
Human OLIG2-1248HCL Recombinant Human OLIG2 cell lysate N/A
Human OLIG2-1769HFL Recombinant Full Length Human OLIG2 Protein, C-Flag-tagged Mammalian cells Flag
Human OLIG2-3842H Recombinant Human OLIG2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human OLIG2-4438H Recombinant Human OLIG2 protein, His-SUMO-tagged E.coli His-SUMO
Human OLIG2-353HF Active Recombinant Full Length Human OLIG2 Protein, GST-tagged In Vitro Cell Free System GST
Human OLIG2-1578H Recombinant Human OLIG2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human OLIG2-1578H-B Recombinant Human OLIG2 Protein Pre-coupled Magnetic Beads HEK293
Mouse Olig2-4590M Recombinant Mouse Olig2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Zebrafish OLIG2-9574Z Recombinant Zebrafish OLIG2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • OLIG2 Related Articles
  • OLIG2 Related Research Area

OLIG2 involved in several pathways and played different roles in them. We selected most pathways OLIG2 participated on our site, such as Neural Crest Differentiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with OLIG2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Neural Crest DifferentiationZIC1;DCT;TXLNB;HEY2;CDH6;TBX6;ASCL1;CDH7;PMP22

OLIG2 has several biochemical functions, for example, DNA binding, HMG box domain binding, protein homodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by OLIG2 itself. We selected most functions OLIG2 had, and list some proteins which have the same functions with OLIG2. You can find most of the proteins on our site.

Function Related Protein
DNA bindingZNF43;RPS15;NFE2L1A;KDM5B;ZIC4;RABGEF1;MYCLA;ZNF296;ZFP668
HMG box domain bindingPAX3;MEOX1;GATA3;CEBPA;POU3F3;DLX5;HOXA3;EGR2;SP1
protein homodimerization activityUGT1A9;DMRT1;PEX7;FOXP2;PRLR;CAMK2A;HELT;OXCT1;ASNSD1
transcription factor activity, RNA polymerase II distal enhancer sequence-specific bindingT;MEF2A;NR5A2;ATF1;SOX7;MITF;NKX2-1;SOX9;TEAD2

OLIG2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with OLIG2 here. Most of them are supplied by our site. Hope this information will be useful for your research of OLIG2.

Stanton, GB; Kohler, SJ; et al. Cytogenesis in the Adult Monkey Motor Cortex: Perivascular NG2 Cells Are the Major Adult Born Cell Type. JOURNAL OF COMPARATIVE NEUROLOGY 523:849-868(2015).
Olausson, KH; Maire, CL; et al. Prominin-1 (CD133) Defines Both Stem and Non-Stem Cell Populations in CNS Development and Gliomas. PLOS ONE 9:-(2014).
  • Q&As
  • Reviews

Q&As (7)

Ask a question
How does OLIG2 (Oligodendrocyte Transcription Factor 2) regulate the development and maturation of oligodendrocytes? 09/23/2022

OLIG2 is essential for the development and maturation of oligodendrocytes, which form myelin in the nervous system.

What is the impact of OLIG2 on the pathogenesis of gliomas and other brain tumors? 02/03/2021

OLIG2 is implicated in the development of gliomas, influencing tumor cell differentiation and growth.

What role does OLIG2 play in neural stem cell differentiation, particularly in the central nervous system? 06/05/2020

OLIG2 plays a crucial role in directing neural stem cells to differentiate into oligodendrocytes and neurons in the CNS.

How does OLIG2 influence neuronal and glial cell interactions during brain development? 12/11/2019

OLIG2 affects interactions between neurons and glial cells, essential for proper brain development.

How do alterations in OLIG2 expression or function affect neurodevelopmental disorders? 06/05/2019

Changes in OLIG2 can lead to neurodevelopmental disorders due to altered brain cell development and function.

How does OLIG2 contribute to the repair and regeneration of myelin in demyelinating diseases? 04/21/2018

OLIG2 contributes to myelin repair and regeneration, crucial in demyelinating diseases like multiple sclerosis.

What are the mechanisms by which OLIG2 modulates gene expression in neurodevelopmental processes? 01/09/2018

OLIG2 modulates gene expression, guiding key neurodevelopmental processes and cell fate decisions.

Customer Reviews (3)

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Reviews
01/24/2019

    Swift protein sequencing, invaluable for protein identification.

    07/05/2018

      Consistent western blot results, a lab necessity for us.

      05/26/2018

        Great protein crystallization service, vital for structural biology studies.

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